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Wyświetlanie 1-4 z 4
Tytuł:
Przemoc domowa a możliwości pomocy pokrzywdzonym
The domestic violence − the possibilities of help the victims
Autorzy:
Bzowska, Monika
Powiązania:
https://bibliotekanauki.pl/articles/38913241.pdf
Data publikacji:
2008
Wydawca:
Katolicki Uniwersytet Lubelski Jana Pawła II. Towarzystwo Naukowe KUL
Tematy:
Niebieska Karta
Ogólnopolskie Pogotowie dla Ofiar Przemocy w Rodzinie
ośrodki pomocy dla osób dotkniętych przemocą domową
Państwowa Agencja Rozwiązywania Problemów Alkoholowych (PARPA)
patologia społeczna
punkt konsultacyjny dla osób w sytuacji kryzysowej i ofiar przemocy w rodzinie
rodzina z problemem alkoholowym
telefon zaufania
the Blue Card
the National Network for the Domestic Violence Victims
the centres of the domestic violence victims' assistance
The National Alcohol Problem Solving Agency
the social pathology
the consulting crisis intervention point for the domestic violence victims
the family with the alcohol problem
the trust phone
Opis:
The domestic violence called the family violence is any kind of the deliberate behaviour connected with the taking advantage from the force predomination directed against the family member which violates the family member's rights and results in physical and psychical suffering. The violence is a kind of pathology. Simultaneously, the domestic violence is a crime, but most of its victims are not aware of the fact that this behavior pattern is rooted in their families. They allowed to be abused as well as they permit the child abuse and treat it as normal. The examinations conducted amongst the domestic violence victims show that the victims act unconsciously according to the stereotypes and thought schemes repeated from generation to generation. There are many forms and methods of the violence victims’ assistance, but the efficiency most of all depends on the reaction time of the adequate services and their assistance. Therefore, the construction of the assistance net for the domestic violence victims is so crucial. The net should react in the adequate way as soon as it is possible. There must be the change in the society attitude towards the specialists helping the domestic violence victims as well as the change in the victims attitude. Only then the full success in carrying help to the domestic violence victims will be possible.
Źródło:
Roczniki Wydziału Nauk Prawnych i Ekonomicznych KUL; 2008, 4, 1; 87-96
1896-6365
Pojawia się w:
Roczniki Wydziału Nauk Prawnych i Ekonomicznych KUL
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Structure and functions of tumor necrosis factor-α converting enzyme.
Autorzy:
Mężyk, Renata
Bzowska, Monika
Bereta, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1043435.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
secretase
shedding
TNFα
TACE
ADAM family
Opis:
Tumor necrosis factor-α converting enzyme (TACE) is the first described and best characterized secretase. In this review the structure and the possible roles for TACE are summarized. The substrate specificity and the regulation of TACE activity as well as redundancy and possible cooperations of distinct secretases are also discussed.
Źródło:
Acta Biochimica Polonica; 2003, 50, 3; 625-645
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antibody-based antiangiogenic and antilymphangiogenic therapies to prevent tumor growth and progression
Autorzy:
Bzowska, Monika
Mężyk-Kopeć, Renata
Próchnicki, Tomasz
Kulesza, Małgorzata
Klaus, Tomasz
Bereta, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1039514.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
monoclonal antibodies
antiangiogenic therapy
antilymphangiogenic therapy
VEGF- A
VEGF-C
VEGF-D
Opis:
Blood and lymphatic vessel formation is an indispensable factor for cancer progression and metastasis. Therefore, various strategies designed to block angiogenesis and lymphangiogenesis are being investigated in the hope to arrest and reverse tumor development. Monoclonal antibodies, owing to their unequalled diversity and specificity, might be applied to selectively inhibit the pathways that cancer cells utilize to build up a network of blood vessels and lymphatics. Among the possible targets of antibody-based therapies are proangiogenic and prolymphangiogenic growth factors from the VEGF family and the receptors to which they bind (VEGFRs). Here, we present molecular mechanisms of angiogenesis and lymphangiogenesis exploited by tumors to progress and metastasise, with examples of antibody-based therapeutic agents directed at interfering with these processes. The expanding knowledge of vascular biology helps to explain some of the problems encountered in such therapies, that arise due to the redundancy in signaling networks controlling the formation of blood and lymphatic vessels, and lead to tumor drug resistance. Nonetheless, combined treatments and treatments focused on newly discovered proangiogenic and prolymphangiogenic factors give hope that more prominent therapeutic effects might be achieved in the future.
Źródło:
Acta Biochimica Polonica; 2013, 60, 3; 263-275
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exogenous nitric oxide inhibits shedding of ADAM17 substrates
Autorzy:
Bzowska, Monika
Stalińska, Krystyna
Mężyk-Kopeć, Renata
Wawro, Karolina
Duda, Katarzyna
Das, Sudipta
Bereta, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1040593.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
shedding
ADAM17
TNF receptor 1
TNF
nitric oxide
Opis:
Both ADAM17, the secretase responsible for the shedding of ectodomains of numerous membrane proteins including TNF and its receptors, as well as nitric oxide synthesized by inducible nitric oxide synthase play regulatory roles in inflammation and tumor progression. We analyzed the effect of endogenous and exogenous nitric oxide on the expression and activity of ADAM17 in murine endothelial cells and a monocyte/macrophage cell line. We found that endogenous nitric oxide influenced neither ADAM17 mRNA level nor the shedding of two ADAM17 substrates, TNF and TNFR1. Exogenous NO significantly diminished the release of TNF and TNFR1 without affecting the ADAM17 transcript level. Our data seem contrary to a previous report that showed the activation of ADAM17 by nitric oxide (Zhang et al., 2000, J Biol Chem 275: 15839-15844). We discuss potential mechanisms of NO-mediated inhibition of ectodomain shedding and possible reasons of discrepancy between our results and the previous report.
Źródło:
Acta Biochimica Polonica; 2009, 56, 2; 325-335
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-4 z 4

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