- Tytuł:
- Distribution of Calretinin-Immunoreactive Interneurons in Dorsal Part of Hippocampus in Animal Model of Depression
- Autorzy:
-
Nowak, Barbara
Braniewska, Alicja
Zadrożna, Monika - Powiązania:
- https://bibliotekanauki.pl/articles/1033787.pdf
- Data publikacji:
- 2012
- Wydawca:
- Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
- Tematy:
-
bulbectomy
calretinin
hippocampus
interneuron - Opis:
- Calretinin-containing (CR+) GABAergic neurons in the dorsal part of hippocampal formation (HF), including the subi-culum, Cornu Ammonis (CA1-4), and dentate gyrus (DG) were visualized with immunocytochemistry. General distribution of CR+ cells was similar in each studying group. Olfactory bulbectomy caused significant increase in CR+ density in stratum oriens of CA1 and stratum moleculare of suprapyramidal blade of DG (three times, p<0.05 and twice, p=0.05, respectively), and tendency to increase in majority of other sub-regions of HF. CR+ cells were generally resistant to administration of amitriptyline as an antidepressant following bulbectomy, although the tendency of increase in CR+ cell density can be observed in CA1. Our findings indicate CR+ neurons site-specific response to bulbectomy model of depression. This could involve the trisynaptic pathway and temporo-ammonic tract by controlling other interneurons terminating on different compartments of principal cells.
- Źródło:
-
Medicina Internacia Revuo; 2012, 25, 99; 35-40
0465-5435 - Pojawia się w:
- Medicina Internacia Revuo
- Dostawca treści:
- Biblioteka Nauki
Artykuł