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    Tytuł:
    Cancer therapeutics strategy using nano-carrier mediated natural drugs
    Autorzy:
    Shaw, S.
    Singh, P.
    Mishra, R.
    Singh, R.
    Nayak, R.
    Bose, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/2201053.pdf
    Data publikacji:
    2022
    Wydawca:
    Stowarzyszenie Komputerowej Nauki o Materiałach i Inżynierii Powierzchni w Gliwicach
    Tematy:
    breast cancer
    porous silicon nanocarrier
    quercetin
    nucleolin
    targeted therapy
    rak piersi
    krzem porowaty
    nanonośniki
    kwercetyna
    terapia celowana
    Opis:
    Purpose Nucleolin is a multifactorial protein, having a significant role in chromatin remodelling, mRNA stability, ribosome biogenesis, stemness, angiogenesis, etc., thus, it is potential therapeutic target in cancer. The purpose of this paper is to study porous silicon (pSi) nanocarrier-based natural drug delivery system targeting dysregulated nucleolin expression for cancer therapeutics. Design/methodology/approach Quercetin was loaded in pre-synthesized and characterized pSi nanoparticles, and release kinetics was studied. The study compared the inhibitory concentration (IC50) of quercetin, synthetic drug doxorubicin, and quercetin-loaded pSi nanoparticles. Further, mRNA expression of a target gene, nucleolin, was tested with a quercetin treated breast cancer cell line (MCF-7). Findings Quercetin-loaded pSi nanoparticles followed first-order release kinetics. IC50 was determined at concentrations of 312 nM, 160 µM, and 50 µM against doxorubicin, quercetin, and quercetin-loaded pSi nanoparticles, respectively. The results further indicated 16-fold downregulation of nucleolin mRNA expression after 48h of quercetin treatment of exponentially growing MCF-7 cells. Research limitations/implications Whether pSi nanoparticle loaded quercetin can significantly downregulate nucleolin protein expression and its impact on apoptosis, cell proliferation, and angiogenic pathways need further investigation. Practical implications The practical application of the proposed nanocarrier-based drug delivery system potentially lays out a path for developing targeted therapy against nucleolin-dysregulated cancer using natural products to minimize the side effects of conventional chemotherapeutic drugs. Originality/value Inhibition of nucleolin and nucleolin regulated pathways using natural compounds and its targeted delivery with nanocarrier is not yet done.
    Źródło:
    Journal of Achievements in Materials and Manufacturing Engineering; 2022, 114, 1; 32--41
    1734-8412
    Pojawia się w:
    Journal of Achievements in Materials and Manufacturing Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Seismic and non-seismic soft-sediment deformation structures in the Proterozoic Bhander Limestone, central India
    Autorzy:
    Sarkar, S.
    Choudhuri, A.
    Banerjee, S.
    Van Loon, A. J.
    Bose, P. K.
    Powiązania:
    https://bibliotekanauki.pl/articles/94668.pdf
    Data publikacji:
    2014
    Wydawca:
    Uniwersytet im. Adama Mickiewicza w Poznaniu
    Tematy:
    seismites
    soft-sediment deformation structures
    basin subsidence
    Proterozoic
    India
    sejsmity
    struktury deformacji
    osady miękkie
    proterozoik
    Indie
    Opis:
    Numerous soft-sediment deformation structures occur within the Proterozoic Bhander Limestone of an intracratonic sag basin in a 750 m long section along the Thomas River, near Maihar, central India. Part of these deformation structures have most probably a non-seismic origin, but other structures are interpreted as resulting from earthquake-induced shocks. These seismic structures are concentrated in a 60 cm thick interval, which is interpreted as three stacked seismites. These three seismites are traceable over the entire length of the section. They divide the sedimentary succession in a lower part (including the seismites) deposited in a hypersaline lagoon, and an upper open-marine (shelf) part. Most of the soft-sediment deformations outside the seismite interval occur in a lagoonal intraclastic and muddy facies association. The SSDS within the seismite interval show a lateral continuity. They record simultaneous fluidisation and liquefaction. The bases of each of the three composing seismite bands are defined by small-scale shear folds, probably recording an earthquake and aftershocks. The presence of the three seismite bands at the boundary between the lagoonal and the overlying open-marine oolitic facies association suggests that the seismic event also triggered basin subsidence.
    Źródło:
    Geologos; 2014, 20, 2; 89-103
    1426-8981
    2080-6574
    Pojawia się w:
    Geologos
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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