- Tytuł:
- Searching for anti-glioma activity. Ribonucleoside analogues with modifications in nucleobase and sugar moieties
- Autorzy:
-
Framski, Grzegorz
Wawrzyniak, Dariusz
Jahnz-Wechmann, Zofia
Szymanska-Michalak, Agnieszka
Kraszewski, Adam
Barciszewski, Jan
Boryski, Jerzy
Stawinski, Jacek - Powiązania:
- https://bibliotekanauki.pl/articles/1038738.pdf
- Data publikacji:
- 2016
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
ribonucleoside analogues
anti-glioblastoma activity
anticancer ribonucleotides - Opis:
- Several ribonucleoside analogues with modifications in the nucleobase and sugar moiety have been screened for anti-glioma activity in the T98G glioma cell line using cervical (HeLa) cell line as reference human malignant cells, and lung fibroblast (MCR-5) cell line as non-cancerous reference cells. Among the investigated compounds, ribonucleosides containing 6-chloropurine (3), 7-guanine (5) and a pyrrolopyrimidine (18) as nucleobases, show promising anti-glioma activity with good selectivity indices, and can be considered as lead structures for further anti-cancer studies.
- Źródło:
-
Acta Biochimica Polonica; 2016, 63, 4; 765-771
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł