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Wyświetlanie 1-2 z 2
Tytuł:
Bufadienolides - natural, biologically active compounds for medicines and cosmetics. A review.
Autorzy:
Szymczak, Kamil
Bonikowski, Radosław
Powiązania:
https://bibliotekanauki.pl/articles/24200472.pdf
Data publikacji:
2023
Wydawca:
Politechnika Łódzka. Wydawnictwo Politechniki Łódzkiej
Tematy:
bufadienolides
Bufo
Kalanchoe
natural cosmetics
medicine
ethnomedicine
bufadienolidy
kosmetyki naturalne
medycyna
etnomedycyna
Opis:
Toad skin secretions are a rich source of various biologically active compounds, such as alkaloids, bufadienolides, biogenic amines, or peptides. Also plants from Hyacinthaceae and Crassulaceae can be a potent source of these groups of molecules. These compounds play a crucial role in amphibians’ and plants’ physiology such as defense against predators or pathogenic microorganisms. Among them, bufadienolides are the focus of many researches in recent years. These molecules have a very interesting, steroidal chemical structure and have potent activity at the cellular level. They possess cardiotonic, antiviral, antibacterial, antitumor, anti-inflammatory, hemostatic, bacteriostatic, wound-healing, and antiparasitic properties. Although the structures of about 500 bufadienolides are known, it is strongly suggested that this group of compounds is still very poorly examined. Moreover, bufadienolides may be an excellent basis for the chemical synthesis of new drugs with selective bioactivity. The aim of this paper is to briefly overview bufadienolides as potent compounds for medicines and cosmetics.
Źródło:
Biotechnology and Food Science; 2023, 85, 1; 3--15
2084-0136
2299-6818
Pojawia się w:
Biotechnology and Food Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exhaled volatile organic compounds (VOCs) for prediction of asthma exacerbation in children
Autorzy:
Gmachowska, Katarzyna
Podlecka, Daniela
Bonikowski, Radosław
Majak, Paweł
Kapka, Karolina
Jerzyńska, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/45905286.pdf
Data publikacji:
2024-09-10
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
children
asthma
atopy
lung function tests
asthma monitoring
VOCs
Opis:
Objectives To find possible relationship between asthma exacerbation and metabolomic profile of airways, assessed by non-invasive method – free volatile organic compounds (VOCs) in exhaled air in children. Material and Methods The study included 80 children aged 4–18 years with asthma: 42 children with a min. 3 asthma exacerbations in the past 12 months, and 38 children without a history of exacerbations in the past year. During the study visit, each patient was examined, medical history (including information regarding atopy and eosinophil blood count) was taken, spirometry and fractional exhaled nitric oxide (FeNO) were tested, an exhaled air sample was taken to test for the presence of VOCs, and the patient also completed standardized form – Asthma Control Questionnaire. Volatile organic compounds were measured by combined gas chromatography coupled to mass spectrometry. Results The obtained results of VOCs were correlated with the history of the disease. The 2 gas profiles were defined and they formed 2 clinically distinct clusters (p = 0.085). Cluster 2 was characterized for children with a higher number of bronchial asthma exacerbations and worse lung function parameters (predicted percentage forced expiratory volume in 1 s [FEV1] [p = 0.023], FEV1/ forced vital capacity ratio [FVC] [p = 0.0219]). The results were independent of the age, sex, BMI, atopy (house dust mite allergy) and eosinophil blood count. Conclusions The study findings suggest that a relative group of gases may be a useful predictor of having asthma exacerbations in children. Additionally, a single FeNO value was unlikely to be clinically useful in predicting asthma exacerbations in children. The VOCs profile reflecting the metabolism of the airway epithelium and local microbiota was associated with the course of asthma, which strongly justifies further prospective validation studies.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2024, 37, 3; 351-359
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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