Autor: Boncler, Magdalena - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Znaczenie uwarunkowań genetycznych w dysfunkcjach układu hemostazy w cukrzycy - potencjalne czynniki ryzyka powikłań naczyniowych
Significance of genetic po lymorphisms in haemostatic dysfunctions in diabetes mellitus - potential risk factors of vascular complications
Autorzy:: Watała, Cezary
Boncler, Magdalena
Różalski, Marcin
Powiązania:: https://bibliotekanauki.pl/articles/945055.pdf
Data publikacji:: 1999
Wydawca:: Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Opis:: The unambiguous determination of etiopathogenetic factors underlying the increased risk of vascular disease in diabetic patients remains to be established. Evidence accumulated hitherto points that such an increased risk might be a constellation of metabolic disorders and genetic background. Thus, the impairments in coagulation and fibrinolysis, which are believed to partly result from metabolic disorders encountered in diabetes, and genetic factors might be compounding in predisposing a diabetic individual to develop the late diabetic sequelae sooner. The role of the latter seems superior with respect to some dysfunctions in haemostasis. Hence, the monitoring of the frequency and distribution of genetic polymorphisms of selected haemostatic proteins might be promising in an attempt to define the reasons of altered haemostatic imbalance in patients with diabetes mellitus. Based on such a knowledge one could discriminate the groups of patients with high risk for the development of vascular disease, in whom pharmacological strategy to attenuate haemostatic impairments would be desirable.
Źródło:: Acta Universitatis Lodziensis. Folia Biochimica et Biophysica; 1999, 14
0208-614X
Pojawia się w:: Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Regulation of cell function by isoforms of C-reactive protein: A comparative analysis
Autorzy:: Boncler, Magdalena
Watała, Cezary
Powiązania:: https://bibliotekanauki.pl/articles/1040607.pdf
Data publikacji:: 2009
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: inflammation
native CRP
atherosclerosis
modified CRP
C-reactive protein
Opis:: Despite the emerging evidence suggesting a proatherogenic role of C-reactive protein (CRP) in atherosclerosis, the contribution of CRP in pathogenesis of atherosclerosis and atherothrombosis has not been unequivocally defined. The role of CRP in pathophysiology/pathology seems to largely depend on its structure. Two CRP isoforms, the native pentameric and the modified monomeric one, differ substantially in their physiological functions, which is thought to origin from the considerable structural heterogeneity of the CRP molecule. The present review provides an overview of the experimental evidence with relevance to the clinical role(s) of various CRP isoforms. The biological role of the protein, its structure and distribution are discussed with particular emphasis on the diverse properties of the pentameric and monomeric forms of CRP. Some methodological aspects, related to experimental models and techniques of CRP preparation, are also critically reviewed.
Źródło:: Acta Biochimica Polonica; 2009, 56, 1; 17-31
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Inhibition of collagen-induced platelet reactivity by DGEA peptide.
Autorzy:: Luzak, Boguslawa
Golanski, Jacek
Rozalski, Marcin
Boncler, Magdalena
Watala, Cezary
Powiązania:: https://bibliotekanauki.pl/articles/1043398.pdf
Data publikacji:: 2003
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: collagen
platelet receptor antagonists
collagen receptors
GPIaIIa
DGEA
platelet reactivity
Opis:: Direct interactions between collagen, the most thrombogenic component of the extracellular matrix, and platelet surface membrane receptors mediate platelet adhesion and induce platelet activation and aggregation. In this process two glycoproteins are crucial: integrin α2β1, an adhesive receptor, and GPVI, which is especially responsible for signal transduction. Specific antagonists of the collagen receptors are useful tools for investigating the complexity of platelet-collagen interactions. In this work we assessed the usefulness of DGEA peptide (Asp-Gly-Glu-Ala), the shortest collagen type I-derived motif recognised by the collagen-binding integrin α2β1, as a potential antagonist of collagen receptors. We examined platelet function using several methods including platelet adhesion under static conditions, platelet function analyser PFA-100TM, whole blood electric impedance aggregometry (WBEA) and flow cytometry. We found that DGEA significantly inhibited adhesion, aggregation and release reaction of collagen activated blood platelets. The inhibitory effect of DGEA on static platelet adhesion reached sub-maximal values at millimolar inhibitor concentrations, whereas the specific blocker of α2β1 - monoclonal antibodies Gi9, when used at saturating concentrations, had only a moderate inhibitory effect on platelet adhesion. Considering that 25-30% of total collagen binding to α2β1 is specific, we conclude that DGEA is a strong antagonist interfering with a variety of collagen-platelet interactions, and it can be recognised not only by the primary platelet adhesion receptor α2β1 but also by other collagen receptors.
Źródło:: Acta Biochimica Polonica; 2003, 50, 4; 1119-1128
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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