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    Tytuł:
    CIDE-A gene expression in patients with abdominal obesity and LDL hyperlipoproteinemia qualified for surgical revascularization in chronic limb ischemia
    Autorzy:
    Feldo, Marcin
    Kocki, Janusz
    Łukasik, Sylwia
    Bogucki, Jacek
    Feldo, Jan
    Terlecki, Piotr
    Kęsik, Jan
    Wroński, Jacek
    Zubilewicz, Tomasz
    Powiązania:
    https://bibliotekanauki.pl/articles/1396483.pdf
    Data publikacji:
    2013-11-01
    Wydawca:
    Index Copernicus International
    Tematy:
    CIDE-A gene
    obesity
    femoro-popliteal revascularisation
    dyslipidemia
    Opis:
    According to the latest data, CIDE -A gene plays a key role in the regulation of body weight in both humans and mice, and therefore it is regarded a potential candidate gene for human obesity. The aim of the study was to define the role of CIDEA gene in patients with dyslipidemia and symptomatic limb ischemia. Material and methods. The study group contained 28 patients, including 17 men and 11 women. Patients were enrolled in the study group, depending on the value of body mass index (BMI); there was BMI>30 for obese patients. The group included untreated patients (n=14) and patients (n=14) receiving atorvastatin 20 mg/day for at least three months prior to the initiation of the study. The control group (n=16) contained patients with no lipid disorders. A one-step isolation of RNA from lymphocytes and adipose tissue cells was carried out using the TRI method modified by Chomczyński and Sacchi. Next, gene expression was tested using real-time PCR. Results. The highest mean relative expression of CIDE -A gene occurred in patients with normal body weight. The lowest mean relative expression of CIDE-A gene was observed in obese patients with lipid disorders. A high negative correlation (r=-0.7919) of CIDE -A gene expression, depending on BMI, was reported in the group of obese patients with lipid disorders. Conclusions. Due to an important role of Cide-A protein demonstrated in the development of metabolic diseases such as obesity, metabolic syndrome, type 2 diabetes and their vascular complications, CIDE -A gene and protein are potential therapeutic targets in the case of these diseases.
    Źródło:
    Polish Journal of Surgery; 2013, 85, 11; 644-648
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Depositional conditions of the Upper Younger Loess during the Last Glacial Maximum in central and eastern Europe
    Autorzy:
    Dzierżek, Jan
    Lindner, Leszek
    Chlebowski, Roman
    Szymanek, Marcin
    Bogucki, Andriy
    Tomeniuk, Olena
    Powiązania:
    https://bibliotekanauki.pl/articles/24024703.pdf
    Data publikacji:
    2022
    Wydawca:
    Polska Akademia Nauk. Czasopisma i Monografie PAN
    Tematy:
    North European Loess Belt
    Vistulian glaciation
    aeolian processes
    palaeowind circulation
    heavy minerals
    północnoeuropejski pas lessowy
    zlodowacenie Wisły
    procesy eoliczne
    minerały ciężkie
    Opis:
    This paper is a summary of the results of research on the accumulation conditions of the Upper Younger Loess (LMg) in Poland and Bug loess (bg) in Ukraine from the maximum stage (MIS 2) of the Vistulian (Weichselian) Glaciation in central and eastern Europe. These studies included an analysis of the morphological (topographic) situation of the loess cover, its grain size and heavy mineral composition, the preserved structures of loess sedimentation as well as mollusc and pollen analyses of this loess. They revealed that the accumulation of Upper Younger Loess (UYL) might have been more dependent on the prevailing moisture conditions than previously thought. These conditions could have been caused by cold air masses from an ice sheet and warm air masses from the Mediterranean Sea and Atlantic coming together in the Carpathians and the Holy Cross Mountains and favouring the formation of dust storms and precipitation. In this process, a loading of loess dust (formed from local rocks weathering in periglacial conditions) by atmospheric moisture particles was especially significant. The moist substrate not only favoured the periodic development of vegetation and molluscs but also enabled the interception of dust and the accumulation of an increasingly thick loess cover. Westerly and south-westerly winds predominated in the UYL as indicated by the topographic position of loess patches and the mineral composition of the studied loess. Periodically an increased air circulation from the east and northeast occurred.
    Źródło:
    Acta Geologica Polonica; 2022, 72, 4; 369--389
    0001-5709
    Pojawia się w:
    Acta Geologica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-10 z 10

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