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    Wyświetlanie 1-4 z 4
    Tytuł:
    Hepatitis C - new developments in the studies of the viral life cycle
    Autorzy:
    Rychłowska, Małgorzata
    Bieńkowska-Szewczyk, Krystyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1040855.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    hepatitis C virus
    HCV replicons
    HCVcc-cell culture-derived
    HCV pseudoparticles
    Opis:
    Hepatitis C virus (HCV) is a causative agent of chronic liver disease leading to cirrhosis, liver failure and hepatocellular carcinoma. The prevalence of HCV is estimated as 3% of the world population and the virus is a major public health problem all over the world. For over 16 years, since HCV had been discovered, studies of the mechanisms of the viral life cycle and virus-host interactions have been hampered by the lack of a cell culture system allowing the virus to be grown in laboratory conditions. However, in recent years some new model systems to study HCV have been developed. The major breakthrough of the last two years was the cell culture system for maintaining the virus in an adapted hepatocyte-derived cell line. This review describes the techniques and applications of most of the in vitro systems and animal models currently used for working with hepatitis C virus.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 4; 703-715
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Introduction to molecular biology of influenza a viruses
    Autorzy:
    Szewczyk, Bogusław
    Bieńkowska-Szewczyk, Krystyna
    Król, Ewelina
    Powiązania:
    https://bibliotekanauki.pl/articles/1039236.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Orthomyxoviridae
    influenza A virus
    virion structure
    genome
    entry
    release
    new polypeptides
    Opis:
    This minireview presents an overview of current knowledge on virion structure, genome organization and basic events in the development of influenza A virus. The processes of entry, transcription/replication and viral release are described. In this context, the roles of viral proteins (including recently discovered minor polypeptides) in the subsequent stages of viral development are also discussed.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 3; 397-401
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    How short RNAs impact the human ribonuclease Dicer activity: putative regulatory feedback-loops and other RNA-mediated mechanisms controlling microRNA processing
    Autorzy:
    Koralewska, Natalia
    Hoffmann, Weronika
    Pokornowska, Maria
    Milewski, Marek
    Lipinska, Andrea
    Bienkowska-Szewczyk, Krystyna
    Figlerowicz, Marek
    Kurzynska-Kokorniak, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1038739.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    ribonuclease Dicer
    miRNA processing
    regulatory RNAs
    regulation of Dicer activity
    regulatory feedback-loops
    Opis:
    Ribonuclease Dicer plays a pivotal role in RNA interference pathways by processing long double-stranded RNAs and single-stranded hairpin RNA precursors into small interfering RNAs (siRNAs) and microRNAs (miRNAs), respectively. While details of Dicer regulation by a variety of proteins are being elucidated, less is known about non-protein factors, e.g. RNA molecules, that may influence this enzyme's activity. Therefore, we decided to investigate the question of whether the RNA molecules can function not only as Dicer substrates but also as its regulators. Our previous in vitro studies indicated that the activity of human Dicer can be influenced by short RNA molecules that either bind to Dicer or interact with its substrates, or both. Those studies were carried out with commercial Dicer preparations. Nevertheless, such preparations are usually not homogeneous enough to carry out more detailed RNA-binding studies. Therefore, we have established our own system for the production of human Dicer in insect cells. In this manuscript, we characterize the RNA-binding and RNA-cleavage properties of the obtained preparation. We demonstrate that Dicer can efficiently bind single-stranded RNAs that are longer than ~20-nucleotides. Consequently, we revisit possible scenarios of Dicer regulation by single-stranded RNA species ranging from ~10- to ~60-nucleotides, in the context of their binding to this enzyme. Finally, we show that siRNA/miRNA-sized RNAs may affect miRNA production either by binding to Dicer or by participating in regulatory feedback-loops. Altogether, our studies suggest a broad regulatory role of short RNAs in Dicer functioning.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 4; 773-783
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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