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    Wyświetlanie 1-2 z 2
    Tytuł:
    Formalin safety in anatomic pathology workflow and integrated air monitoring systems for the formaldehyde occupational exposure assessment
    Autorzy:
    Dugheri, Stefano
    Massi, Daniela
    Mucci, Nicola
    Berti, Nicola
    Cappelli, Giovanni
    Arcangeli, Giulio
    Powiązania:
    https://bibliotekanauki.pl/articles/2085773.pdf
    Data publikacji:
    2021-06-28
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    formaldehyde
    mitigation
    formalin
    exposure monitoring
    anatomic pathology
    occupational exposure
    Opis:
    The potential carcinogenicity of formaldehyde (FA) has prompted increasing preventive measures in anatomic pathology (AP) laboratories and new strategies aimed at innovating airborne FA monitoring systems. This review provides an updated overview of the most recent improvements in preventive measures, safe practices, and exposure monitoring tools in the FA usage and handling. A computer-based search of scientific and non-scientific sources was performed on PubMed, Web of Science, Google and Google Patents databases, querying the main topics of real-time, in-continuous FA monitoring instruments for sale, and commercially available tools for improving preventive measures in formalin management. In order to simplify the sampling process and to choose a better analytic solution to FA assessment, the main characteristics of each FA monitoring instrument were described. The novel technical tools recently introduced on the global market, aimed at reducing FA emissions in AP laboratories, were summarized. This review is directed at anatomic pathologists to draw their attention to the rapidly growing field of safe formalin practices. A repeated exposure assessment is recommended to evaluate technical changes in air monitoring programs to keep FA emissions low, in compliance with the limit value; thus, evolved monitoring devices are needed.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2021, 34, 3; 319-338
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Monitoring surface contamination for thirty antineoplastic drugs: a new proposal for surface exposure levels (SELs)
    Autorzy:
    Dugheri, Stefano
    Mucci, Nicola
    Bucaletti, Elisabetta
    Squillaci, Donato
    Cappelli, Giovanni
    Trevisani, Lucia
    Bonari, Alessandro
    Cecchi, Michele
    Mini, Enrico
    Ghiori, Andrea
    Tognoni, Daniela
    Berti, Nicola
    Alderighi, Francesca
    Li Vigni, Nicola
    Orlandi, Irene
    Arcangeli, Giulio
    Powiązania:
    https://bibliotekanauki.pl/articles/2152946.pdf
    Data publikacji:
    2022
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    health risk assessment
    antineoplastic drugs
    wipe test
    ultra-high performance liquid chromatography
    surface exposure level
    tandem mass spectrometry
    Opis:
    Background Chemotherapy drugs are widely used to treat cancer, but their active compounds represent a danger for workers who could be exposed to them. However, they aren’t yet included in directive CE No. 1272/2008 and the European Biosafety Network has only recommended a limit value of 100 pg/cm2 for surface contamination. Thus, it is crucial to assess surface contaminations in healthcare environments. Currently, the technique of choice is surface wipe test combined with liquid chromatography tandem mass spectrometry to achieve high sensibility. Material and Methods A campaign involving Careggi University Hospital (Florence, Italy) was performed from January 2020 to December 2021, collecting 1449 wipe samples between administration units, preparation unit, and personnel gloves. From the obtained data, the 90th percentile was calculated for 30 antiblastic drugs and proposed as surface exposure levels (SELs); while from data concerning personnel glove contamination, weekly contamination was estimated. Results In the 2-year period only 417 wipe samples were found positive (28.8%), the majority of which regard samples coming from administration unit bathrooms. The proposed SELs are almost all <100 pg/cm2, except for few drugs which produce higher contamination on bathroom surfaces. Also, the estimation of pharmacy personnel’s glove contamination highlighted very low results (ng/week). Conclusions Deeply established protocols and procedures for safe handling of ADs allow for obtaining excellent cleaning results and thus a safer work environment, however, the risk of cytostatic contaminations cannot be avoided in healthcare workplaces, and thus a harmonization of classification and labeling of chemotherapy drugs throughout the European Union should be done.
    Źródło:
    Medycyna Pracy; 2022, 73, 5; 383-396
    0465-5893
    2353-1339
    Pojawia się w:
    Medycyna Pracy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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