- Tytuł:
- Development in pharmacotherapy and diagnostics of tuberculosis. Review
- Autorzy:
-
Beňo, Pavol
Meravý, Peter - Powiązania:
- https://bibliotekanauki.pl/chapters/1955284.pdf
- Data publikacji:
- 2020
- Wydawca:
- Śląski Uniwersytet Medyczny w Katowicach
- Opis:
- Introduction. In 1993, tuberculosis (TB) was declared a global public health emergency by the WHO. TB remains one of most important global threats in public health. Aim. In this work we provide an overview of TB. First, we provide historical development, then a short epidemiology, followed by progress in anti TB-drugs and TB diagnosis. Core of work. The introduction of rifampicin (RIF) has revolutionized the treatment of TB. The last ten years have made progress, producing some new drugs such as bedaquiline, delamanid, pretomanid. Nonetheless, no new drugs could be added to the first line regimen in the last 60 years. The drug-resistant form of TB, extensively drug-resistant tuberculosis (XDR-TB) is very difficult to treat and is a growing threat. Earlier WHO guidelines (2011) recommended that the choice of drugs for TB therapy should be based on efficacy and toxicity in a step down manner, from Group 1 to Group 5. In 2016, WHO provided an important and useful evidence-based new classification of anti-TB drugs to help clinicians design anti-TB drug regimens more accurately. Acid-fast staining and culture for mycobacteria remain at the core of any diagnostic algorithm. Following growth in culture and molecular technologies are used to identify definitive species. Conclusions. Despite 90 years of vaccination, 60 years of chemotherapy and recent advances in diagnostics, TB has not been eliminated as a global public health problem. Many people do not have access to adequate initial diagnosis. These “missing“ people with TB are the root of ongoing TB transmission, including their resistant forms. The goals of the End TB strategy, which aims to achieve a 90% reduction in TB incidence and 95% reduction in TB mortality by 2035, will not be achieved without increased availability of diagnostics in resource limited settings, especially for anti-TB drug resistance.
- Źródło:
-
Zdrowie człowieka w ontogenezie – aspekty biomedyczne i psychospołeczne. Studia badaczy, polskich, słowackich i czeskich. T. 1. Aspekty biomedyczne; 73-78
9788375094053 - Dostawca treści:
- Biblioteka Nauki
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