- Tytuł:
- Molecular modelling of membrane activity of amphotericin B, a polyene macrolide antifungal antibiotic
- Autorzy:
-
Baginski, Maciej
Sternal, Kamil
Czub, Jacek
Borowski, Edward - Powiązania:
- https://bibliotekanauki.pl/articles/1041370.pdf
- Data publikacji:
- 2005
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
antifungal agents
lipid membrane
cholesterol
amphotericin B
molecular modelling
ergosterol - Opis:
- Amphotericin B (AmB) is a well known polyene macrolide antibiotic used to treat systemic fungal infections. Despite its toxicity AmB is still regarded as a life-saving drug. The lack of adequate knowledge of the AmB mechanism of action is a serious obstacle to efficient development of new less toxic derivatives. Complementary to various experimental approaches, computational chemistry methods were used to study AmB mechanism of action. A programme lasting for a decade, that was run by our group covered studies of: i) molecular properties of AmB and its membrane targets, ii) structure and properties of AmB membrane channels, and iii) interaction of AmB with the membrane.
- Źródło:
-
Acta Biochimica Polonica; 2005, 52, 3; 655-658
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł