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Wyszukujesz frazę "Akhtar, Mahmood" wg kryterium: Autor

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    Wyświetlanie 1-4 z 4
    Tytuł:
    Biochemical study of trehalase activity in Aspergillus niger conidia
    Autorzy:
    Chrungu, Deepti
    Sharma, Sukesh Chander
    Akhtar, Mahmood
    Powiązania:
    https://bibliotekanauki.pl/articles/1178299.pdf
    Data publikacji:
    2017
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Aspergillus niger
    Conidia
    Enzyme Activity
    Trehalase
    Opis:
    Trehalase (α, α-trehalose-1-C-glucohydrolase, EC 3.2.1.28) is a glycoside hydrolase enzyme that catalyzes the conversion of trehalose to glucose. Trehalose hydrolysis by trehalase enzyme is an important physiological process for various organisms, such as fungal spore germination, insect flight, and the resumption of growth in resting cells. So by studying biochemical properties of trehalase we can control the spore germination of harmful fungus, Apergillus niger. Till now trehalase has been reported from many other organisms including plants and animals, Trehalase has been purified and characterized from various organisms such as Saccharomyces cerevisiae, Lentinula edodes, Acidobacterium capsulatum, and Medicago sativa, as well as root nodules of Phaseolus vulgaris, soybean and from the from the seeds of Triticum aestivum. In this study, trehalase was purified from Aspergillus niger grown on cellulosic medium. And this purified trehalase was tested for various requirements it may need for enzymatic activity such as inorganic phosphate and Magnesium ions (Mg2+).
    Źródło:
    World Scientific News; 2017, 86, 3; 349-356
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Anti-schizophrenic activities of histamine H3 receptor antagonists in rats treated with MK-801
    Autorzy:
    Mahmood, D.
    Akhtar, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/972708.pdf
    Data publikacji:
    2015
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    animal model
    antischizophrenic activity
    histamine H3 receptor
    antagonist
    rat
    treatment
    MK-801
    dizocilpine zob.MK-801
    Opis:
    Animal models based on N-methyl-d-aspartate (NMDA) receptor blockade have been widely reported. Ketamine and MK-801, the two noncompetitive antagonists of NMDA receptors, produce behaviors related to schizophrenia and exacerbated symptoms in patients with schizophrenia. The study presented here investigated the effect of subchronic dosing (once-daily, 7 day) of histamine H3 receptor (H3R) antagonists, ciproxifan (CPX) (3 mg/kg, i.p.) and clobenpropit (CBP) (15 mg/kg, i.p) including clozapine (CLZ) (3.0 mg/kg, i.p.) and chlorpromazine (CPZ) (3.0 mg/kg, i.p.), the atypical and typical antipsychotic, respectively, on MK-801(0.2 mg/kg, i.p.)-induced locomotor activity, and dopamine and histamine levels in rats. Atypical and typical antipsychotic was used to serve as clinically relevant reference agents to compare the effects of the H3R antagonists. MK-801 significantly increased horizontal activity which was reduced with CPX and CBP. The attenuation of MK-801-induced locomotor hyperactivity produced CPX and CBP were comparable to CLZ and CPZ. Dopamine and histamine levels were measured in striatum and hypothalamus, respectively, of rat brain. The MK-801 induced increase of the striatal dopamine level was reduced in rats pretreated with CPX and CBP including CLZ. CPZ also significantly lowered striatal dopamine levels, though the decrease was less robust compared to CLZ, CPX and CBP. MK-801 increased histamine content although to a lesser degree. Subchronic treatment with CPX and CBP exhibited further increased histamine levels in the hypothalamus compared to MK-801 treatment alone. Histamine H3 receptor agonist, R-α methylhistamine (10 mg/kg, i.p.) counteracted the effect of CPX and CBP. The findings of the present study support our previous work showing positive effects of CPX and CBP on MK-801-induced schizophrenia like behaviors in rodents. However, clinical studies have reported no antipsychotic effects with histamine H3 receptor antagonists.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2015, 09, 1; 11-17
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Dynamic Traffic Control and Management System for Smart Cities
    Autorzy:
    Abdul, Mateen
    Sabeen, Sher
    Amjad, Rehman
    Zahid, Hanif
    Akhtar, Tooba
    Ashraf, Mahmood
    Powiązania:
    https://bibliotekanauki.pl/articles/102834.pdf
    Data publikacji:
    2018
    Wydawca:
    Stowarzyszenie Inżynierów i Techników Mechaników Polskich
    Tematy:
    traffic flow
    management
    mutual dependent
    infrared
    ruch uliczny
    zarządzanie
    wzajemna zależność
    Opis:
    The computational capabilities of computers enable a human being to control the vehicles and their traffic. Automatic traffic control system not only reduces the effort of human but also provides secure and accurate results. Here, the architecture of Agent-Based Autonomous Controller (ABAC) that manages vehicles at traffic signals intelligently was proposed. The proposed solution is followed by a vehicle counting by infrared (IR) sensor; providing solution for independent and mutual dependent signals for smooth traffic flow; emergency vehicles alert and priority over public vehicles through Radio Frequency Identification (RFID). Finally, the proposed research was tested through simulation that reveals the performance over the previous traffic control and management architectures.
    Źródło:
    Advances in Science and Technology. Research Journal; 2018, 12, 4; 216-225
    2299-8624
    Pojawia się w:
    Advances in Science and Technology. Research Journal
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Selective arylation of phenol proteted propygyl bromide via pd-catalysed Suzuki coupling reaction: synthesis, mechanistic studies by DFT calculations and Their Pharmacological Aspects
    Autorzy:
    farooq, hira
    rasool, nasir
    Ansari, Muhammad T.
    rizwan, komal
    mahmood, tariq
    israr, hira
    Ayub, Khurshid
    rasheed, tahir
    Zareen, Seema
    Akhtar, muhammad N.
    iqbal, sarosh
    Powiązania:
    https://bibliotekanauki.pl/articles/895304.pdf
    Data publikacji:
    2018-08-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    biofilm
    phenol
    DFT
    Suzuki coupling
    organoboron
    Biaryl
    Opis:
    Biaryls are the potential source of synthetic drugs. The present study describes the synthesis of a series of functionalized biphenyl derivatives (3a-3g) using Pd-catalyzed Suzuki coupling reaction. The experimental results revealed the facile synthesis of biphenyl derivatives (3a-3g) with notably high yield (80-88 %). Density functional theory (DFT) studies were performed by Gaussian 09 software in order to rationalize the selectivity of coupling at C-Br bond instead of C-Cl bond. In addition of synthesis, the biological activities (biofilm inhibition, hemolytic and anti-thrombolytic) of these novel compounds were investigated. These results exhibited good biofilm inhibition (5.86-65.8 %), hemolytic (1.32-30.1 %) and anti-thrombolytic activities (9.64-42.5 %), indicating the potential use of these compounds for pharmaceutical applications.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 4; 911-919
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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