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Wyszukujesz frazę "Ahmed, Mahmood" wg kryterium: Autor

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    Wyświetlanie 1-9 z 9
    Tytuł:
    PEGYLATED GEMCITABINE AND METHOTREXATE: IN VITRO CYTOTOXICITY ANALYSIS AND IN VIVO DRUG RELEASE PROFILING TO ASSESS THEIR ENHANCED BLOOD CIRCULATION
    Autorzy:
    Ahmed, Mahmood
    Powiązania:
    https://bibliotekanauki.pl/articles/895274.pdf
    Data publikacji:
    2019-08-30
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    drug delivery
    anti-proliferation
    Pegylation
    spheroids
    Opis:
    In the present study, four new pegylated drugs were synthesized to investigate the anticancer activity. All the compounds were characterized on the basis of FTIR and 1HNMR. The new compounds were evaluated against HCT116 cell line by CellTiter-Glo® 3D cell viability assay. The sustained release pattern of newly synthesized compounds were also evaluated, slow released lasts for 240 h which was confirmed by in vivo and in vitro drug release profile. The sustained and controlled release behavior of pegylated drugs over the extended period of time showed a linear profile and this release pattern was not limited to diffusion process instead supporting chemically controlled release pattern which was dependent only on how fast the compound hydrolyzed. The newly designed pegylated drugs showed almost same killing effect against the cancer cells as the free drugs. The compounds with lower cLogP value showed more antiproliferative (lower IC50) effect due their higher cell permeability.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 4; 653-659
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Novel approach for big data classification based on hybrid parallel dimensionality reduction using spark cluster
    Autorzy:
    Ali, Ahmed Hussein
    Abdullah, Mahmood Zaki
    Powiązania:
    https://bibliotekanauki.pl/articles/305766.pdf
    Data publikacji:
    2019
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
    Tematy:
    big data
    dimensionality reduction
    parallel processing
    Spark
    PCA
    LDA
    Opis:
    The big data concept has elicited studies on how to accurately and efficiently extract valuable information from such huge dataset. The major problem during big data mining is data dimensionality due to a large number of dimensions in such datasets. This major consequence of high data dimensionality is that it affects the accuracy of machine learning (ML) classifiers; it also results in time wastage due to the presence of several redundant features in the dataset. This problem can be possibly solved using a fast feature reduction method. Hence, this study presents a fast HP-PL which is a new hybrid parallel feature reduction framework that utilizes spark to facilitate feature reduction on shared/distributed-memory clusters. The evaluation of the proposed HP-PL on KDD99 dataset showed the algorithm to be significantly faster than the conventional feature reduction techniques. The proposed technique required >1 minute to select 4 dataset features from over 79 features and 3,000,000 samples on a 3-node cluster (total of 21 cores). For the comparative algorithm, more than 2 hours was required to achieve the same feat. In the proposed system, Hadoop’s distributed file system (HDFS) was used to achieve distributed storage while Apache Spark was used as the computing engine. The model development was based on a parallel model with full consideration of the high performance and throughput of distributed computing. Conclusively, the proposed HP-PL method can achieve good accuracy with less memory and time compared to the conventional methods of feature reduction. This tool can be publicly accessed at https://github.com/ahmed/Fast-HP-PL.
    Źródło:
    Computer Science; 2019, 20 (4); 411-429
    1508-2806
    2300-7036
    Pojawia się w:
    Computer Science
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Improvement of a subgrade soil by using EarthZyme and cement kiln dust waste
    Autorzy:
    Abdulkareem, Ahmed Hazim
    Eyada, Saadoon O.
    Mahmood, Nabeel S.
    Powiązania:
    https://bibliotekanauki.pl/articles/1852537.pdf
    Data publikacji:
    2021
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    stabilizacja gruntu
    ściskanie nieskrępowane
    EarthZyme
    pył z pieca cementowego
    nanomateriał
    soil stabilization
    unconfined compressions
    cement kiln dust
    nanomaterial
    Opis:
    Soil stabilization techniques are widely used for road construction to improve the properties of the subgrade materials. Using new additives and stabilizers to improve soil properties can reduce the costs of construction and reduce the possible negative effects of these materials on the environment. The purpose of this study was to evaluate the use of a liquid based nano-material called EarthZyme (EZ) and cement kiln dust (CKD) as admixtures to improve the soil properties. A mixture of two soils was used in this study which were prepared from mixing sand soil and fine-grained soil. Compaction tests were performed on the soil that was stabilized with the CKD to determine the density-water content relationships. Unconfined compression tests were also conducted on specimens without treatment, specimen treated with the CKD only, and specimens treated with the CKD and the EZ after curing period for seven days. The obtained results indicated that adding the CKD to the soil decreased the values of the unconfined compression strength (UCS) from 5 to 15 percent. However, adding the CKD reduced the maximum dry density (MDD) from 10 to 12 %. As discussed herein, soil stabilization with the EZ had insignificant effects on the results obtained from the unconfined compression test.
    Źródło:
    Archives of Civil Engineering; 2021, 67, 2; 525-536
    1230-2945
    Pojawia się w:
    Archives of Civil Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mechanical vapour compression refrigeration system: review part 1: environment challenge
    Autorzy:
    Mahmood, Raid Ahmed
    Ali, Omar M.
    Noor, M. M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1839710.pdf
    Data publikacji:
    2020
    Wydawca:
    Uniwersytet Zielonogórski. Oficyna Wydawnicza
    Tematy:
    czynnik chłodniczy
    układ chłodniczy
    warstwa ozonowa
    alternative refrigerant
    mixture refrigerants
    vapour compression refrigeration system
    ozone depletion potential
    global worming potential
    R507A refrigerant
    natural refrigerant
    R-718 (water/steam)
    Opis:
    In Australia and others developed countries, concerns about global warming have increased, and these concerns influence the use of refrigerants as working fluids in mechanical vapour compression refrigeration systems. One of the most important aspects of refrigerant selection is to reduce its impact on the environment and the ozone layer. This paper provides a comprehensive review of various theoretical and experimental studies which have been carried out on air conditioning and refrigeration applications to investigate the effect of refrigerants on the environment. The analysis in this paper reveals that alternative refrigerants are the most suitable working fluids that can be used in refrigeration systems to meet the needs of the environment. This study also suggests that natural types of refrigerants such as water, carbon dioxide, and hydrocarbon will play a significant role in protecting the environment and providing alternative friendly refrigerants to be used in refrigeration and air conditioning systems.
    Źródło:
    International Journal of Applied Mechanics and Engineering; 2020, 25, 4; 130-147
    1734-4492
    2353-9003
    Pojawia się w:
    International Journal of Applied Mechanics and Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Optimal reshaping and stress controlling of double-layer spherical structures under vertical loadings
    Autorzy:
    Manguri, Ahmed
    Saeed, Najmadeen
    Mahmood, Aram
    Katebi, Javad
    Jankowski, Robert
    Powiązania:
    https://bibliotekanauki.pl/articles/2174098.pdf
    Data publikacji:
    2022
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    Architectural structures’ nodal coordinates are significant to shape appearance; vertical overloading causes displacement of the joints resulting in shape distortion. This research aims to reshape the distorted shape of a double-layer spherical numerical model under vertical loadings; meanwhile, the stress in members is kept within the elastic range. Furthermore, an algorithm is designed using the fmincon function to implement as few possible actuators as possible to alter the length of the most active bars. Fmincon function relies on four optimization algorithms: trust-region reflective, active set, Sequential quadratic progra mming (SQP), and interior-point. The fmincon function is subjected to the adjustment technique to search for the minimum number of actuators and optimum actuation. The algorithm excludes inactive actuators in several iterations. In this research, the 21st iteration gave optimum results, using 802 actuators and a total actuation of 1493 mm.MATLAB analyzes the structure before and after adjustment and finds the optimum actuator set. In addition, the optimal actuation found in MATLAB is applied to the modeled structure in MATLAB and SAP2000 to verify MATLAB results.
    Źródło:
    Archives of Civil Engineering; 2022, 68, 4; 591--606
    1230-2945
    Pojawia się w:
    Archives of Civil Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    New generators for minimal circular generalised neighbour designs in blocks of two different sizes
    Autorzy:
    Nadeem, Muhammad
    Noreen, Khadija
    Kashif Rasheed, H. M.
    Ahmed, Rashid
    Hassan, Mahmood Ul
    Powiązania:
    https://bibliotekanauki.pl/articles/14769686.pdf
    Data publikacji:
    2023-03-15
    Wydawca:
    Główny Urząd Statystyczny
    Tematy:
    direct effects
    neighbour effects
    method of cyclic shifts
    generalised NDs
    GN2-designs
    Opis:
    Minimal neighbour designs (NDs) are used when a response of a treatment (direct effect) is affected by the treatment(s) applied in the neighbouring units. Minimal generalised NDs are preferred when minimal NDs cannot be constructed. Through the method of cyclic shifts (Rule I), the conditions for the existence of minimal circular generalised NDs are discussed, in which v/2 unordered pairs do not appear as neighbours. Certain generators are also developed to obtain minimal circular generalised NDs in blocks of two different sizes, where k2 = 3, 4 and 5. All these designs are constructed using i sets of shifts for k1 and two for k2.
    Źródło:
    Statistics in Transition new series; 2023, 24, 2; 85-92
    1234-7655
    Pojawia się w:
    Statistics in Transition new series
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Proximate analysis of lignocellulosic biomass and its utilization for production, purification and characterization of ligninolytic enzymes by Aspergillus flavus
    Autorzy:
    Khan, Jehangir
    Asad, Muahammad Javaid
    Mahmood, Raja Tahir
    Wattoo, Feeroza Hamid
    Zainab, Tayyaba
    Nazir, Sidrah
    Shah, Muhammad Basir
    Ahmed, Dawood
    Powiązania:
    https://bibliotekanauki.pl/articles/205277.pdf
    Data publikacji:
    2020
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    Aspergillus flavus
    acid detergent lignin
    ammonium sulfate
    ligninolytic enzymes
    Platanus orientalis
    Opis:
    Ligninolytic enzymes are employed for the production of second-generation biofuel to minimize fuel crisis. Additionally, they play a crucial role in global carbon cycle and a variety of applications in food, agriculture, paper and textile industries. On a large scale production of ligninolytic enzymes, microorganisms can be cultured on lignocellulosic wastes. In the present study, proximate analysis including acid detergent lignin (ADL), acid detergent cellulose (ADC), acid detergent fiber (ADF) and acid insoluble ash (AIA) were performed for Platanus orientalis (chinar), Bauhinia variegata (orchid tree), Pinus roxburghii (chirpine), wheat straw and wheat husk. Platanus orientalis was selected as substrate because of higher lignin contents for the production of ligninolytic enzymes by Aspergillus flavus. Solid State Fermentation was used and Response Surface Methodology was employed for optimizing various parameters and enzymes production. Maximum production was achieved at temperature 32°C, fermentation period 120 hours, pH 4.5, inoculums size 3.5 mL, substrate mesh size 80 mm, substrate size 7 g. Maximum purification of laccase, manganese peroxidase (MnP) and lignin peroxidase (LiP) was achieved with 50%, 60% and 40% ammonium sulfate respectively and it was enhanced by gel filtration chromatography. Characterization of enzymes shows that Laccase has 35°C optimum temperature, 4.5 pH, 0.289 mM Km and 227.27 μM/ml Vmax. Manganese peroxidase has 30°C optimum temperature, 5.5 pH, 0.538 mM Km and 203.08 μM/ml Vmax. Lignin peroxidase has 30°C optimum temperature, 3 pH, 2 mM Km and 2000 uM/ml Vmax. Protein concentrations found in crude extracts and partially purified enzymes are respectively: laccase 1.78 and 0.71 mg/ml, MnP 1.59 and 0.68 mg/ml. LiP, 1.70 and 0.69 mg/ml.
    Źródło:
    Archives of Environmental Protection; 2020, 46, 1; 3-13
    2083-4772
    2083-4810
    Pojawia się w:
    Archives of Environmental Protection
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Application of LandGEM mathematical model for the estimation of gas emissions from contaminated sites. A case study of a dumping site in Lahore, Pakistan
    Autorzy:
    Alam, Asifa
    Chaudhry, M. Nawaz
    Ahmad, Sajid Rashid
    Ullah, Rizwan
    Batool, Syeda Adila
    Butt, Talib E.
    Alghamdi, Huda Ahmed
    Mahmood, Adeel
    Powiązania:
    https://bibliotekanauki.pl/articles/2057619.pdf
    Data publikacji:
    2022
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    mathematical model
    greenhouse gas
    energy supply
    garbage dump
    model matematyczny
    gaz cieplarniany
    źródło energii
    wysypisko śmieci
    Opis:
    Decomposition of organic waste in dumping sites and landfills prompts the uncontrolled emission of greenhouse gases which enhances global warming and related issues. The present investigation estimated the total landfill gas, methane, carbon dioxide and non-methane organic compounds emissions from Mahmood Booti dumping site located at Lahore, Pakistan from 1996 to 2045. LandGEM 3.02 model was utilized to evaluate the gas emission with the volumetric methane 50%, production potential (170 m3/Mg), and methane generation rate (0.050/year). The findings demonstrated that organic and food wastes had the maximum quantity in the solid waste stream (63.46%). Methane measured from solid waste was 1.150E+03 (Mg/year) in 1997 in the first year after waste was accepted by landfill while the maximum methane generation rate happened from 2014 to 2018, i.e., from 4.049×104 to 4.654×104 Mg/year, respectively. The study finding highlighted that all gases emissions have an increasing/rising trend up to 2021 and then gradually their level will decrease because most of the organic fractions of solid waste would degrade with time. The findings of this study can be used to identify the impacts and contribution of MBODS in the global emission of greenhouse gases. The study concludes that proper management of landfill gas will not only decreases greenhouse gas emissions, diminishing adverse impacts on public health but can also be used as a sustainable energy source.
    Źródło:
    Environment Protection Engineering; 2022, 48, 1; 69--81
    0324-8828
    Pojawia się w:
    Environment Protection Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Baseline study in environmental risk assessment : site-specific model development and application
    Autorzy:
    Alam, Asifa
    Mahmood, Adeel
    Chaudhry, M. Nawaz
    Ahmad, Sajid Rashid
    Safa, Noor Ul
    Alghamdi, Huda Ahmed
    Alhamdi, Heba Waheeb
    Ullah, Rizwan
    Powiązania:
    https://bibliotekanauki.pl/articles/2203136.pdf
    Data publikacji:
    2022
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    baseline study
    risk assessment models
    risk management
    mathematical approaches
    landfills
    dumping sites
    environmental risk estimation
    Opis:
    Environmental risk assessment is one of the key tools in environmental engineering. This risk assessment can be qualitative or quantitative and it is based on preliminary studies i.e., baseline study for waste disposal sites. Even though the literature exists on baseline study in general, still there is a lack of guidance regarding development of a site-specific baseline study model for a waste disposal site. This study has two-fold aim, firstly, how to develop site-specific baseline study model for a selected dumping site, and secondly, how this site-specific baseline study can support the environmental engineering via mathematical risk estimation. Mahmood Booti Open Dumping Site (MBODS) is selected to demonstrate the development and application of site-specific baseline study model. This is followed by building a framework that shows how the output of the baseline study can lead to environmental engineering via mathematical risk estimation. The paper provides a mechanism of how to construct a bespoke baseline-study model that is readily useable, avoiding procurement of expensive computer software and yet smoothly connecting with the follow-on stages of the risk assessment. The work presented in this paper can be reproduced repeatedly to create site-specific baseline study models for risk assessment of other waste disposal sites in a cost-effective, consistent and cohesive manner.
    Źródło:
    Archives of Environmental Protection; 2022, 48, 3; 80--88
    2083-4772
    2083-4810
    Pojawia się w:
    Archives of Environmental Protection
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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