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Wyszukujesz frazę "Ahmed, Hanaa" wg kryterium: Autor

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    Wyświetlanie 1-5 z 5
    Tytuł:
    Neuroprotective effects of dehydroepiandrosterone (DHEA) in rat model of Alzheimers disease
    Autorzy:
    Aly, Hanan
    Metwally, Fateheya
    Ahmed, Hanaa
    Powiązania:
    https://bibliotekanauki.pl/articles/1039841.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    dehydroepiandrosterone
    Alzheimer's disease
    apoptosis
    oxidative stress
    Opis:
    The current study was undertaken to elucidate a possible neuroprotective role of dehydroepiandrosterone (DHEA) against the development of Alzheimer's disease in experimental rat model. Alzheimer's disease was produced in young female ovariectomized rats by intraperitoneal administration of AlCl3 (4.2 mg/kg body weight) daily for 12 weeks. Half of these animals also received orally DHEA (250 mg/kg body weight, three times weekly) for 18 weeks. Control groups of animals received either DHAE alone, or no DHEA, or were not ovariectomized. After such treatment the animals were analyzed for oxidative stress biomarkers such as hydrogen peroxide, nitric oxide and malondialdehyde, total antioxidant capacity, reduced glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase and catalase activities, antiapoptotic marker Bcl-2 and brain derived neurotrophic factor. Also brain cholinergic markers (acetylcholinesterase and acetylcholine) were determined. The results revealed significant increase in oxidative stress parameters associated with significant decrease in the antioxidant enzyme activities in Al-intoxicated ovariectomized rats. Significant depletion in brain Bcl-2 and brain-derived neurotrophic factor levels were also detected. Moreover, significant elevations in brain acetylcholinesterase activity accompanied with significant reduction in acetylcholine level were recorded. Significant amelioration in all investigated parameters was detected as a result of treatment of Al-intoxicated ovariectomized rats with DHEA. These results were confirmed by histological examination of brain sections. These results clearly indicate a neuroprotective effect of DHEA against Alzheimer's disease.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 4; 513-520
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Current concepts in pathophysiology and management of hepatocellular carcinoma
    Autorzy:
    Hamza, Amal
    Abdulfattah, Hanaa
    Mahmoud, Rasha
    Khalil, Wagdy
    Ahmed, Hanaa
    Powiązania:
    https://bibliotekanauki.pl/articles/1039009.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    hepatocellular carcinoma
    grape seed extract
    apoptosis
    antioxidant
    HCC pathophysiology
    Opis:
    Additional approaches to control malignancies are needed due to the emerging trends in the incidence of cancer of different organ sites. Due to the high frequency of hepatocellular carcinoma (HCC) and its poor prognosis, preventing HCC is an urgent priority. To explore the antioxidant and apoptotic pathways of grape seed extract (GSE) we induce HCC experimentally by diethylnitrosoamine (DEN) and treated the animals with low and high doses of GSE. The results indicate good therapeutic possibilities for GSE use in treatment of HCC., This was evidenced via regression of liver enzymes' function (ALT&AST), the HCC markers; α-fucosidase, α-fetoprotein and carcinoembrionic antigen (CEA) in HCC groups treated with the grape seed extract. Also, tumor necrosis factor (TNF-α) showed a significant decrease using GSE in HCC bearing animals. Regarding the apoptotic pathways of GSE, we found a significant down regulation of apoptosis enhancing nuclease (Aen), Bcl2-associated X protein (Bax), B-cell translocation gene 2(Btg2), Cyclin G1 (Ccng1) and Cyclin-dependent kinase inhibitor 1A (Cdkn1a) gene expression in HCC+GSE groups as compared to HCC bearing group. In the same trend, the necrotic/apoptotic rates were significantly higher in the HCC groups treated with GSE vs. the HCC bearing group. Finally, the 8-OHdG/2-dG generation decreased by 73.8% and 52.9% in HCC+GSE at low and high doses, respectively. Based on these encouraging observations, grape seed extract could be a promising natural remedy for attenuating hepatocellular carcinoma that has a great future in approaches directed towards control of HCC.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 3; 573-580
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biochemical and molecular evidences for the antitumor potential of Ginkgo biloba leaves extract in rodents
    Autorzy:
    Ahmed, Hanaa
    Shousha, Wafaa
    El-Mezayen, Hatem
    El-Toumy, Sayed
    Sayed, Alaa
    Ramadan, Aesha
    Powiązania:
    https://bibliotekanauki.pl/articles/1038680.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Hepatocellular carcinoma
    Ginkgo biloba
    AFP
    CEA
    GPC-3
    ING-3
    Foxp-1
    histopathology
    Opis:
    Hepatocellular carcinoma (HCC) is one of the deadliest primary cancers, with a 5-year survival rate of 10% or less. This study was undertaken to elucidate the underlying biochemical and molecular mechanisms in favor of N-nitrosodiethylamine-induced hepatocellular carcinoma. Furthermore, the aim of this work was extended to explore the efficacy of Ginkgo biloba leaves extract in deterioration of HCC in rats. In the current study, HCC group experienced significant downregulation of ING-3 gene expression and upregulation of Foxp-1 gene expression in liver. Treatment of HCC groups with Ginkgo biloba leaves extract resulted in upregulation of ING-3 and downregulation of Foxp-1 gene expression in liver. In addition, there was significant increase in serum alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA) and glypican-3 (GPC-3) levels in HCC group versus the negative control group. In contrast, the groups with HCC subjected to either high or low dose of Ginkgo biloba leaves extract elicited significant reduction (P<0.05) of AFP, CEA and GPC-3 in serum compared to the untreated HCC rats. Besides, histological examination of liver tissue sections of rats in HCC group revealed typical anaplasia. Interestingly, treatment with Ginkgo biloba leaves extract elicited marked improvement in the histological feature of liver tissue in HCC groups. In conclusion, this research indicated that the carcinogenic potency of N-nitrosodiethylamine targeted multiple systems on the cellular and molecular levels. In addition, the results of the current study shed light on the promising anticancer activity of Ginkgo biloba leaves extract in treatment of hepatocellular carcinoma induced chemically in the experimental model through its apoptotic and antiproliferative properties.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 1; 25-33
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluating the connectivity level of Fayoum city roads network: a new method using GIS
    Ocena poziomu spójności sieci dróg miejskich Fayoum: nowa metoda wykorzystująca GIS
    Autorzy:
    Saleh, Ahmed Younes
    Abdu, Saeed Ahmed
    Ali, Hanaa Nazer
    Powiązania:
    https://bibliotekanauki.pl/articles/2089773.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Gdański. Komisja Geografii Komunikacji Polskiego Towarzystwa Geograficznego
    Tematy:
    connectivity level
    GIS
    map algebra
    network analysis
    urban road network
    poziom spójności
    algebra mapy
    analiza sieci
    sieć dróg miejskich
    Opis:
    Road networks within cities are a vital component of the socio-economic development processes. Many countries have sought to examine and evaluate the efficiency of road networks within urban areas because of the increasing demand for transportation. Thus, networks should be evaluated to guide the development of transport systems and infrastructure within cities. This study evaluates the connectivity level of the road network parts in Fayoum city, Egypt, through the application of some indicators of connectivity measurement, such as Beta, Alpha, Gamma, Connectivity degree, and the density of edges and nodes. The study follows a new method for evaluation; it does not apply the indicators on the network as a whole; however, it divides the city into zones and calculates the indicators of each zone using the Arc GIS 10.2.1 program. The authors applied the map Algebra method to map the results of the six indicators in one index called the Total Connectivity Index (TCI). The TCI gives more consistent results than other indices, and it is more related to different spatial patterns of roads. According to this indicator, most of the city road network seem to have a good connectivity level, whereas the city marginal areas prove to have a poor connectivity level. Therefore, any efforts to develop or construct new roads should be in the marginal areas of the city.
    Źródło:
    Prace Komisji Geografii Komunikacji PTG; 2018, 21(4); 60-72
    1426-5915
    2543-859X
    Pojawia się w:
    Prace Komisji Geografii Komunikacji PTG
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    On the Existence of Continuous Positive Monotonic Solutions of a Self-Reference Quadratic Integral Equation
    Autorzy:
    EL-Sayed, Ahmed M.A.
    Ebead, Hanaa R.
    Powiązania:
    https://bibliotekanauki.pl/articles/1818643.pdf
    Data publikacji:
    2020
    Wydawca:
    Politechnika Rzeszowska im. Ignacego Łukasiewicza. Oficyna Wydawnicza
    Tematy:
    self-reference
    quadratic integral equation
    existence of solutions
    uniqueness of solution
    continuous dependence
    Schauder fixed point theorem
    równanie całkowe
    rozwiązania
    zależność ciągła
    punkt stały Schaudera
    Opis:
    In this work we study the existence of positive monotonic solutions of a self-reference quadratic integral equation in the class of continuous real valued functions. The continuous dependence of the uniquesolution will be proved. Some examples will be given.
    Źródło:
    Journal of Mathematics and Applications; 2020, 43; 67--80
    1733-6775
    2300-9926
    Pojawia się w:
    Journal of Mathematics and Applications
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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