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    Wyświetlanie 1-9 z 9
    Tytuł:
    USE OF GLUTARIC ACID TO IMPROVE THE SOLUBILITY AND DISSOLUTION PROFILE OF GLIPIZIDE THROUGH PHARMACEUTICAL COCRYSTALLIZATION
    Autorzy:
    Batool, Fakhra
    Ahmad, Mahmood
    Minhas, Muhammad U.
    Khalid, Qandeel
    Idrees, Hafiz A.
    Khan, Fahad M.
    Powiązania:
    https://bibliotekanauki.pl/articles/895470.pdf
    Data publikacji:
    2019-02-28
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    FTIR
    SEM
    PXRD
    thermal analysis
    glipizide
    glutaric acid
    Opis:
    The purpose of current study was to improve the solubility and dissolution profile of BCS class-II drug Glipizide using glutaric acid as a coformer via various cocrystalization techniques i.e., dry grinding, liquid assisted grinding, slurry and solvent evaporation. Fourier Transform Infrared Spectroscopy (FTIR) was performed to determine the interaction between components of glipizide-glutaric acid (GPZ-GLU) cocrystals. Powder X-ray Diffraction (PXRD) studies confirmed the crystalline nature of formulated cocrystals. Scanning Electron Microscopy (SEM) revealed cylindrical to rectangular shape of cocrystals. Flow properties of GPZ-GLU cocrystals were evaluated by micromeritics analysis. Size and surface morphology was determined by zeta sizer analysis and optical microscopy. Differential scanning calorimetry (DSC) and Thermogravimetric (TGA) analysis were performed to determine the melting points as well as thermal stability of pure components and formulated GPZ-GLU cocrystals. In-vitro drug release studies were carried out using dissolution apparatus-II. GPZ-GLU cocrystals showed higher drug release at pH 6.8 as compared to pH 1.2. However, percent drug release of optimum formulations at pH 6.8 was determined as; 24%-92.2% (F3) and 12.0%-93.5% (F7). Solubility studies revealed improved solubility as compared to pure drug in water i.e., 53 folds and 54.27 folds from F3 and F7 cocrystals, respectively. Finally it was concluded that glutaric acid has improved the solubility and dissolution profile of glipizide. However, many cocrystal formers have been reported in literature that can be used to enhance the physicochemical properties as well as bioavailability of poorly soluble drugs via cocrystalization technique.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 1; 103-114
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Toxicological evaluation of xanthan gum based hydrogel formulation in Wistar rats using single dose study
    Autorzy:
    Malik, Nadia S.
    Ahmad, Mahmood
    Minhas, Muhammad U.
    Tulain, Ruqia
    Khalid, Ikrima
    Barkat, Kashif
    Rashid, Ayesha
    Powiązania:
    https://bibliotekanauki.pl/articles/895609.pdf
    Data publikacji:
    2020-04-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    rats
    Histopathology
    Hydrogel
    acute toxicity
    Maximal tolerated dose
    Opis:
    Xanthan gum-based hydrogel formulation FXG3 was prepared by a free radical polymerization technique. To assess safety of FXG3 hydrogel for potential application as new drug delivery system, a single oral dose toxicity study was conducted according to OECD guidelines. Female adult rats of Wistar strain were divided into group A and group B. Group A served as the control and was given 1mL/100 g body weight 0.9% saline. Group B received a dose of 5g/kg body weight of FXG3 hydrogel. Rats were observed continuously for 14 days for clinical signs, and prior to terminal sacrifice, blood samples were taken to assess for haematology and biochemical parameters. Selected organs (heart, liver, lung, kidneys, spleen, and stomach) were removed and examined macroscopically, washed, sliced and stained with haematoxylin-eosin for histopathological investigation. No mortality or any signs of acute toxicity was observed during the observation period. No macroscopic alteration was found in the selected organs. Histopathological examination did not show any pathological changes. Thus, the maximal tolerated dose of FXG3 was calculated to be higher than 5g/kg body weight. It can be concluded that FXG3, a xanthan gum-based hydrogel formulation, was non-toxic after acute oral administration at 5g/kg body weight, and thus may be a promising candidate in controlled drug delivery system.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 353-360
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The power of ADKAR change model in innovative technology acceptance under the moderating effect of culture and open innovation
    Autorzy:
    Ali, Muhammad Ahmad
    Zafar, Usman
    Mahmood, Asif
    Nazim, Muhammad
    Powiązania:
    https://bibliotekanauki.pl/articles/2021479.pdf
    Data publikacji:
    2021
    Wydawca:
    Wyższa Szkoła Logistyki
    Tematy:
    ADKAR change model
    reinforcement
    uncertainty avoidance
    perceived ease of use
    inbound and outbound open innovation
    perceived usefulness
    model ADKAR
    wzmocnienie
    unikanie niepewności
    łatwość użytkowania
    Opis:
    Background: Continuous change is a vital factor for organization’s sustainable growth and success. The implementation of modern information technology in business has become a core need of the hour. This study endeavours to answer how to cope with resistance to change when implementing new technology in the banking sector. A theoretical model has been developed with the blend of ADKAR change model, Technology Acceptance Model (TAM), and Hofstede dimensions of national culture to investigate the impact of the ADKAR change model on Technology Acceptance under the moderation of two national culture’s dimensions. Materials and Methods: In order to collect data, 500 self-administered questionnaires were dropped personally in five major banks of five cities of Pakistan using the convenience-based employee intercept sampling technique. The validated response rate was 68% by having 340 fit questionnaires for analysis using covariance-based structure equation modelling with the help of SmartPLS. Results: The results uncover the significant existence of covariance between dimensions of the ADKAR change model and technology acceptance model. The findings are statistically significant, inferring the influential role of change management on technology adoption. Conclusion: The study results provide promising implications based on these conclusions and findings for both theoretical aspects of these different models and practitioners.
    Źródło:
    LogForum; 2021, 17, 4; 485--502
    1734-459X
    Pojawia się w:
    LogForum
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Manufacturing Cu-Pb alloys and studying efficiency in resisting oxidation
    Wytwarzanie stopów Cu-Pb i badanie ich odporności na utlenianie
    Autorzy:
    Sufian, Amina
    Hamood, Mahmood Ahmad Al- Jiboori
    Powiązania:
    https://bibliotekanauki.pl/articles/41153190.pdf
    Data publikacji:
    2023
    Wydawca:
    Wydawnictwo SIGMA-NOT
    Tematy:
    copper
    lead
    binary alloys
    oxidation
    miedź
    ołów
    stopy binarne
    utlenianie
    Opis:
    Binary alloys of copper and lead were produced by casting these elements in specially designed moulds with dimensions appropriate to the tests to be carried out on them. The effectiveness of these alloys in resisting oxidation was then studied in an atmosphere of a mixture of sodium chloride vapour and sodium sulphate at specific concentrations and heating the mixture to 180°C. Recently, corrosion has become a major problem in the overall performance of many engineering devices due to automotive exhaust gases produced by the internal combustion engine, which leads to corrosion of materials that make up some components of engineering industries. Copper also has good corrosion performance due to the formation of a copper oxide layer, which has made it the most important material in industrial applications. Through this research, we have achieved the desired goal as the alloys produced have shown their efficiency in resisting saline and acidic conditions and at high levels. The best sample is Cu95Pb5 and Cu90Pb10 with little difference between them in terms of efficiency. The aim of this work is to produce alloys and study their efficiency in resisting oxidation at high temperatures.
    Binarne stopy miedzi i ołowiu zostały wytworzone metodą odlewania w specjalnie zaprojektowanych formach o wymiarach dostosowanych do badań. Odporność stopów na utlenianie została zbadana w atmosferze mieszaniny oparów chlorku sodu i siarczanu sodu w określonych stężeniach i po podgrzaniu mieszaniny do 180°C. Korozja jest poważnym problemem, zaburza funkcjonowanie wielu urządzeń inżynieryjnych. Jej źródłem są m.in. spaliny wytwarzane przez silniki spalinowe. Miedź ma dobre właściwości antykorozyjne ze względu na warstwę tlenku miedzi, tworzącą się na jej powierzchni w wyniku utleniania. Z tego względu jest głównym materiałem stosowanym w przemyśle. Badane stopy miedzi i ołowiu wykazały wysoką odporność na działanie soli i kwasów w dużych stężeniach. Najlepsze wyniki uzyskano dla stopów Cu95Pb5 i Cu90Pb10 (różnica między nimi była niewielka). Celem pracy było zbadanie odporności wytworzonych stopów na utlenianie w wysokich temperaturach.
    Źródło:
    Ochrona przed Korozją; 2023, 12; 388-392
    0473-7733
    2449-9501
    Pojawia się w:
    Ochrona przed Korozją
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    DETERMINATION OF ACYCLOVIR IN RABBIT PLASMA BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC (HPLC) TECHNIQUE
    Autorzy:
    Malik, Nadia S.
    Ahmad, Mahmood
    Minhas, Muhammad U.
    Khalid, Qandeel
    Powiązania:
    https://bibliotekanauki.pl/articles/895236.pdf
    Data publikacji:
    2019-06-28
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    plasma
    acyclovir
    Reversed phase high-performance liquid chromatography
    Opis:
    A rapid, sensitive and simple reversed-phase high-performance liquid chromatographic (HPLC) method has been developed and validated for the determination of acyclovir (ACV) in rabbit plasma. BDS C18 column was used to conduct analysis using ammonium dihydrogen phosphate buffer (50mM) and methanol as mobile phase (98:2), with pH adjusted to 2.5 using orthophosphoric acid. Flow rate was kept at 1 mL/min. Selective precipitation of plasma proteins were done by adding 5% perchloric acid. Precipitated plasma proteins were separated by centrifugation. ACV moves in a supernatant, which was snapped and passed through a syringe filtration assembly. Direct injection of supernatant was given into a BDS C18 column and ACV was detected at 256 nm. The limit of detection for ACV in plasma was estimated as 15ng/mL whereas the limit of quantitation was calculated as 25 ng/mL. Moreover, the developed method has been found to be selective and linear into concentration range of 25 – 2000 ng/mL. The present method could be successfully applied to samples from bioavailability and bioequivalence studies.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 3; 421-429
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Design and analysis of a soft pneumatic actuator to develop modular soft robotic systems
    Autorzy:
    Tahir, Ahmad Mahmood
    Zoppi, Matteo
    Powiązania:
    https://bibliotekanauki.pl/articles/384581.pdf
    Data publikacji:
    2019
    Wydawca:
    Sieć Badawcza Łukasiewicz - Przemysłowy Instytut Automatyki i Pomiarów
    Tematy:
    soft actuator
    pneumatic actuation
    soft robotic mechanism
    modularity
    scalability
    siłownik
    modułowość
    skalowalność
    Opis:
    In this paper, we describe the design and analysis of a Soft Cubic Module (SCM) with a single internal pneumatically actuated chamber. The actuation chamber’s shape, size and, orientation have been evaluated to realize a soft robotic actuator which can be further employed for the development of modular soft robotic systems. SCM can be easily manufactured through the molding process and it is composed of single soft material, the silicone polymer. Its external shape allows utilization of this module as a single block actuator as well as makes it easy to combine multiple SCM modules to build multiunit soft robotic systems. We consider it as our first tool to investigate whether the SCM scheme is sufficient to build soft robots which would be able to perform certain given tasks in various configurations like a soft gripper, bio-mimetic crawling mechanism or multi-axis manipulator. So far, the results obtained are encouraging in order to further develop and employ the SCM design scheme, focusing on its further geometrical optimization for both standalone configuration and assembly of multiple modules to realize novel, economic and easy to fabricate soft robotic systems.
    Źródło:
    Journal of Automation Mobile Robotics and Intelligent Systems; 2019, 13, 1; 30-36
    1897-8649
    2080-2145
    Pojawia się w:
    Journal of Automation Mobile Robotics and Intelligent Systems
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Baseline study in environmental risk assessment : site-specific model development and application
    Autorzy:
    Alam, Asifa
    Mahmood, Adeel
    Chaudhry, M. Nawaz
    Ahmad, Sajid Rashid
    Safa, Noor Ul
    Alghamdi, Huda Ahmed
    Alhamdi, Heba Waheeb
    Ullah, Rizwan
    Powiązania:
    https://bibliotekanauki.pl/articles/2203136.pdf
    Data publikacji:
    2022
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    baseline study
    risk assessment models
    risk management
    mathematical approaches
    landfills
    dumping sites
    environmental risk estimation
    Opis:
    Environmental risk assessment is one of the key tools in environmental engineering. This risk assessment can be qualitative or quantitative and it is based on preliminary studies i.e., baseline study for waste disposal sites. Even though the literature exists on baseline study in general, still there is a lack of guidance regarding development of a site-specific baseline study model for a waste disposal site. This study has two-fold aim, firstly, how to develop site-specific baseline study model for a selected dumping site, and secondly, how this site-specific baseline study can support the environmental engineering via mathematical risk estimation. Mahmood Booti Open Dumping Site (MBODS) is selected to demonstrate the development and application of site-specific baseline study model. This is followed by building a framework that shows how the output of the baseline study can lead to environmental engineering via mathematical risk estimation. The paper provides a mechanism of how to construct a bespoke baseline-study model that is readily useable, avoiding procurement of expensive computer software and yet smoothly connecting with the follow-on stages of the risk assessment. The work presented in this paper can be reproduced repeatedly to create site-specific baseline study models for risk assessment of other waste disposal sites in a cost-effective, consistent and cohesive manner.
    Źródło:
    Archives of Environmental Protection; 2022, 48, 3; 80--88
    2083-4772
    2083-4810
    Pojawia się w:
    Archives of Environmental Protection
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Application of LandGEM mathematical model for the estimation of gas emissions from contaminated sites. A case study of a dumping site in Lahore, Pakistan
    Autorzy:
    Alam, Asifa
    Chaudhry, M. Nawaz
    Ahmad, Sajid Rashid
    Ullah, Rizwan
    Batool, Syeda Adila
    Butt, Talib E.
    Alghamdi, Huda Ahmed
    Mahmood, Adeel
    Powiązania:
    https://bibliotekanauki.pl/articles/2057619.pdf
    Data publikacji:
    2022
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    mathematical model
    greenhouse gas
    energy supply
    garbage dump
    model matematyczny
    gaz cieplarniany
    źródło energii
    wysypisko śmieci
    Opis:
    Decomposition of organic waste in dumping sites and landfills prompts the uncontrolled emission of greenhouse gases which enhances global warming and related issues. The present investigation estimated the total landfill gas, methane, carbon dioxide and non-methane organic compounds emissions from Mahmood Booti dumping site located at Lahore, Pakistan from 1996 to 2045. LandGEM 3.02 model was utilized to evaluate the gas emission with the volumetric methane 50%, production potential (170 m3/Mg), and methane generation rate (0.050/year). The findings demonstrated that organic and food wastes had the maximum quantity in the solid waste stream (63.46%). Methane measured from solid waste was 1.150E+03 (Mg/year) in 1997 in the first year after waste was accepted by landfill while the maximum methane generation rate happened from 2014 to 2018, i.e., from 4.049×104 to 4.654×104 Mg/year, respectively. The study finding highlighted that all gases emissions have an increasing/rising trend up to 2021 and then gradually their level will decrease because most of the organic fractions of solid waste would degrade with time. The findings of this study can be used to identify the impacts and contribution of MBODS in the global emission of greenhouse gases. The study concludes that proper management of landfill gas will not only decreases greenhouse gas emissions, diminishing adverse impacts on public health but can also be used as a sustainable energy source.
    Źródło:
    Environment Protection Engineering; 2022, 48, 1; 69--81
    0324-8828
    Pojawia się w:
    Environment Protection Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Application of EASEWASTE model for assessing environmental impacts from solid waste landfilling
    Autorzy:
    Alam, Asifa
    Chaudhry, Muhammad Nawaz
    Ahmad, Sajid Rashid
    Batool, Aadila
    Mahmood, Adeel
    Al-Ghamdi, Huda Ahmad
    Powiązania:
    https://bibliotekanauki.pl/articles/2073793.pdf
    Data publikacji:
    2021
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    EASEWASTE
    risk assessment
    dumping sites
    gas emissions
    toxicity
    Opis:
    Dumping sites or landfills are considered as foremost common option of waste management worldwide. Dumping sites, often not lined, represent a potential environmental issue causing a long-term risk to the environment and health. A number of computers model-based studies have described the solid waste collection and its management, but provide little information about the relative contributions regarding environmental impacts of landfilling especially in the context of developing world. The aim of study was to estimate environmental impacts from dumping site by using EASEWASTE model. A case study was carried out at an old and closed dumping site filled with mixed waste without bottom liner, no leachate collection and gas collection. On the basis of the existing dumping site investigation, a Mahmood Booti Dumping Site Scenario was developed, and related data of waste generation & composition was collected and added to assess environmental impacts. The results show that human toxicity via soil (9.14E+09 m3 soil) had the highest potential impact, followed by global warming (8.83E+11 Kg CO2-eq), eco-toxicity in water (6.25E+11 m3 water), and eco-toxicity in soil (6.54E+10 m3 soil). This is mostly caused by leaching of heavy metals from ashes (e.g. residues from roads cleaning and vacuum cleaning bags), batteries, paper and metals. The adopted risk analysis approach uses easily accessible computer aided models, for open dumping sites, appears to be a key tool to assist decision makers in establishing priorities for remediation action.
    Źródło:
    Archives of Environmental Protection; 2021, 47, 4; 84--92
    2083-4772
    2083-4810
    Pojawia się w:
    Archives of Environmental Protection
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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