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Wyświetlanie 1-15 z 79
Tytuł:
19F MRI As a tool for imaging drug delivery to tissue and individual cells
Autorzy:
Bober, Zuzanna
Aebisher, David
Ożóg, Łukasz
Tabarkiewicz, Jacek
Tutka, Piotr
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454941.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
drug delivery
drug tracking
fluorine
magnetic resonance imaging
Opis:
Over the past few decades, magnetic resonance imaging (MRI) has proven to be extremely successful in medical applications. More recently, the biomedical applications of MRI have been gaining more use in the field of clinical pharmacy. In 1977, perfluorocarbon compounds (PFC), which form emulsions that can carry drugs, were analyzed by 19F MRI and emulsified PFC compounds have been investigated as potential blood substitutes since the early 1960s and now a wide variety of PFC compounds are currently available as 19F MRI biomarkers. Molecules with 19F substituents are particularly attractive for use in drug tracking by 19F MRI due to 100% 19F abundance, high 19F MRI sensitivity (0.83 relative to 1H MRI) and an impressively large chemical shift range (400 ppm). Another benefit in the use of 19F MRI is a zero background signal in biological samples due to lack of endogenous fluorine. Therefore, drugs containing fluorine atom have potential for 19F MRI imaging drug delivery to tissue. This article will review recent developments in the use of 19F MRI in imaging drug delivery to tissue and individual cells.
Źródło:
European Journal of Clinical and Experimental Medicine; 2017, 2; 99-109
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A 16-year-old patient with Charcot Marie Tooth disease in variant c.217G>C of the INF2 gene and focal glomerulosclerosis – a case report
Autorzy:
Przygoda, Maria
Matias, Dawid
Jurczak, Maciej
Sokołowska, Aldona
Raba, Karolina
Wołkanowski, Juliusz
Rydzanicz, Małgorzata
Kosińska, Joanna
Płoski, Rafał
Aebisher, David
Pyrkosz, Antoni
Powiązania:
https://bibliotekanauki.pl/articles/2040499.pdf
Data publikacji:
2021-12-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
exome sequencing
neuropathy
nephropathy
Opis:
Introduction. Charcot Marie Tooth disease (CMT) is currently one of the most commonly diagnosed and commonly hereditary sensorimotor neuropathies. Concluding from the literature, this is the first study describing the case of a patient with CMT disease in the c.217G> C variant of the INF2 gene and focal segmental glomerulosclerosis. Aim. To present a case of a 16-year-old patient suffering from CMT disease in variant c.217G> C of the INF2 gene and focal glomerulosclerosis. Description of the case. The text describes the CMT disease in a patient who underwent the WES / WGS-NGS genetic test and found a mutation within the INF2 gene at the chromosomal position hg38 14: 104701582-G> C, cDNA level c.217 G> C , notation at the p protein level (Gly73Arg). Genotype record according to Human Genome Variation Society: NM_022489.4: c. [217G> C]; [217 =]. The publication includes data on genetics, molecular mechanisms of the disease, diagnostic methods, rehabilitation and surgical treatment. Conclusion. CMT disease is a heterogeneous group of diseases caused by mutations in various genes. The incidence of this pathology has increased significantly in the last century. Currently, there are no treatments available to combat this disease, and symptomatic treatment is the only treatment available.
Źródło:
European Journal of Clinical and Experimental Medicine; 2021, 4; 341-346
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adrenomyeloneuropathy – a case report
Autorzy:
Leksa, Natalia
Aebisher, David
Galiniak, Sabina
Uberman-Kluz, Dominika
Bartosz, Serweryn
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454995.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
adrenoleukodystrophy
fatty acids
steroid therapy
Opis:
Introduction. Adrenoleukodystrophy is a genetic disorder linked to the X chromosome, in which the peroxisomal beta-oxidation process is disturbed. It is a metabolic disease that results in the accumulation of very long chain fatty acids (VLCFAs - very long chain fatty acids) responsible for the symptoms of damage to the adrenal cortex, gonads and the brain. Aim. A clinical case is reported. Description of case. This article describes the case of a 64-year-old woman who had neurological symptoms for many years, gradually increasing without significant improvement after the treatment (periodic steroid therapy). Conclusion. Based on tests (including the determination of the ABCD1 gene and very long chain fatty acids - VLCFA), adrenoleukodystrophy was suspected.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 3; 274-276
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An iliac artery aneurysm
Autorzy:
Leksa, Natalia
Leksa, Dawid
Gałuszka, Łukasz
Uryniak, Adam
Aebisher, David
Galiniak, Sabina
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/2038415.pdf
Data publikacji:
2020-09-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
arteriograph
iliac artery aneurysms
intravascular therapy
Stent-Graft
Opis:
Introduction. Isolated common iliac artery aneurysms (CIAs) are rare. The rarer are rupture of the common iliac artery. We can treat them surgically: classic or endovascular. Open surgery has a main role in the management of aneurysms not suitable for repair by endovascular techniques. Aim. The aim of the study is to present the possibility of occurrence of such a disease at a young age, to indicate non-characteristic symptoms that may predict the above-mentioned disease entity at the level of a primary care physician or SOR. Review of medical publications from 2000-2019 regarding guidelines or methods of conduct in that cases. Description of the case. A patient 39 years old, admitted to the Department of Vascular Surgery, in an interview: about 15 years ago severely beaten, as a result of injuries total loss of hearing, memory and basic skills such as: speech, writing, reading, hospitalized over 6 months. Conclusion. Good rehabilitation and patient persistence restored cognitive skills. Advances in surgical has lowered the mortality and morbidity rates even in patients.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 3; 242-244
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anticancer properties of Viburnum
Autorzy:
Stępień, Agnieszka
Aebisher, David
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454949.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
antitumor activity
Viburnum species
cytotoxic activity
Opis:
Aim. The aim of this paper is to provide an overview of the anticancer properties of different species of Viburnum. Materials and methods. Forty nine papers that discuss the medicinal history and current research of Viburnum species as phytotherapeutic agent were used for this discussion. Literature analysis. The results of scientific research conducted in vitro indicate that the compounds present in the extracts of Viburnum significantly affect the development of cancer cells such as leukemia, cervical cancer, breast, colon, lung, skin and stomach. This indicates that they may be used as a therapeutic agent to support oncological therapies.
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 1; 47-52
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Applications of cytisine extraction and detection in biological materials for clinical medicine
Autorzy:
Bartusik-Aebisher, Dorota
Aebisher, David
Courtney, Ryan
Sobczak, Andrzej
Bober, Zuzanna
Podgórski, Rafał
Kołodziejczyk, Patrycjusz
Tutka, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/895314.pdf
Data publikacji:
2019-10-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
smoking cessation
chromatography
Biomedicine
cytisine extraction
biopharmacy
Opis:
Tobacco use is a leading cause of preventable mortality worldwide. New cost-effective smoking cessation treatments are needed especially in some low-to-middle income countries where smoking rates are rising, and current pharmacotherapy treatments remain cost-prohibitive. Since the 1960’s, cytisine has been used as an effective nicotine substitution agent to aid in smoking cessation albeit limited to a selected few Eastern/Central Europe and Central Asian countries. Cytisine is a biologically active alkaloid of plant origin and is known to be a ligand of nicotinic acetylcholinergic receptors (nAChRs). For several decades, the properties of cytisine have been investigated and reported in the biomedical and pharmaceutical literature. Due to the beneficial impact of cytisine on smoking cessation and its costly multistep synthesis, there is a growing interest in extraction from natural sources as well as in analytical identification and quantification for clinical medicine and forensic toxicology. In this paper, we present several current analytical approaches to cytisine extraction and identification from biological samples of plant and human origin. The development of extraction techniques will allow for the widespread use of the drug in experimental and clinical pharmacology, toxicology and forensic medicine.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 797-804
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
ASL (Arterial Spin Labeling) – historical and current perfusion MR methods
Autorzy:
Guz, Wiesław
Bober, Zuzanna
Ożóg, Łukasz
Truszkiewicz, Adrian
Przypek, Aneta
Aebisher, David
Bartusik-Aebisher, Dorota
Urbanik, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/454978.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
perfusion
MR
ASL
Opis:
Despite continuous scientific and technological advances in MR imaging, MR perfusion methods have not yet been widely deployed for routine clinical diagnostics. This is especially true for ASL (arterial spin labelling) methods used to evaluate cerebral perfusion. This method does not require a contrast agent, as new discoveries about gadolinium accumulation in the cerebellum and brain nucleus appear to be a valuable asset and provide the opportunity to be more widely deployed in clinical practice. The aim of this paper is to present the historical determinants of the development of MR perfusion techniques, the disadvantages and advantages and possible clinical applications and prospects of ASL development. Both historical articles published on MR in the 1990s and current research between 2006-2016 have been reviewed. The authors present in the work the MR perfusion method focusing on issues related to arterial spin labeling (ASL). Historically CASL (continuous ASL) and PCSL (pulsed ASL) techniques have been described and the pseudocontinuous ASL (pseudocontinuous ASL) 3D technique presents its technical and methodological considerations, advantages and disadvantages over previous methods. The methods of test protocol optimization and accompanying artifacts, as well as possible clinical applications and development perspectives, have been described.
Źródło:
European Journal of Clinical and Experimental Medicine; 2017, 2; 145-150
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biological properties of Cistus species
Autorzy:
Stępień, Agnieszka
Aebisher, David
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454751.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
biological properties
Cistus sp.
medicinal plants
Opis:
Aim. This paper presents a review of scientific studies analyzing the biological properties of different species of Cistus sp. Materials and methods. Forty papers that discuss the current research of Cistus sp. as phytotherapeutic agent were used for this discussion. Literature analysis. The results of scientific research indicate that extracts from various species of Cistus sp. exhibit antioxidant, antibacterial, antifungal, anti-inflammatory, antiviral, cytotoxic and anticancer properties. These properties give rise to the possibility of using Cistus sp. as a therapeutic agent supporting many therapies
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 2; 27-132
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bladder leiomyoma: diagnostics, laparoscopy, and treatment
Autorzy:
Godlewski, Dominik
Pszczółkowski, Patryk
Fedus, Tadeusz
Aebisher, David
Powiązania:
https://bibliotekanauki.pl/articles/2038414.pdf
Data publikacji:
2020-09-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
bladder leiomyoma
endometriosis
laparoscopic surgery
Opis:
Introduction. Leiomyosarcoma is the most common benign tumor of the bladder. However, it is only a small percentage of all proliferative changes of this organ. Aim. Presentation based on two clinical cases of diagnostics and surgical treatment from laparoscopic access of bladder leiomyoma. Description of the cases. Case 1. The work contains a diagnosis based on transvaginal ultrasound (TVUS), cystoscopy and computed tomography (CT), as well as partial laparoscopic bladder re section of leiomyoma in young women. Case 2. The case of young women with the histopathological result confirmed bladder leiomyoma. Conclusions. Leiomyoma is a rare bladder cancer. Laparoscopic bladder resection is a safe method that leads to healing
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 3; 237-241
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bladder Mullerianosis – a case report
Autorzy:
Ostańska, Elżbieta
Aebisher, David
Kaznowska, Ewa
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454913.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
endocericosis
endosalpingiasis
mullerianosis
urinary bladder
Opis:
Introduction. Bladder mullerianosis is a rare and proliferative lesion that contains at least two types of ectopic Mullerian tissue in its wall. Aim. To present case of bladder mullerianosis. Description of case. The text contains a description of a clinical case of a 50-year-old woman admitted to a gynecological ward due to diarrheal symptoms and abdominal pain. In a CT examination of the abdominal cavity with contrast, within the posterior left-sided wall of the bladder a 43x25mm proliferative lesion suggestive of neoplastic character was revealed. Transurethral resection of the lesion (TURB) was performed. Histopathology revealed endosalpingiosis with small endocervical foci. The picture of hyperplasia met the criterion of mullerianosis. Conclusion. Bladder Mullerianosis is a very rare disease that occurs mainly in women of reproductive age. It has very good prognosis. It is important to differentiate the lesion with malignant tumor. The basis for the diagnosis is the histopathological examination of the lesion tissues taken during the surgery.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 3; 277-280
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Brachial artery injury
Autorzy:
Milik, Krzysztof
Pasternak, Grzegorz
Aebisher, David
Powiązania:
https://bibliotekanauki.pl/articles/2037693.pdf
Data publikacji:
2020-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
broken bone
traumatic joint dislocation
vascular injuries
Opis:
Introduction. Arterial damage associated with musculoskeletal injuries at room conditions is very common. Aim. It is worth remembering that examining a patient who has suffered an accident with a broken bone or traumatic joint dislocation may be accompanied by vascular damage. A dislocation or fracture often masks damage to the artery. Description of the case. In this paper, a 20-year-old patient being a passenger suffered upper right limb trauma in a car accident. Conclusion. The effects of vascular injuries appear only after a few hours after setting the fracture. It is not known then whether the artery was damaged at the same time with the fracture, whether the injury occurred during the adjustment, or whether the ischemia is finally the result of the pressure exerted by too tight plaster casts.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 2; 141-145
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chemiluminescence-driven Dye Excitation for Dark Photodynamic Therapy
Autorzy:
Ożóg, Łukasz
Tabarkiewicz, Jacek
Aebisher, David
Powiązania:
https://bibliotekanauki.pl/articles/454676.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
singlet oxygen
chemiluminescence bioluminescence
photodynamic therapy
Opis:
Photodynamic therapy is a treatment that uses a combination of light-absorbing photosensitizers and dissolved oxygen to kill cancer. One specific limitation of photodynamic therapy is that the visible light used for photosensitizer excitation has a short tissue penetration depth of several millimeters. This limits the application of photodynamic therapy to surface cancers in the absence of a technique to illuminate deeper tissue. Efforts to extend tissue depth to which photodynamic therapy can be applied have been attempted with use of up-conversion and persistent-luminescent nanoparticles that absorb near infrared light and emit visible light for photosensitizer excitation, yet an initial excitation with an external light source is still required. More recently, systems employing chemiluminescence as an excitation energy source designed to bypass the use of external light have been developed and investigated as potential agents that could overcome the problem of achieving photodynamic therapy in deep tissue. We wish to provide an overview of several systems that have been recently reported that employ both radiative and non-radiative chemiluminescent energy transfer for photosensitizer excitation that have been developed in the hope of achieving “dark” photodynamic therapy. This article reviews several of these important new developments in the design of photodynamic therapeutic systems that utilize chemiluminescence.
Źródło:
European Journal of Clinical and Experimental Medicine; 2017, 2; 95-98
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clinical application of advanced neuroimaging techniques – Magnetic Resonance Spectroscopy
Autorzy:
Guz, Wiesław
Bober, Zuzanna
Ożóg, Łukasz
Truszkiewicz, Adrian
Przypek, Aneta
Aebisher, David
Bartusik-Aebisher, Dorota
Urbanik, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/454826.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
spectroscopy
MR
SVS
CSI
Opis:
Continuous scientific research and the increasing saturation of the medical market in Poland implements the possibilities of using advanced MR techniques including MRS in everyday practice. This method, which has so far been used primarily for research purposes, can bring measurable benefits to patients not only in terms of clarifying diagnosis and narrowing differential diagnosis, but also monitoring the course of various diseases and their treatment. Here we present the basic principles of performing and interpreting spectroscopic spectra and possible clinical applications and development prospects of MRS. The literature reviewed both Polish and foreign articles both historically and in the past 10 years. The paper presents methodological issues related to the proper performance of magnetic resonance spectroscopy (MRS) and spectral composition and the role of major metabolites, as well as current clinical applications and directions of MRS development.
Źródło:
European Journal of Clinical and Experimental Medicine; 2017, 2; 133-140
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Coagulation markers in diagnostic and monitoring of thromboembolic complication in COVID-19
Autorzy:
Czarnecka-Czapczyńska, Magdalena
Bartusik-Aebisher, Dorota
Krupka-Olek, Magdalena
Aebisher, David
Cieślar, Grzegorz
Latos, Wojciech
Kawczyk-Krupka, Aleksandra
Powiązania:
https://bibliotekanauki.pl/articles/2040166.pdf
Data publikacji:
2021-09-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
anticoagulation
coagulation abnormalities
COVID-19
Opis:
Introduction. Coronavirus disease 2019 (COVID-19) was first observed in China in Wuhan city, Hubei province in December, 2019, and specified as a pandemic by the World Health Organization (WHO). COVID-19 is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV2). Aim. The aim of this article is to discuss epidemiology of thromboembolic complication in COVID-19. Material and methods. This article is a review done in regards to discuss clinical features of the anticoagulation treatment in COVID-19. Analysis of the literature. A review is discussed an anticoagulation treatment in 41 manuscripts. Conclusion. Most commonly coagulation abnormalities in patient with COVID-19 is mild thrombocytopenia. Apart from their typical role in thrombosis and hemostasis, platelets mediate key aspects of immune and inflammatory.
Źródło:
European Journal of Clinical and Experimental Medicine; 2021, 3; 241-245
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Congenital adrenal hyperplasia: clinical symptoms and diagnostic methods
Autorzy:
Podgórski, Rafał
Aebisher, David
Stompor, Monika
Podgórska, Dominika
Mazur, Artur
Powiązania:
https://bibliotekanauki.pl/articles/1038519.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Congenital Adrenal Hyperplasia
CAH
steroidogenesis
21-hydroxylase deficiency
Opis:
The aim of this paper is a straightforward presentation of the steroidogenesis process and the most common type of congenital adrenal hyperplasia (CAH) - 21-hydroxylase deficiency - as well as the analytical diagnostic methods that are used to recognize this disease. CAH is a family of common autosomal recessive disorders characterized by impaired adrenal cortisol biosynthesis with associated androgen excess due to a deficiency of one or more enzymes in the steroidogenesis process within the adrenal cortex. The most common and prototypical example of the CAH disorders group (90-95%) is caused by 21-hydroxylase deficiency. Less frequent types of CAH are 11β-hydroxylase deficiency (up to 8% of cases), 17α-hydroxylase deficiency, 3β-hydroxysteroid dehydrogenase deficiency, P450 oxidoreductase deficiency and StAR deficiencies. In the 21-hydroxylase and 11β-hydroxylase deficiency, only adrenal steroidogenesis is affected, whereas a defect in 3β-hydroxysteroid dehydrogenase or 17α-hydroxylase also involves gonadal steroid biosynthesis. Many countries have introduced newborn screening programs based on immunoassays measuring 17-hydroxyprogesterone from blood spots used for other neonatal screening tests which enable faster diagnosis and treatment of CAH. Currently, chromatographic techniques coupled with mass spectrometry are gaining popularity due to an increase in the reliability of the test results.
Źródło:
Acta Biochimica Polonica; 2018, 65, 1; 25-33
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
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