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Wyświetlanie 1-3 z 3
Tytuł:
Dydaktyczne aspekty powieści dla dziewcząt na przykładzie wybranych utworów Marty Fox
Didactic aspects of a novel for girls on the example of selected works of Marta Fox
Autorzy:
Świercz, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/956363.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
a novel for girls
marta fox
didacticism
Opis:
Literary works dedicated to adolescent girls are primarily aimed at preparing young readers for the roles that await them in adulthood. The type of didacticism chosen by authors of this type of prose has been evolving along with the history of the subgenre and transformations in the field of pedagogy. The direct, narrative moralizing of the young reader gave way to the place of presentation of educational assumptions that are introduced to the books by constructing the fates of heroes, allowing readers to draw their conclusions and assessments independently. The prose for the youth by Marta Fox refers to the historical determinants of the novel for girls and didactic traditions of this genre. The author, however, avoids direct instructions, at the same time remembering about the educational message while constructing various elements of the presented world.
Źródło:
Dydaktyka Polonistyczna; 2019, 5 (14); 160-170
2451-0939
Pojawia się w:
Dydaktyka Polonistyczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Metabolism and in vitro assessment of the mutagenic activity of urinary extracts from rats after inhalation exposure to 1-methylnaphthalene
Autorzy:
Świercz, Radosław
Stępnik, Maciej
Gromadzińska, Jolanta
Domeradzka-Gajda, Katarzyna
Roszak, Joanna
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2152982.pdf
Data publikacji:
2022
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
rats
inhalation
micronucleus test
toxicokinetics
1-methylonaphthalene
1-naphthoic acid
Opis:
Objectives 1-Methylnaphthalene (1-MN) is composed of 2 benzene rings and belongs to polycyclic aromatic hydrocarbons. The metabolism of 1-MN in laboratory animals and bacteria leads to the formation of 1-naphthoic acid (1-NA). Material and Methods In this study the distribution of 1-NA in lung, liver, spleen, kidney and urinary excretion of 1-NA in rats after single and repeated inhalation exposure to 1-MN vapors were investigated. The activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and cytochrome were measured of the rats. Genotoxic effects were evaluated with the in vitro micronucleus test on V79 hamster fibroblasts. Results The concentrations of 1-NA in the tissues of rats after single and repeated exposure to 1-MN were dependent on the exposure dose. High levels of 1-NA were found in kidneys of animals after the single and repeated exposure to 1-MN. With an increase of 1-MN dose, an increase in the activity of cytochrome P450 (CYP1A1 and CYP1A2) was observed in the liver of rats. Compared to control animals, significantly higher ALT activity was noted in serum of rats exposed to 1-MN. The micronuclei frequency in V79 cells exposed to 1-MN (in the range of analyzable concentrations; i.e., 5–25 μg/ml) did not differ significantly from the vehicle control, whereas urine extracts from rats exposed to 1-MN induced a significant increase in the frequency of micronuclei compared to urine extracts from the group of control animals. Conclusions Metabolism of 1-MN in rats after the inhalation exposure leading to 1-NA was mainly observed during the first day after the end of exposure. It is likely that 1-MN metabolites present in rat urine can induce the increased micronuclei frequency as was shown in V79 cells.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2022, 35, 6; 731-746
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clara cells protein, prolactin and transcription factors of protein NF-ĸB and c-Jun/AP-1 levels in rats inhaled to stainless steel welding dust and its soluble form
Autorzy:
Hałatek, Tadeusz
Stanisławska, Magdalena
Świercz, Radosław
Domeradzka-Gajda, Katarzyna
Kuraś, Renata
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2162014.pdf
Data publikacji:
2018-10-23
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
prolactin
stainless welding
Clara cells protein
NF-kB
c-Jun/AP-1
LA-ICP-MS
Opis:
Objectives Welding processes that generate fumes containing toxic metals, such as hexavalent chromium (Cr(VI)), manganese, and nickel (Ni), have been implicated in lung injury, inflammation, and lung tumor promotion in animal models. Bronchiolar epithelium Clara cells/club cells, coordinate these inflammatory responses. Clara cells secretory protein (CC16) with ant-inflammatory role. Material and Methods The pulmonary toxicity of welding dust (WD) was assessed for Wistar rats exposed to 60 mg/m³ of respirable-size welding dust (mean diameter 1.17 μm for 1 and 2 weeks (6 h/day, 5 days/week)) or the aerosols of soluble form (SWD) in the nose-only exposure chambers. Additionally the effect of antiinflammatory betaine supplementation was assessed. Clara cells secretory protein, differential cell counts, total protein concentrations and cellular enzyme (lactate dehydrogenase – LDH) activities were determined in bronchoalveolar lavage fluid, and corticosterone and thiobarbituric acid reactive substances (TBARS) and prolactin concentrations were assessed in serum. Histopathology examination of lung, brain, liver, kidney, spleen was done. Additionally slices of brain and lung were exanimated in laser ablation inductively coupled plasma mass spectrometry. Results Both WD and SWD exposure evoked large bronchiolar infiltration shoved in histopathology examination. In this study, TBARS inversely correlated with a significant decrease of CC16 concentration that occurred after instillation of both WD and SWD indicating decreased anti- inflammatory potential in the lung. In WD exposed rats prolactin correlated with nuclear factor-kappa B (NF-κB), LDH, TBARS and serum levels Cr, Ni and inversely with c-Jun. In SWD exposed rats prolactin correlated with CC16 indicated effect of prolactin on the population of epithelial cells. Conclusions In the current study, deleterious effects of repeated inhalation stainless steel welding dust form on club (Clara) cell secretory protein (CC16) were demonstrated. Clara cells secretory protein relation with prolactin in exposed rats to welding dust were shown and explored whether the NF-κB and c-Jun/activator protein 1 related pathway was involved. Int J Occup Med Environ Health 2018;31(5):613–632
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 5; 613-632
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-3 z 3

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