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    Wyświetlanie 1-5 z 5
    Tytuł:
    Investigation of interactions between dermorphin analogs and µ-opioid receptor
    Autorzy:
    Karczyńska, A.
    Zaborowski, B.
    Ślusarz, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1935820.pdf
    Data publikacji:
    2014
    Wydawca:
    Politechnika Gdańska
    Tematy:
    molecular modeling
    opioid receptors
    defmorphin
    molecular docking
    drug design
    modelowanie molekularne
    receptory opioidowe
    dokująca molekularna
    projektowanie leków
    dermorfina
    Opis:
    Opioid receptors play the pain control function in the body. Most of the research is carried out to find the most effective analgesic. The earliest analgesic is morphine, however, unfortunately it has many side effects [Mizoguchi H et al. 2003 J. Pharmacol Sci. 93 423]. At a later time dermorphin was discovered as another potent analgesic [Mont ecucchi P C et al. 1981 Int. J. Pept. Protein Res. 17 275]. Unfortunately, this peptide is not resistant to enzymatic metabolism [Kisara K et al. 1986 Br. J. Pharmacol. 87 183; Sasaki Y et al. 1985 Neuropeptides 5 391]. The objective of this study is to search for new opioid analgesics by investigation of interactions between dermorphin analogs and the μ -opioid receptor using molecular modeling methods. MOPR ( μ -Opioid Peptide Receptor) complexes with several ligands (with known biological activity) were modeled to explain how the structure of the complex was related to the biological activity. The investigated dermorphin analogs containing [ DMT1, D -Arg 2 ] (especially tetrapeptides) may become a good alternative for the currently used an algesics.
    Źródło:
    TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2014, 18, 4; 331--336
    1428-6394
    Pojawia się w:
    TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of the frequency of childhood hospitalization due to thermal injuries in the Provincial Polyclinical Hospital in Torun, Poland, 2007–2011
    Autorzy:
    Barczykowska, E.
    Cyran, M.
    Zreda-Pikies, A.
    Kowalczyk, M.
    Ślusarz, R.
    Kurylak, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2081550.pdf
    Data publikacji:
    2018
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    burns
    children
    hospitalization
    Opis:
    Introduction. Burns constitute the most common and severe injuries suffered in childhood. Objective. The study was aimed at providing a retrospective analysis of the etiology, location, extent and depth of burns, as well as treatment methods and length of hospital stay. Materials and method. A retrospective analysis of 508 cases of children treated due to a thermal injury between 1 January 2007 31 December 2011 was conducted at the Department of Paediatrics, Urology and Paediatric Surgery, Children’s Hospital, L. Rydygier Provincial Hospital in Toruń, Poland. Results. The sample group included more boys (58.9%) than girls (41.1%). The most numerous group comprised children aged 1–2 years (44.5%). Burns were largely suffered at home (91.9%). Injuries were largely caused by thermal burns (99.2%). Half of the children sustained injury to one body area (51.4%), while every third sufferer (37.9%) was affected by burns to body parts prone to trigger shock. Burns up to 5% of the Total Body Surface Area (TBSA) were suffered by half (51.2%) of the children. Most of the patients underwent conservative treatment (89.4%). Conclusions. Burns were mostly suffered by children at 1–2 years of age, with boys prevailing over girls. Injuries were largely suffered at the child’s family home, in the afternoon or evening, while the child was in the care of the parents. Scalds, caused by hot liquid, constituted the most frequent type of injury. The most numerous group of affected children comprised burns to limb areas, and thorax with limbs, with the TBSA of up to 5%. The great majority of the patients underwent conservative treatment, with a hospitalization period of up to 3 days.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2018, 25, 1; 26-30
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Egzopolisacharydy bakteryjne : budowa i funkcje
    Bacterial exopolysaccharides : structure and functions
    Autorzy:
    Samaszko-Fiertek, J.
    Kuźma, M.
    Dmochowska, B.
    Ślusarz, R.
    Madaj, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/172244.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    egzopolisacharydy
    kwas hialuronowy
    celuloza bakteryjna
    dekstran
    żelan
    ksantan
    exopolysaccharides
    hyaluronic acid
    bacterial cellulose
    dextran
    gellan
    xanthan
    Opis:
    Exopolysaccharides fulfil protective functions and allow bacteria live in the communities, single or mixed, by facilitating adhesion to surfaces and to each other. Microbes prefer to exist in the form of a biofilm. The term biofilm was introduced in 1978 and is the group of microorganisms surrounded by extracellular, highly hydrated mucus, which allows adhesion on various surfaces and adhesion of cells to each other [1]. The extracellular slime owes its character mainly due to the presence of exopolysaccharides. Bacteria living in biofilms, have a high resistance to external factors, such as changes in temperature, pH, humidity, oxygenation, presence of bacteriocins, antibodies or antibiotics. They may be up to 1,000 times more resistant to antibiotics than planktonic forms. They can be synthesized inside and outside bacteria cell. The structure of the bacterial exopolysaccharide is very diverse, but very often, due to the presence of uronic acid residues, or non-sugar organic acids as pyruvic acid, succinic acid, as well as residues of inorganic acids such as phosphoric acid or sulfuric acid, they are negatively charged particles. In addition, a characteristic of most of the exopolysaccharides (EPS) is their enormous molecular mass of up to several million g/mol [11]. Thanks to its rheological properties, ease of isolation, and often biodegradable antioxidant activity extracellular polysaccharides are increasingly used in industry as a gelling agents, hardening and thickening agents, emulsifiers, food coatings and pharmaceutical products. In addition, they can be used as bandages, anti-cancer agents, cholesterol-lowering, antiulcer or immunomodulators [20–27]. This article discusses in details the selected exopolysaccharides such as xanthan, gellan, exopolysaccharides of lactic acid bacteria, dextran, bacterial cellulose, alginic acid, hyaluronic acid, mannans.
    Źródło:
    Wiadomości Chemiczne; 2016, 70, 7-8; 473-496
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Metody określania struktury polisacharydów
    Methods for determining polysaccharides structure
    Autorzy:
    Samaszko-Fiertek, J.
    Kuźma, M.
    Dmochowska, B.
    Ślusarz, R.
    Madaj, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/172410.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    polisacharydy
    monosacharydy
    degradacja oksydacyjna
    analiza metylacyjna
    acetoliza
    NMR
    magnetyczny rezonans jądrowy
    MS
    polysaccharides
    monosaccharides
    oxidative degradation
    methylation analysis
    acetolysis
    nuclear magnetic resonance (NMR)
    Opis:
    Sequencing of polysaccharides is difficult to achieve because of the heterogeneous nature of the polysaccharide structure, high molecular weight (the size of a polysaccharide varies between approximately 16,000 and 16,000,000 daltons (Da)), and polydispersity of the polymer chains. The following information is essential to determine the primary structure of a polysaccharide: • monosaccharide composition: nature and molar ratios of the monosaccharide building blocks; • relative configuration of monosaccharides: d or l; • anomeric configuration: α- or β-configuration of the glycosidic linkage; • ring size: presence and distinction of furanosidic and pyranosidic rings; • linkage patterns: linkage positions between the monosugars and branches; • sequences of monosaccharide residues in the repeating units; • substitutions: position and nature of OH–modifications, such as O–phosphorylation, acetylation, O-sulfation, etc.; • molecular weight and molecular weight distribution. A polysaccharide extracted from plant materials or food products is usually purified before being subjected to structural analysis. The first step of characterizing a polysaccharide is the determination of its purity, which is reflected by its chemical composition, including total sugar content, level of uronic acids, proteins, ash, and moisture of the preparation. The second step is the determination of monosaccharide composition, which will unveil structural information such as the number of monosaccharides present in the polysaccharide and how many of each sugar unit. NMR spectroscopy has become the most powerful and noninvasive physicochemical technique for determining polysaccharide structures. It can provide detailed structural information of carbohydrates, including identification of monosaccharide composition, elucidation of α- or β-anomeric configurations, establishment of linkage patterns, and sequences of the sugar units in oligosaccharides and/or polysaccharides. Monosaccharide composition can be determined also by analysis of totally acid hydrolyzed polysacharide using high performance liquid chromatography (HPLC) or gas chromatography (GC). The ring size and glycosidic linkage positions of sugar units in a polysaccharide could be established by methylation analysis and/or cleavage reduction. The anomeric configuration is conventionally determined by oxidation, and this method can be combined with mass spectrometry to obtain more structural information.
    Źródło:
    Wiadomości Chemiczne; 2016, 70, 5-6; 299-318
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analiza porównawcza testów emisji związków szkodliwych spalin silnika turbinowego
    Comparative analysis of exhaust emission tests for a turbine engine
    Autorzy:
    Merkisz, J.
    Markowski, J.
    Ślusarz, G.
    Galant, M.
    Karpiński, D.
    Wirkowski, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/133551.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Naukowe Silników Spalinowych
    Tematy:
    emisja
    samolot wielozadaniowy
    test LTO
    emission
    multipurpose aircraft
    LTO test
    Opis:
    Lotnicze silniki turbinowe o sile ciągu większej od 27,6 kN podlegają normom emisji związków szkodliwych spalin zgodnie z Aneksem 16 Konwencji Chicagowskiej ustalonymi przez ICAO. Normy emisji silników odrzutowych określone są wg przyjętego jako wzorcowy - cyklu startu i lądowania LTO (ang. Landing and take-off cycle). Normy te stosuje się również dla silników wykorzystywanych w wojskowych samolotach wielozadaniowych. Jednak eksploatacja samolotów wielozadaniowych różni się od eksploatacji cywilnych statków powietrznych. W związku z tym przeprowadzono analizę wyników emisji zanieczyszczeń uzyskanych w przeprowadzonych testach badawczych z wartościami emisji wynikających z wytycznych zawartych w normach.
    Aviation gas turbines with thrust greater than 27.6 kN are subject to exhaust emission norms and regulations for harmful compounds outlined in Annex 16 of the Chicago Convention as established by ICAO. Jet engine emission standards are defined with the use of an established takeoff and landing model known as the LTO cycle (Landing and take-off). These standards also apply to engines used in multi-role combat aircraft. However, multi-role combat aircraft operation differs from the operation of civilian aircraft. Therefore, the analysis of the emission results obtained in the carried out research was done with the use of emission values contained in the norm guidelines.
    Źródło:
    Combustion Engines; 2015, 54, 3; 449-455
    2300-9896
    2658-1442
    Pojawia się w:
    Combustion Engines
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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