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Wyszukujesz frazę "subcellular localization" wg kryterium: Wszystkie pola

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    Wyświetlanie 1-15 z 15
    Tytuł:
    Subcellular localization of UDP-GlcNAc, UDP-Gal and SLC35B4 transporters
    Autorzy:
    Maszczak-Seneczko, Dorota
    Olczak, Teresa
    Olczak, Mariusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1039897.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    MDCK-RCAr
    nucleotide sugar transporter
    Golgi apparatus
    endoplasmic reticulum
    Opis:
    The mechanisms of transport and distribution of nucleotide sugars in the cell remain unclear. In an attempt to further characterize nucleotide sugar transporters (NSTs), we determined the subcellular localization of overexpressed epitope-tagged canine UDP-GlcNAc transporter, human UDP-Gal transporter splice variants (UGT1 and UGT2), and human SLC35B4 transporter splice variants (longer and shorter version) by indirect immunofluorescence using an experimental model of MDCK wild-type and MDCK-RCAr mutant cells. Our studies confirmed that the UDP-GlcNAc transporter was localized to the Golgi apparatus only and its localization was independent of the presence of endogenous UDP-Gal transporter. After overexpression of UGT1, the protein colocalized with the Golgi marker only. When UGT2 was overexpressed, the protein colocalized with the endoplasmic reticulum (ER) marker only. When UGT1 and UGT2 were overexpressed in parallel, UGT1 colocalized with the ER and Golgi markers and UGT2 with the ER marker only. This suggests that localization of the UDP-Gal transporter may depend on the presence of the partner splice variant. Our data suggest that proteins involved in nucleotide sugar transport may form heterodimeric complexes in the membrane, exhibiting different localization which depends on interacting protein partners. In contrast to previously published data, both splice variants of the SLC35B4 transporter were localized to the ER, independently of the presence of endogenous UDP-Gal transporter.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 3; 413-419
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biochemical and immunological relationships of prostatic and leukocytic acid phosphatases and their subcellular localization
    Autorzy:
    Zwirner, Axel
    Seitz, Jürgen
    Aumüller, Gerhard
    Powiązania:
    https://bibliotekanauki.pl/articles/1045961.pdf
    Data publikacji:
    1986
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Źródło:
    Acta Biochimica Polonica; 1986, 33, 2; 127-131
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    maf1 Mutation alters the subcellular localization of the Mod5 protein in yeast
    Autorzy:
    Murawski, Marcin
    Szcześniak, Barbara
    Żołądek, Teresa
    Hopper, Anita
    Martin, Nancy
    Boguta, Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/1045309.pdf
    Data publikacji:
    1994
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Źródło:
    Acta Biochimica Polonica; 1994, 41, 4; 441-448
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prediction of protein subcellular localization using support vector machine with the choice of proper kernel
    Autorzy:
    Hasan, M.A.M.
    Ahmad, S.
    Molla, M.K.I.
    Powiązania:
    https://bibliotekanauki.pl/articles/81150.pdf
    Data publikacji:
    2017
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    subcellular localization
    protein
    prediction
    support vector machine
    model selection
    kernel
    radial base function
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2017, 98, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Regulation of subcellular localization of muscle FBPase in cardiomyocytes. The decisive role of calcium ions
    Autorzy:
    Majkowski, Michal
    Wypych, Dorota
    Pomorski, Pawel
    Dzugaj, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/1042732.pdf
    Data publikacji:
    2010
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    cardiomyocytes
    Z-line
    insulin
    calcium
    intercalated disc
    muscle FBPase
    Opis:
    Glyconeogenesis, the synthesis of glycogen from carbohydrate precursors like lactate, seems to be an important pathway participating in replenishing glycogen in cardiomyocytes. Fructose-1,6-bisphosphatase (FBPase), an indispensible enzyme of glyconeogenesis, has been found in cardiomyocytes on the Z-line, in the nuclei and in the intercalated discs. Glyconeogenesis may proceed only when FBPase accumulates on the Z-line. Searching for the mechanism of a FBPase regulation we investigated the effects of the calcium ionophore A23187, a muscle relaxant dantrolene, glucagon, insulin and medium without glucose on the subcellular localization of this enzyme in primary culture of neonatal rat cardiomyocytes. Immunofluorescence was used for protein localization and the intracellular calcium concentration was measured with Fura. We found that the concentration of calcium ions was the decisive factor determining the localization of muscle FBPase on the Z-line. Calcium ions had no effect on the localization of the enzyme in the intercalated discs or in the nuclei, but accumulation of FBPase in the nuclei was induced by insulin.
    Źródło:
    Acta Biochimica Polonica; 2010, 57, 4; 597-605
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The activities and subcellular localization of cathepsin B and cysteine proteinase inhibitors in human ovarian carcinoma
    Autorzy:
    Haczyńska, Halina
    Gerber, Jerzy
    Osada, Jerzy
    Warwas, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/1044971.pdf
    Data publikacji:
    1997
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Źródło:
    Acta Biochimica Polonica; 1997, 44, 1; 113-120
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Inhibition of poly(ADP-ribose) polymerase activity affects its subcellular localization and DNA strand break rejoining
    Autorzy:
    Ryabokon, Nadezhda
    Cieślar-Pobuda, Artur
    Rzeszowska-Wolny, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1040571.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    DNA strand break rejoining
    efficiency of PARP inhibition
    PARP foci
    poly(ADP-ribose) polymerase (PARP)
    PARP inhibitors
    Opis:
    Poly(ADP-ribose) polymerase (PARP) plays a crucial role in DNA repair. Modulation of its activity by stimulation or inhibition is considered as a potentially important strategy in clinical practice, especially to sensitize tumor cells to chemo- and radiotherapy through inhibition of DNA repair. Here we studied the effect of the three PARP inhibitors, 5-iodo-6-amino-benzopyrone (INH2BP), 1,5-isoquinolinediol (1,5-dihydroxyisoquinolinediol (1,5-IQD) and 8-hydroxy-2-methylquinazolin-4-[3H]one (NU1025), and for two of them the efficiency in slowing the rejoining of DNA strand breaks induced by H2O2 was compared. Inhibition of PARP changed its intranuclear localization markedly; cells exposed to the inhibitor NU1025 showed a significant tendency to accumulate PARP in large foci, whereas in untreated cells its distribution was more uniform. The speed and efficiency of rejoining of H2O2-induced DNA strand breaks were lower in cells incubated with a PARP inhibitor, and the kinetics of rejoining were modulated in a different manner by each inhibitor. At a concentration of 100 µM the efficiency of the inhibitors could be ranked in the order NU1025 > IQD > INH2BP. The two first compounds were able to decrease the overall PARP activity below the level detected in control cells, while INH2BP showed up to 40% PARP activity after exposure to H2O2.
    Źródło:
    Acta Biochimica Polonica; 2009, 56, 2; 243-248
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The subcellular localization of UVR3 and two putative photolyases, PHR2 and At4g25290
    Autorzy:
    Aggarwal, C.
    Labuz, J.
    Sztatelman, O.
    Banas, A.K.
    Powiązania:
    https://bibliotekanauki.pl/articles/80533.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    subcellular localization
    putative photolyase
    chloroplast
    gene encoding
    ultraviolet irradiation
    DNA damage
    Arabidopsis
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Identification, phylogenetic analyses and subcellular localization of protein phosphatases 2c type (PP2Cs) in Populus trichocarpa
    Autorzy:
    Betlinski, B.
    Vashutina, K.
    Gawronski, P.
    Karpinski, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/79950.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    protein phosphatase 2C
    protein kinase
    mitogen-activated protein kinase
    subcellular localization
    Populus trichocarpa
    phylogenetic analysis
    identification
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cloning and partial characterization of a gene in Bombyx mori homologous to a human adiponectin receptor
    Autorzy:
    Zhu, Minfeng
    Chen, Keping
    Wang, Yong
    Guo, Zhongjian
    Yin, Huijuan
    Yao, Qin
    Chen, Huiqin
    Powiązania:
    https://bibliotekanauki.pl/articles/1040735.pdf
    Data publikacji:
    2008
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    BmAdipoR
    bioinformatics study
    subcellular localization
    real-time quantitative PCR
    BmNPV
    Opis:
    In this study, we report the cloning and characteristics of an adiponectin-like receptor gene from Bombyx mori (BmAdipoR) with highly conserved deduced amino-acid sequences and similar structure to the human adiponectin receptor (AdipoR). Structural analysis of the translated cDNA suggested it encoded a membrane protein with seven transmembrane domains. BmAdipoR was found to be expressed in multiple tissues and highly expressed in Malpighian tubules, fat body and testis. BmNPV (Bombyx mori nucleopolyhedrovirus) bacmid system combined with confocal microscopy revealed that BmAdipoR was targeted to the cell membrane. We also found that infection with BmNPV did not have an effect on BmAdipoR mRNA quantity in the midgut of susceptible Bombyx mori strain (306) at 48 h, but BmAdipoR mRNA quantity increased significantly at 72 h. We concluded that BmAdipoR gene was a membrane protein ubiquitously expressed in Bombyx mori tissues and that its expression was altered by treating with BmNPV.
    Źródło:
    Acta Biochimica Polonica; 2008, 55, 2; 241-249
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Modulation of GAPDH expression and cellular localization after vaccinia virus infection of human adherent monocytes.
    Autorzy:
    Nahlik, Krystyna
    Mleczko, Anna
    Gawlik, Magdalena
    Rokita, Hanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1043440.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    human adherent monocytes
    vaccinia virus
    subcellular localization
    glyceraldehyde-3-phosphate dehydrogenase
    apoptosis
    Opis:
    Vaccinia virus is able to replicate in many cell types and is known to modulate apoptosis in infected cells. In this study, expression of apoptosis-related genes was screened in human adherent monocytes after vaccinia infection using a DNA array. A marked increase of the key glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression was found. Increased expression and nuclear translocation of GAPDH have recently been reported to participate in apoptosis of many cell types. To confirm the array results, levels of GAPDH mRNA were estimated by RT-PCR, showing an increase at 4 h p.i. followed by a slight decrease, which correlated with the viral anti-apoptotic E3L gene transcript levels. Subcellular localization of the enzyme in human monocytes was examined by Western blot and immunostaining of the infected cells. Both experiments revealed accumulation of GAPDH in the nucleus at 14 h p.i., which was completely suppressed at 24 h p.i. This might indicate GAPDH as a novel target for vaccinia anti-apoptotic modulation.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 3; 667-676
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    ROSMETER: a bioinformatic tool for the identification of reactive oxygen species (ROS) transcriptomic imprints
    Autorzy:
    Rosenwasser, S.
    Sela, N.
    Fluhr, R.
    Friedman, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/80882.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    reactive oxygen species
    subcellular localization
    leaf
    transcriptome
    abiotic stress
    biotic stress
    molecular mechanism
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-15 z 15

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