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    Wyświetlanie 1-12 z 12
    Tytuł:
    Sensitivity analysis of mathematical models of signalling pathways
    Autorzy:
    Charzynska, A.
    Nalecz, A.
    Rybinski, M.
    Gambin, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/80205.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    membrane receptor
    differential equation
    stochastic model
    modelling
    sensitivity analysis
    mathematical model
    signalling pathway
    dynamic behaviour
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2012, 93, 3
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The mTOR signalling pathways in the pathogenesis and treatment of neuroendocrine tumours
    Autorzy:
    Kolasińska-Ćwikła, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/1064993.pdf
    Data publikacji:
    2016
    Wydawca:
    Medical Education
    Tematy:
    mTOR inhibitors
    mTOR signalling pathway
    neuroendocrine tumours (NETs)
    Opis:
    Neuroendocrine tumours (NET) are a rare and heterogeneous group of neoplasms. The majority of patients are diagnosed with locally advanced or metastatic disease, and curative surgery is rarely an option. Treatment approaches involving targeted therapy, including the use of agents inhibiting the mTOR signalling pathways involved in neuroendocrine tumourigenesis, provide new therapeutic options for patients with NETs.
    Źródło:
    OncoReview; 2016, 6, 1; A37-42
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Crosstalk between the TGF-β and WNT signalling pathways during cardiac fibrogenesis
    Autorzy:
    Działo, Edyta
    Tkacz, Karolina
    Błyszczuk, Przemysław
    Powiązania:
    https://bibliotekanauki.pl/articles/1038355.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    TGF-beta
    Smad
    WNT
    beta-catenin
    RhoA-ROCK
    p38
    JNK
    Erk1/2
    MAPK
    cardiac fibrosis
    tissue remodelling
    cardiac fibroblasts
    heart
    Opis:
    Cardiac fibrosis is referred to as an excessive accumulation of stromal cells and extracellular matrix proteins in the myocardium. Progressive fibrosis causes stiffening of the cardiac tissue and affects conduction of electrical impulses, leading to heart failures in a broad range of cardiac conditions. At the cellular level, activation of the cardiac stromal cells and myofibroblast formation are considered as hallmarks of fibrogenesis. At the molecular level, transforming growth factor β (TGF-β) is traditionally considered as a master regulator of the profibrotic processes. More recently, the WNT signalling pathway has also been found to be implicated in the development of myocardial fibrosis. In this review, we summarize current knowledge on the involvement of TGF-β and WNT downstream molecular pathways to cardiac fibrogenesis and describe a crosstalk between these two profibrotic pathways. TGF-β and WNT ligands bind to different receptors and trigger various outputs. However, a growing body of evidence points to cross-regulation between these two pathways. It has been recognized that in cardiac pathologies TGF-β activates WNT/β-catenin signalling, which in turn stabilizes the TGF-β/Smad response. Furthermore both, the non-canonical TGF-β and non-canonical WNT signalling pathways, activate the same mitogen-activated protein kinases (MAPKs): the extracellular signal-regulated kinase (Erk), the c-Jun N-terminal kinases (JNKs) and p38. The crosstalk between TGF-β and WNT pathways seems to play an essential role in switching on the genetic machinery initiating profibrotic changes in the heart. Better understanding of these mechanisms will open new opportunities for development of targeted therapeutic approaches against cardiac fibrosis in the future.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 3; 341-349
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Elements of signalling pathways in the response of Solanum species to Phytophthora infestans
    Autorzy:
    Polkowska-Kowalczyk, L.
    Olszak, K.
    Tarwacka, J.
    Szczegielniak, J.
    Muszynska, G.
    Wielgat, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/80244.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    signalling pathway
    Solanum species
    Phytophthora infestans
    reactive oxygen species
    mitogen-activated protein kinase
    calcium-dependent protein kinase
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cross-talk between the ATP and ADP nucleotide receptor signalling pathways in glioma C6 cells.
    Autorzy:
    Czajkowski, Rafał
    Barańska, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/1043690.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    ATP
    cross-talk
    glioma C6 cells
    ADP
    phospholipase C
    nucleotide receptors
    adenylyl cyclase
    signalling pathways
    adenosine
    Opis:
    In this review we summarize the present status of our knowledge on the enzymes involved in the extracellular metabolism of nucleotides and the receptors involved in nucleotide signalling. We focus on the mechanism of the ATP and ADP signalling pathways in glioma C6, representative of the type of nonexcitable cells. In these cells, ATP acts on the P2Y2 receptor coupled to phospholipase C, whereas ADP on two distinct P2Y receptors: P2Y1 and P2Y12. The former is linked to phospholipase C and the latter is negatively coupled to adenylyl cyclase. The possible cross-talk between the ATP-, ADP- and adenosine-induced pathways, leading to simultaneous regulation of inositol 1,4,5-trisphosphate and cAMP mediated signalling, is discussed.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 4; 877-889
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The importance of the nuclear and cytoplasmic signalling in the cellular response to ionizing radiation
    Autorzy:
    Szumiel, I.
    Powiązania:
    https://bibliotekanauki.pl/articles/146716.pdf
    Data publikacji:
    2000
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    cellular signalling pathways
    ionizing radiation
    radiation sensitivity
    Opis:
    DNA is the universal primary target for ionizing radiation; however, the cellular response is highly diversified not only by differential DNA repair ability. The monitoring system for the ionizing radiation-inflicted DNA damage consists of 3 apparently independently acting enzymes which are activated by DNA breaks: two protein kinases, Atm (ataxia telangiectasia mutated) and DNA-PK (DNA-dependent protein kinase) and a poly(ADP-ribose) polymerase, PARP-1. These 3 enzymes are the source of alarm signals, which affect to various extents DNA repair, progression through the cell cycle and eventually the pathway to cell death. Their functions probably are partly over-lapping. On the side of DNA repair their role consists in recruiting and/or activating the repair enzymes, as well as preventing illegitimate recombination of the damaged sites. A large part of the nuclear signalling pathway, including the integrating role of Tp53 has been revealed. Two main signalling pathways start at the plasma membrane: the MAPK/ERK (mitogen and extracellular signal regulated protein kinase family) "survival pathway" and the SAPK/JNK (stress-activated protein kinase/c-Jun N-terminal kinase) "cell death pathway". The balance between them is likely to determine the cell’s fate. When DNA break rejoining is impaired, the cell is unconditionally radiation sensitive. The fate of a repair-competent cell is determined by the time factor: the cell cycle arrest should be long enough to ensure the completion of repair. Incomplete repair or misrepair may be tolerated, when generation of the death signal is prevented. So, the character and timing of the signals are, to a large part, responsible for the cellular intrinsic radiation sensitivity and depend on the characteristics of the cellular signalling web.
    Źródło:
    Nukleonika; 2000, 45, 4; 215-220
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Novel properties of antimicrobial peptides.
    Autorzy:
    Kamysz, Wojciech
    Okrój, Marcin
    Łukasiak, Jerzy
    Powiązania:
    https://bibliotekanauki.pl/articles/1043622.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    tumour
    cells
    mitogen
    immunity
    signalling pathways
    antimicrobial peptides
    Opis:
    Endogenous peptide antibiotics are known as evolutionarily old components of innate immunity. Due to interaction with cell membrane these peptides cause permeabilization of the membrane and lysis of invading microbes. However, some studies proved that antimicrobial peptides are universal multifunctional molecules and their functions extend far beyond simple antibiotics. In this review we present an overview of the general mechanism of action of antimicrobial peptides and discuss some of their additional properties, like antitumour activity, mitogenic activity, role in signal transduction pathways and adaptive immune response.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 2; 461-469
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The bystander effect: is reactive oxygen species the driver?
    Autorzy:
    Szumiel, I.
    Powiązania:
    https://bibliotekanauki.pl/articles/148463.pdf
    Data publikacji:
    2003
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    bystander effect
    reactive oxygen species
    ionising radiation
    DNA repair
    signalling pathways
    Opis:
    The paper reviews selected examples of the bystander effect, such as clonogenic survival decrease, chromosomal aberrations and mutations. The similarities and differences between the biological effects in directly targeted and bystander cells are briefly discussed. Also reviewed are the experimental data which support the role of reactive oxygen species (ROS), especially *O2-, as mediators of the bystander effect. Endogenously generated ROS, due to activation of NAD(P)H oxidases, play a key role in the induction of DNA damage in bystander cells. All the observed effects in bystander cells, such as alterations in gene expression patterns, chromosomal aberrations, sister chromatid exchanges, mutations, genome instability, and neoplastic transformation are the consequence of DNA damage.
    Źródło:
    Nukleonika; 2003, 48, 3; 113-120
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Contribution of protein kinase A and protein kinase C signalling pathways to the regulation of HSD11B2 expression and proliferation of MCF-7 cells.
    Autorzy:
    Rubiś, Błażej
    Grodecka-Gazdecka, Sylwia
    Lecybył, Remigiusz
    Ociepa, Marta
    Krozowski, Zygmunt
    Trzeciak, Wiesław
    Powiązania:
    https://bibliotekanauki.pl/articles/1041503.pdf
    Data publikacji:
    2004
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    MCF-7 proliferation
    HSD11B2 gene expression
    11β-hydroxysteroid dehydrogenase type II
    signalling pathways
    Opis:
    Contribution of the protein kinase A (PKA) and protein kinase C (PKC) signalling pathways to the regulation of 11β-hydroxysteroid dehydrogenase type II (HSD11B2) gene expression was investigated in human breast cancer cell line MCF-7. Treatment of the cells with an adenylyl cyclase activator, forskolin, known to stimulate the PKA pathway, resulted in an increase in HSD11B2 mRNA content. Semi-quantitative RT-PCR revealed attenuation of the effect of forskolin by phorbol ester, tetradecanoyl phorbol acetate (TPA), an activator of the PKC pathway. It was also demonstrated that specific inhibitors significantly reduced the effect of activators of the two pathways. Stimulation of the PKA pathway did not affect, whereas stimulation of the PKC pathway significantly reduced MCF-7 cell proliferation in a time-dependent manner. A cell growth inhibitor, dexamethasone, at high concentrations, caused a 40% decrease in proliferation of MCF-7 cells and this effect was abolished under conditions of increased HSD11B2 expression. It was concluded that in MCF-7 cells, stimulation of the PKA signal transduction pathway results in the induction of HSD11B2 expression and that this effect is markedly reduced by activation of the PKC pathway. Activation of the PKC pathway also resulted in inhibition of cell proliferation, while activation of the PKA pathway abolished the antiproliferative effect of dexamethasone. These effects might be due to oxidation of dexamethasone by the PKA-inducible HSD11B2g.
    Źródło:
    Acta Biochimica Polonica; 2004, 51, 4; 919-924
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Androgen receptor and c-Myc transcription factors as putative partners in the in vivo cross-talk between androgen receptor-mediated and c-Met-mediated signalling pathways
    Autorzy:
    Dudkowska, Magdalena
    Jaworski, Tomasz
    Grzelakowska-Sztabert, Barbara
    Manteuffel-Cymborowska, Małgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/1041070.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    HGF/c-Met; c-Myc
    cross-talk
    androgen receptor
    antifolate/folate-injured kidney
    Opis:
    Cross-talk between two signal transduction pathways leads to a negative regulation of androgen-induced ornithine decarboxylase (ODC) gene expression in the mouse kidney. One pathway is triggered by testosterone via the intracellular androgen receptor, AR, and the other is induced by antifolate CB 3717 or folate via hepatocyte growth factor and its cell membrane receptor c-Met. Here we report the studies of the expression of AR and c-Myc transcription factors involved in ODC transactivation. Administration of CB 3717 or folate decreased the expression of AR. In contrast, testosterone did not modify AR mRNA content but augmented the AR protein. Furthermore, we demonstrate that administration of folate, but not testosterone, increases c-Myc transcript and protein level. We also document that activation of both examined pathways does not decrease the testosterone-induced AR protein level, but markedly increases c-Myc protein which is nearly 2-fold up-regulated compared to its level evoked solely by testosterone. We suspect that this pronounced increase of c-Myc protein might have functional consequences mirrored by down-regulated expression of AR target genes, among them ODC.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 2; 253-259
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    In silico study by using ProTox-II webserver for oral acute toxicity, organ toxicity, immunotoxicity, genetic toxicity endpoints, nuclear receptor signalling and stress response pathways of synthetic pyrethroids
    Autorzy:
    Ghosh, Subhasis
    Tripathi, Puja
    Talukdar, Partha
    Talapatra, Soumendra Nath
    Powiązania:
    https://bibliotekanauki.pl/articles/1065392.pdf
    Data publikacji:
    2019
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    In silico study
    Molecular mechanism of toxicity
    Nuclear receptor signalling and stress response pathways
    Predictive toxicology
    Synthetic pyrethroids
    Opis:
    Till date, it is well-known that synthetic pyrethroids are safe to mammal but toxic to non-mammals. The present objective was an in silico study to detect oral acute toxicity, organ toxicity, immunotoxicity, genetic toxicity endpoints, nuclear receptor signalling, and stress response pathways of common synthetic pyrethroids by using ProTox-II webserver. The chemical compounds especially different synthetic pyrethroids such as pyrethrin I, Cinerin I and Jasmolin I (esters of Chrysanthemic acid), Pyrethrin-II, Cinerin II and Jasmolin II (Esters of Pyrethric acid), type I pyrethroids (esters without alpha-cyano group) such as allethrin, resmethrin, permethrin and bifenthrin and type II pyrethroids (esters with alpha-cyano group) such as fenvalerate, cyhalothrin, cypermethrin and deltamethrinwere selected from available literature. ProTox-II webserver was used for toxicological assessment in organism, organs, cell and gene level along with molecular mechanisms of toxicity. The predictive results for the toxicity of common synthetic pyrethroids compounds, Deltamethrin showed highly toxic compound among 14 compounds as fatal if swallowed as class II followed by Cypermethrin, Cyhalothrin, Bifenthrin, Resmethrin, Fenvalerate and Permethrin but hepatotoxic potential was only Deltamethrin and Fenvalerate while immunotoxic was obtained Permethrin. On the other hand, none of the compounds were obtained cytotoxic and carcinogenic but 9 compounds viz. Pyrethrin I, II Cinerin I, II, Jasmolin I, II, Allethrin, Resmethrin and Permethrin were observed mutagenic active. In case of NR signalling pathways, all compounds were inactive but eight compounds such as Pyrethrin I, II, Cinerin I, II, Jasmolin I, II, Allethrin and Resmethrin were obtained nrf2/ARE and HSE active while MMP active compounds were obtained Fenvalerate, Cyhalothrin and Deltamethrin respectively. For p53 and ATAD5 parameters, all fourteen compounds such as were obtained inactive. In conclusion, the present predictive results are suitable for academician, researchers, industries, etc. those who are making drugs and environmental chemicals. This web server helps faster screening of large numbers of compounds within short duration and no animal testing. This present in silico study easily detects toxin(s), which can be validated in future through in vitro and in vivo experimental assay.
    Źródło:
    World Scientific News; 2019, 132; 35-51
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    NO-induced alleviation of dormancy of apple embryos is related to modification of phytohormonal signaling pathways
    Autorzy:
    Andryka, P.
    Wisniewska, A.
    Gniazdowska, A.
    Krasuska, U.
    Bogatek, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/80008.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    apple embryo
    embryo dormancy
    morphological abnormality
    seed dormancy
    abscisic acid
    transduction pathway
    gibberellin
    phytohormone
    signalling pathway
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-12 z 12

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