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Wyświetlanie 1-10 z 32
Tytuł:
Electrospinning Production of PLLA Fibrous Scaffolds for Tissue Engineering
Autorzy:
Wojasiński, M.
Faliszewski, K.
Ciach, T.
Powiązania:
https://bibliotekanauki.pl/articles/115815.pdf
Data publikacji:
2013
Wydawca:
Fundacja na Rzecz Młodych Naukowców
Tematy:
nanofibre
electrospinning
poly(L-lactic acid)
tissue engineering
biomaterial
degradation
Opis:
Nonwoven fibrous mats were produced in the process of solution electrospinning. Polymeric fibres generated in this process consist of poly(L-lactic) acid (PLLA), biodegradable and biocompatible polymer. Produced fibrous mats were examined by scanning electron microscopy and additionally degradation rate of fibrous material was investigated. Obtained fibres exhibit porous surface and fibre diameter varied from 200 nm to 1,2 ım, depending on the process parameters. Low degradation rate of scaffold material was designed for long-term scaffold usage. The influence of solvent type and solution concentration as well as the solution flow rate, applied voltage and the setup geometry on the fibres morphology and diameter were examined and presented. The influence of polymer concentration on the solution viscosity was also evaluated. Further, the degradation rate of obtained fibres was investigated, as well as the influence of degradation process on surrounding environment. Materials produced in electrospinning process have potential application as long-term biodegradable scaffold for tissue engineering, especially in bone tissue, vascular tissue or cartilage tissue engineering.
Źródło:
Challenges of Modern Technology; 2013, 4, 1; 9-15
2082-2863
2353-4419
Pojawia się w:
Challenges of Modern Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preparation of psyllium husk powder based microporous composite scaffolds for tissue engineering
Autorzy:
Poddar, S.
Agarwal, P. S.
Mahto, S. K.
Powiązania:
https://bibliotekanauki.pl/articles/284676.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
composites
tissue engineering
regeneration
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 48
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Highly porous polurethane-based gradient scaffolds for tissue engineering of osteochondral defects
Autorzy:
Domalik-Pyzik, Patrycja
Kosowska, Karolina
Hunger, Martyna
Pielichowska, Kinga
Chłopek, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1844966.pdf
Data publikacji:
2020
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
tissue engineering
polyurethanes
properties
inżynieria tkankowa
poliuretany
właściwości
Źródło:
Engineering of Biomaterials; 2020, 23, 158 spec. iss.; 66
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preparation of psyllium husk powder based microporous composite scaffolds for tissue engineering
Autorzy:
Poddar, S.
Agarwal, P. S.
Mahto, S. K.
Powiązania:
https://bibliotekanauki.pl/articles/285978.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
psyllium husk powder
EDC-NHS coupling reaction
microporous scaffolds
hydrogel
freeze-drying
vacuum desiccation
Opis:
This study demonstrates the comparison in the method of fabrication and thus evaluates the potential of psyllium husk powder and gelatin-based composite microporous scaffolds for tissue engineering applications. The scaffold is being prepared in three different ratios of 50:50, 75:25 and 100 (w/w of psyllium husk powder and gelatin, respectively) by employing a suitable cross-linking agent, EDC-NHS, followed drying. We have demonstrated the use and outcomes of two different methods of scaffold drying, i.e., vacuum desiccation along with liquid nitrogen dip and lyophilization. It was concluded from the SEM micrographs that the scaffolds dried under vacuum accompanied with liquid nitrogen exposure exhibited less porous architecture when compared to those prepared using a lyophilizer, that resulted in pores in the range of 60-110 μm. Scaffolds fabricated using the former technique lost porosity and sponge-like characteristics of a scaffold. In spite of the above fact, water retaining capacity and stability in the cell culture of such scaffolds is significant, nearly 40-50% of its initial dry weight. Cell culture experiments support the potential of the scaffolds prepared from different methods of fabrication for its cytocompatibility and suitability for cell growth and proliferation for a substantial duration. Erosion in the porous design of the scaffolds was observed after 14 days via SEM micrographs. It was inferred that freeze-drying is a better technique than vacuum desiccation for scaffold preparation. The present investigation has been conducted keeping in mind the importance of drying a scaffold. Scaffold drying is a necessary step to increase its shelf-life, makes it easy to transport and much importantly, controlling the pore size of the scaffold.
Źródło:
Engineering of Biomaterials; 2018, 21, 147; 2-6
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of supercritical foaming conditions on properties of polymer scaffolds for tissue engineering
Autorzy:
Kosowska, K.
Henczka, M.
Powiązania:
https://bibliotekanauki.pl/articles/185451.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
supercritical fluids
supercritical foaming
poly(ε-caprolactone)
tissue engineering
scaffold
płyny nadkrytyczne
pienienie nadkrytyczne
inżynieria tkankowa
szafot
Opis:
The results of experimental investigations into foaming process of poly(ε-caprolactone) using supercritical CO2 are presented. The objective of the study was to explore the aspects of fabrication of biodegradable and biocompatible scaffolds that can be applied as a temporary three-dimensional extracellular matrix analog for cells to grow into a new tissue. The influence of foaming process parameters, which have been proven previously to affect significantly scaffold bioactivity, such as pressure (8-18 MPa), temperature (323-373 K) and time of saturation (1-6 h) on microstructure and mechanical properties of produced polymer porous structures is presented. The morphology and mechanical properties of considered materials were analyzed using a scanning electron microscope (SEM), x-ray microtomography (μ-CT) and a static compression test. A precise control over porosity and morphology of obtained polymer porous structures by adjusting the foaming process parameters has been proved. The obtained poly(ε-caprolactone) solid foams prepared using scCO2 have demonstrated sufficient mechanical strength to be applied as scaffolds in tissue engineering.
Źródło:
Chemical and Process Engineering; 2017, 38, 4; 535-541
0208-6425
2300-1925
Pojawia się w:
Chemical and Process Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
One step 3D printing of surface functionalized composite scaffolds for tissue engineering applications
Autorzy:
Kotlarz, M.
Jordan, R.
Wegner, E.
Dobrzyński, P.
Neunzehn, J.
Lederer, A.
Wolf-Brandstetter, C.
Pamula, E.
Scharnweber, D.
Powiązania:
https://bibliotekanauki.pl/articles/306484.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
druk 3D
PLGA
węglan wapnia
właściwości powierzchniowe
3D printing
calcium carbonate
amphiphilic poly(2-oxazoline)
degradation
surface properties
Opis:
A successful approach widely used in materials science to adapt approved materials to specific applications is to design their surface properties. A main challenge in this area is the development of processing routes enabling for a simple but efficient surface design of complex shaped geometries. Against this background, this work aimed at the implementation of self-assembly principles for surface functionalization of 3D-printed poly(lactic-co-glycolic acid) (PLGA)-based constructs with macro- and microporous geometries via precision extruding deposition. Methods: Three-component melts from PLGA, CaCO3 and amphiphilic polymers (poly(2-oxazoline) block copolymer) were printed and their bulk and surface properties were studied. Results: Melts with up to 30 mass % of CaCO3 could be successfully printed with homogeneously distributed mineral particles. PLGA degradation during the printing process was temperature and time dependent: the molecular weight reached 10 to 15% of the initial values after ca. 120 min of heat exposure. Filament surfaces from melts containing CaCO3 show an increasing microroughness along with increasing CaCO3 content. Surface roughness and amphiphilic polymer content improve scaffold wettability with both factors showing synergistic effects. The CaCO3 content of the melts affected the inner filament structure during in vitro degradation in PBS, resulting in a homogeneous mineral particle-associated microporosity for mineral contents of 20 mass % and above. Conclusions: These results provide novel insights into the behavior of three-component melts from PLGA, CaCO3 and amphiphilic polymers during precision extruding deposition and show for the first time that self-assembly processes can be used to tailor scaffolds surface properties under such processing conditions.
Źródło:
Acta of Bioengineering and Biomechanics; 2018, 20, 2; 35-45
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Double crosslinking of chitosan/vanillin hydrogels as a basis for mechanically strong gradient scaffolds for tissue engineering
Autorzy:
Hunger, Martyna
Domalik-Pyzik, Patrycja
Reczyńska, Katarzyna
Chłopek, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1844976.pdf
Data publikacji:
2020
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hydrogel
chitosan
vanillin
tripolyphosphate
tissue engineering
Opis:
Polysaccharides, such as chitosan (CS), are widely used in many biomedical applications. However, they require crosslinking agents to achieve chemical stability and appropriate mechanical properties. In this work, chitosan-based hydrogels were crosslinked using vanillin and/or sodium tripolyphosphate, as chemical and physical crosslinking agents, respectively. Microstructural (digital microscope, SEM), structural (FTIR-ATR), mechanical (static compression test), and in vitro biological (chemical stability and swelling ratio in PBS, cytotoxicity) properties of the obtained materials were evaluated to assess materials potential as biomedical scaffolds. The optimal ratio of vanillin to chitosan (DD = 89%) to crosslink the polymer was found to be 1.2:1. Moreover, the double crosslinking with vanillin caused a two-time increase in the compression strength of the samples and led to the slower biodegradability. Cytotoxicity studies showed that the cells prefer double vanillin crosslinked hydrogels over those treated with TPP. Further studies, such as bioactivity are required to determine the specific functionality of the hydrogels and the specific tissue which may be treated with the tested materials. The optimal material was chosen to the next step of the study, which may be obtaining composite hydrogels with hydroxyapatite and/or graphene oxide to tailor or improve properties towards specific tissue regeneration.
Źródło:
Engineering of Biomaterials; 2020, 23, 155; 2-11
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wybrane metody otrzymywania porowatych rusztowań w inżynierii tkankowej
Selected methods of preparation of porous scaffolds for tissue engineering
Autorzy:
Dziadek, M.
Cholewa-Kowalska, K.
Powiązania:
https://bibliotekanauki.pl/articles/262146.pdf
Data publikacji:
2014
Wydawca:
Politechnika Wrocławska. Wydział Podstawowych Problemów Techniki. Katedra Inżynierii Biomedycznej
Tematy:
inżynieria tkankowa
rusztowania porowate
termicznie indukowana separacja faz
separacja faz w układzie rozpuszczalnik–nierozpuszczalnik
tissue engineering
porous scaffolds
thermally induced phase separation
liquid induced phase separation
Opis:
Inżynieria tkankowa jest interdyscyplinarną dziedziną, której celem jest opracowanie biologicznych substytutów umożliwiających regenerację lub zastąpienie uszkodzonych lub zmienionych chorobowo tkanek czy organów. Dąży się do tego, aby rusztowania tkankowe posiadały wymagane korzystne cechy oraz spełniały przynajmniej niektóre funkcje naturalnej macierzy zewnątrzkomórkowej. Jednym z najważniejszych etapów opracowania podłoży jest projektowanie i wytwarzanie przestrzennej, wysoko porowatej struktury o pożądanym kształcie i rozmiarze porów. W niniejszym opracowaniu przedstawiono stan wiedzy na temat najpopular-niejszych metod wytwarzania przestrzennych rusztowań w inżynierii tkankowej, do których należą: odlewanie z roztworu z wymywaniem porogenu, termicznie indukowana separacja faz oraz separacja faz w układzie rozpuszczalnik–nierozpuszczalnik.
Tissue engineering is an interdisciplinary field aiming to develop of biological substitutes, that are able to regenerate or replace damaged or diseased tissues or organs. The approach to tissue engineering is to use scaffolds that mimics multiple advantageous characteristics of the native extracellular matrix. One of the most important stages of building scaffolds is the design and preparation of a porous, three-dimensional structure with high porosity, and required size and shape of the pores. In this review, state of the art of the most common fabrication methods of three-dimensional biomimetic scaffolds are presented that include: solvent casting particle leaching (SCPL), thermally induced phase separation (TIPS), and liquid induced phase separation (LIPS).
Źródło:
Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna; 2014, 20, 4; 193-203
1234-5563
Pojawia się w:
Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bioactive hydroxyapatite ceramics as scaffolds for bone tissue engineering – a preliminary study
Autorzy:
Soukup, D.
Horakova, D.
Sumberova, H.
Andertova, J.
Bacakova, M.
Bacakova, L.
Powiązania:
https://bibliotekanauki.pl/articles/285204.pdf
Data publikacji:
2011
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hydroxyapatite
tissue engineering
scaffolds
Źródło:
Engineering of Biomaterials; 2011, 14, no. 106-108; 13-16
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of 3D hybrid microfiber/nanofiber scaffolds for bone tissue engineering
Autorzy:
Ostrowska, B.
Jaroszewicz, J.
Zaczyńska, E.
Tomaszewski, W.
Swieszkowski, W.
Kurzydłowski, K. J.
Powiązania:
https://bibliotekanauki.pl/articles/200803.pdf
Data publikacji:
2014
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
rapid prototyping
RP
Electrospinning
ESP
Hybrid scaffolds
Opis:
Fabrication of scaffolds for tissue engineering (TE) applications becomes a very important research topic in present days. The aim of the study was to create and evaluate a hybrid polymeric 3D scaffold consisted of nano and microfibers, which could be used for bone tissue engineering. Hybrid structures were fabricated using rapid prototyping (RP) and electrospinning (ES) methods. Electrospun nanofibrous mats were incorporated between the microfibrous layers produced by RP technology. The nanofibers were made of poly(L-lactid) and polycaprolactone was used to fabricate microfibers. The micro- and nanostructures of the hybrid scaffolds were examined using scanning electron microscopy (SEM). X-ray microtomographical (μCT) analysis and the mechanical testing of the porous hybrid structures were performed using SkyScan 1172 machine, equipped with a material testing stage. The scanning electron microscopy and micro-tomography analyses showed that obtained scaffolds are hybrid nanofibers/microfibers structures with high porosity and interconnected pores ranging from 10 to 500um. Although, connection between microfibrous layers and electrospun mats remained consistent under compression tests, addition of the nanofibrous mats affected the mechanical properties of the scaffold, particularly its elastic modulus. The results of the biocompatibility tests didn’t show any cytotoxic effects and no fibroblast after contact with the scaffold showed any damage of the cell body, the cells had proper morphologies and showed good proliferation. Summarizing, using RP technology and electrospinning method it is possible to fabricate biocompatible scaffolds with controllable geometrical parameters and good mechanical properties.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2014, 62, 3; 551-556
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 32

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