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Tytuł:
QUERCETIN ATTENUATES OXIDATIVE STRESS, INFLAMMATION AND CARDIAC DYSFUNCTION IN ACRYLAMIDE- INDUCED CARDIOTOXICITY
Autorzy:
Kushwah, Ajay S.
KALIA, TARANBIR S.
Powiązania:
https://bibliotekanauki.pl/articles/895356.pdf
Data publikacji:
2020-04-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
cardiotoxicity
acrylamide
quercetin
myocardial damage
Opis:
Acrylamide (ACR) is a foodborne toxic agent, formed in food when processed at high temperature. This study aimed at evaluating the biochemical changes induced by ACR and the effect of Quercetin as a treatment against ACR induced cardiotoxicity in rats. Wistar rats of either sex (n=6) were divided into four groups as follows: normal control, an Acrylamide control group, Quercetin groups (25 and 50 mg/kg). Diagnostics characteristics were assessed daily, at the end of the study (4 weeks) evaluate hemodynamic parameters, the blood sample was collect for estimation of biochemical and rats were decapitated excised hearts, cleaned and weighed. Heart homogenate was used to determine antioxidants and oxidative levels, and histopathological evaluations were carried out to determine changes induced by Acrylamide. As compared control groups, ACR treated rats show altered significantly (P < 0.05) general characteristic and also elevated myocardial damage markers, altered hemodynamic, oxidative stress level, increased expression of inflammatory cytokines and induced histopathological changes. Treatment with Quercetin at 25 mg/kg and 50 mg/kg recouped the above changes significantly (P < 0.05), 50 mg/kg being more prominent. The present study has concluded that Quercetin protects against Acrylamide-induced cardiotoxicity.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 343-352
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study of antioxidant activity of liposomal forms of quercetin and curcumin in ischemic heart disease
Autorzy:
Pylypenko, D.
Gorbach, T.
Krasnopolsky, Y.
Powiązania:
https://bibliotekanauki.pl/articles/2096332.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
curcumin
antioxidant
quercetin
liposomes
oxidative stress markers
Opis:
Quercetin and curcumin are plant polyphenolic antioxidants with proven pharmacological efficacy. Their use is, however, limited due to low bioavailability and oral administration route. The encapsulation of lipophilic compounds in liposomes enables to increase their bioavailability and to create an injectable form. The present study aimed to comparatively investigate the antioxidant activity of a complex liposomal preparation containing two lipophilic antioxidants (quercetin and curcumin) and their monopreparations in liposomal forms. This study was conducted on Wistar line rats with experimental model of ischemic heart disease. Oxidative stress markers such as total antioxidant activity, malondialdehyde, and peroxidized proteins were analyzed in blood serum and cardiac tissue. Ischemic heart disease is accompanied with lipid peroxidation and changes in the activity of the antioxidant system. The obtained results demonstrated the antioxidant activity of monopreparations of curcumin and quercetin and their complex in liposomal forms. Quercetin and curcumin showed different antioxidant activities in terms of oxidative stress markers. The complex of the two antioxidants showed the synergistic effect of their lipophilic compounds in liposomal forms, which led to the normalization of test parameters according to the level of the control sample.
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2020, 101, 4; 273-282
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis of quercetin-functionalized silver nanoparticles by rapid one-pot approach
Autorzy:
Pandian, S.R.K.
Kunjiappan, S.
Ravishankar, V.
Sundarapandian, V.
Powiązania:
https://bibliotekanauki.pl/articles/2096369.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
quercetin
bioflavonoid
one-pot synthesis
AgNPs
antioxidant
Opis:
Nanotechnology plays a pivotal role in all areas of science, and the synthesis and surface modification of nanoparticles are crucial in this field. Metal nanoparticles synthesized using plant extracts or phytocompounds are highly significant in the development of various therapeutics and diagnostics. In the present study, we report the one-pot and rapid synthesis of silver nanoparticles (AgNPs) by quercetin, a flavonoid found in various edible plants. The nanoparticles were then characterized using UV-VIS spectrophotometry, Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The role of quercetin in the synthesis of silver nanoparticles was demonstrated. The nanomaterial was 20–30 nm in size and spherical in shape. The silver nanoparticles were also confirmed to show antioxidant activity at 80 μg/ml concentration in vitro by DPPH, FRAP, and power reduction methods.
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2021, 102, 1; 75-84
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of quercetin on oxidative DNA damage and myelosuppression induced by etoposide in bone marrow cells of rats
Autorzy:
Papież, Monika
Powiązania:
https://bibliotekanauki.pl/articles/1039316.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
quercetin
etoposide
myelosuppression
oxidative DNA damage
comet assay
Opis:
There is increasing evidence for the existence of an association between the presence of etoposide phenoxyl radicals and the development of treatment-related acute myeloid leukemia (t-AML), which occurs in a few percent of patients treated with this chemotherapeutic agent. The most common side effect caused by etoposide is myelosuppression, which limits the use of this effective drug. The goal of the study was to investigate the influence of antioxidant querectin on myelosuppression and oxidative DNA damage caused by etoposide. The influence of quercetin and/or etoposide on oxidative DNA damage was investigated in LT-12 cell line and bone marrow cells of rats via comet assay. The effect of quercetin on myelosuppression induced by etoposide was invetsigated by cytological analysis of bone marrow smears stained with May-Grünwald-Giemsa stain. Etoposide caused a significant increase in oxidative DNA damage in bone marrow cells and LT-12 cell line in comparison to the appropriate controls. Quercetin significantly reduced the oxidative DNA damage caused by etoposide both in vitro and in vivo. Quercetin also significantly protected against a decrease in the percentage of myeloid precursors and erythroid nucleated cells caused by etoposide administration in comparison to the group treated with etoposide alone. The results of the study indicate that quercetin could be considered a protectively acting compound in bone marrow cells during etoposide therapy.
Źródło:
Acta Biochimica Polonica; 2014, 61, 1; 7-11
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Quercetin influences BSA alpha-helical structures of native, ACR- and NaNO2-modified BSAs
Autorzy:
Rorbach-Dolata, Anna
Żurawska-Płaksej, Ewa
Piwowar, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/895290.pdf
Data publikacji:
2018-12-31
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
albumin
quercetin
nitrosylation
alkylation
conformational changes
circular dichroism
Opis:
Quercetin (QUE) is a plant flavonoid with a multifarious spectrum of properties. It is a prominent component of the human diet, considered to be safe and beneficial for human health. Acrylamide (ACR) and sodium nitrate III (NaNO2) are also present in the diet and may demonstrate adverse and toxic effects on the macromolecules and tissues of the human organism. Albumin, the most abundant blood protein, is the most susceptible to the action of various exogenous factors, which may lead to structural damage and functional disturbances. The aim of this study was to estimate ACR- and NaNO2-induced changes in the secondary structure of bovine serum albumin (BSA), using circular dichroism (CD), and to determine the impact of quercetin on these modifications. BSA was incubated with ACR and NaNO2 solutions in the absence and presence of QUE in two different concentrations (3 mM and 500 µM), and changes in albumin alpha-helical structure were determined by CD. BSA secondary structure was vulnerable to alterations upon treatment with acrylamide and NaNO2, as well as quercetin. QUE, depending on concentration and incubation time, caused a decrease of around 13-19% in the alpha-helix content of BSA molecules, but also prevented the changes in the protein alpha-helical structure initiated by ACR and NaNO2. The most spectacular inhibition was revealed for QUE in lower concentrations after 24h of incubation with NaNO2. Although QUE reveals protective effect towards albumin modifications, it is difficult to unambiguously define whether this effect is advantageous, because quercetin itself causes alterations in BSA structure.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 6; 1339-1346
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
QUERCETIN AMELIORATES INSULIN RESISTANCE CONCOMITANT EARLY CARDIOVASCULAR CHANGES IN EXPERIMENTAL RATS
Autorzy:
KUSHWAH, AJAY S.
GUPTA, GHANSHYAM D.
Powiązania:
https://bibliotekanauki.pl/articles/895413.pdf
Data publikacji:
2018-08-31
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
insulin resistance
oxidative stress
myocardium
quercetin
high-fructose diet
5' Adenosine Monophosphate-activated Protein Kinase
Opis:
Quercetin is a dietary flavonoid found in a wide range of fruits and vegetables; it has diverse biological activities, possesses beneficial effects in ameliorating diabetic complications, apart from the effect of quercetin on fructose feed induced insulin resistance (IR) linked cardiac dysfunction have not been entirely revealed. This study aspires to explore the effect of quercetin on metabolism, oxidative stress, cardiomyocytes damage and cardiac function in IR state. Wistar rats either sex weighing 220-250 g (n ꞊8), were divided into four groups, kept on either control diet and high fructose diet and supplement with a quercetin as a test drug and metformin as a standard, at the dose of 50 and 200 mg/ kg; p.o., respectively. Daily measured body weight, feed, and water intake for 35 days, Oral glucose tolerance test (OGTT) performed in animals on the 32nd day. At end of the study (36th day), measured hemodynamic parameters after that estimation of various biochemical parameters. Finally, the animals were sacrificed for isolation of tissues and measured heart weight, the oxidative stress level of heart and histopathological changes. Treatment of quercetin with fructose-fed ameliorated all the parameters revile by the contrast of IR rats. The outcome of quercetin associated improves insulin sensitivity, normalized lipid profile, abolish hemodynamic changes, oxidative stress and cardiac injury markers within fructose-fed, and lesser histopathological changes were observed contrast with IR rats. These beneficial effects of quercetin mediated by improving insulin sensitivity and metabolism; reduced oxidative stress could potentially be used to ameliorate the myocardial damage.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 4; 977-987
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Quercetin: health benefits with relevance to TNF-alpha-linked inflammatory diseases
Autorzy:
Harrison, A.P.
Cooper, R.G.
Powiązania:
https://bibliotekanauki.pl/articles/3012.pdf
Data publikacji:
2008
Wydawca:
Instytut Medycyny Wsi
Tematy:
quercetin
health benefit
tumour necrosis factor-alpha
human disease
inflammatory disease
flavonoids
fruit
human health
Źródło:
Journal of Pre-Clinical and Clinical Research; 2008, 02, 2
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exogenous quercetin as a proliferation stimulator in tobacco BY-2 cells
Autorzy:
Kobylińska, A.
Powiązania:
https://bibliotekanauki.pl/articles/960260.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Opis:
Quercetin (Q) is a prominent flavonoid with a remarkable spectrum of biochemical activities. Its impact on human health as well as its endogenous role in the development of plants have been studied extensively. However, the impact of exogenous quercetin on plant cells is still uncharted. In this study, the influence of exogenous quercetin on Nicotiana tabacum, L. cv Bright Yellow 2 cell growth, viability, morphology and DNA content was investigated. The cells were exposed to quercetin at different concentrations (0.001, 0.01, 0.1 and 1 mM) during two phases of cell growth: from the start of a new culture (day 0), that is during the lag phase, when the cells are transferred to a new medium and they adapt to new growth conditions (model A), and on the fourth day after passaging (day 4) during the logarithmic phase of growth (the log phase), when the number of new cells appearing per unit time is proportional to the present population (model B). This is a period of intensive proliferation. The BY-2 cultures were maintained for 8 days. The proliferation level of BY-2 cells as well as their viability were analyzed every day during the experiment. The results showed that quercetin in a dose below 0.1 mM stimulated cell proliferation and viability, thus it could be a promising biostimulator. On the other hand, the highest concentration (1 mM) arrested the cell cycle in G2 phase and led to cell death. Application of 1 mM Q during the lag phase dramatically increased cell mortality and at the end of the experiment all BY-2 cells were dead, whereas an application during the log phase had a significantly milder effect; under the same concentration only 34% of cells were dead at the end of the stationary phase of growth. Thus, the results suggest that Q was less toxic even in very high concentrations when it was added to cells in the log phase of growth. This is probably related to the transfer of cells to a fresh medium, which causes great stress and supplementation with a high concentration of Q seems to aggravate this stress.
Źródło:
Journal of Elementology; 2017, 22, 1
1644-2296
Pojawia się w:
Journal of Elementology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The antioxidant quercetin protects HL-60 cells with high myeloperoxidase activity against pro-oxidative and apoptotic effects of etoposide
Autorzy:
Papież, Monika
Krzyściak, Wirginia
Powiązania:
https://bibliotekanauki.pl/articles/1039217.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
apoptosis
etoposide
quercetin
myeloperoxidase
reactive oxygen species
4-aminobenzoic acid hydrazide
Opis:
The protective action of quercetin against the pro-oxidant and apoptotic effect of etoposide was investigated in HL-60 cells with a high level of myeloperoxidase (MPO) activity and in cells treated with MPO inhibitor, 4-aminobenzoic acid hydrazide (ABAH). Quercetin significantly protected MPO-rich cells against the pro-oxidative (p<0.05) and apoptotic (p<0.05) effects of etoposide. Pre-treatment with ABAH abolished this protective influence of quercetin on apoptosis induced by etoposide but actually enhanced the action effect of quercetin against etoposide-generated reactive oxygen species (ROS) level by this cytostatic drug. Thus quercetin can protect HL-60 cells against the pro-oxidative activity of etoposide regardless of MPO activity.
Źródło:
Acta Biochimica Polonica; 2014, 61, 4; 795-799
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Protective effects of quercetin on cadmium fluoride induced oxidative stress at different intervals of time in mouse liver
Autorzy:
Zargar, Seema
Siddiqi, Nikhat
Al Daihan, Sooad
Wani, Tanveer
Powiązania:
https://bibliotekanauki.pl/articles/1039092.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cadmium fluoride
quercetin
oxidative stress
flavonoids
histology
adverse effect
Opis:
Quercetin, a member of the flavonoid family is a major antioxidant acquired in humans by food consumption, while Cadmium fluoride (CdF2) is one of the naturally occurring chemicals having adverse effects. The protective effect of quercetin on time dependent oxidative damage induced in mice liver by CdF2 was studied in the following groups of mice consisting of six mice each: (i) control group; (ii) mice treated with single i.p injection of 2 mg/kg bw CdF2 for 24 h; (iii) mice treated with single i.p injection of 2 mg/kg bw CdF2 for 48 h; (iv) mice treated with single i.p injection of quercetin (100 mg/kg bw); (v) mice treated with i.p injection of 100 mg/kg bw of quercetin followed by i.p injection of CdF2 (2 mg/kg bw) for 24 h; and (vi) mice treated with i.p injection of 100mg/kg bw of quercetin followed by CdF2 (2 mg/kg bw) for 48 h. Administration of quercetin two hours before CdF2 significantly reduced the biochemical alterations in reduced glutathione, ascorbic acid, lipid peroxidation, super oxide dismutase, catalase and total protein (p<0.05). Histopathology also showed the protective effect of quercetin. The livers treated with CdF2 were atrophic, markedly nodular, inflamed and necrotic. However, this effect was reduced to a minimum in the mice pre-treated for two hours with quercetin.
Źródło:
Acta Biochimica Polonica; 2015, 62, 2; 207-213
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
In silico assessment of the inhibitory effect of four flavonoids (chrysin, naringin, quercetin, kaempferol) on tyrosinase activity using the MD simulation approach
Autorzy:
Farasat, A.
Ghorbani, M.
Gheibi, N.
Shariatifar, H.
Powiązania:
https://bibliotekanauki.pl/articles/2097135.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
tyrosinase
chrysin
quercetin
kaempferol
naringin
MD simulation
Opis:
Tyrosinase is a tetrameric enzyme that plays an important role in pigment production. Overproduction of melanin, which may lead to several skin disorders, is a result of tyrosinase activity. Hence, tyrosinase inhibitors are of key importance in the treatment of these disorders. In the present study, four flavonoid inhibitors, namely chrysin, naringin, quercetin, and kaempferol, were evaluated physiochemically, and the inhibitory effects of these compounds on tyrosinase activity were evaluated using the molecular dynamics (MD) simulation method. To create the best conformation of the enzyme-substrate/inhibitor, the docking process for enzyme-substrate, i.e., enzyme-chrysin, enzyme-quercetin, enzyme-naringin, and enzyme-kaempferol, was performed. The complexes with the best binding energies were selected as the models for the MD simulation process. Furthermore, the structural (RMSD, Rg, RMSF, and Distance) and the thermodynamics properties of the complexes were evaluated. Additionally, the PMF was conducted to calculate the binding free energies. The results showed that chrysin, quercetin and the substrate were at similar distances to the amino acids of the active site, but naringin and kaempferol were closer to the active site of the enzyme than the substrate. Moreover, the analysis of the binding energy revealed that the substrates, chrysin, kaempferol, quercetin, and naringin bound to the enzyme with binding energies of -7.8, -3.1, -7.1, -3.9, and -8.4 kcal/mol, respectively, which confirms that naringin has the highest inhibitory effect on tyrosinase among other inhibitors, which makes it an appropriate candidate as a whitening agent in skin disorders.
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2020, 101, 3; 193-204
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antidiabetic cataract effects of GbE, rutin and quercetin are mediated by the inhibition of oxidative stress and polyol pathway
Autorzy:
Lu, Qian
Hao, Meng
Wu, Wenya
Zhang, Nan
Isaac, Adelusi
Yin, Jiale
Zhu, Xia
Du, Lei
Yin, Xiaoxing
Powiązania:
https://bibliotekanauki.pl/articles/1038521.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Ginkgo biloba extract
rutin
quercetin
diabetic cataract
Opis:
One of the earliest critical secondary complications of diabetes is the opacification of the eye lens - a condition strictly associated with diabetic cataract. The study presented here was designed to investigate the effect of Ginkgo biloba extract (GbE), rutin and quercetin on streptozotocin (STZ) induced diabetic cataract (DC) rats. Ten weeks after administration of GbE, rutin and quercetin, the opacity of diabetic rats' lenses was graded under a slit lamp. Then, the levels of malondialdehyde (MDA), reduced glutathione (GSH), advanced glycosylation end products (AGEs), and the activities of aldose reductase (AR) were estimated. The DC-induced rats produced less GSH, higher levels of MDA and AGEs as well as elevated AR activity when compared to the normal group. Administration of GbE, rutin and quercetin remarkably inhibited the AR activity, stimulated the production of glutathione, and decreased the levels of MDA and AGEs in the lenses of DC-induced rats, which eventually delayed the progression of lens opacification in diabetic rats to various degrees. Our results revealed that quercetin had the highest significant (P<0.05) potential to delay the progression of STZ-induced diabetic cataract when compared with rutin and GbE. The mechanism dictating this interesting prowess of quercetin might be attributed to its AR inhibitory strength, anti-lipid peroxidation potential and anti-AGEs activity.
Źródło:
Acta Biochimica Polonica; 2018, 65, 1; 35-41
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Aktywność antyutleniająca wodnych roztworów kwercetyny zawierających beta-cyklodekstrynę
Antioxidant activity of quercetin water solutions containing beta-cyclodextrin
Autorzy:
Lukasiewicz, M.
Kowalski, S.
Kulig, M.
Gambus, H.
Achremowicz, B.
Powiązania:
https://bibliotekanauki.pl/articles/35038.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Instytut Agrofizyki PAN
Tematy:
kwercetyna
roztwory wodne
przeciwutleniacze
aktywnosc przeciwutleniajaca
cyklodekstryny
beta-cyklodekstryna
rozpuszczalnosc
quercetin
aqueous solution
antioxidant
antioxidant activity
cyclodextrin
beta-cyclodextrin
solubility
Opis:
W pracy przedstawiono wyniki badań nad właściwościami trójskładnikowych układów, kwercetyna/-cyklodektryna/woda. Stwierdzono zwiększenie rozpuszczalności kwercetyny w wodzie na drodze kompleksowania tego związku przez cyklodesktrynę. Określono zdolność zmiatania wolnych rodników przez otrzymane układy oraz podstawowe parametry opisujące proces kompleksowania. Po raz pierwszy zastosowano modele Apelblata i Buchowskiego-Ksiazczaka do modelowania procesu zwiększenia rozpuszczalności kwercetyny na drodze kompleksowania. W pracy przeprowadzono także badania nad dynamiką procesu kompleksowania. Stwierdzono, że kwercetyna tworzy z -cyklodektryną kompleksy o stechiometrii 1:1. Powstanie kompleksu zwiększa rozpuszczalność kwercetyny w wodzie, jednak nie wiąże się to bezpośrednio ze wzrostem właściwości antyutleniających otrzymanych roztworów. Fakt ten jest najprawdopodobniej konsekwencją ograniczenia dostępności niektórych grup funkcyjnych kwercetyny na drodze maskowania wewnątrz cząsteczki cyklodekstryny.
The paper presents the results of research on the properties of ternary systems, quercetin/-cyclodextrin/water. There was observed an increase in water solubility of quercetin by means of complexation with cyclodextrin. It was shown that the systems derived have a high ability to scavenge free radicals, and some basic parameters describing the complexation process were determined. For the first time, Apelblat and Buchowski-Ksiazczak solubility models were used to describe the process of increasing the solubility of quercetin by complexation. The paper presents also a study on the dynamics of the complexation process. It was found that quercetin forms 1:1 stoichiometry complexes with -cyclodextrin. Formation of the complex increases the solubility of quercetin in water, but that does not relate directly to an increase in antioxidant properties of the solutions obtained. This fact is probably the consequence of limiting the availability of certain functional groups of quercetin by masking them inside of the cyclodextrin molecule.
Źródło:
Acta Agrophysica; 2013, 20, 3
1234-4125
Pojawia się w:
Acta Agrophysica
Dostawca treści:
Biblioteka Nauki
Artykuł
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