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Wyświetlanie 1-10 z 31
Tytuł:
Plasma membrane rafts and chaperones in cytokine/ STAT signaling.
Autorzy:
Sehgal, Pravin
Powiązania:
https://bibliotekanauki.pl/articles/1043429.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cytokine receptors
chaperones
fever
heat shock protein 90 (HSP90)
signal transducers and activators of transciption (STATs)
caveolin
lipid rafts
Opis:
We and others have recently obtained data suggesting that cytokine-STAT signaling in many different cell-types is a chaperoned pathway initiated at the level of specialized plasma membrane microdomains called "rafts" (the "raft-STAT signaling hypothesis"). These findings are of broad significance in that all cytokines and growth factors initiate signaling in target cells by interacting with respective cell-surface receptors. The new data suggest that raft microdomains represent the units of function at the cell-surface through which ligand-stimulated STAT signaling is initiated. Moreover, recent evidence shows the involvement of chaperone proteins in regulating the STAT signaling pathway. These chaperones include the human homolog of the tumorous imaginal disc 1 protein (hTid1) which associates with Janus kinase 2 (JAK2) at the level of the plasma membrane, heat shock protein 90 (HSP90) which associates with STAT3 and STAT1 proteins in caveolin-1-containing raft and cytoplasmic complexes, and glucose regulated protein 58 (GRP58/ER-60/ERp57), a thiol dependent protein-disulfide isomerase, found in association with STAT3 "statosome" complexes in the cytosol and in the raft fraction. We suggest a function of the HSP90 chaperone system in preserving IL-6/STAT3 signaling in liver cells in the context of fever. The identification and function of protein partners associated with specific STAT species in rafts and in cytosolic complexes, and in the efficient departure of cytokine-activated STATs from the cytosolic face of rafts towards the cell nucleus are now areas of active investigation.
Źródło:
Acta Biochimica Polonica; 2003, 50, 3; 583-594
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Plasma membrane Ca2+ -ATPase in excitable and nonexcitable cells.
Autorzy:
Żylińska, Ludmiła
Soszyński, Mirosław
Powiązania:
https://bibliotekanauki.pl/articles/1044284.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
calcium homeostasis
brain
erythrocytes
plasma membrane Ca2+ -ATPase
Opis:
There is a significant number of data confirming that the maintenance of calcium homeostasis in a living cell is a complex, multiregulated process. Calcium efflux from excitable cells (i.e., neurons) occurs through two main systems - an electrochemically driven Na+/Ca2+ exchanger with a low Ca2+ affinity (K0.5 = 10-15 μM), and a plasmalemmal, specific Ca2+-ATPase, with a high Ca2+ affinity (K0.5 < 0.5-1 μM), whereas in nonexcitable cells (i.e., erythrocytes) the calcium pump is the sole system responsible for the extrusion of calcium ions. The plasma membrane Ca2+-ATPase (PMCA) is a ubiquitously expressed protein, and more than 26 transcripts of four PMCA genes are distributed in a tissue specific manner. Differences in the structure and localization of PMCA variants are thought to correlate with specific regulatory properties and may have consequences for proper cellular Ca2+ signaling. The regulatory mechanisms of calcium pump activity have been studied extensively, resulting in a new view of the functioning of this important molecule in the membranes.
Źródło:
Acta Biochimica Polonica; 2000, 47, 3; 529-539
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Profiling of plasma membrane bound peroxidases in maize (Zea mays L.)
Autorzy:
Perrineau, F.
Decker, D.
Luthje, S.
Powiązania:
https://bibliotekanauki.pl/articles/80819.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
plasma membrane
profiling
peroxidase
maize
Zea mays
heavy metal
cadmium
oxidative stress
reactive oxygen species
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Cancer Cell Plasma Membrane Potentials As Energetic Equivalents to Astrophysical Properties
Autorzy:
Persinger, M. A.
Lafrenie, R. M.
Powiązania:
https://bibliotekanauki.pl/articles/411648.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
kT boundary
magnetic energy
cancer cell
entropy
noise band
Hubble's parameter
Opis:
The primary physical and chemical parameters that define the hypopolarized plasma cell membrane of malignant (cancer) cells compared to non-malignant cells reflect universal characteristics. The median value for the resting membrane potential is the constant for the Nernst equation without reference to discrepancies in ion concentrations and is identical to Boltzmann energies at 37 °C. The threshold energy defining space-time converges with access to entropic processes that are reflected in the morphology of cancer cells and tumors. Slowing of growth in cancer cell lines but not normal cells following exposure to weak (~1 to 10 μT) patterned magnetic fields occurs when the energy induced within the cell corresponds to the energy equivalent of the hypopolarized membrane potential. The optimal temporal parameters for the efficacy of these fields can be derived from Hubble‟s parameter and the transform function for “noise” or “random” patterns within the system. Quantitative solutions and experimental data indicate that the cancer cell may be dominated by entropic process that can be attenuated or blocked by temporally-structured applied magnetic fields whose intensity matches the increment of energy associated with this threshold.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 17, 1; 67-77
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Alteration of plasma membrane NADPH oxidase and NADP-recycling enzymes in cucumber roots stressed with cadmium
Autorzy:
Jakubowska, D.
Kabala, K.
Reda, M.
Janicka-Russak, M.
Powiązania:
https://bibliotekanauki.pl/articles/80528.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
plasma membrane
NADPH oxidase
glucose-6-phosphate dehydrogenase
6-phosphogluconate dehydrogenase
malic enzyme
isocitrate dehydrogenase
cucumber
root stress
heavy metal
cadmium
enzyme activity
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mitochondrial uncoupling does not influence the stability of the intracellular signal activating plasma membrane calcium channels.
Autorzy:
Zabłocki, Krzysztof
Makowska, Agnieszka
Duszyński, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1044178.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Jurkat cells
store-operated calcium entry
mitochondrial uncoupling
thapsigargin
Opis:
The effects of various concentrations of thapsigargin, a specific inhibitor of Ca2+-ATPase in the endoplasmic reticulum (ER) membrane, on calcium homeostasis in lymphoidal T cells (Jurkat) were investigated. Preincubation of these cells suspended in nominally calcium-free medium with 0.1 μM thapsigargin resulted in a complete release of Ca2+ from intracellular calcium stores. When the medium was supplemented with 3 mM CaCl2 the cells maintained constantly elevated level of cytosolic Ca2+. However, thapsigargin applied at lower concentration produced only a partial depletion of the stores. For example, in the cells pretreated with 1 nM thapsigargin and suspended in calcium-free medium approximately 75% of the calcium content was released from the intracellular stores. The addition of 3 mM CaCl2 to such cell suspension led to a transient increase in cytosolic calcium concentration, followed by a return to a lower steady-state. This phenomenon, related to the refilling of the ER by Ca2+, allowed to estimate the half-time for the process of cell recovery after activation of store-operated calcium channels. By this approach we have found that carbonyl cyanide m-chlorophenylhydrazone, which has been documented to inhibit calcium entry into Jurkat cells, does not influence the stability of the intracellular signal involved in the activation of store-operated calcium channels.
Źródło:
Acta Biochimica Polonica; 2001, 48, 1; 157-161
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Constitutively active guard cell plasma membrane Hplus-ATPase impairs ozone – elevated CO2־ and darkness-induced stomatal closur
Autorzy:
Nuhkat, M.
Roelfsema, M.R.G.
Kollist, H.
Powiązania:
https://bibliotekanauki.pl/articles/81254.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
air pollutant
plasma membrane
guard cell
ATPase
ozone
reactive oxygen species
stomatal conductance
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mikrodomeny błony komórkowej miejscem zapoczątkowania szlaków sygnałowych przez immunoreceptory
Plasma membrane rafts as centers for signal transduction by immunoreceptors
Autorzy:
Kwiatkowska, Katarzyna
Sobota, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1199437.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Przyrodników im. Kopernika
Opis:
Sphingolipids and cholesterol of the plasma membrane self-organize into microdomains named rafts. They are 30-50 nm dynamic lipid assemblies that facilitate local accumulation of GPI-anchored proteins and Src family protein tyrosine kinases in their outer and inner leaflet, respectively. It has been demonstrated in the last five years that immunoreceptors, including TCR, BCR and Fc receptors, associate with rafts upon binding of their polyvalent ligands. Within rafts, tyrosine residues of the receptor signaling sequence ITAM are phosphorylated by kinases of the Src family, being convert simultaneously into docking sites for Syk and Zap70 tyrosine kinases. The joint activity of the Src and Syk/Zap70 families of tyrosine kinases triggers signaling cascades leading eventually to proper responses of cells. An important feature of this process is a fusion of rafts of various composition bringing together molecules required for formation of signaling complexes at activated immunoreceptors.
Źródło:
Kosmos; 2004, 53, 2; 113-122
0023-4249
Pojawia się w:
Kosmos
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Accelerated and natural ageing processes change the properties of plasma membrane in Norway spruce (Picea abies (L.) Karst.) seeds during storage
Autorzy:
Nowakowska, J
Rakowski, K.
Powiązania:
https://bibliotekanauki.pl/articles/41613.pdf
Data publikacji:
2002
Wydawca:
Polska Akademia Nauk. Instytut Dendrologii PAN
Tematy:
plasma membrane
Norway spruce
natural aging process
Picea abies
vitality
vigor
storage
seed
Opis:
The present study examines the mechanism of natural and accelerated ageing processes in Norway spruce (Picea abies [L.] Karst.) seeds stored at low temperature for one (control) and eight years. The analyses of vitality, electrolyte leakage, protein composition and activity of the proton-pump ATPase (P-ATPase, EC.3.6.1.35) in plasma membrane of Norway spruce seeds have been investigated. Seeds collected in 1999 from northeastern Poland have been treated with accelerated ageing method and compared to the seeds of the same provenance, collected in 1992 (control). The vigor and the vitality of the Norway spruce seeds depend on the age of seeds. After 6 days of experiment both samples of seeds (artificially aged seeds and control) expressed the same percentage of germination and similar electrolyte leakage. Analysis of protein composition in the extracts showed an increased amount of some low molecular-weight proteins in artificially and naturally aged seeds compared to the control. Our results indicate similar level of P-ATPase activity in natural, artificially aged and control seeds. This suggests that natural ageing process can involve changes in plasma membrane protein composition but does not affect the P-ATPase activity.
Źródło:
Dendrobiology; 2002, 47 Supplement
1641-1307
Pojawia się w:
Dendrobiology
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 31

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