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Wyszukujesz frazę "plasma cell" wg kryterium: Wszystkie pola


Wyświetlanie 1-32 z 32
Tytuł:
Plasma cell myeloma as one of the causes of bone pain in family medicine
Autorzy:
Kade, Grzegorz
Michalak, Maciej
Kade, Bartosz
Spaleniak, Sebastian
Podgórska, Agnieszka
Hałka, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/22676881.pdf
Data publikacji:
2023-05-12
Wydawca:
Medical Education
Tematy:
myeloma
hypercalcaemia
treatment
Opis:
The article draws attention to the need to maintain oncological vigilance in the daily practice of a family doctor. Diagnosis and effective treatment of hypercalcemia and plasma cell myeloma are presented.
Źródło:
OncoReview; 2023, 13, 1; 33-35
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The mucosal mast cell and IgA plasma cell responses to primary Trichinella spiralis infection in BALB-c mice treated with ketotifen
Autorzy:
Doligalska, M
Laskowska, M.
Powiązania:
https://bibliotekanauki.pl/articles/836928.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
ketotifen
plasma cell
mucosal mast cell
mouse
infection
mice
mast cell
inflammation
Trichinella spiralis
Opis:
The effect of ketotifen on inflammation in the intestine during T. spiralis infection in BALB/c mice was examined. The lack of enteropathy in treated mice was accompanied to affected the size of worms and the number of worms, but did not prevent the retardation of nematodes in the intestine. Fecundity of females in vitro and the number of muscle larvae were not statistically changed after treatment. Ketotifen reduced the number of mast cells and IgA plasma cells in the intestine. As inflammatory influx, epithelial damage and IgA response are related to the action of T cells, ketotifen affected T dependent reactions in the gut of T. spiralis infected mice.
Źródło:
Annals of Parasitology; 2001, 47, 4
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Periodic dynamics in a model of immune system
Autorzy:
Bodnar, Marek
Foryś, Urszula
Powiązania:
https://bibliotekanauki.pl/articles/1208224.pdf
Data publikacji:
2000
Wydawca:
Polska Akademia Nauk. Instytut Matematyczny PAN
Tematy:
autocorrelation function
antibody
antigen
immune system organ-target
Hopf bifurcation
plasma cell
periodicity
Opis:
The aim of this paper is to study periodic solutions of Marchuk's model, i.e. the system of ordinary differential equations with time delay describing the immune reactions. The Hopf bifurcation theorem is used to show the existence of a periodic solution for some values of the delay. Periodic dynamics caused by periodic immune reactivity or periodic initial data functions are compared. Autocorrelation functions are used to check the periodicity or quasiperiodicity of behaviour.
Źródło:
Applicationes Mathematicae; 2000, 27, 1; 113-126
1233-7234
Pojawia się w:
Applicationes Mathematicae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The mucosal mast cell and IgA plasma cell responses to primary Trichinella spiralis infection in BALB-c mice treated with ketotifen
WPŁYW KETOTIFENU NA ODPOWIEDŹ KOMÓREK TUCZNYCH I PLAZMOCYTÓW IgA W PIERWOTNEJ INWAZJI TRICHINELLA SPIRALIS U MYSZY BALB/c
Autorzy:
Doligalska, M.
Laskowska, M.
Powiązania:
https://bibliotekanauki.pl/articles/2148474.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
ketotifen
plasma cell
mucosal mast cell
mouse
infection
mice
mast cell
inflammation
Trichinella spiralis
Opis:
The effect of ketotifen on inflammation in the intestine during T. spiralis infection in BALB/c mice was examined. The lack of enteropathy in treated mice was accompanied to affected the size of worms and the number of worms, but did not prevent the retardation of nematodes in the intestine. Fecundity of females in vitro and the number of muscle larvae were not statistically changed after treatment. Ketotifen reduced the number of mast cells and IgA plasma cells in the intestine. As inflammatory influx, epithelial damage and IgA response are related to the action of T cells, ketotifen affected T dependent reactions in the gut of T. spiralis infected mice.
Źródło:
Wiadomości Parazytologiczne; 2001, 47, 4; 597-601
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Complementary analysis of the initial value problem for a system of o.d.e. modelling the immune system after vaccinations
Autorzy:
Foryś, Urszula
Żołek, Norbert
Powiązania:
https://bibliotekanauki.pl/articles/1208222.pdf
Data publikacji:
2000
Wydawca:
Polska Akademia Nauk. Instytut Matematyczny PAN
Tematy:
VT-complex
antibody
antigen
B-cell
plasma cell
stationary state
stability
ordinary differential equations
lymphocyte
phase space
Opis:
Complementary analysis of a model of the human immune system after a series of vaccinations, proposed in [7] and studied in [6], is presented. It is shown that all coordinates of every solution have at most two extremal values. The theoretical results are compared with experimental data.
Źródło:
Applicationes Mathematicae; 2000, 27, 1; 103-111
1233-7234
Pojawia się w:
Applicationes Mathematicae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Behaviour of Solutions to Marchuks Model Depending on a Time Delay
Autorzy:
Bodnar, M.
Foryś, U.
Powiązania:
https://bibliotekanauki.pl/articles/929743.pdf
Data publikacji:
2000
Wydawca:
Uniwersytet Zielonogórski. Oficyna Wydawnicza
Tematy:
antygen
przeciwciało
opóźnienie różniczkowe
antigen
antibody
plasma cell
organ-target
delay differential equation
stationary state
stability
bifurcation point
Opis:
Marchuk's model of an immune reaction is a system of differential equations with a time delay. The aim of this paper is to study the behaviour of solutions to Marchuk's model depending upon the delay of immune reaction and the history of an illness. We study Marchuk's model without delays, with aconstant delay and with an infinite delay. A continuous dependence on thedelay is considered. Bifurcation points are found using computer simulations.
Źródło:
International Journal of Applied Mathematics and Computer Science; 2000, 10, 1; 97-112
1641-876X
2083-8492
Pojawia się w:
International Journal of Applied Mathematics and Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ocena przydatności oznaczania w surowicy krwi stężenia wolnych łańcuchów lekkich immunoglobulin w diagnostyce chorych z dyskrazjami plazmocytowymi*
The usefulness of evaluating serum immunoglobulin light free chains concentration in diagnosis of patients with plasma cell disorder
Autorzy:
Gumółka, Izabela
Dryńska-Lichoń, Ewa
Basa, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1034994.pdf
Data publikacji:
2013
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
slfc (serum light free chain)
mm (multiple myeloma)
smm (smouldering myeloma)
mgus (monoclonal
gammopathy of undetermined significance)
cll (non-hodgkin lymphoma)
al (amyloidosis)
lcmm (light
chain myeloma)
Opis:
Patients with plasma cell disorder require a medical examination that will enable in a quick way to make a diagnosis, treatment selection and conduct patient monitoring during drug therapy. The aim of this study was to determine the concentration of serum immunoglobulin and light free chains in patients with monoclonal gammopathy. The blood serum of patients was evaluated in the Beskid Hematological Clinic Cancer Center – City Hospital in Bielsko-Biała. The serum of immunoglobulin light free chains was determined by using commercially available tests by the Binding Site company. Assay validation was performed in the serum light free chains of immunoglobulin by setting the analytical range of the method, linearity, precision, analytical sensitivity, recurrence and limit of detection as well as quantification methods. The results obtained indicate that the determination of serum immunoglobulin and light free chains is important in the diagnosis of patients with multiple myeloma and other monoclonal gammopathy, such as smouldering myeloma, light chain disease, gammopathy of undetermined significance, non-Hodgkin lymphoma and amyloidosis.
Źródło:
Annales Academiae Medicae Silesiensis; 2013, 67, 4; 249-255
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Cancer Cell Plasma Membrane Potentials As Energetic Equivalents to Astrophysical Properties
Autorzy:
Persinger, M. A.
Lafrenie, R. M.
Powiązania:
https://bibliotekanauki.pl/articles/411648.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
kT boundary
magnetic energy
cancer cell
entropy
noise band
Hubble's parameter
Opis:
The primary physical and chemical parameters that define the hypopolarized plasma cell membrane of malignant (cancer) cells compared to non-malignant cells reflect universal characteristics. The median value for the resting membrane potential is the constant for the Nernst equation without reference to discrepancies in ion concentrations and is identical to Boltzmann energies at 37 °C. The threshold energy defining space-time converges with access to entropic processes that are reflected in the morphology of cancer cells and tumors. Slowing of growth in cancer cell lines but not normal cells following exposure to weak (~1 to 10 μT) patterned magnetic fields occurs when the energy induced within the cell corresponds to the energy equivalent of the hypopolarized membrane potential. The optimal temporal parameters for the efficacy of these fields can be derived from Hubble‟s parameter and the transform function for “noise” or “random” patterns within the system. Quantitative solutions and experimental data indicate that the cancer cell may be dominated by entropic process that can be attenuated or blocked by temporally-structured applied magnetic fields whose intensity matches the increment of energy associated with this threshold.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 17, 1; 67-77
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Inflammatory myofibroblastic tumor in the maxillary sinus with asymptomatic course excised during endoscopic surgery – a case report and review of the literature
Zapalny guz miofibroblastyczny zatoki szczękowej o bezobjawowym przebiegu usunięty podczas operacji endoskopowej – opis przypadku i przegląd literatury
Autorzy:
Poślednik, Krzysztof
Anurin, Igor
Kantor, Ireneusz
Powiązania:
https://bibliotekanauki.pl/articles/1399686.pdf
Data publikacji:
2019-10-16
Wydawca:
Index Copernicus International
Tematy:
endoscopic sinus surgery
inflammatory myofibroblastic tumor
inflammatory pseudotumor of the maxillary sinus
plasma cell granuloma
endoskopowa operacja zatok
zapalny guz miofibroblastyczny
zapalny guz rzekomy zatoki szczękowej
ziarniniak plazmatycznokomórkowy
Opis:
Introduction: Inflammatory myofibroblastic tumor (IMT) is a rare condition that can mimic potentially more dangerous states such as malignant tumors. The tumor itself can also show local malignancy as well as malignant transformation. The paranasal sinus IMT is quite a rare case in the literature. The manifestation of the disease can include face swelling, nasal obstruction, epistaxis, vision acuity worsening, numbness of the face, pain. Etiology of this type of lesion still remains uncertain but there are a few assumptions on the issue: viral and genetic, as well as posttraumatic and postinflammatory. We report a case of an adult woman with IMT detected in the right maxillary sinus after endoscopic sinus surgery. Case report: We report the case of an adult woman with IMT detected in right maxillary sinus after endoscopic sinus surgery.
Wstęp: Zapalny guz miofibroblastyczny (IMT) jest rzadkim stanem, który może naśladować potencjalnie bardziej niebezpieczne choroby, takie jak nowotwory złośliwe. Sam guz może również wykazywać miejscową złośliwość, a także złośliwą transformację. IMT zatok przynosowych jest dość rzadko opisywany w literaturze. Objawem choroby może być obrzęk twarzy, niedrożność nosa, krwawienie z nosa, pogorszenie ostrości wzroku, drętwienie twarzy, ból. Etiologia tego typu zmian nadal pozostaje niejasna, ale rozważa się następujące przyczyny powstawania guza: wirusową, genetyczną, a także pourazową i pozapalną. Niniejszy opis przypadku dotyczy dorosłej kobiety z IMT wykrytym w prawej zatoce szczękowej po endoskopowej operacji zatok. Opis przypadku: Niniejszy opis przypadku dotyczy dorosłej kobiety z IMT wykrytym w prawej zatoce szczękowej po endoskopowej operacji zatok.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2019, 8, 4; 38-41
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The stimulation and inhibition of T cell proliferation by Helicobacter pylori components
Autorzy:
Chmiela, M
Lelwala-Guruge, J.A.
Wadstrom, T.
Rudnicka, W.
Powiązania:
https://bibliotekanauki.pl/articles/69409.pdf
Data publikacji:
1996
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
polyacrylamide gel electrophoresis
blood leucocyte
sodium dodecyl sulphate
horse
stimulation
macrophage
chronic active gastritis
Helicobacter pylori
antibody
gastric carcinoma
cell proliferation
peripheral blood
ulcer
plasma cell
lymphocyte
infiltration
inhibition
gastric lymphoma
Źródło:
Journal of Physiology and Pharmacology; 1996, 47, 1
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Constitutively active guard cell plasma membrane Hplus-ATPase impairs ozone – elevated CO2־ and darkness-induced stomatal closur
Autorzy:
Nuhkat, M.
Roelfsema, M.R.G.
Kollist, H.
Powiązania:
https://bibliotekanauki.pl/articles/81254.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
air pollutant
plasma membrane
guard cell
ATPase
ozone
reactive oxygen species
stomatal conductance
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Surface modifications of biomaterial with different cold plasma reactors to improve cell adhesion
Autorzy:
Terebun, Piotr
Kwiatkowski, Michał
Zarzeczny, Dawid
Pawłat, Joanna
Wójcik, Michał
Trzaskowska, Marta
Kazimierczak, Paulina
Przekora, Agata
Powiązania:
https://bibliotekanauki.pl/articles/2172008.pdf
Data publikacji:
2022
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
curdlan
agarose
gliding arc discharge reactor
dielectric barrier discharge plasma jet
dielectric barrier discharge surface reactor
surface modification
Opis:
There is a growing trend in the engineering of biomaterials, focusing on surface modifications of biomaterials to improve their mechanical strength, corrosion resistance, and biological properties. Cold plasma treatment may improve biological properties of biomaterials for biomedical applications by enhancing their integration with host tissue. This study investigated the influence of different cold plasma treatments on the surface properties of a polysaccharides- -based biomaterial to improve cell adhesion to its surface. The samples were subjected to plasma treatment using three different reactors operating at atmospheric pressure: gliding arc discharge (GAD) reactor, dielectric barrier discharge (DBD) plasma jet, and DBD surface reactor. Next, surface chemistry of the biomaterial after plasma treatment was determined by ATR-FTIR analysis. Furthermore, a cell adhesion assay on the samples was carried out using normal human skin fibroblasts (BJ cell line). The attenuated total reflection Fourier transform infrared analysis (ATR- -FTIR) showed that new potential functional groups could be formed on the material surface after plasma treatment. However, plasma treatment of the samples did not enhance cell adhesion to the surface of the polysaccharides-based biomaterial. Thus, the obtained results indicate that plasma treatment using GAD reactor, DBD plasma jet, and DBD surface reactor was not effective for surface modification and cell responses.
Źródło:
Engineering of Biomaterials; 2022, 25, 165; 2--6
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Red blood cell and plasma glutathione peroxidase activities and selenium concentration in patients with chronic kidney disease: A review
Autorzy:
Zachara, Bronisław
Gromadzińska, Jolanta
Wąsowicz, Wojciech
Zbróg, Zbigniew
Powiązania:
https://bibliotekanauki.pl/articles/1041155.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
hemodialysis
selenium
kidney transplantation
glutathione peroxidase
chronic kidney disease
antioxidants
plasma
Opis:
The metabolism of oxygen in aerobic organisms leads to generation of reactive oxygen species (ROS). These entities are able to oxidize almost all classes of macromolecules, including proteins, lipids and nucleic acids. The physiological level of ROS is usually regulated by antioxidant defense mechanisms. There are at least three groups of antioxidant enzymes: superoxide dismutases, catalases and glutathione peroxidases (GSH-Pxs) which neutralize ROS. The trace elements (copper, zinc and selenium) bound to the active sites of the above listed enzymes play an important role in the antioxidant defense system. In mammals, a major function of selenium (Se) and Se-dependent GSH-Pxs is to protect cells from oxidative stress. Selenium concentrations and GSH-Px activities are altered in blood components of chronic kidney disease (CKD) patients. The Se level is frequently lower than in healthy subjects and the concentration very often decreases gradually with advancing stage of the disease. Studies on red cell GSH-Px activity in CKD patients reported its values significantly lower, significantly higher and lower or higher, but not significantly as compared with healthy subjects. On the other hand, all authors who studied plasma GSH-Px activity have shown significantly lower values than in healthy subjects. The degree of the reduction decreases gradually with the progression of the disease. High inverse correlations were seen between plasma GSH-Px activity and creatinine level. A gradual decrease in plasma GSH-Px activity in CKD patients is due to the fact that this enzyme is synthesized predominantly in the kidney and thus the impairment of this organ is the cause of the enzyme's lower activity. Se supplementation to CKD patients has a slightly positive effect in the incipient stage of the disease, but usually no effect was observed in end-stage CKD. Presently, kidney transplantation is the only treatment that may restore plasma Se level and GSH-Px activity in patients suffering from end-stage CKD. A few studies have shown that in kidney recipients, plasma Se concentration and GSH-Px activity are restored to normal values within a period of 2 weeks to 3 months following surgery and thus it can be acknowledged that Se supplementation to those patients has a positive effect on plasma GSH-Px activity.
Źródło:
Acta Biochimica Polonica; 2006, 53, 4; 663-677
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An MPI-based parallel code for high performance 3-D particle-in-cell ion source plasma simulation
Autorzy:
Turek, Marcin
Brzuszek, Marcin
Sielanko, Juliusz
Powiązania:
https://bibliotekanauki.pl/articles/764503.pdf
Data publikacji:
2007
Wydawca:
Uniwersytet Marii Curie-Skłodowskiej. Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej
Źródło:
Annales Universitatis Mariae Curie-Skłodowska. Sectio AI, Informatica; 2007, 6, 1
1732-1360
2083-3628
Pojawia się w:
Annales Universitatis Mariae Curie-Skłodowska. Sectio AI, Informatica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Multi-element analysis of urine using dynamic reaction cell inductively coupled plasma mass spectrometry (ICP-DRC-MS) — A practical application
Autorzy:
Brodzka, Renata
Trzcinka-Ochocka, Małgorzata
Janasik, Beata
Powiązania:
https://bibliotekanauki.pl/articles/2179785.pdf
Data publikacji:
2013-04-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
metals
trace elements
exposure
urine
ICP-MS
Opis:
Objectives: The method for the determination of As, Al, Cd, Ni, Pb (toxic elements) and Cr, Co, Cu, Fe, Mn, Zn (essential elements) in human urine by the use of Inductively Coupled Plasma Mass Spectrometry (quadrupole ICP-MS DRCe Elan, Perkin Elmer) with the dynamic reaction cell (DRC) was developed. Materials and Methods: The method has been applied for multi-element analysis of the urine of 16 non-exposed healthy volunteers and 27 workers employed in a copper smelter. The analysis was conducted after initial 10-fold dilution of the urine samples with 0,1% nitric acid. Rhodium was used as an internal standard. The method validation parameters such as detection limit, sensitivity, precision were described for all elements. Accuracy of the method was checked by the regular use of certified reference materials ClinCheck®-Control Urine (Recipe) as well as by participation of the laboratory in the German External Quality Assessment Scheme (G-EQUAS). Results: The detection limits (DL 3s) of the applied method were 0.025, 0.007, 0.002, 0.004, 0.004, 0.086, 0.037, 0.009, 0.016, 0.008, 0.064 (μg/l) for Al, As, Cd, Cr, Co, Cu, Fe, Mn, Ni, Pb, Zn in urine, respectively. For each element linearity with correlation coefficient of at least 0.999 was determined. Spectral interferences from some of the ions were removed using DRC-e with addition of alternative gas: methane for cobalt, copper, cadmium, chromium, iron, manganese, nickel and rhodium, and oxygen for arsenic. Conclusions: The developed method allows to determine simultaneously eleven elements in the urine with low detection limits, high sensitivity and good accuracy. Moreover, the method is appropriate for the assessment of both environmental and occupational exposure.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2013, 26, 2; 302-312
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Microfluidic design for continuous separation of blood particles and plasma using dielectrophoretic force principle
Autorzy:
Pakhira, Writtick
Kumar, Rajagopal
Panwala, Fenil Chetankuma
Ibrahimi, Khalid Mohd
Powiązania:
https://bibliotekanauki.pl/articles/38702917.pdf
Data publikacji:
2023
Wydawca:
Instytut Podstawowych Problemów Techniki PAN
Tematy:
blood cell separation
dielectrophoresis
microfluidic device
plasma separation
separacja komórek krwi
dielektroforeza
urządzenie mikroprzepływowe
separacja plazmy
Opis:
Nowadays, various microfluidic platforms are developed with a focus on point-of-care diagnostics in the biomedical field. Segregation of blood cells and plasma remains an essential part of medical diagnosis in which isolation of platelets (PLTs), red blood cells (RBCs), and white blood cells (WBCs) is a requirement for analysis of diseases associated with thrombocytopenia, anemia, and leukopenia. However, a separated plasma contains proteins, nucleic acids, and viruses, for which a microfluidic device is introduced for continuous separation of PLTs, RBCs, and WBCs with a diameter range of 1.8–2 m, 5–6 m, and 9.4–14 m, respectively, and plasma using the negative dielectrophoresis (DEP) force principle. In this study, design of the device is explored utilizing COMSOL Multiphysics 5.4 tool. This design consists of triangular micro-tip electrodes at the top, which are effective in generating a nonuniform electrical field with a significantly small AC voltage. Furthermore, the blood cells are subjected to the negative DEP force resulting in deflection toward their respective outlets, due to which blood cell separation purity and efficiency from the sample, i.e., of PLTs, RBCs, and WBCs, improve and are obtained at a blood sample flow velocity of 700 m/s and buffer solution flow velocity of 1200 m/s with 12 Vpp electrode voltage, after experimenting and testing at multiple flow velocities. Additionally, a curved microchannel is introduced, producing better plasma flow velocity than a flat microchannel at the side outlets (top and bottom). The cell-free diluted plasma is collected at side outlets (top and bottom) with high purity and improved separation efficiency.
Źródło:
Computer Assisted Methods in Engineering and Science; 2023, 30, 3; 323-345
2299-3649
Pojawia się w:
Computer Assisted Methods in Engineering and Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modeling of planar plasma diode
Autorzy:
Wijewardena Gamalath, K. A. I. L.
Samarakoon, A. M.
Powiązania:
https://bibliotekanauki.pl/articles/412368.pdf
Data publikacji:
2013
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Plasma diode
plasma boundary
current density
Particle-In-Cell simulation
anode cathode gap
potential field
Opis:
To investigate the dynamics of a planar plasma diode system (PDS), a model based on the current density equilibrium at the interface was developed. The current densities and plasma boundary variations with the potential fields were obtained by simulating a single square pulse. The variation of an observed overshoot current density with the applied voltage is presented. Planar plasma diode system was also simulated for periodic, sine, square, triangular and saw tooth voltage patterns by varying the amplitude and frequencies. A method to find the lower bound of the electron density of plasma for a specified PDS is presented. Particle-In-Cell simulation technique was used to investigate the plasma particles and electric field distributions over the anode cathode gap for different intensities of external electric fields. The system became stable after few time steps and this time depends upon the intensity and polarization of the external field.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2013, 8, 3; 220-242
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Particle-in-Cell electrostatic numerical algorithm
Algorytm numeryczny Particle-in-Cell dla problemu elektrostatycznego
Autorzy:
Konior, W.
Powiązania:
https://bibliotekanauki.pl/articles/212864.pdf
Data publikacji:
2017
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Lotnictwa
Tematy:
plasma
neutral particles
Particle-In-Cell
Monte-Carlo method
plazma
heliosfera
Particle-in-Cell
Monte-Carlo
Opis:
Existing global models of interaction between the solar wind (SW) and the local interstellar medium (LISM) describe the heliosphere that arises as a result of this interaction. There is a strong motivation to develop a kinetic model using the Particle-in-Cell (PIC) method to describe phenomena which appear in the heliosphere. This is however a long term scientific goal. This paper describes an electrostatic Particle-in-Cell numerical model developed in the Institute of Aviation in Warsaw, winch includes mechanical and charge exchange collisions between particles in the probabilistic manner using Direct Simulation Monte Carlo method. This is the first step into developing simulations of the heliosphere incorporating kinetic effects in collisionless plasmas. In this paper we focus only on presenting the work, which have been done on the numerical PIC algorithm.
Istniejące globalne modele oddziaływania wiatru słonecznego (SW) z lokalną materią międzygwiazdową (LISM) opisują heliosferę, która powstaje w wyniku interakcji tych dwóch ośrodków. Istnieje silna motywacja do opracowania modelu kinetycznego wykorzystującego metodę Particle-in-Cell (PIC) w celu opisu zjawisk, które zachodzą w heliosferze. Jednakże jest to długoterrninowy cel naukowy. W artykule przedstawiono elektrostatyczny model numeryczny PIC. opracowany w Instytucie Lotnictwa w Warszawie, który obejmuj e kolizje mechaniczne i rezonansową wymianę ładunków pomiędzy cząstkami w sposób probabilistyczny metodą Direct Simulation Monte Carlo. Jest to pierwszy krok w opracowywaniu symulacji heliosfery zawierającej efekty kinetyczne w plazmach bezzderzeniowych. W tym artykule koncentrujemy się tylko na prezentowaniu prac, które zostały wykonane z wykorzystaniem algorytmu numerycznego PIC.
Źródło:
Prace Instytutu Lotnictwa; 2017, 3 (248); 24-45
0509-6669
2300-5408
Pojawia się w:
Prace Instytutu Lotnictwa
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Architecture of the exocyst complex in plant cells
Autorzy:
Kasprowicz, A.
Pihan, K.
Ochocki, M.
Kwiatkowski, W.
Wojtaszek, P.
Powiązania:
https://bibliotekanauki.pl/articles/80552.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
exocytosis
plant cell
eukaryotic cell
plasma membrane
protein-protein interaction
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
POSIX threads parallelization for example of Particle-In-Cell density calculations in plasma computer simulations
Autorzy:
Sasak, Anna
Brzuszek, Marcin
Powiązania:
https://bibliotekanauki.pl/articles/764783.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Marii Curie-Skłodowskiej. Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej
Źródło:
Annales Universitatis Mariae Curie-Skłodowska. Sectio AI, Informatica; 2010, 10, 2
1732-1360
2083-3628
Pojawia się w:
Annales Universitatis Mariae Curie-Skłodowska. Sectio AI, Informatica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Vascular smooth muscle cells in cultures on low density polyethylene modified with plasma discharge and biofunctionalization
Autorzy:
Parizek, M.
Kasalkova, N.
Bacakova, L.
Kolarova, K.
Lisa, V.
Svorcik, V.
Powiązania:
https://bibliotekanauki.pl/articles/285087.pdf
Data publikacji:
2009
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
Ar plasma discharge
biomaterials
low-density polyethylene
cell adhesion
cell proliferation
grafting
tissue engineering
vascular smooth muscle cells
Opis:
Low density polyethylene (LDPE) was modified by an Ar plasma discharge and then grafted with glycine (Gly), bovine serum albumin (BSA) or polyethylene glykol (PEG). Some plasma-treated samples and samples grafted with BSA were exposed to a suspension of colloidal carbon particles (C, BSA+C). Pristine LDPE and tissue culture polystyrene dishes (PSC) were used as control samples. The materials were seeded with rat aortic smooth muscle cells and incubated in a medium DMEM with 10% of fetal bovine serum. On day 1 after seeding, the cells on LDPE modified with plasma only, Gly, BSA and BSA+C adhered in similar numbers as on PSC, while the values on non-modified and PEG-modified samples were significantly lower. On day 5, the highest cell numbers were found again on LDPE with Gly, BSA and BSA+C. On day 7, the highest number of cells was found on LDPE modified only with plasma. The latter cells also dis-played the largest cell spreading area. The increased cell colonization was probably due to the formation of oxygen-containing chemical functional groups after plasma irradiation, and also due to positive effects of grafted Gly, BSA and BSA in combination with colloidal C particles.
Źródło:
Engineering of Biomaterials; 2009, 12, no. 89-91; 25-28
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Improved adhesion and growth of vascular smooth muscle cells in cultures on polyethylene modified by plasma discharge
Autorzy:
Parizek, M.
Kasalkova, N.
Bacakova, L.
Kolarova, K.
Lisa, V.
Svorcik, V.
Powiązania:
https://bibliotekanauki.pl/articles/284295.pdf
Data publikacji:
2007
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
biomateriały
inżynieria tkankowa
Ar plasma discharge
high density and low density polyethylene
cell adhesion
cell proliferation
vascular smooth muscle cells
biomaterials
tissue engineering
Opis:
The attractiveness of synthetic polymers for cell colonization can be affected by physical and chemical modification of the polymer surface. In this study, high density polyethylene (HDPE, m.w. 0.952g/cm3) and low density polyethylene (LDPE, m.w. 0.922g/cm3) were modified by an Ar plasma discharge using Balzers SCD 050 device (exposure time 10, 50, 150 and 400 seconds, discharge power 1.7W). The material was then seeded with rat aortic smooth muscle cells (RASMC; passages 8 to 9, 17 000 cells/cm3) and incubated in a DMEM medium with 10% of fetal calf serum. On day 1 after seeding, the number of initially adhered cells was significantly higher on all modified HDPE and LDPE samples. On day 2, this difference persisted in HDPE, whereas in LDPE only the values on the samples modified by 150 and 400 seconds were significantly higher. On the 5th and 7th day, there were no significant differences in cell number among all LDPE samples. However, on the HDPE foils, significant differences were still apparent on the samples modified for 400 seconds. The cell spreading areas measured on day 1 after seeding were significantly larger on all modified LDPE samples, and, on day 2, on the HDPE samples exposed for 150s. The increased cell colonization was probably due to the formation of oxygen-containing chemical functional groups in the polymer. These results suggest that the responsiveness of the cell to the changes in physiochemical surface properties was more pronounced in HDPE than in LDPE. On both types of polyethylene, the most appropriate exposure time for the enhancement of cell adhesion and growth seemed to be 150 and 400 seconds.
Źródło:
Engineering of Biomaterials; 2007, 10, no. 67-68; 1-4
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of hypothermia on the insulin - receptor interaction in adipose plasma membranes
Autorzy:
Torlinska, T
Mackowiak, P.
Nogowski, L.
Kozlik, J.
Powiązania:
https://bibliotekanauki.pl/articles/70049.pdf
Data publikacji:
1995
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
lipolysis
receptor
insulin
hypothermia
fat cell
lipid metabolism
epididymal adipose tissue
carbohydrate
rat
normothermia
hypoinsulinemia
adipose plasma membrane
Źródło:
Journal of Physiology and Pharmacology; 1995, 46, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Implementation of a Monte Carlo method to a two-dimensional particle-in-cell solver using algebraic meshes
Autorzy:
Sengil, N.
Tümüklü, Ö.
Çelenligil, M. C.
Powiązania:
https://bibliotekanauki.pl/articles/146470.pdf
Data publikacji:
2012
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
particle-in-cell (PIC)
plasma flows
Monte Carlo (MC) method
coordinate transformation
Poisson's equation
Boltzmann relation
Opis:
Particle-in-cell (PIC) technique is a widely used computational method in the simulation of low density collisionless plasma flows. In this study, a new two-dimensional (2-D) electrostatic particle-in-cell solver is developed that can be applied to non-rectangular configurations.
Źródło:
Nukleonika; 2012, 57, 2; 313-316
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A possible involvement of plasma membrane NAD(P)H oxidase in the switch mechanism of the cell death mode from apoptosis to necrosis in menadione-induced cell injury.
Autorzy:
Niemczyk, Edyta
Majczak, Anna
Hallmann, Anna
Kędzior, Jakub
Woźniak, Michał
Wakabayashi, Takashi
Powiązania:
https://bibliotekanauki.pl/articles/1041516.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
menadione
NADPH oxidase
necrosis
superoxide
apoptosis
Opis:
The effects of inhibitors of plasma membrane NADPH oxidase on menadione-induced cell injury processes were studied using human osteosarcoma 143B cells. The intracellular level of superoxide in the cells treated with menadione for 6 h reached a maximum followed by an abrupt decrease. The population of apoptotic cells detected by Annexin V and propidium iodide double staining also reached its maximum at 6 h of menadione-treatment while that of necrotic cells increased continuously reaching 90% of the total population at 9 h of the treatment. Pretreatment of the cells with inhibitors of NADPH oxidase, including diphenyliodonium chloride, apocynin, N-vanillylnonanamide and staurosporine was effective in lowering the menadione-induced elevations of superoxide, and also in the suppression of the switch of the cell death mode from apoptosis to necrosis in menadione-treated cells except for the case of staurosporine. These results strongly suggest that superoxide generated by NADPH oxidase, besides that generated by the mitochondria, may contribute to the remarkable increase in the intracellular level of superoxide in the cells treated with menadione for 6 h resulting in the switch from apoptosis to necrosis, although a direct evidence of the presence of active and inactive forms of NADPH oxidase in control and menadione-treated 143B cells is lacking at present.
Źródło:
Acta Biochimica Polonica; 2004, 51, 4; 1015-1022
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Numerical simulations of generation of high-energy ion beams driven by a petawatt femtosecond laser
Autorzy:
Domański, J
Badziak, J.
Jabłoński, S.
Powiązania:
https://bibliotekanauki.pl/articles/146458.pdf
Data publikacji:
2015
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
laser acceleration
laser plasma
ions
particle-in-cell simulations
Opis:
This contribution presents results of a Particle-in-Cell simulation of ion beam acceleration via the interaction of a petawatt 25 fs laser pulse of high intensity (up to ~1021 W/cm2) with thin hydrocarbon (CH) and erbium hydride (ErH3) targets of equal areal mass density (of 0.6 g/m2). A special attention is paid to the effect that the laser pulse polarization and the material composition of the target have on the maximum ion energies and the number of high energy (>10 MeV) protons. It is shown that both the mean and the maximum ion energies are higher for the linear polarization than for the circular one. A comparison of the maximum proton energies and the total number of protons generated from the CH and ErH3 targets using a linearly polarized beam is presented. For the ErH3 targets the maximum proton energies are higher and they reach 50 MeV for the laser pulse intensity of 1021 W/cm2. The number of protons with energies higher than 10 MeV is an order of magnitude higher for the ErH3 targets than that for the CH targets.
Źródło:
Nukleonika; 2015, 60, 2; 229-232
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zrobotyzowane stanowisko ukosowania blach metodą cięcia plazmowego
Robotised cell for metal sheets bevelling with use of plasma cutting
Autorzy:
Hylla, R.
Pilat, Z.
Powiązania:
https://bibliotekanauki.pl/articles/277623.pdf
Data publikacji:
2010
Wydawca:
Sieć Badawcza Łukasiewicz - Przemysłowy Instytut Automatyki i Pomiarów
Tematy:
cięcie metali
ukosowanie blach
robotyzacja
metal cutting
sheets bevelling
robotization
Opis:
Ukosowanie blach tradycyjnie jest wykonywane ręcznie, za pomocą tzw. sekatorów. Tak realizowany proces jest pracochłonny, a jego efekt często nie jest zadowalający pod względem jakości. Proces ukosowania ręcznego stwarza ponadto bardzo niebezpieczne warunki pracy. Te mankamenty nie występują w zrobotyzowanych stanowiskach ukosowania. W artykule przedstawiono techniczne, organizacyjne i ekonomiczne aspekty robotyzacji ukosowania blach z zastosowaniem technologii cięcia plazmowego. Wykorzystano doświadczenia z wdrożenia w TAGOR S.A. zrobotyzowanego stanowiska ukosowania opracowanego przez zespół aplikacyjny PIAP przy udziale specjalistów z TAGOR. Opisane stanowisko jest eksploatowane w zakładzie od blisko dwóch lat.
Traditionally, metal sheets bevelling has been performed manually. It is a very laborious process, whose effects are often not satisfactory in terms of quality. Moreover, manual bevelling is performed in highly hazardous work environment. Robotized cells eliminate all such disadvantages. The economic, organizational and technical aspects of the robotised metal sheets bevelling with of plasma cutting are presented in the paper. Authors have utilised the experiences from preparation and application of robotized cell for metal sheets bevelling by plasma cutting. It was first developed through the joint effort of PIAP's design & implementation team with the help of specialists from TAGOR S.A. In this factory the cell was installed and is exploited since two years.
Źródło:
Pomiary Automatyka Robotyka; 2010, 14, 10; 22-27
1427-9126
Pojawia się w:
Pomiary Automatyka Robotyka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Apoptosis in the gastric mucosa: molecular mechanisms, basic and clinical implications
Autorzy:
Szabo, I.
Tarnawski, A.S.
Powiązania:
https://bibliotekanauki.pl/articles/69195.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
plasma membrane
molecular mechanism
epithelial cell
gastric gland
gastric mucosa
mucosal surface
stomach
apoptosis
Helicobacter pylori
clinical implication
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 1
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Kinetic and thermodynamic characterization of the interactions between the components of human plasma kinin-forming system and isolated and purified cell wall proteins of Candida albicans
Autorzy:
Seweryn, Karolina
Karkowska-Kuleta, Justyna
Wolak, Natalia
Bochenska, Oliwia
Kedracka-Krok, Sylwia
Kozik, Andrzej
Rapala-Kozik, Maria
Powiązania:
https://bibliotekanauki.pl/articles/1038926.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Candida albicans cell wall
candidiasis
contact system
surface plasmon resonance
Opis:
Cell wall proteins of Candida albicans, besides their best known role in the adhesion of this fungal pathogen to host's tissues, also bind some soluble proteins, present in body fluids and involved in maintaining the biochemical homeostasis of the human organism. In particular, three plasma factors - high-molecular-mass kininogen (HK), factor XII (FXII) and prekallikrein (PPK) - have been shown to adhere to candidal cells. These proteins are involved in the surface-contact-catalyzed production of bradykinin-related peptides (kinins) that contribute to inflammatory states associated with microbial infections. We recently identified several proteins, associated with the candidal cell walls, and probably involved in the binding of HK. In our present study, a list of potential FXII- and PPK-binding proteins was proposed, using an affinity selection (on agarose-coupled FXII or PPK) from a whole mixture of β-1,3-glucanase-extrated cell wall-associated proteins and the mass-spectrometry protein identification. Five of these fungal proteins, including agglutinin-like sequence protein 3 (Als3), triosephosphate isomerase 1 (Tpi1), enolase 1 (Eno1), phosphoglycerate mutase 1 (Gpm1) and glucose-6-phosphate isomerase 1 (Gpi1), were purified and characterized in terms of affinities to the human contact factors, using the surface plasmon resonance measurements. Except Gpm1 that bound only PPK, and Als3 that exhibited an affinity to HK and FXII, the other isolated proteins interacted with all three contact factors. The determined dissociation constants for the identified protein complexes were of 10-7 M order, and the association rate constants were in a range of 104-105 M-1s-1. The identified fungal pathogen-host protein interactions are potential targets for novel anticandidal therapeutic approaches.
Źródło:
Acta Biochimica Polonica; 2015, 62, 4; 825-835
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hot electron refluxing in the short intense laser pulse interactions with solid targets and its influence on K-α radiation
Autorzy:
Horný, W.
Klimo, O.
Powiązania:
https://bibliotekanauki.pl/articles/148753.pdf
Data publikacji:
2015
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
electron recirculation
electron refluxing
K-α radiation
laser–plasma interactions
particle-in-cell simulation
Opis:
Fast electrons created as a result of the laser beam interaction with a solid target penetrate into the target material and initialize processes leading to the generation of the characteristic X-ray K-α radiation. Due to the strong electric field induced at the rear side of a thin target the transmitted electrons are redirected back into the target. These refl uxing electrons increase the K-α radiation yield, as well as the duration of the X-ray pulse and the size of the radiation emitting area. A model describing the electron refl uxing was verifi ed via particle- -in-cell simulations for non-relativistic electron energies. Using this model it was confi rmed that the effect of the electron refluxing on the generated X-ray radiation depends on the target thickness and the target material. A considarable increase of the number of the emitted K-α photons is observed especially for thin targets made of low-Z materials, and for higher hot electron temperatures.
Źródło:
Nukleonika; 2015, 60, 2; 233-237
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Human plasma and cerebrospinal fibronectins differ in the accessibility of the epitopes on the N-terminal domains
Autorzy:
Pupek, Małgorzata
Lemańska-Perek, Anna
Jasonek, Jolanta
Kątnik-Prastowska, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/1040377.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cerebrospinal fluid
cell-binding fibronectin domain
N-terminal fibronectin domain
C-terminal fibronectin domain
fibronectin
Opis:
Three monoclonal antibodies specific to the central cell-binding and the C- and N-terminal domains of fibronectin (FN) were used to test antigenic epitope accessibility on human plasma and cerebrospinal fibronectins. In the plasma group, the mean N-terminal FN domain immunoreactivity was about one fourth that of the cell-binding and C-terminal domains, whereas in cerebrospinal fluid they were nearly equal. In the presence of 0.5-6 M urea N-terminal domain immunoreactivity in the plasma increased 3-6-fold, but it decreased 0.7-3-fold in the cerebrospinal fluid. Analysis of fibronectin domain immunoreactivities of the cell-binding and N-terminal domains by a panel of specific monoclonal antibodies may reveal N-terminal fibronectin domain accessibility for reaction with biological partner ligand(s) and/or processes in which FN could be implicated. Such determinations may have important clinical implications.
Źródło:
Acta Biochimica Polonica; 2010, 57, 3; 333-337
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
NADPH oxidase mediated ROS control susceptibility of Arabidopsis plants to a parasite
Autorzy:
Siddique, S.
Matera, C.
Hassan, S.
Sobczak, M.
Rozanska, E.
Gutbrod, P.
Grundler, F.
Powiązania:
https://bibliotekanauki.pl/articles/81102.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
NADPH oxidase
reactive oxygen species
pathogen infection
programmed cell death
plasma membrane
plant-pathogen interaction
parasitic nematode
Arabidopsis
plant parasite
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
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