Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "oxidative homeostasis" wg kryterium: Wszystkie pola

  Lista filtrów
Wyrównaj
    Wyświetlanie 1-7 z 7
    Tytuł:
    Lipid peroxidation product 4-hydroxynonenal as factor of oxidative homeostasis supporting bone regeneration with bioactive glasses
    Autorzy:
    Mrakovcic, Lidija
    Wildburger, Renate
    Jaganjac, Morana
    Cindric, Marina
    Cipak, Ana
    Borovic-Sunjic, Suzana
    Waeg, Georg
    Milankovic, Andrea
    Zarkovic, Neven
    Powiązania:
    https://bibliotekanauki.pl/articles/1040400.pdf
    Data publikacji:
    2010
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    bone regeneration
    4-hydroxynonenal
    bioactive glass
    oxidative homeostasis
    lipid peroxidation
    Opis:
    Bone regeneration is a process of vital importance since fractures of long bones and large joints have a highly deleterious impact on both, individuals and society. Numerous attempts have been undertaken to alleviate this severe medical and social problem by development of novel bioactive materials, among which bioactive glass is the most attractive because of its osteoconductive and osteostimulative properties. Since lipid peroxidation is an important component of systematic stress response in patients with traumatic brain injuries and bone fractures, studies have been undertaken of the molecular mechanisms of the involvement of 4-hydroxynonenal (HNE), an end product of lipid peroxidation, in cellular growth regulation. We found that HNE generated in bone cells grown in vitro on the surfaces of bioactive glasses 45S5 and 13-93. This raises an interesting possibility of combined action of HNE and ionic bioglass dissolution products in enhanced osteogenesis probably through a mitogen-activated protein kinase (MAPK) pathway. While the proposed mechanism still has to be elucidated, the finding of HNE generation on bioglass offers a new interpretation of the osteoinducting mechanisms of bioglass and suggests the possibility of tissue engineering based on manipulations of oxidative homeostasis.
    Źródło:
    Acta Biochimica Polonica; 2010, 57, 2; 173-178
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Interval hypoxic training in complex treatment of Helicobacter pylori-associated peptic ulcer disease
    Autorzy:
    Semen, Khrysyna
    Yelisyeyeva, Olha
    Kaminskyy, Danylo
    Cherkas, Andriy
    Zarkovic, Kamelija
    Lutsyk, O
    Cipak, Ana
    Jaganjac, Morana
    Zarkovic, Neven
    Powiązania:
    https://bibliotekanauki.pl/articles/1040404.pdf
    Data publikacji:
    2010
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    heart rate variability
    peptic ulcer
    oxidative homeostasis
    interval hypoxic training
    oxidative stress
    Opis:
    This study was aimed to demonstrate the efficacy of interval hypoxic training (IHT) in complex treatment of Helicobacter pylori-associated duodenal peptic ulcer disease (DPUD) by parameters of aerobic metabolism and indexes of heart rate variability (HRV). Eighty patients with H. pylori-associated DPUD were included into the study, mean age 32±1.8 yrs, duration of the disease up to 10 years (66.3 %). IHT was modulated using Frolov's hypoxicator (TDI-01) for 30 days after standard eradication therapy. Daily hypoxic sessions consisted of three one-minute sessions, one two-minute, and one three-minute sessions separated by one-minute intervals of room-air breathing. Use of IHT resulted in more efficient elimination of clinical symptoms, histological hallmarks of inflammation and signs of oxidative stress in glandulocytes of the gastric mucosa as determined by 4-hydroxynonenal accumulation. Moderate prooxidant activity of IHT was demonstrated by the increased level of TBARS and oxidatively modified products, normalization of hydroperoxides, middle mass molecules and atherogenic beta-lipoproteins with simultaneous increase in catalase activity and mild decline of SOD activity. Therefore, IHT appeared to be accompanied by higher intensity of redox reactions and enhanced regeneratory processes in cells and tissues. Significant increase in HRV was also noted. Such changes were associated with reduction of inflammation signs and modulation of the autonomic homeostasis in DPUD patients. In general, use of IHT in complex treatment of H. pylori in DPUD patients can be recommended to increase resistance to oxidative stress and to modulate autonomic balance and oxidative homeostasis.
    Źródło:
    Acta Biochimica Polonica; 2010, 57, 2; 199-208
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Growth suppression of human breast carcinoma stem cells by lipid peroxidation product 4-hydroxy-2-nonenal and hydroxyl radical-modified collagen
    Autorzy:
    Cipak, Ana
    Mrakovcic, Lidija
    Ciz, Milan
    Lojek, Antonin
    Mihaylova, Boryana
    Goshev, Ivan
    Jaganjac, Morana
    Cindric, Marina
    Sitic, Sanda
    Margaritoni, Marko
    Waeg, Georg
    Balic, Marija
    Zarkovic, Neven
    Powiązania:
    https://bibliotekanauki.pl/articles/1040399.pdf
    Data publikacji:
    2010
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    collagen
    4-hydroxynonenal
    breast cancer stem cells
    extracellular matrix
    oxidative homeostasis
    SUM159
    Opis:
    Breast cancer is a leading cause of mortality and morbidity in women, mostly due to high metastatic capacity of mammary carcinoma cells. It has been revealed recently that metastases of breast cancer comprise a fraction of specific stem-like cells, denoted as cancer stem cells (CSCs). Breast CSCs, expressing specific surface markers CD44+CD24-/lowESA+ usually disseminate in the bone marrow, being able to spread further and cause late metastases. The fundamental factor influencing the growth of CSCs is the microenvironment, especially the interaction of CSCs with extracellular matrix (ECM). The structure and function of ECM proteins, such as the dominating ECM protein collagen, is influenced not only by cancer cells but also by various cancer treatments. Since surgery, radio and chemotherapy are associated with oxidative stress we analyzed the growth of breast cancer CD44+CD24-/lowESA+ cell line SUM159 cultured on collagen matrix in vitro, using either native collagen or the one modified by hydroxyl radical. While native collagen supported the growth of CSCs, oxidatively modified one was not supportive. The SUM159 cell cultures were further exposed to a supraphysiological (35 µM) dose of the major bioactive lipid peroxidation product 4-hydroxynonenal (HNE), a well known as 'second messenger of free radicals', which has a strong affinity to bind to proteins and acts as a cytotoxic or as growth regulating signaling molecule. Native collagen, but not oxidised, abolished cytotoxicity of HNE, while oxidized collagen did not reduce cytotoxicity of HNE at all. These preliminary findings indicate that beside direct cytotoxic effects of anticancer therapies consequential oxidative stress and lipid peroxidation modify the microenvironment of CSCs influencing oxidative homeostasis that could additionally act against cancer.
    Źródło:
    Acta Biochimica Polonica; 2010, 57, 2; 165-171
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The effect of citrus flavanones on the redox homeostasis in cells exposed to oxidative stress – studies in vitro
    Wpływ flawanonów cytrusowych na homeostazę redoks komórek narażonych na stres oksydacyjny – badania in vitro
    Autorzy:
    Kurzeja, Ewa
    Synowiec-Wojtarowicz, Agnieszka
    Spiołek, Katarzyna
    Derewniuk, Małgorzata
    Pawłowska-Góral, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1035565.pdf
    Data publikacji:
    2016
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    "cell culture"
    "flavanones"
    "oxidative stress"
    "redox homeostasis"
    Opis:
    Introduction: Flavanones (an important group of antioxidants in citrus fruits) are beneficial for health, which is connected with their anti-inflammatory, anti-atherogenic and anti-carcinogenic properties. The present study was undertaken to investigate whether – and in what way – the presence of flavanones influences the redox homeostasis of fibroblasts and alleviates the effects of oxidative stress. Material and methods: The study was conducted on murine fibroblast cell cultures with the addition of flavanones (hesperidin, hesperetin, naringin, naringenin), exposed to oxidative stress (Fe/Asc). In cell homogenates, the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) was measured; in the medium, the concentration of nitric oxide was measured. Results and conclusion: Our results demonstrate that the addition of naringenin, hesperetin, naringin and hesperidin has a protective effect on cells subjected to oxidative stress The changes observed are particularly visible in the case of aglycone forms of both compounds. Despite the protective properties against oxidative stress which flavanones display, we determined distrubances in redox homeostasis in comparison to the control culture.
    Wstęp: Flawanony, będące głównymi związkami bioaktywnymi cytrusów, wykazują działanie prozdrowotne, co wynika z ich właściwości przeciwzapalnych, przeciwmiażdżycowych i przeciwnowotworowych. Celem badania była ocena wpływu flawanonów na homeostazę redoks fibroblastów oraz czy ich obecność łagodzi skutki stresu oksydacyjnego. Materiały i metody: Badanie przeprowadzono na hodowlach mysich fibroblastów z dodatkiem flawanonów (hesperydyna, hesperetyna, naringina, naringenina) poddanych stresowi oksydacyjnemu (Fe/Asc). W homogenatach komórkowych oznaczono aktywność dysmutazy ponadtlenkowej (SOD) i peroksydazy glutationowej (GPx), a bezpośrednio w pożywce stężenie tlenku azotu. Wyniki i wnioski: Wyniki naszej pracy wskazują, że dodatek naringeniny, hesperetyny, naringiny i hesperydyny działa ochronnie na komórki poddane stresowi oksydacyjnemu. Pomimo stwierdzonego ochronnego działania flawanonów zaobserwowaliśmy również zaburzenie homeostazy redoks w odniesieniu do hodowli kontrolnej.
    Źródło:
    Medycyna Środowiskowa - Environmental Medicine; 2016, 19, 2; 32-39
    1505-7054
    2084-6312
    Pojawia się w:
    Medycyna Środowiskowa - Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ethylene mediates in the early oxidative stress induced by mercury
    Autorzy:
    Montero-Palmero, M.
    Martin-Barranco, A.
    Alonso, J.
    Escobar, C.
    Hernandez, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/81164.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    oxidative stress
    plant
    mercury
    homeostasis
    reactive oxygen species
    alfalfa
    Medicago sativa
    1-methylcyclopropene
    NADPH oxidase
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of short-term ammonium supply on ROS metabolism in Arabidopsis
    Autorzy:
    Podgorska, A.
    Rasmusson, A.G.
    Szal, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/80357.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    ammonium
    reactive oxygen species
    Arabidopsis
    leaf cell
    oxidative stress
    homeostasis
    antioxidative enzyme
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Labile iron pool correlates with iron content in the nucleus and the formation of oxidative DNA damage in mouse lymphoma L5178Y cell lines.
    Autorzy:
    Kruszewski, Marcin
    Iwaneńko, Teresa
    Powiązania:
    https://bibliotekanauki.pl/articles/1043668.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    iron homeostasis
    hydrogen peroxide
    comet assay
    Opis:
    Labile iron pool (LIP) constitutes a crossroad of metabolic pathways of iron-containing compounds and is midway between the cellular need for iron, its uptake and storage. In this study we investigated oxidative DNA damage in relation to the labile iron pool in a pair of mouse lymphoma L5178Y (LY) sublines (LY-R and LY-S) differing in sensitivity to hydrogen peroxide. The LY-R cells, which are hydrogen peroxide-sensitive, contain 3 times more labile iron than the hydrogen peroxide-resistant LY-S cells. Using the comet assay, we compared total DNA breakage in the studied cell lines treated with hydrogen peroxide (25 μM for 30 min at 4°C). More DNA damage was found in LY-R cells than in LY-S cells. We also compared the levels of DNA lesions sensitive to specific DNA repair enzymes in both cell lines treated with H2O2. The levels of endonuclease III-sensitive sites and Fapy-DNA glycosylase-sensitive sites were found to be higher in LY-R cells than in LY-S cells. Our data suggest that the sensitivity of LY-R cells to H2O2 is partially caused by the higher yield of oxidative DNA damage, as compared to that in LY-S cells. The critical factor appears to be the availability of transition metal ions that take part in the OH radical-generating Fenton reaction (very likely in the form of LIP).
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 1; 211-215
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

      Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies