Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Wyszukujesz frazę "oxadiazole" wg kryterium: Wszystkie pola


Wyświetlanie 1-14 z 14
Tytuł:
Synthesis and antimicrobial activity of oxadiazole nucleus containing 2,5-substituted 1,3,4-oxadiazole derivatives
Autorzy:
Gajera, Jayesh L
Sutariya, Jignesh K.
Rakesh Gothwal, Rakesh
Sharma, Vinay S.
Ram, Haresh
Godhaviya, Pankaj K.
Powiązania:
https://bibliotekanauki.pl/articles/1839273.pdf
Data publikacji:
2021
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
cyclohexanecarbohydrazide
antibacterial
antifungal
1,3,4-oxadiazole
Opis:
In this study, we report the synthesis of 2,5-substituted 1,3,4-oxadiazole derivatives using condensation of cyclohexanecarbohydrazide derivatives and carbon disulfide. In present study, we have prepared total seven derivatives based on 1,3,4-oxadiazole core further functionalized with thiol moieties. The structures of synthesized compounds (C1-C9) were confirmed by the 1H NMR, and Mass spectrometry. These synthesized molecules were subjected to antibacterial and fungal activity against selected microbial and fungal strains. Some of derivatives showed good biological behaviour against gram positive and gram negative bacteria.
Źródło:
World Scientific News; 2021, 162; 75-86
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Solid phase synthesis of novel 1,3,4-oxadiazole derivatives and evaluation of their antimicrobial activity
Autorzy:
Gadara, Shobhana A.
Ladva, Kartik D.
Powiązania:
https://bibliotekanauki.pl/articles/1031813.pdf
Data publikacji:
2020
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
4-oxadiazole
Aminoazole
in vitro antimicrobial assay
s-methylthioamide
Opis:
A series of 5-(N-Aryl/Arylalkyl)-2-(3-Chclorophenyl)-1,3,4-oxadiazole have been synthesized. The constitution of the products has been delineated by elemental analysis and spectral analyses. All the synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus MTCC-96, Escherichia coli MTCC-443, B. subtilis MTCC-441, P. aeruginosa MTCC-1688, and antifungal activity against Aspergillus niger MTCC-282 and Penicillium SP.at different concentration and compared with standards drugs. The minimum inhibition concentration (MIC) of the compounds was studied by micro broth dilution method.
Źródło:
World Scientific News; 2020, 147; 35-44
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Microwave synthesis and antibacterial activities of some 2-amino-6-(phenylthio)pyridine-3,5-dicarbonitrile derivatives containing 1,3,4-oxadiazole moiety
Autorzy:
Bhola, Yogesh O.
Naliapara, Yogesh T.
Powiązania:
https://bibliotekanauki.pl/articles/1076113.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
antibacterial
oxadiazole
pyridine
Opis:
5-(4-Aminophenyl)-2-thiol-1,3,4-oxadiazole (3) was synthesized via the reaction of carbon disulfide with 4-aminobenzoyl hydrazide in presence of potassium hydroxide in absolute ethanol. Compound 3 was converted to the corresponding diazonium salt which was introduced in coupling reaction with alkaline solution of 2-hydroxybenzaldehyde as coupling reagent to give azooxadiazole derivative (4) containing aldehyde group. The resulting aldehyde (4) was then introduced in condensation reactions with the aromatic Thiophenol derivatives including using microwave irradiation technique in absolute ethanol to produce ten 2-amino-4-(2-hydroxy-5-((4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl)diazenyl)phenyl)-6-(phenylthio)pyridine-3,5-dicarbonitrile derivatives (5a-j), respectively in vitro Antibacterial activity of the target compounds were investigated using two types of bacteria, Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative). The results indicated that the newly synthesized 2-amino-4-(2-hydroxy-5-((4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl) diazenyl)phenyl)-6-(phenylthio)pyridine-3,5-dicarbonitrile derivatives (compounds 5d and 5f) showed enhanced activity against Gram-negative bacteria when compared with that of the control drug (gentamycin).
Źródło:
World Scientific News; 2019, 117; 221-227
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis, characterization and evaluation of mosquito larvicidal effect of 1,3,4-oxadiazole derivatives against Culex quinquefasciatus
Autorzy:
Santhanalakshmi, K.
Kalyanasundharam, S.
Muthukumar, S.
Rosy, P. Jacquline
Powiązania:
https://bibliotekanauki.pl/articles/1112036.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
1
3
4-oxadiazole
Culex quinquefasciatus
Larvicidal bioassay
ultrasonic irradiation
Opis:
A new series of 1,3,4-oxadiazole derivatives were prepared from the condensation of acid hydrazide,5-bromo-2-(trifluoromethoxy)benzoic acid in POCl3 by ultrasonic irradiation method. The new synthetic method furnished the desired products in shorter time and good yields. The chemical structures of compounds 4a-h were confirmed by Fourier transform infrared spectroscopy (IR), proton nuclear magnetic resonance (1H-NMR), carbon nuclear magnetic resonance (13C-NMR) and elemental analyses. Larvicidal bioassay tests were performed using several 2-(5-bromo-2-(trifluoromethoxy) phenyl)-5-aryl-1,3,4-oxadiazole. These synthesized compounds presented strong larvicidal activity against urban mosquitoes Culex quinquefasciatus. The results suggest that larvicidal activity might be correlated with the presence of electron-withdrawing substituents in the para position of the phenyl ring. The alterations observed in the larvae spiracular valves of the siphon and anal papillae by 1,3,4-oxadiazoles in the larvicidal bioassay are responsible for larvae’s death.
Źródło:
World News of Natural Sciences; 2018, 19; 58-64
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
3,4-Bis(4'-nitrofurazan-3'-yl)furoxan: a Melt Cast Powerful Explosive and a Valuable Building Block in 1,2,5-Oxadiazole Chemistry
Autorzy:
Stepanov, A. I.
Dashko, D. V.
Astrat'ev, A. A.
Powiązania:
https://bibliotekanauki.pl/articles/358174.pdf
Data publikacji:
2012
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
3,4-bis(4'-nitrofurazan-3'-yl)furoxan
furazan
furoxan
1,2,5-oxadiazole
azepine
Opis:
The results of our studies on the reactivity of 3,4-bis(4'-nitrofurazan-3'- yl)furoxan (BNFF), with some O- and N-nucleophiles are presented. It is shown that both nitro groups of BNFF can be easily replaced by nucleophiles. Depending on the identity of the nucleophile, BNFF may be transformed into two types of 1,2,5-oxadiazole derivatives, notably 4-R substituted bis(4-R-furazan-3-yl) furoxanes or 7-R substituted 7H(7R)-tris[1,2,5]oxadiazolo[3,4-b:3',4-d:3",4"-f]]azepine-1-oxides - a new heterocyclic system comprised of an azepine ring annelated with three 1,2,5-oxadiazole rings.
Źródło:
Central European Journal of Energetic Materials; 2012, 9, 4; 329-342
1733-7178
Pojawia się w:
Central European Journal of Energetic Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis, Characterization and Biological evaluation of some newer 5-[6-chloro/fluoro/nitro-2-(p-chloro/ fluoro/ methyl phenyl)-quinolin-4-yl]-1,3,4-oxadiazole-2-thiols
Autorzy:
Faldu, V. J.
Talpara, P. K.
Bhuva, N. H.
Vachharajani, P. R.
Shah, V. H.
Powiązania:
https://bibliotekanauki.pl/articles/412197.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Quinolines
1,3,4-oxadiazole-2-thiols
therapeutic agents
antimicrobial assai
Opis:
Recent study shows that quinolines represent one of the most active classes of compounds possesses wide spectrum biodynamic activities and use as potent therapeutic agents. In present research work, 5-[6-chloro/fluoro/nitro-2-(p-chloro/fluoro/methyl phenyl)-quinolin-4-yl]-1,3,4-oxadiazole-2-thiols have been synthesized by condensation of substituted quinoline-4-carbohydrazides and mixture of carbon disulphide and potassium hydroxide. All of these compounds were screened for their in vitroanti microbial assay against gram (+ve), gram (-ve) bacteria and fungi activity compared with standard drugs viz., Ampicilin, Chloramphenicol, Ciprofloxacin, Norfloxacin, Griseofulvin and Nystatin at different concentrations.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 6; 26-32
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Acoustical studies on binary liquid mixtures of some 1,3,4-oxadiazole derivatives with acetone at 303.15 K
Autorzy:
Alamelumangai, G.
Santhi, N.
Powiązania:
https://bibliotekanauki.pl/articles/411889.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Acoustical properties
hydrogen bonding
binary mixtures
Opis:
The wide spread use of 1,3,4-oxadiazoles as a scaffold in medicinal chemistry establishes this moiety as an important bioactive class of heterocycles. In the present study ultrasonic velocity (u), density (ρ) and viscosity (η) have been measured at frequency 2 MHz in the binary mixtures of 1,3,4-oxadiazole derivatives in acetone at 303.15 K using ultrasonic interferometer technique. The measured value of ultrasonic velocity, density and viscosity have been used to estimate the acoustical parameters namely adiabatic compressibility (βad), relaxation time (τ), acoustic impedance (Zi), free length (Lf), free volume (Vf) and internal pressure (πi), with a view to investigate the nature and strength of molecular interactions. The obtained result support the occurrence of molecular association through hydrogen bonding in the binary liquid mixtures.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 5; 124-133
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Convenient synthesis of the 2,5-di-substituted 1,3,4-oxadiazole derivatives under microwave
Autorzy:
Namera, D. L.
Bhoya, U. C.
Powiązania:
https://bibliotekanauki.pl/articles/412441.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
substituted cinnamic acid
substituted 1,3,4-oxadiazoles
phosphoric anhydride
Opis:
We have reported some novel 1,3,4-oxadiazole synthesized by conventional method as well as microwave assisted method. The reaction of different substituted cinnamic acid 2a-o with 2-(4-chlorophenyl) acetohydrazide by using phosphoric anhydride as catalyst, yielded a series of 2,5-di-substituted 1,3,4-oxadiazole 6a-o. The structures of all synthesized compounds are well characterized by Mass, FT-IR, 1H NMR, 13C NMR and elemental analysis. After obtaining experimental data regarding the yield and the time taken for the synthesis by both the methods, conventional and microwave assisted method, it was proved that the microwave assisted method is convenient for synthesis of this type of 2,5-di-substituted 1,3,4-oxadiazole 6a-o.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 11, 2; 159-166
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cyclization and antimicrobial evolution of 1,3,4-oxadiazoles by carbohydrazide
Autorzy:
Godhani, Dinesh R.
Mulani, Vishal B.
Mehta, Jignasu P.
Powiązania:
https://bibliotekanauki.pl/articles/1063054.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
1
3
4-oxadiazole
antimicrobial activity
cytotoxicity
dihydropyrimidine
haemolysis
Opis:
A series of dihydropyrimidine substituted 1,3,4-oxadiazole derivatives was synthesized by cyclization of carbohydrazide by phosphoryl chloride and benzoic acid in acidic condition. The structures were perceived on the establishment of spectral tools and their purity by elemental analysis. Every compound was primary assessed for their in vitro antimicrobial activities against 5 bacterial strains viz [Staphylococcus aureus (MRSA; ATCC 43300), Klebsiella pneumoniae (ATCC 700603), Escherichia coli (ATCC 25922), Acinetobacter baumannii (ATCC 19606), Pseudomonas aeruginosa (ATCC 27853)] and 2 fungi Strains viz. [Candida albicans (ATCC 90028), Cryptococcus neoformans var. grubii (H99; ATCC 208821)]. Some compounds displayed significant antimicrobial activity, out of 15 compounds, 11 compounds indicated promising antifungal activities without any indications of human cells cytotoxic [Hk: Human Embryonic Kidney cells (ATCC CRL-1573)] and haemolytic activity [RBC (ARCBS 5400 00150)].
Źródło:
World Scientific News; 2019, 124, 2; 304-311
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis, characterization and biological evaluation of 2,5-di-substituted 1,3,4-oxadiazole derivatives
Autorzy:
Makwana, H.
Naliapara, Y. T.
Powiązania:
https://bibliotekanauki.pl/articles/412282.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
substituted 1,2,3,4-oxadiazoles
phosphoric anhydride
antimicrobial activity
Opis:
We have reported some novel 1,3,4-oxadiazole synthesized by conventional method .The reaction of 5-bromothiophene-2-carbohydrazide and different benzoic acid derivatives reflux in toluene using phosphorus oxychloride as a catalyst, yielded a series of 2,5-di-substituted 1,3,4-oxadiazole HM-2a to HM-2t. The newly synthesized 2,5-di-substituted 1,3,4-oxadiazole were purified by column chromatography and characterized by IR, Mass, 1H NMR, 13C NMR spectroscopy and elemental analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed moderate to good antimicrobial activity and anti fungal activity.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 15; 48-54
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Microwave assisted synthesis of 2,5-distyryl-1,3,4-oxadiazole derivatives as anti microbial agents
Autorzy:
Namera, D. L.
Rathod, J. B.
Maheta, R. H.
Bhoya, U. C.
Powiązania:
https://bibliotekanauki.pl/articles/411519.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
substituted cinnamic acid
substituted 1,3,4-oxadiazoles
antimicrobial activity
Opis:
A new series of 2,5-distyryl-1,3,4-oxadiazoles derivatives have been synthesized from cinnamic hydrazide on reaction with various cinnamic acid derivatives. The structures of synthesized compounds have been elucidated by spectral studies like IR, 1HNMR, Mass and also Elemental Analysis. Furthermore, all synthesized compounds were screened for in vitro anti microbial activity against the gram positive (Staphylococcus aureus, Pseudomonas aeruginosa) and gram negative (Escherichia coli) bacterial strain. In which some the compounds show potential inhibition against the test organisms.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 10; 46-54
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Benzofuroxan (Benzo[1,2-c]1,2,5-oxadiazole N-oxide) Derivatives as Potential Energetic Materials: Studies on Their Synthesis and Properties
Autorzy:
Šarlauskas, J.
Anusevičius, Z.
Misiunas, A.
Powiązania:
https://bibliotekanauki.pl/articles/358164.pdf
Data publikacji:
2012
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
heterocyclic nitro compounds
X-ray diffraction
structure analysis
density
HEDM
5,6-DNBF
Opis:
The objective of this work was to prepare benzofuroxan derivatives as new, dense, potentially energetic materials and to investigate their properties, with the main focus being on 5,6-dinitrobenzofuroxan (5,6-DNBF). 5,6-DNBF was prepared by a 3-step reaction sequence: a) 1-azido-3-nitrobenzene was synthesized by diazotation of 3-nitroaniline with sodium nitrite and subsequent reaction with sodium azide in acetic/sulfuric mixed acids; b) it was nitrated with HNO3/H2SO4 to 1-azido-2,4,5-trinitrobenzene; c) thermal cyclization of the latter compound in a polar solvent gave the desired 5,6-DNBF (m.p. 177 °C). It was fully characterized by UV/VIS, FT-IR and NMR spectroscopy, mass spectrometry and single crystal X-ray diffraction. The density of the compound (X-ray) was found to be comparatively high (1.88 g/cm3), and to be superior to the previously known, isomeric energetic material ? 4,6-dinitrobenzofuroxan (4,6-DNBF) (1.76 g/cm3). Furthermore, the synthesis of some other benzofuroxan derivatives, potentially interesting as high energy, density materials (HEDMs), has been carried out. The densities of the compounds obtained were calculated using ACD Labs software (version 4.0). Based on the results obtained, it could be concluded that 5,6-DNBF is one of the densest nitro derivatives of the benzofuroxan series, comparable to CL-14, CL-17, CL-18, and thus could have potential applications as an HEDM.
Źródło:
Central European Journal of Energetic Materials; 2012, 9, 4; 365-386
1733-7178
Pojawia się w:
Central European Journal of Energetic Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis, Characterization and biological activity of various substituted (E)-5-benzylidene-2-((4-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)methoxy)phenyl)amino)thiazol-4(5H)-one derivatives
Autorzy:
Tejani, Rasik
Mokariya, Devang
Manwar, Rohit
Shah, Manish K.
Powiązania:
https://bibliotekanauki.pl/articles/1076007.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
In vitro antibacterial
antibacterial
antifungal
oxadiazole
thiazolone
Opis:
2-(chloromethyl)-5-(4-nitrophenyl)-1,3,4-oxadiazole was synthesized via reaction of chloroacetic acid with 4-nitrobenzohydrazide in phosphonyl chloride(4). Compound 4 was treated with 4-aminophenol to form 4-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)methoxy)aniline(5) having free -NH2 group,which is reacted with chloroacetyl chloride to give 2-chloro-N-(4-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)methoxy)phenyl)acetamide(6). Compound 6 was cyclized by ammonium thiocyanate to form 2-((4-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)methoxy)phenyl)amino)thiazol-4(5H)-one(7) with thiazolone ring. Compound was reacted different aldehydes to form (E)-5-benzylidene -2-((4-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl) methoxy)phenyl) amino)thiazol-4(5H)-one derivatives(8a-j). In vitro antibacterial activity of the target compounds were investigated using two types of bacteria, Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative). The results indicated that the newly synthesized (E)-5-benzylidene-2-((4-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)methoxy) phenyl)amino)thiazol-4(5H)-one derivatives (compounds 8d and 8f) showed enhanced activity against Gram-negative bacteria when compared with that of the control drug (gentamycin).
Źródło:
World Scientific News; 2019, 118; 265-272
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Experimental Study on the Heat Resistant Explosive 5,5’-Bis(2,4,6-trinitrophenyl)-2,2’-bi(1,3,4-oxadiazole) (TKX-55): the Jet Penetration Capability and Underwater Explosion Performance
Autorzy:
Klapötke, T. M.
Witkowski, T. G.
Wilk, Z.
Hadzik, J.
Powiązania:
https://bibliotekanauki.pl/articles/951486.pdf
Data publikacji:
2016
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
thermally stable explosive
TKX-55
shaped charge
underwater detonation
Opis:
Ongoing research to find new explosives which are stable at high temperatures focuses on compounds which comply with the strict requirements which must be fulfilled in order for a compound to be of use in deep oil-well and gas drilling applications. Great efforts have been focused on the development of new, thermally stable explosives which are stable at even higher temperatures than hexanitrostilbene, and which also show superior performance. In the group of recently synthesized thermally stable explosives, 5,5’-bis(2,4,6-trinitrophenyl)-2,2’-bi(1,3,4-oxadiazole) (TKX-55) is one of the most promising prospective candidates for use in practical applications, due to its physicochemical properties as well as its convenient synthesis. Therefore, further investigation into the performance of TKX-55 in shaped charge applications was undertaken. This study was focused on the investigation of the jet penetration capability of conical shaped charges filled with TKX-55, in comparison with recently used other explosives. The kinetic energy of the jet depends on the brisance of the explosive which is used. In order to experimentally investigate the shattering effect of TKX-55, the Underwater Explosion Test was applied. Based on the collected data, the total energy, as the sum of the primary shock wave energy (the brisance) and the bubble gas energy (the heaving effect), was calculated.
Źródło:
Central European Journal of Energetic Materials; 2016, 13, 4; 821-837
1733-7178
Pojawia się w:
Central European Journal of Energetic Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-14 z 14

    Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies