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Wyświetlanie 1-15 z 18
Tytuł:
Features reduction for computer user profiling based on mouse activity
Autorzy:
Palys, M.
Wesołowski, T. E.
Powiązania:
https://bibliotekanauki.pl/articles/334021.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:
user profile
intruder detection
mouse activity
user verification
profil użytkownika
wykrywanie intruza
aktywność myszy
weryfikacja użytkownika
Opis:
The article is related to the computer systems security and to the problem of detecting the masqueraders, intruders who pretend to be legitimate users of computer systems, in particular. The research concerns computer user verification based on analysis of the mouse activity in computer system. The article presents an improvement of user verification method by introducing a new method of user profiling. The new user profiling method is based on the reduced number of features without the loss of information is introduced. The presented method of user profiling allows to simplify and speed up a user’s activity data analysis and is not causing the deterioration of intrusion detection. Additionally, a method of aggregating mouse activity basic events into a higher level events is described. This article presents the preliminary research and conclusions.
Źródło:
Journal of Medical Informatics & Technologies; 2015, 24; 45-51
1642-6037
Pojawia się w:
Journal of Medical Informatics & Technologies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Glutathione-S-transferase activity in mouse muscle during experital trichinellosis
Autorzy:
Derda, M.
Wandurska-Nowak, E.
Boczoń, K.
Powiązania:
https://bibliotekanauki.pl/articles/2147897.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
glutathione s-transferase
infection
muscle
mouse
Trichinella
mice
trichinellosis
host
skeletal muscle
Opis:
The role of glutathione-S-transferase (GST, EC 2.5.1.18) in biochemical host defence in experimental trichinellosis was evaluated. The activity of GST in mouse skeletal muscles was measured during the muscular phase of trichinellosis, starting from the 3rd week post infection (w.p.i.) to the 11th w.p.i. Activity was determined spectrophotometrically by monitoring the formation of thioether (S-2,4-dinitrophenylglutathione) from the reduced form of glutathione and 1-chloro-2,4-dinitrobenzene used as a substrate and as an example of xenobiotics. The changes in the activity of GST were as follows: an increase in activity starts in the 4th w.p.i., peaks (up to 310% of the normal value) in the 6th w.p.i., decreases in the 8th week and a final, weak rise was observed in week 11. The statistically significant changes in GST activity in this phase of experimental trichinellosis suggest that this enzyme participates in the biochemical defence of the host against Trichinella infection.
Źródło:
Wiadomości Parazytologiczne; 2001, 47, 2; 227-232
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Glutathione-S-transferase activity in mouse muscle during experital trichinellosis
Autorzy:
Derda, M
Wandurska-Nowak, E.
Boczon, K.
Powiązania:
https://bibliotekanauki.pl/articles/837806.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
glutathione s-transferase
infection
muscle
mouse
Trichinella
mice
trichinellosis
host
skeletal muscle
Opis:
The role of glutathione-S-transferase (GST, EC 2.5.1.18) in biochemical host defence in experimental trichinellosis was evaluated. The activity of GST in mouse skeletal muscles was measured during the muscular phase of trichinellosis, starting from the 3rd week post infection (w.p.i.) to the 11th w.p.i. Activity was determined spectrophotometrically by monitoring the formation of thioether (S-2,4-dinitrophenylglutathione) from the reduced form of glutathione and 1-chloro-2,4-dinitrobenzene used as a substrate and as an example of xenobiotics. The changes in the activity of GST were as follows: an increase in activity starts in the 4th w.p.i., peaks (up to 310% of the normal value) in the 6th w.p.i., decreases in the 8th week and a final, weak rise was observed in week 11. The statistically significant changes in GST activity in this phase of experimental trichinellosis suggest that this enzyme participates in the biochemical defence of the host against Trichinella infection.
Źródło:
Annals of Parasitology; 2001, 47, 2
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Metformin reduces NAD(P)H oxidase activity in mouse cultured podocytes through purinergic dependent mechanism by increasing extracellular ATP concentration
Autorzy:
Piwkowska, Agnieszka
Rogacka, Dorota
Jankowski, Maciej
Angielski, Stefan
Powiązania:
https://bibliotekanauki.pl/articles/1039452.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
AMP-activated kinase
free radicals
metformin
NAD(P)H oxidase
podocytes
purinoceptors
Opis:
Hyperglycemia affects the functioning numbers of podocytes and leads to a gradual decline of renal function. The normalization of glucose level is a principle therapeutic goal in diabetic patients and metformin is a popular hypoglycemic drug used in type 2 diabetes mellitus. Metformin activates AMP-activated kinase (AMPK) and decreases NAD(P)H oxidase activity in podocytes leading to reduction of free radical generation. Similar effects are observed after activation of P2 receptors. Therefore, we investigated whether metformin increases extracellular ATP concentration and affects the activities of NAD(P)H oxidase and AMPK through P2 receptors. Experiments were performed on cultured mouse podocytes. NAD(P)H oxidase activity was measured by chemiluminescence and changes in AMPK activity were estimated by immunoblotting against AMPKα-Thr172-P. Metformin increased extracellular ATP concentration by reduction of ecto-ATPase activity, decreased NAD(P)H oxidase activity and increased AMPK phosphorylation. A P2 receptor antagonist, suramin (300 µM), prevented metformin action on NAD(P)H oxidase and AMPK phosphorylation. The data suggests a novel mechanism of metformin action, at least in podocytes. Metformin, which increases extracellular ATP concentration leads to activation of P2 receptors and consequent modulation of the podocytes' metabolism through AMPK and NAD(P)H oxidase which, in turn, may affect podocyte functioning.
Źródło:
Acta Biochimica Polonica; 2013, 60, 4; 607-612
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Badania in vivo nad granulopoetyczną aktywnością tkanek myszy
Issledovanie in vitro granulopoehticheskojj aktivnosti tkanejj myshi
In vivo investigations on the granulopoetic activity of mouse tissues
Autorzy:
Szmitkowski, M.
Powiązania:
https://bibliotekanauki.pl/articles/2188668.pdf
Data publikacji:
1978
Wydawca:
Polskie Towarzystwo Diagnostyki Laboratoryjnej
Źródło:
Diagnostyka Laboratoryjna; 1978, 14, 1; 3-8
0867-4043
Pojawia się w:
Diagnostyka Laboratoryjna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A Comparison of Muscular Activity Involved in the Use of Two Different Types of Computer Mouse
Autorzy:
Kumar, R.
Kumar, S.
Powiązania:
https://bibliotekanauki.pl/articles/90400.pdf
Data publikacji:
2008
Wydawca:
Centralny Instytut Ochrony Pracy
Tematy:
muscular activity
EMG
computer mouse
Opis:
Two types of computer input devices, a conventional mouse and a roller bar one, were studied in terms of muscular activitiy in m. trapezius dexter, m. deltoideus anterior dexter and m. extensor digitorum dexter, and comfort rating. Fifteen university students and employees participated in this study. The order of the devices was random. While a task was performed, electromyography (EMG) data were recorded for each test. Muscular activity was found to be significantly lower for the roller bar mouse than for the conventional one. Comfort rating indicated there was a significant difference in moving a cursor with the conventional mouse compared to the roller bar one. It is concluded that a roller bar mouse allowed the subjects to work closer to the body compared to the conventional one, thus the former can be recommended as a general means of reducing upper extremity musculoskeletal disorders.
Źródło:
International Journal of Occupational Safety and Ergonomics; 2008, 14, 3; 305-311
1080-3548
Pojawia się w:
International Journal of Occupational Safety and Ergonomics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Czasowa i przestrzenna aktywność nornicy rudej Myodes (Clethrionomys) glareolus i myszy leśnej Apodemus flavicollis w siedlisku grądowym Puszczy Białowieskiej
Temporal and spatial activity of bank vole Myodes (Clethrionomys) glareolus and yellow-necked mouse Apodemus flavicollis in an oak-hornbeam habitat of the Bialowieza Forest
Autorzy:
Kołakowski, M.
Jancewicz, E.
Kielan, E.
Powiązania:
https://bibliotekanauki.pl/articles/985864.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Leśne
Tematy:
lesnictwo
Puszcza Bialowieska
siedliska gradowe
runo lesne
drobne ssaki
nornica ruda
Clethrionomys glareolus
mysz lesna
Apodemus flavicollis
aktywnosc dobowa
aktywnosc przestrzenna
activity patterns
microhabitat factors
rodents
small mammals
Opis:
The aim of the study was to investigate the pattern of daily activity and connections between daily and spatial activity in relation to the forest undergrowth phytocenosis of the two most common rodent species – bank vole Myodes (Clethrionomys) glareolus (Cricetidae) and yellow−necked mouse Apodemus flavicollis (Muridae). The research was carried out in July 2017 in the oak−hornbeam habitat in the Browsk Forest District in the northern part of the Białowieża Forest. For rodents catching and vegetation evaluation the 1 ha study plot was divided into 100 squares of 10×10 m. Catches were made according to the catch−mark−release method. Wooden live traps (with bait and food for caught animals in the form of the grains of cereals, juicy fruits and aromatic fat) were set in the center of each square. The traps were controlled during 4 days at 3−hour intervals (0 a.m., 3 a.m., 6 a.m., 9 a.m., 12 p.m., 3 p.m., 6 p.m. and 9 p.m.). Traps occupied by rodents were marked with colored adhesive cards according to the established code. Twice a day – at 6 a.m. and 6 p.m. caught rodents were identified to the species and released next to the traps. The catch time was recorded. In total, 151 catches were registered. The daily activity of rodents was determined based on the total catches into assumed time intervals and at different times of the day (day, night, dawn/twilight). We provided a detailed description of undergrowth features of the area where rodents were caught. In each square we assessed the dominant species (on this basis the plants communities were established), the average height of vegetation and the degree of soil coverage with plants (undergrowth density). Collected data were used to the interpretation of the spatial activity of rodents in relation to the different undergrowth characteristics. The bank vole was distinguished by an even, day−and−night activity rhythm, while the yellow−necked mouse by monophasic – remarkably nocturnal activity. The dependence of the phytocenosis characteristics and spatial distribution of rodents was revealed for the daily activity of bank vole and twilight−dawn activity of both species. At dawn and dusk voles and mice were active in places with high vegetation. The density of undergrowth was the most important feature for bank voles during the day.
Źródło:
Sylwan; 2018, 162, 12; 1029-1037
0039-7660
Pojawia się w:
Sylwan
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anticonvulsant activity of convntional antiepileptic drugs unaltered by vinpocetine in mouse model of epilepsy
Autorzy:
Borowicz, K.K.
Swiader, M.
Banach, M.
Powiązania:
https://bibliotekanauki.pl/articles/3020.pdf
Data publikacji:
2007
Wydawca:
Instytut Medycyny Wsi
Źródło:
Journal of Pre-Clinical and Clinical Research; 2007, 01, 1
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Histochemical study of the nitric oxide synthase activity in experimental trichinellosis
Autorzy:
Hadas, E.
Gustowska, L.
Boczon, K.
Janczewska, D.
Powiązania:
https://bibliotekanauki.pl/articles/837102.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
nitric oxide synthase
mouse
mice
trichinellosis
enzyme
nitric oxide
Trichinella spiralis
synthase activity
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
ANTINOCICEPTIVE ACTION OF ONONIS SPINOSA LEAF EXTRACT IN MOUSE PAIN MODELS
Autorzy:
Abbas, Manal
Jaffal, Sahar M.
Powiązania:
https://bibliotekanauki.pl/articles/895326.pdf
Data publikacji:
2019-04-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
analgesic activity
Ononis spinosa
opioid receptor
Opis:
Ononis spinosa (spiny restharrow) is a perennial herb that belongs to the Fabaceae family. Among several uses, the aerial parts of O. spinosa are used in traditional medicine for toothache. In this study, analgesic activity of the methanolic extract of leaves was studied. In writhing test, the 300 mg/kg and 600 mg/kg doses of O. spinosa extract produced 90.1% and 94.5% inhibition of abdominal cramps, respectively compared to 23.6% inhibition produced by 30 mg/kg diclofenac sodium. O. spinosa methanolic extract reduced the time of licking in early and late phases of formalin test. The inhibitory effect of O. spinosa extract was more pronounced in late phase. The lowest dose tested (300 mg/kg) of O. spinosa extract produced 81.0% inhibition compared to 50.5% inhibition in 30 mg/kg diclofenac sodium in the late phase of formalin test. This effect was not abrogated by glibenclamide, naloxone or atropine indicating that the action of O. spinosa in formalin test is not mediated by ATP-sensitive K+ channel, opioid or muscarinic receptors. In tail-flick and hot-plate tests, O. spinosa increased the latency time at 30 min and 150 min. Naloxone antagonized the action of O. spinosa in both tests suggesting an interaction with opioid receptor as a possible mechanism of O. spinosa in thermal pain models at the spinal and supraspinal levels. Phytochemical screening indicated the presence of phenolics, saponins, flavonoids, and terpenoids. Alkaloids, sterols, and anthraquinone glycosides were absent. HPLC analysis confirmed the presence kaempferol, apigenin and myricetin in the extract.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 2; 299-304
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biochemical investigations of the dynamics of proteinase activity at different stages of trichinellosis in mice
Autorzy:
Hadas, E
Derda, M.
Boczon, K.
Wandurska-Nowak, E.
Powiązania:
https://bibliotekanauki.pl/articles/839657.pdf
Data publikacji:
1994
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
Trichinella pseudospiralis
mice
blood serum
proteinase activity
enzyme activity
enzymatic change
mouse
muscle
man
trichinellosis
Trichinella spiralis
dynamics
tissue
Opis:
In the literature available hitherto there are many reports on enzymatic changes in tissues and a correlated rise in enzymatic activity in blood serum during experimental and human trichinellosis. In this study we were characterised proteinase activity in crude extracts from muscles of mice infected with Trichinella spiralis and T. pseudospiralis and the dynamics of their changes in different stages of disease. The activity of proteinase in muscle of mice infected with T. spiralis showed an increase in the 1 st- 5th week post infection, and then a slight decrease. The biggest proteinase activity was observed in 5th- 6th week post infection. In the muscle of mice infected with T. pseudospiralis the increase of proteinase activity was observed in 1st-4th week post infection. In the 4th week the activity reached its maximum and in the 5th- 10th week post infection there was a decrease of the activity in comparison with the control. As we could see, the dynamics of the changes of proteinase activity in mice is similar in the case of the disease with other biochemical and immunological indices observed in trichinellosis and with the increase of regeneration and transformation processes observed in histopathological studies.
Źródło:
Annals of Parasitology; 1994, 40, 4
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of silver nanoparticles on splenocytes activity and selected cytokine levels in the mouse serum at early stage of experimental endotoxemia
Autorzy:
Malaczewska, J.
Powiązania:
https://bibliotekanauki.pl/articles/31226.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
The objective of this study was to determine the effect of a nonionic silver nanocolloid administered orally for 7 or 14 days at three concentration levels (25 ppm, 2.5 ppm, and 0.25 ppm) on the phagocytic activity and mitogenic response of splenocytes and selected cytokine serum levels (IL-1β, IL-6, IL-10, IL-12 p70, TNF-α) in NMRI mice at the early stage of experimental endotoxemia induced with single 30 μg/mouse dose of bacterial LPS. Regardless of the period of administration, silver nanoparticles enhanced the production of proinflammatory cytokines and anti-inflammatory cytokine IL-10, and they inhibited IL-12 p70 levels in response to LPS challenge. The studied nanoparticles' effect on splenocyte activity was determined by the period of administration. After 7 days of use, silver nanoparticles enhanced the phagocytic activity, and doses of 2.5 ppm stimulated the mitogenic response of splenocytes. After 14 days of administration, silver nanoparticles lowered the phagocytic activity regardless of the dose applied. Although the results obtained are ambiguous, they suggest that silver nanoparticles administered via the alimentary tract are more likely to increase an inflammatory response of an organism than offer protection after LPS challenge.
Źródło:
Polish Journal of Veterinary Sciences; 2011, 14, 4
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biochemical investigations of the dynamics of proteinase activity at different stages of trichinellosis in mice
Autorzy:
Hadaś, E.
Derda, M.
Boczoń, K.
Wandurska-Nowak, E.
Powiązania:
https://bibliotekanauki.pl/articles/2151484.pdf
Data publikacji:
1994
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
Trichinella pseudospiralis
mice
blood serum
proteinase activity
enzyme activity
enzymatic change
mouse
muscle
man
trichinellosis
Trichinella spiralis
dynamics
tissue
Opis:
In the literature available hitherto there are many reports on enzymatic changes in tissues and a correlated rise in enzymatic activity in blood serum during experimental and human trichinellosis. In this study we were characterised proteinase activity in crude extracts from muscles of mice infected with Trichinella spiralis and T. pseudospiralis and the dynamics of their changes in different stages of disease. The activity of proteinase in muscle of mice infected with T. spiralis showed an increase in the 1 st- 5th week post infection, and then a slight decrease. The biggest proteinase activity was observed in 5th- 6th week post infection. In the muscle of mice infected with T. pseudospiralis the increase of proteinase activity was observed in 1st-4th week post infection. In the 4th week the activity reached its maximum and in the 5th- 10th week post infection there was a decrease of the activity in comparison with the control. As we could see, the dynamics of the changes of proteinase activity in mice is similar in the case of the disease with other biochemical and immunological indices observed in trichinellosis and with the increase of regeneration and transformation processes observed in histopathological studies.
Źródło:
Wiadomości Parazytologiczne; 1994, 40, 4; 329-335
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
No effect of agmatine on the protective activity of clobazam and pregabalin against maximal electroshock-induced seizures in mice
Autorzy:
Luszczki, J.J.
Jaskolska, A.
Dworzanski, W.
Kominek, M.
Mazurkiewicz, L.P.
Ossowska, G.
Powiązania:
https://bibliotekanauki.pl/articles/3584.pdf
Data publikacji:
2010
Wydawca:
Instytut Medycyny Wsi
Tematy:
agmatine
protective activity
clobazam
pregabalin
maximal electroshock-induced seizure
mice
mouse
Źródło:
Journal of Pre-Clinical and Clinical Research; 2010, 04, 1
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
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