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Tytuł:
Assessment of liver antioxidant status and mitochondrial membrane composition of Plasmodium berghei-infected mice treated with selected antimalarials
Autorzy:
Adisa, Rahmat
Sulaimon, Lateef
Powiązania:
https://bibliotekanauki.pl/articles/1038594.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Plasmodium berghei
Artecxin
Lonart
P-Alaxin
Chloroquine
oxidative stress
mitochondrial membrane fluidity
Opis:
The present study was aimed at determining and comparing the effects of Artecxin (ART), P - Alaxin (P-ALA), Lonart (LON) and Chloroquine (CQ) on oxidative stress parameters and mitochondrial membrane composition in the course of malaria infection. Six groups of five mice each categorized as healthy control (non-parasitized non-treated group), parasitized-non-treated (PnT), parasitized-chloroquine-treated (positive control), parasitized-Artecxin, -Lonart and -P-Alaxin-treated groups were used for the study. Hepatic antioxidant status was assessed with levels of malondialdehyde (MDA) and reduced glutathione (GSH) as well as activity of superoxide dismutase (SOD) and catalase (CAT) in the post mitochondrial and mitochondrial fractions. Mitochondrial membrane integrity was also evaluated with activity of succinate dehydrogenase and levels of phospholipids, cholesterol and proteins in the liver mitochondria. Results revealed that treatment of parasitized mice with the antimalarial drugs significantly (p<0.05) decreased hepatic malondialdehyde (MDA) and mitochondrial membrane phospholipids compared to parasitized untreated group. On the other hand, significantly (p<0.05) elevated succinate dehydrogenase (SDH) activity, mitochondrial membrane cholesterol level, GSH concentration, catalase (CAT) and superoxide dismutase (SOD) activity in the post mitochondrial fraction were obtained. Thus, antimalarial drugs distort mitochondrial membrane integrity and electron transfer but reduce the malaria-induced oxidative stress on the host.
Źródło:
Acta Biochimica Polonica; 2017, 64, 3; 485-491
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clinical Manifestations of Plasmodium berghei ANKA Infection in Juvenile Mice: A Short Case Report
Autorzy:
Ajayi, J. B.
Agbeyangi, A. O.
Daniel, A.
Omobolaji, I.
Mogaji, H. O.
Powiązania:
https://bibliotekanauki.pl/articles/1113684.pdf
Data publikacji:
2017
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
ECM
Juvenile
Malaria
Mice
Neonates
Plasmodium berghei
Opis:
Malaria is an important health and development challenge in Africa, Animal models most particularly mice, have long been employed to study malaria pathogenesis. This paper describes clinical manifestations due to Plasmodium berghei ANKA infection in juvenile mice as a model for understanding the complications of congenital malaria in neonates. Forty-five juvenile mice (5-7 days old) were acquired from University College Hospital, Ibadan and injected with 2×107 (0.2 ml) Plasmodium berghei ANKA parasitized red blood cells (PRBCs). The mice were then transported to the study site, kept in well-ventilated cages and fed daily with a balanced ration. Post-P. berghei infection, the mice were monitored daily for mortality. Clinical manifestations of experimental cerebral malaria (ECM) were assessed and confirmed if at least ruffled fur, hunching, wobbly gait, limb paralysis, convulsions, or coma was observed. Each sign was given a score of 1. Animals with scores ≥4 were considered to have severe ECM. In the experiment, 20 (44%) mice were lost due to natural cause (i.e. stress) at day 2. Between day 4 and 9, 25 (56%) of the study mice presented clinical signs of ECM. This included: ruffled fur – 25 (100%), hunching - 21 (84%), wobbly gait - 17 (68%), limb paralysis - 20 (80%), convulsions - 25 (100%). Survival rate and severity of ECM in the mice differs, 22 (88.0%) had severe ECM and 3 (12.0%) had mild ECM. This study has shown that parasite establishment and malaria complications can manifest as early as 4 days’ post P. berghei infection in 5-7 days old mice.
Źródło:
World News of Natural Sciences; 2017, 14; 90-96
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preparation and primary evaluation of 66Ga-DTPA-chitosan in fibrosarcoma bearing mice
Autorzy:
Akhlaghi, M.
Pourjavadi, A.
Powiązania:
https://bibliotekanauki.pl/articles/147065.pdf
Data publikacji:
2011
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
DTPA-chitosan
degree of modification (DM)
gallium-66
radiolabeled
intratumoral injection
Opis:
Chitosan was chemically modified by diethylenetetraaminepentaacetic acid (DTPA) in different degrees of modification (DM = 6.1, 10.3, 15.7 and 20.9%). DTPA-chitosans were radiolabeled with gallium-66 radionuclide. The effect of several factors on labeling yield such as degree of modification, acidity and concentration of DTPA-chitosan solution, contact time and radioactivity was investigated. Radiolabeled DTPA chitosans were intratumorally injected to fibrosarcoma bearing mice and the leakage of radioactivity from the injection site was evaluated. In comparison with chitosan, all DTPA chitosans showed better efficiency in preventing the leakage of radioactivity from tumor lesion and DTPA-chitosan (DM = 10.3%) was the best which led to remaining 97% of injected dose in the injection site after 54 h of injection. The highest leaked radioactivity from the injection site was in the lungs, liver, spleen and the kidneys. Our results indicated that the DTPA modified chitosan can be an effective carrier for therapeutic radionuclides for tumor treatment by the intratumoral injection technique.
Źródło:
Nukleonika; 2011, 56, 1; 41-47
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
THE EFFECT OF A SINGLE OR MULTIPLE DOSES OF GRAPEFRUIT JUICE ON SOME PHARMACOKINETIC AND PHARMACODYNAMIC EFFECTS OF PARACETAMOL IN MICE
Autorzy:
AL ZA'ABI, MOHAMMED
ALI, BADRELDIN H.
AL-HDHRAMI, ASMA
Powiązania:
https://bibliotekanauki.pl/articles/895589.pdf
Data publikacji:
2019-08-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
mice
paracetamol
pharmacokinetic
grapefruit juice
pharmacodynamic
Opis:
Grapefruit juice (GFJ), a commonly consumed dietary substance, has been shown to alter the disposition of several commonly used drugs. The available data on the effects of GFJ on the paracetamol pharmacokinetics and pharmacodynamics are at variance. The aim of this study was to evaluate the effect of a single or multiple dose of GFJ on some pharmacokinetics and pharmacodynamics aspects of orally given paracetamol (400 mg/Kg). Male mice were randomly divided into three equal groups: mice in the first group were given paracetamol; the second group was given a single oral dose (10 mL/Kg) of GFJ one hour prior to paracetamol administration; the third group was administered multiple oral doses of GFJ (10 mL/Kg) for five consecutive days, and on the last day it was treated with paracetamol. Blood samples were collected 10, 20, 30, and 40 min, and 1, 2, 4, 6 and 8 h after paracetamol administration for subsequent pharmacokinetic analysis. Some mice in the same three groups were also tested for their reactions to thermal (hotplate) and chemical (acetic acid induced – abdominal constriction) nociceptive stimuli. GFJ increased the plasma concentration and area under the plasma concentration curve of paracetamol, to a greater extent after a single dose than multiple doses. It also increased the reaction time in the hotplate test, and reduced abdominal constrictions. GFJ administration increased the plasma concentration and the analgesic effect of paracetamol in mice. The possible implications of these changes in humans and their clinical relevance need to be further investigated.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 4; 753-759
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oral Supplementation with Three Vegetable Oils Differing in Fatty Acid Composition Alleviates High-Fat Diet-Induced Obesity in Mice by Regulating Inflammation and Lipid Metabolism
Autorzy:
Aldamarany, Waleed
Taocui, Huang
Liling, Deng
Wanfu, Yang
Zhong, Geng
Powiązania:
https://bibliotekanauki.pl/articles/16538537.pdf
Data publikacji:
2023-02-28
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
perilla oil
sunflower oil
tea seed oil
anti-obesity effect
inflammation
lipid metabolism
Opis:
Obesity has become one of the most prevalent chronic diseases worldwide, which affects people's health and daily lives. Therefore, this study aimed to investigate the anti-obesity effects of perilla seed oil (PSO), sunflower oil (SFO), and tea seed oil (TSO) and their potential mechanisms in mice fed a high-fat diet (HFD). Mice were divided into five groups: ND, mice fed a normal diet; HFD, mice fed a high-fat diet; PSO, SFO, and TSO, mice fed a high-fat diet supplemented with PSO, SFO, and TSO at 2 g/kg body weight per day, respectively. Our findings showed that oral supplementation with all three oils for 8 weeks significantly reduced body weight, tissue weight, insulin resistance index, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and free fatty acids (FFA), and markedly alleviated hyperglycemia, hyperlipidemia, and hepatic steatosis in obese mice. It also decreased leptin, pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, and (IL)-1beta (IL-1β), and increased anti-inflammatory adipokine adiponectin at both secretion and mRNA expression levels in the epididymal adipose tissue (EAT). Moreover, PSO, SFO, and TSO administration increased the expression levels of fatty acid β-oxidation-related genes, including peroxisome proliferator-activated receptor-alpha (PPAR-α), carnitine palmitoyltransferase 1a (CPT1a) and CPT1b, and thermogenesis-related genes such as uncoupling protein 1 (UCP1), and decreased the expression levels of lipid synthesis-related genes, including fatty acid synthase (FAS) and PPAR-γ in EAT. In conclusion, PSO, SFO, and TSO supplementation could have potential anti-obesity effects in HFD-fed mice by reducing inflammation and improving lipid metabolism.
Źródło:
Polish Journal of Food and Nutrition Sciences; 2023, 73, 1; 80-94
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The relationship between the alkaline phosphatase network and the haematopoiesis in mice subjected to whole-body irradiation
Autorzy:
Almohamad, K. M.
Alsheikh, F. M.
Powiązania:
https://bibliotekanauki.pl/articles/971516.pdf
Data publikacji:
2014
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
haematopoiesis
whole-body irradiation
alkaline phosphatase (ALP) network
Levamisole
Lisinopril
Opis:
To investigate the relationship between the alkaline phosphatase (ALP) network of the marrow stroma and the haematopoietic regeneration after mice whole-body irradiation. Materials and methods: Three groups of mice were irradiated with a non-lethal ionising radiation dose: the fi rst one received an intraperitoneal injection of Levamisole, ALP inhibitor, 24 h before irradiation; the second one received an intraperitoneal injection of Lisinopril, haematopoiesis inhibitor, 24 h before irradiation; the third was left untreated, but irradiated. The fourth group, untreated and not irradiated, was the control. The total surface occupied by ALP positive processes, revealed by means of ALP cytochemistry in the marrow area, was evaluated semi-quantitively. Nucleated bone marrow cells were also counted. Results: ALP network began to increase 24 h after irradiation to reach a maximum after 72 h, when the bone marrow was almost become completely empty of the haematopoietic cells. This increase advances the haematopoietic recovery. This process was substantially delayed when the mice were injected with Levamisole 24 h before irradiation. On the contrary, ALP network increased strongly since the fi rst day after irradiation when the mice were injected with Lisinopril 24 h before irradiation. Conclusions: These data have indicated that the haematopoietic recovery and repopulation of the bone marrow were advanced by the ALP network recovery.
Źródło:
Nukleonika; 2014, 59, 3; 105-110
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Production of functional transgenic mice by DNA pronuclear microinjection.
Autorzy:
Auerbach, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1043315.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
functional transgenics
transgenic mouse production
transgenesis
transgene random integration
pronuclear microinjection
Opis:
Successful experiments involving the production of transgenic mice by pronuclear microinjection are currently limited by low efficiency of random transgene integration into the mouse genome. Furthermore, not all transgenic mice express integrated transgenes, or in other words are effective as functional transgenic mice expressing the desired product of the transgene, thus allowing accomplishment of the ultimate experimental goal - in vivo analysis of the function of the gene or gene network. The purpose of this review is to look at the current state of transgenic technology, utilizing a pronuclear microinjection method as the most accepted way of gene transfer into the mouse genome.
Źródło:
Acta Biochimica Polonica; 2004, 51, 1; 9-31
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Teratogenic effects in mice exposed to single dose of x-rays and prolonged administration of caffeine during pregnacy
Teratogennne skutki przewlekłej ekspozycji ciężarnych myszy na kofeinę i jednorazową dawkę promieniowania x
Autorzy:
Auerbach, B.A.
Slowikowska, M.G.
Lenarczyk, M.
Gajewski, A.K.
Powiązania:
https://bibliotekanauki.pl/articles/874397.pdf
Data publikacji:
1986
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Źródło:
Roczniki Państwowego Zakładu Higieny; 1986, 37, 4
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Morphometric abnormalities in spleen and kidney of the progeny of mice fed American cranberry extract (Vaccinium macrocarpon) during pregnancy and lactation
Autorzy:
Balan, B.J.
Lewicki, S.
Siwicki, A.K.
Stelmasiak, M.
Skopinski, P.
Skopinska-Rozewska, E.
Wasiutynski, A.
Zdanowski, R.
Powiązania:
https://bibliotekanauki.pl/articles/30729.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
Cranberries and cranberry-derived diet supplements are often recommended for the treatment of urinary tract infections, also during pregnancy. These products contain strongly anti-angiogenic chemical compounds which could not be indifferent to the developing fetus. In the present work we evaluated the effect of feeding pregnant and lactating mice American cranberry extract (daily dose 0.88 mg) on the morphology and some parameters of spleen and kidney function of their adult progeny. Six weeks after delivery the morphometry of spleen and kidney, cytometric analysis of spleen lymphocytes, evaluation of humoral response to SRBC (Sheep Red Blood Cells), and examination of serum creatinine/urea concentration, were performed in the offspring. Spleens of progeny from experimental (E) group differed from the spleens of progeny of control mice in the lower number of lymphatic nodules and their larger diameter. Cytometry of spleen cells from progeny of E mothers revealed more CD19⁺ and CD8⁺ lymphocytes than in the control group. No difference was seen in the response to immunization by red blood cells of sheep (SRBC) between control and E offspring. An increase in the diameter of glomeruli was observed in the kidneys of the experimental group in comparison with the control group. No abnormalities in creatinine and urea serum level were observed. A higher concentration of VEGF and bFGF in E offspring sera in comparison to the controls was seen. Conclusion: Although the observed differences between the control and experimental group were not large, caution is recommended in using cranberries and their extracts during pregnancy until more research will be done on this topic.
Źródło:
Polish Journal of Veterinary Sciences; 2017, 20, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Morphometric abnormalities in the spleen of the progeny of mice fed epigallocatechin during gestation and nursing
Autorzy:
Balan, B.J.
Skopinska-Rozewska, E.
Skopinski, P.
Zdanowski, R.
Lesniak, M.
Kiepura, A.
Lewicki, S.
Powiązania:
https://bibliotekanauki.pl/articles/31390.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
It is very difficult to cure pregnant females suffering from infections, because of the risk which might occur during treatment by several, even herbal, medications. Many of these substances, among them extracts from plants, have antimicrobial, anti-inflammatory and immunostimulatory properties owing to their polyphenols content, but also may reveal unwanted effects on the fetal development because of their anti-angiogenic properties. The aim of the present study was to elucidate whether daily feeding pregnant and nursing mice 0.2 mg/kg epigallocatechin (EGC), previously recognized as angiogenesis inhibitor, may lead to abnormalities in morphology of spleen and in some parameters of immune function of their adult, 6-week old progeny. Morphometry of EGC offspring spleens revealed lower number of lymphatic nodules and their larger diameter than those found in the control offspring. Cellularity of spleens was lower in EGC offspring than in the controls. Cytometric analysis showed that this decline concerns lymphocytes with CD335 (p<0.001), CD19 (p<0.01) and CD4 (p<0.05) markers. No differences were observed in the humoral response to the immunization with SRBC, and in the proliferative response of splenocytes to mitogens PHA, ConA and LPS.
Źródło:
Polish Journal of Veterinary Sciences; 2017, 20, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of Four-Week Intake of Blackthorn Flower Extract on Mice Tissue Antioxidant Status and Phenolic Content
Autorzy:
Balta, Vedran
Đikić, Domagoj
Crnić, Irena
Odeh, Dyna
Orsolic, Nada
Kmetič, Ivana
Murati, Teuta
Dragović Uzelac, Verica
Landeka Jurčević, Irena
Powiązania:
https://bibliotekanauki.pl/articles/1363304.pdf
Data publikacji:
2021
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
pharmacokinetic
flavan-3-ol
flavonoids
bioavailability
phenolic compounds
Prunus spinosa L
Opis:
The study examined the antioxidative physiological effects of phenolics from an ethanol-water extract of blackthorn flowers orally administrated to C57/BL6 mice for 28 days in daily doses of 25 mg of total phenolics/kg body weight. Contents of phenolics in the intestine, liver, and kidneys collected after 1, 7, 14, 21, and 28 days of extract administration were analyzed by UPLC-MS/MS method. In the same tissues, the antioxidative properties were determined as ferric reducing antioxidant power (FRAP), ABTS•+ scavenging activity, content of reduced glutathione (GSH), and activity of superoxide dismutase (SOD) and catalase (CAT). The lipid peroxidation in tissues was also evaluated by thiobarbituric acid reactive substances (TBARS) assay. The exposed mice (compared to the control ones) had a lower content of TBARS in all tissues mostly on the third/fourth week of daily consumption. SOD activity and GSH content increased on the 28th day in tissues. CAT activity was higher only in the liver after one week of consumption but remained unchanged in other organs throughout the experiment. Phenolic profiles were different in individual tissues. The most prominent increases compared to the control were determined for contents of 3-O-feruloylquinic acid, 4-O-p-coumaroylqiunic acid, kaempferol pentoside, and quercetin rhamnoside in the intestine; for ferulic acid and quercetin 3-O-rutinoside in the liver; and for quercetin 3-O-rutinoside, ferulic acid, and 4-O-p-coumaroylquinic acid in the kidneys. The screened phenolics with different distribution in tissues could be responsible for slight differences in the recorded antioxidative effects.
Źródło:
Polish Journal of Food and Nutrition Sciences; 2020, 70, 4; 361-375
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Activity of natural killer [NK] cells in the course of experimental trichinellosis in mice
Aktywnosc komorek NK w przebiegu eksperymentalnej trichinellozy u myszy
Autorzy:
Bany, J
Janiak, M.K.
Budzynski, W.
Powiązania:
https://bibliotekanauki.pl/articles/839913.pdf
Data publikacji:
1992
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
wlosnica
myszy
pasozyty
nicienie
Trichinellidae
komorki NK
wlosien krety
choroby inwazyjne
parazytologia
Trichinella spiralis
zwierzeta doswiadczalne
immunologia
aktywnosc immunologiczna
Opis:
B6C3F₁ mice were infected with 200 or 500 larvae of Trichinella spiralis per mouse and pulmonary NK cell-mediated clearance of semisyngeneic tumour cells was determined in vivo on days 10, 20, 30, and 60 after the infection. Cytotoxic activity of NK cells in the lungs was substantially elevated on days 20 and 30 after challenge with both „doses" of the parasite. At the same time large granular lymphocytes (LGLs) as well as cells expressing surface asialo-GM₁ molecules were isolated in elevated numbers from spleens of the infected as opposed to the normal mice. Expression of other markers of differentiation, such as THy 1, CD4, and CD8 was also enhanced on splenocytes isolated from the infected mice on day 30 but not 20 after administration of the larvae. The present results indicate that NK cell-mediated activity in vivo is stimulated above the baseline level during migration and early muscle phases of the infection with T. spiralis in mice. The possible impact of this effect upon the course of trichinellosis as well as upon the growth of tumours in the infected host is discussed.
Źródło:
Annals of Parasitology; 1992, 38, 3-4; 117-126
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Activity of natural killer [NK] cells in the course of experimental trichinellosis in mice
Aktywność komórek NK w przebiegu eksperymentalnej trichinellozy u myszy
Autorzy:
Bany, J.
Janiak, M.K.
Budzyński, W.
Powiązania:
https://bibliotekanauki.pl/articles/2152262.pdf
Data publikacji:
1992
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
wlosnica
myszy
pasozyty
nicienie
Trichinellidae
komorki NK
wlosien krety
choroby inwazyjne
parazytologia
Trichinella spiralis
zwierzeta doswiadczalne
immunologia
aktywnosc immunologiczna
Opis:
B6C3F₁ mice were infected with 200 or 500 larvae of Trichinella spiralis per mouse and pulmonary NK cell-mediated clearance of semisyngeneic tumour cells was determined in vivo on days 10, 20, 30, and 60 after the infection. Cytotoxic activity of NK cells in the lungs was substantially elevated on days 20 and 30 after challenge with both „doses" of the parasite. At the same time large granular lymphocytes (LGLs) as well as cells expressing surface asialo-GM₁ molecules were isolated in elevated numbers from spleens of the infected as opposed to the normal mice. Expression of other markers of differentiation, such as THy 1, CD4, and CD8 was also enhanced on splenocytes isolated from the infected mice on day 30 but not 20 after administration of the larvae. The present results indicate that NK cell-mediated activity in vivo is stimulated above the baseline level during migration and early muscle phases of the infection with T. spiralis in mice. The possible impact of this effect upon the course of trichinellosis as well as upon the growth of tumours in the infected host is discussed.
Źródło:
Wiadomości Parazytologiczne; 1992, 38, 3-4; 117-126
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Efficacy of albendazole against Trichinella pseudospiralis and Trichinella spiralis in mice
Wplyw albendazolu na przebieg zakazenia Trichinella pseudospiralis i Trichinella spiralis u myszy
Autorzy:
Bany, J
Lach, J.
Golinska, Z.
Powiązania:
https://bibliotekanauki.pl/articles/838080.pdf
Data publikacji:
1992
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
Trichinella pseudospiralis
zwierzeta doswiadczalne
Trichinella spiralis
parazytologia
albendazol
myszy
nicienie
pasozyty
inwazja pasozytnicza
Trichinellidae
Opis:
Albendazole (Smith Kline, Beecham) in a dose of 20 mg/kg/day was given to B6C3F₁ mice exposed to 300 larvae of T. pseudospiralis or T. spiralis. The drug was introduced on days 2, 3 and 4; or 4, 5 and 6; or 18, 19 and 20 after infection. It limited the intensity of intestinal and muscle phases of trichinellosis. Given at the stage of maturation of adult forms and production of new-born larvae, the drug caused almost total elimination of both species from the intestines of mice and a decrease in the numbers of muscle larvae, with a tendency towards a greater reduction of larvae and adults of T. pseudospiralis. The drug did not change the course of infection when given at the phase of infectiveness of larvae.
Źródło:
Annals of Parasitology; 1992, 38, 3-4; 143-146
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Efficacy of albendazole against Trichinella pseudospiralis and Trichinella spiralis in mice
Wpływ albendazolu na przebieg zakażenia Trichinella pseudospiralis i Trichinella spiralis u myszy
Autorzy:
Bany, J.
Lach, J.
Golińska, Z.
Powiązania:
https://bibliotekanauki.pl/articles/2152265.pdf
Data publikacji:
1992
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
Trichinella pseudospiralis
zwierzeta doswiadczalne
Trichinella spiralis
parazytologia
albendazol
myszy
nicienie
pasozyty
inwazja pasozytnicza
Trichinellidae
Opis:
Albendazole (Smith Kline, Beecham) in a dose of 20 mg/kg/day was given to B6C3F₁ mice exposed to 300 larvae of T. pseudospiralis or T. spiralis. The drug was introduced on days 2, 3 and 4; or 4, 5 and 6; or 18, 19 and 20 after infection. It limited the intensity of intestinal and muscle phases of trichinellosis. Given at the stage of maturation of adult forms and production of new-born larvae, the drug caused almost total elimination of both species from the intestines of mice and a decrease in the numbers of muscle larvae, with a tendency towards a greater reduction of larvae and adults of T. pseudospiralis. The drug did not change the course of infection when given at the phase of infectiveness of larvae.
Źródło:
Wiadomości Parazytologiczne; 1992, 38, 3-4; 143-146
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 355

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