Wszystkie pola: maximal electroshock-induced seizures - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Diltiazem enhances the protective activity of oxcarbazepine against maximal electroshock-induced seizures in mice
Autorzy:: Zadrozniak, A.
Trojnar, M.K.
Trojnar, M.P.
Kimber-Trojnar, Z.
Dudra-Jastrzebska, M.
Andres-Mach, M.M.
Luszczki, J.J.
Powiązania:: https://bibliotekanauki.pl/articles/3526.pdf
Data publikacji:: 2008
Wydawca:: Instytut Medycyny Wsi
Tematy:: calcium channel antagonist
diltiazem
protective activity
oxcarbazepine
maximal electroshock-induced seizure
mice
mouse
drug interaction
pharmacodynamic interaction
Źródło:: Journal of Pre-Clinical and Clinical Research; 2008, 02, 2
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Protective role of curcumin in maximal electroshock induced seizures, memory impairment and neurotransmitters in rat brain
Autorzy:: Jithendra, Ch.
Murthy, T.E.G.K.
Upadyay, L.
Powiązania:: https://bibliotekanauki.pl/articles/3067.pdf
Data publikacji:: 2008
Wydawca:: Instytut Medycyny Wsi
Źródło:: Journal of Pre-Clinical and Clinical Research; 2008, 02, 1
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: No effect of agmatine on the protective activity of clobazam and pregabalin against maximal electroshock-induced seizures in mice
Autorzy:: Luszczki, J.J.
Jaskolska, A.
Dworzanski, W.
Kominek, M.
Mazurkiewicz, L.P.
Ossowska, G.
Powiązania:: https://bibliotekanauki.pl/articles/3584.pdf
Data publikacji:: 2010
Wydawca:: Instytut Medycyny Wsi
Tematy:: agmatine
protective activity
clobazam
pregabalin
maximal electroshock-induced seizure
mice
mouse
Źródło:: Journal of Pre-Clinical and Clinical Research; 2010, 04, 1
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: No effect of3-(N-p-isopropoxyphenylsuccinimidomethylamino)-cinnamic acid on anticonvulsant action of different classical antiepileptic drugs in mouse maximal electroshock-induced seizure model
Autorzy:: Luszczycki, J. J.
Marczewski, T.
Marzeda, E.
Durmowicz, D.
Podgorska, D.
Kocharov, S. L.
Florek-Luszczki, M.
Powiązania:: https://bibliotekanauki.pl/articles/972739.pdf
Data publikacji:: 2012
Wydawca:: Instytut Medycyny Wsi
Tematy:: antiepileptic drugs
maximal electroshock-induced seizures
pharmacokinetic/pharmacodynamic interaction
p-isopropoxyphenylsuccinimide derivative
Opis:: Introduction and objective: The aim of the study was to determine the effects of 3-(N-p-isopropoxyphenylsuccinimidomethylamino)-cinnamic acid (IPPSMA-CA – a new succinimide derivative) on the protective action of 4 classical antiepileptic drugs (AEDs): carbamazepine [CBZ], phenobarbital [PB], phenytoin [PHT] and valproate [VPA]), against maximal electroshock (MES)-induced tonic seizures in mice. Materials and methods: Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25 mA, 500 V, 50 Hz, 0.2 s stimulus duration) delivered via auricular electrodes. Acute adverse-effectprofiles of the combination of IPPSMA-CA and 4 classical AEDs (CBZ, PB, PHT and VPA) with respect to motor performance, long-term memory and skeletal muscular strength were measured in the chimney, passive avoidance and grip-strength tests, respectively. Results: IPPSMA-CA administered at 150 mg/kg (i.p.) significantly elevated the threshold for electroconvulsions in mice (p<0.01). IPPSMA-CA at doses of 50 and 100 mg/kg, however, had no significant impact on the threshold for electroconvulsions in mice. Nor did IPPSMA-CA (100 mg/kg) significantly affect the anticonvulsant activity of CBZ, PB, PHT and VPA in the MES test in mice. None of the examined combinations of IPPSMA-CA (100 mg/kg, i.p.) with CBZ, PB, PHT and VPA (at their ED50 values from the MES-induced seizure test) affected motor coordination in the chimney test, long-term memory in the passive avoidance task, and muscular strength in the grip-strength test in mice. This indicates no possible acute adverse effects in animals. Conclusions: IPPSMA-CA elevated the threshold for electroconvulsions in mice in a dose-dependent manner. However, IPPSMA-CA at a sub-protective dose of 100 mg/kg did not affect the anticonvulsant action of various classical AEDs in the mouse MES model. Thus, the combinations of IPPSMA-CA with CBZ, PB, PHT and VPA are neutral from a preclinical viewpoint.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2012, 06, 1; 20-24
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Additive interaction for three-drug combination of carbamazepine, lacosamide and lamotrigine against maximal electroshock-induced seizures – a type I isobolographic analysis
Autorzy:: Kondrat-Wróbel, Maria
Łuszczki, Jarogniew J.
Powiązania:: https://bibliotekanauki.pl/articles/454877.pdf
Data publikacji:: 2017
Wydawca:: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:: antiepileptic drugs
isobolographic analysis
maximal electroshoc
three-drug combination
Opis:: Introduction. Treatment of epilepsy patients with one antiepileptic drug often fails and then the insufficiently medicated patients need two or three antiepileptic drugs combined together to stop their seizures. However, polytherapy is always associated with drug-drug interactions whose nature may or may not be favorable for epilepsy patients. Preclinical studies on animals can help to select beneficial combinations of antiepileptic drugs that could be used in further clinical settings. Aim. To isobolographically characterize anticonvulsant effects of a combination of three antiepileptic drugs (carbamazepine, lacosamide and lamotrigine) at the fixed drug dose ratio of 1:1:1 in the mouse maximal electroshock-induced seizure test. Material and methods. Maximal electroconvulsions were evoked in male Swiss mice by a current (25 mA, 500 V, 0.2 s stimulus duration) delivered via auricular electrodes. Type I isobolographic analysis was applied to assess the interaction among carbamazepine, lacosamide and lamotrigine. Results. Isobolographic analysis revealed that the combination of carbamazepine, lacosamide and lamotrigine produced additive interaction in the mouse maximal electroshock-induced seizure test. Conclusions. Additivity among carbamazepine, lacosamide and lamotrigine in this preclinical study can be translated to clinical settings and this three-drug combination can be recommended as a treatment option for epilepsy patients who are resistant to standard treatment regimens.
Źródło:: European Journal of Clinical and Experimental Medicine; 2017, 4; 303-309
2544-2406
2544-1361
Pojawia się w:: European Journal of Clinical and Experimental Medicine
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Effects of alizarin, betulin, curcumin, diosmin , linalool, menthofuran, α-terpineol, theobromine, β-thujaplicin and vanillin against maximal electroshock-induced seizures in mice
Autorzy:: Luszczki, J.J.
Wlodarczyk, M.
Glensk, M.
Marzeda, E.
Durmowicz, D.
Florek-Luszczki, M.
Powiązania:: https://bibliotekanauki.pl/articles/3040.pdf
Data publikacji:: 2013
Wydawca:: Instytut Medycyny Wsi
Źródło:: Journal of Pre-Clinical and Clinical Research; 2013, 07, 1
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: SYNTHESIS AND ANTICONVULSANT PROPERTIES OF SOME N-ARYL AND N-ARYLAMINOMETHYL DERIVATIVES OF 3-P-ISOPROPOXYPHENYLPYRROLIDINE-2,5-DIONE
Autorzy:: Kocharov, Sergey L.
Panosyan, Henry
Chmielewski, Jaroslaw
Gworek, Barbara
Łuszczki, Jarogniew J.
Powiązania:: https://bibliotekanauki.pl/articles/895346.pdf
Data publikacji:: 2019-04-30
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: maximal electroshock-induced seizures
3-p-Isopropoxyphenylpyrrolidine-2
5-dione
N-aryl derivatives
N-arylaminomethyl derivatives
Opis:: Introduction: Anticonvulsant properties of newly synthesized compounds and potential antiepileptic drugs are usually assessed in screen tests in experimental animals. One of the most commonly used screen tests in mice is the maximal electroshock-induced seizure test that reflects tonic-clonic seizures in humans. Materials and Method: A series of 3-p-isopropoxyphenylpyrrolidine-2,5-dione derivatives, including N-aryl and N-arylaminomethyl analogs, were characterized for their anticonvulsant properties in the maximal electroshock-induced seizure test in mice. Electroconvulsions (tonic-clonic seizures) were evoked in adult Albino Swiss mice by a current (sine-wave, 25mA, 50Hz, 500V, 0.2s stimulus duration) delivered via auricular electrodes. Results: N-aryl derivatives did not show any anticonvulsant activity, whereas some representatives of N-arylaminomethyl derivatives, i.e. N-Mannich bases, exhibited a distinct protective action against maximal electroshock-induced (MES) convulsions in mice. Conclusions: Several N-arylaminomethyl derivatives of 3-p-isopropoxyphenylpyrrolidine-2,5-dione may become in future new antiepileptic drugs, or they could serve as valuable supporting materials for obtaining new derivatives with stronger anticonvulsant activities than their maternal compounds.
Źródło:: Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 2; 265-273
0001-6837
2353-5288
Pojawia się w:: Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Alantolactone and isoalantolactone suppress maximal electroshock-induced tonic seizures in mice
Autorzy:: Luszczki, J.J.
Marzeda, E.
Kondrat-Wrobel, M.W.
Florek-Luszczki, M.
Powiązania:: https://bibliotekanauki.pl/articles/3044.pdf
Data publikacji:: 2014
Wydawca:: Instytut Medycyny Wsi
Tematy:: alantolactone
isoalantolactone
electroshock-induced tonic seizure
seizure
mice
mouse
treatment
Źródło:: Journal of Pre-Clinical and Clinical Research; 2014, 08, 1
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: WIN 55,212-2 mesylate (a highly potent non-selective cannabinoid CB1 and CB2 receptor agonist) elevates the threshold for maximal electroshock-induced seizures in mice
Autorzy:: Luszczki, J.J.
Misiuta-Krzesinska, M.
Wlaz, A.
Zwolinski, J.
Cioczek, J.D.
Zolkowska, D.
Powiązania:: https://bibliotekanauki.pl/articles/3539.pdf
Data publikacji:: 2009
Wydawca:: Instytut Medycyny Wsi
Źródło:: Journal of Pre-Clinical and Clinical Research; 2009, 03, 2
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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