Wszystkie pola: lymphangiogenesis - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: The shRNA-mediated silencing of VEGF-C illustrates its role in proliferation, chemosensitization, tumour colonization, and anchorage independence
Autorzy:: Tambe, P.
Purohit, I.
Suneja, D.
More, S.
Desai, P.
Shrivastava, N.
Powiązania:: https://bibliotekanauki.pl/articles/80325.pdf
Data publikacji:: 2015
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: vascular endothelial growth factor
gene expression
endothelial cell
breast cancer
lymphangiogenesis
metastasis
proliferation
chemosensitivity
tumour cell
RNAi
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2015, 96, 3
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 2.

Tytuł:: Znaczenie kliniczne ekspresji neuropiliny-1 u chorych na raka jajnika
Clinical signifi cance of neuropilin-1 expression in patients with ovarian cancer
Autorzy:: Klasa-Mazurkiewicz, Dagmara
Narkiewicz, Joanna
Milczek, Tomasz
Lipińska, Barbara
Emerich, Janusz
Wydra, Dariusz
Powiązania:: https://bibliotekanauki.pl/articles/1030638.pdf
Data publikacji:: 2009
Wydawca:: Medical Communications
Tematy:: angiogenesis
lymphangiogenesis
neuropilin
ovarian cancer
prognostic factors
angiogeneza
czynniki prognostyczne
kluczowe: rak jajnika
limfangiogeneza
neuropilina
Opis:: Background: Angiogenesis is a key process in the development of a malignant tumor, enabling both growth of primary lesion and spread of metastases. Most potent stimulators of normal and pathological angiogenesis are proteins of the vascular endothelial growth factor (VEGF) family. Regulation of angiogenesis process is also mediated by neuropilin- 1 (NP-1), as coreceptor VEGFR-2. NP-1 plays a crucial role controlling both normal angiogenesis during embryonal development and pathological angiogenesis in malignant tumors. The aim of this paper was to assess NP-1 expression in ovarian cancer and to analyze correlations between NP-1 expression and selected clinical-pathological factors in a group of ovarian cancer patients. Material and method: Analyzed was the relative level of NP-1 in 168 surgical specimens collected during surgical procedures performed at the Department of Oncologic Gynecology of Medical University in Gdańsk. Tissue samples included: 32 healthy tissues, 42 benign tumors, 10 borderline tumors, 76 ovarian cancers, 8 metastatic tumors. Relative NP-1 level was assessed using Western blotting technology. Results: Overexpression of NP-1 was seen significantly more often in early clinical stages of ovarian cancer (p=0.01), in cancers other than serous (p=0.04) and in patients with peritoneal exudate (p=0.03). Log-rank test did not reveal any significant correlation between NP-1 expression and favorable response to chemotherapy, disease-free survival or total survival time. Conclusions. Elevated NP-1 level seen in initial clinical stages of ovarian cancer may indicate crucial role of neoangiogenesis in the early phase of tumor development.
Źródło:: Current Gynecologic Oncology; 2009, 7, 4; 237-247
2451-0750
Pojawia się w:: Current Gynecologic Oncology
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 3.

Tytuł:: Metastatic and non-metastatic sentinel inguinofemoral lymph nodes in vulvar cancer show an increased lymphangiogenesis
Autorzy:: Piechowicz, M.
Mikos, M.
Banas, T.
Okon, K.
Pietrus, M.
Balajewicz-Nowak, M.
Szczudlik, L.
Kojs, Z.
Czerw, A.
Juszczyk, G.
Pityński, K.
Powiązania:: https://bibliotekanauki.pl/articles/2085422.pdf
Data publikacji:: 2020
Wydawca:: Instytut Medycyny Wsi
Tematy:: anti-D2–40 antibody
lymphatic vessel density
immunohistochemistry
sentinel lymph node
vulvar cancer
Opis:: Introduction and objective. Lymph node involvement is a strong predictor of disease recurrence and patient survival in vulvar cancer. The aim of the study was to evaluate the feasibility of sentinel lymph node (SLN) screening, the incidence of skip metastases, and lymph node lymphangiogenesis. Materials and method. Fifty-five patients participated in this prospective, single centre study. A double SLN screening method was employed using radiocolloid (technetium-99 sulfur colloid) and 1.0% Isosulfan Blue. Immunohistochemistry, using a mouse monoclonal antibody against D2–40, was used to evaluate lymphatic vessel density (LVD). All calculations were performed using STATISTICA software v. 10 (StatSoft, USA, 2011); p<0.05 was considered significant. Results. Using both methods of SLN detection, 100% accuracy was achieved, and skip metastases were diagnosed in only one woman (1.82%). Peri-tumour median LVD was significantly increased compared with matched intra-tumour samples (p<0.001), while median LVD was significantly lower in negative, compared with positive SLN, regardless of whether matched non-SLN were negative (p<0.001) or positive (p=0.005). Metastatic SLN exhibited significantly higher median LVD compared with matched negative non-SLN (p=0.015), while no significant difference in median LVD was detected between positive SLN and matched positive non-SLN. However, negative SLN had a significantly higher median LVD compared with matched negative non-SLN (p = 0.012). Conclusions. SLN detection is a safe and feasible procedure in vulvar cancer. In patients without nodular involvement, SLN, compared with non-SLN, exhibited significantly higher median LVD, which may be an indication of its preparation to host metastases, and thus requires further investigation.
Źródło:: Annals of Agricultural and Environmental Medicine; 2020, 27, 1; 123-128
1232-1966
Pojawia się w:: Annals of Agricultural and Environmental Medicine
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Informacja

Wyszukujesz frazę "lymphangiogenesis" wg kryterium: Wszystkie pola

Źródło danych

Dostawca treści

Kolekcja

Rok wydania

Wydawca

Temat

Autor

Typ dokumentu

Język