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Wyszukujesz frazę "low doses" wg kryterium: Wszystkie pola


Tytuł:
Damage Assessment in Low Doses $\text{}^{30}Si^{+}$-Implanted GaAs
Autorzy:
Desnica Franković, D.
Desnica, V.
Furić, K.
Powiązania:
https://bibliotekanauki.pl/articles/1807802.pdf
Data publikacji:
2009-07
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
78.30.Ly
61.72.Vv
63.50.+x
Opis:
Ion implantation is a widely used technique in device technology, and becoming even more important as the size of devices decreases. The studies of damage and introduced defects have been extensive and, although the overall development and annealing of the implantation damage is relatively well understood, many details remain unclear. Especially, not enough attention has been paid to the effects of very low doses, which are particularly important in controlling the threshold voltage of transistors in the fabrication of GaAs integrated circuits. The reason might be that the induced changes were very often below the detectivity limits of standard methods. In this work, we present the disorder analysis, conducted on GaAs implanted with low ion doses. Czochralski grown, undoped, (100) oriented GaAs samples were implanted with 100 keV $\text{}^{30}Si^{+}$ ions, doses ranging from 3×$10^{11}//cm^{2}$-3×$10^{13}//cm^{2}$, at 21°C. The damage assessment was done by applying Raman scattering and Rutherford backscattering ion channeling (RBS), linked by the inter-cascade distance model and the results were then compared with the results of photoacoustic displacement technique. We have shown that Raman scattering is very sensitive method even if applied on samples implanted with very low doses. Furthermore, the equivalency between the Raman scattering and Rutherford backscattering damage assessment, previously established for high doses via the inter-cascade distance model, proved equally valid also for very low implantation doses, where implanted ions create disordered cascades that are far apart, and most of the layer is still undamaged.
Źródło:
Acta Physica Polonica A; 2009, 116, 1; 42-46
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of ionizing radiation low doses on early stages of odontogenesis
Autorzy:
Cheshko, N. N.
Berlov, H. A.
Pohodenko-Chudakova, I. O.
Powiązania:
https://bibliotekanauki.pl/articles/285617.pdf
Data publikacji:
2008
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
odontogenesis
ionizing radiation low doses
tooth germ
Źródło:
Engineering of Biomaterials; 2008, 11, no. 77-80; 7-8
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Experimental assessment of ionizing radiation low doses impact on teeth development
Autorzy:
Cheshko, N. N.
Berlov, H. A.
Pohodenko-Chudakova, I. O.
Powiązania:
https://bibliotekanauki.pl/articles/285397.pdf
Data publikacji:
2009
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
ionizing radiation
teeth development
laboratory experiment
Źródło:
Engineering of Biomaterials; 2009, 12, no. 89-91; 8-9
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The cancer risk among workers of the nuclear centre at Świerk, Poland
Autorzy:
Fornalski, K.W.
Dobrzyński, L.
Powiązania:
https://bibliotekanauki.pl/articles/148146.pdf
Data publikacji:
2013
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
nuclear workers
low doses
radiation influence
Świerk
Polska
Opis:
Dosimetric information concerning 4606 workers at the nuclear centre at Świerk (Poland) from 1956 to 2001 and medical records of 575 workers are reviewed. The average cumulative doses per person were 34 mSv (effective dose) and 18 mSv (equivalent dose to hands). The calculated odds ratio of cancers, OR = 0.90 (0.62–1.18; 68% CI), shows a statistically insignificant decrease of the cancer risk among the irradiated workers. No cancer cases were detected neither among 52 people exposed to the highest cumulative doses (from 35 to 653 mSv) nor among 43 workers who had been chronically irradiated for a long time (from 13 to 26 years).
Źródło:
Nukleonika; 2013, 58, 4; 537-542
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of low doses of gamma rays on the stability of normal and diabetic erythrocytes
Autorzy:
Kaczmarska, Magdalena
Kopyściańska, Zofia
Fornal, Maria
Grodzicki, Tomasz
Matlak, Krzysztof
Korecki, Józef
Burda, Květoslava
Powiązania:
https://bibliotekanauki.pl/articles/1039830.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
γ rays
diabetes
absorption spectroscopy
Mössbauer spectroscopy
hemoglobin
erythrocytes
hemolysis
Opis:
We studied the influence of low doses of γ radiation (from 0.04 to 1.8 mGy) on the stability of human red blood cells (RBC) from healthy donors and diabetic patients using absorption spectroscopy. Because of the alteration of many enzymatic pathways in diabetic RBCs resulting in strong modification of the lipid and protein membrane components one could expect that the ionizing γ-radiation should influence the stability of the healthy and diabetic cells in a different way. Indeed, distinct discontinuities and monotonic changes of hemolysis detected in the healthy and diabetic RBCs suggest that various enzymatic and chemical processes are activated in these membranes by γ radiation. Mössbauer measurements showed that only the highest applied dose of γ radiation caused modification of hemoglobin in both types of RBCs.
Źródło:
Acta Biochimica Polonica; 2011, 58, 4; 489-496
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nuclear magnetic resonance spectroscopy reveals metabolic changes in living cardiomyocytes after low doses of ionizing radiation
Autorzy:
Gramatyka, Michalina
Skorupa, Agnieszka
Sokół, Maria
Powiązania:
https://bibliotekanauki.pl/articles/1038408.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
ionizing radiation
metabolomics
HR MAS NMR
cardiotoxicity
Opis:
Several lines of evidence indicate that exposure of heart to ionizing radiation increases the risk of cardiotoxicity manifested by heart dysfunction and cardiovascular diseases. It was initially believed that the heart is an organ relatively resistant to radiation. Currently, however, it is suspected that even low doses of radiation (< 2 Gy) may have a negative impact on the cardiovascular system. Cardiotoxicity of ionizing radiation is associated with metabolic changes observed in cardiac cells injured by radiation. In this study, we used human cardiomyocytes as a model system, and studied their metabolic response to radiation using high-resolution magic angle spinning nuclear magnetic resonance techniques (HR-MAS NMR). Human cardiomyocytes cultured in vitro were exposed to ionizing radiation and their survival was assessed by clonogenic assay. Changes in apoptosis intensity and cell cycle distribution after the irradiation were measured as well. NMR spectra of cardiomyocytes were acquired using Bruker Avance 400 MHz spectrometer at a spinning rate of 3200 Hz. Survival of cardiomyocytes after NMR experiments was assessed by the Trypan blue exclusion assay. Exposure of cardiomyocytes to small doses of ionizing radiation had no effect on cell proliferation potential and intensity of cell death. However, analysis of metabolic profiles revealed changes in lipids, threonine, glycine, glycerophosphocholine, choline, valine, isoleucine, glutamate, reduced glutathione and taurine metabolism. The results of this study showed that ionizing radiation affects metabolic profiles of cardiomyocytes even at low doses, which potentially have no effect on cell viability.
Źródło:
Acta Biochimica Polonica; 2018, 65, 2; 309-318
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stimulatory effects of single low-level irradiations with X-rays on functions of murine peritoneal macrophages
Autorzy:
Cheda, A.
Wrembel-Wargocka, J.
Nowosielska, E.
Janiak, M.
Powiązania:
https://bibliotekanauki.pl/articles/147798.pdf
Data publikacji:
2005
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
low doses
X-rays
macrophages
nitric oxide
cytotoxicity
TNF-alfa
Opis:
A number of epidemiological and experimental data indicate that exposures to low doses of low-LET ionising radiation may trigger the activity of natural anti-tumour immune mechanisms and inhibit tumour growth. In the present study, we assessed the cytotoxic activity and production of nitric oxide, superoxide anions, and tumour necrosis factor-alfa in peritoneal macrophages collected from BALB/c mice exposed to single whole-body irradiations with 0.1, 0.2, or 1.0 Gy X-rays. The results indicate that all the tested parameters were significantly up-regulated in macrophages obtained from mice exposed to 0.1 or 0.2 Gy X-rays but not in those collected from the sham-irradiated and 1.0 Gy-exposed animals.
Źródło:
Nukleonika; 2005, 50,suppl.2; 13-16
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Low doses of fenofibrate and bezafibrate stimulate renal 2-oxoglutarate dehydrogenase (2-OGDH) in protein-restricted rats
Autorzy:
Knapik-Czajka, Malgorzata E.
Drag, Jagoda M.
Gawedzka, Anna
Powiązania:
https://bibliotekanauki.pl/articles/895613.pdf
Data publikacji:
2020-04-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
2-oxoglutarate dehydrogenase
Fenofibrate
Bezafibrate
kidney
Opis:
2-oxoglutarate dehydrogenase (2-OGDH) is the key regulatory enzyme of cell metabolism. It has been previously demonstrated that in rats subjected to protein restriction low, clinically relevant doses of fibrates up-regulate liver 2-OGDH and promote 2-oxoglutarate catabolism. The aim of the present study was to evaluate the effect of low doses of fenofibrate and bezafibrate on renal 2-OGDH complex in rats fed low-protein chow. Fibrates were administrated for 14 days to Wistar male rats at one daily doses of 5, 10 and 20 mg/kg b.wt./day. The 2-OGDH activity was assayed spectrophotometrically. The mRNA levels for 2-OGDH catalytic subunits (E1 and E2) and PPARα were quantified by means of semi-quantitative reverse-transcription-PCR. 2-OGDH activity increased in response to administration of fenofibrate and bezafibrate (by 11, 24, 32% and 9, 12, 21%, respectively). The difference was statistically significant for the doses of 10 and 20 mg/kg b.wt of fenofibrate (p<0.001) and the highest dose of bezafibrate (p<0.05). Stimulation of 2-OGDH was not accompanied by changes in mRNA levels for E1 and E2. In addition, mRNA level for PPARα did not change. It is conceivable that fibrate-induced stimulation of 2-OGDH activity can affect renal metabolism and contribute to changes in kidney functions.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 281-288
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Measurements of doses from photon beam irradiation and scattered neutrons in an anthropomorphic phantom model of prostate cancer: a comparison between 3DCRT, IMRT and tomotherapy
Autorzy:
Kowalik, A.
Jackowiak, W.
Malicki, J.
Skórska, M.
Adamczyk, M.
Konstanty, E.
Piotrowski, T.
Polaczek-Grelik, K.
Powiązania:
https://bibliotekanauki.pl/articles/146348.pdf
Data publikacji:
2017
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
3DCRT
IMRT
low doses
neutron doses
thermoluminescent detectors (TLD)
tomotherapy
Opis:
The rapid development of new radiotherapy technologies, such as intensity modulated radiotherapy (IMRT) or tomotherapy, has resulted in the capacity to deliver a more homogenous dose in the target. However, the higher doses associated with these techniques are a reason for concern because they may increase the dose outside the target. In the present study, we compared 3DCRT, IMRT and tomotherapy to assess the doses to organs at risk (OARs) resulting from photon beam irradiation and scattered neutrons. Material and methods. The doses to OARs outside the target were measured in an anthropomorphic Alderson phantom using thermoluminescence detectors (TLD 100) 6Li (7.5%) and 7Li (92.5%). The neutron fluence rate [cm–2·s–1] at chosen points inside the phantom was measured with gold foils (0.5 cm diameter, mean surface density of 0.108 g/cm3). Results. The doses [Gy] delivered to the OARs for 3DCRT, IMRT and tomotherapy respectively, were as follows: thyroid gland (0.62 ± 0.001 vs. 2.88 ± 0.004 vs. 0.58 ± 0.003); lung (0.99 ± 0.003 vs. 4.78 ± 0.006 vs. 0.67 ± 0.003); bladder (80.61 ± 0.054 vs. 53.75 ± 0.070 vs. 34.71 ± 0.059); and testes (4.38 ± 0.017 vs. 6.48 ± 0.013 vs. 4.39 ± 0.020). The neutron dose from 20 MV X-ray beam accounted for 0.5% of the therapeutic dose prescribed in the PTV. The further from the field edge the higher the contribution of this secondary radiation dose (from 8% to ~45%). Conclusion. For tomotherapy, all OARs outside the therapeutic field are well-spared. In contrast, IMRT achieved better sparing than 3DCRT only in the bladder. The photoneutron dose from the use of high-energy X-ray beam constituted a notable portion (0.5%) of the therapeutic dose prescribed to the PTV.
Źródło:
Nukleonika; 2017, 62, 1; 29-35
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effects of experimental administration of low doses of zearalenone on the histology of ovaries in pre-pubertal bitches
Autorzy:
Gajęcka, M.
Powiązania:
https://bibliotekanauki.pl/articles/2087998.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
The experiment involved 30 clinically healthy Beagle bitches aged approximately 70 days with an initial body weight of approximately 8 kg. The animals were randomly divided into two experimental groups (EI and EII) and a control group of 10 animals each. Group EI was administered 50 μg of body weight zearalenone/kg per os for 42 days, group EII received 75 μg of body weight zearalenone/kg per os for 42 days, and the control group was administered placebo per os for 42 days. The bitches were ovariectomized at the end of the treatment period for anatomopathological examination. At the same time, peripheral blood samples were collected for endocrinological analyses (17β-estradiol and progesterone). Administartion of zearalenone particularly higher doses, resulted in the hyperestrogenism degeneration and atrophy of ovarian cells and tissues with accompanying edema and blood extravasation, leading to increased 17β-estradiol concentrations and an insignificant decrease in progesterone levels.
Źródło:
Polish Journal of Veterinary Sciences; 2013, 16, 2
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Structural disorder of tooth germs in the antenatal period under low doses ionizing radiation exposure in acute experiment
Autorzy:
Cheshko, N. N.
Berlov, H. A.
Pohodenko-Chudakova, I. O.
Gontchar, F. L.
Powiązania:
https://bibliotekanauki.pl/articles/285679.pdf
Data publikacji:
2010
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
ionizing radiation
dental system
radiation therapy
Źródło:
Engineering of Biomaterials; 2010, 13, no. 99-101; 9-10
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of repeated low doses of GnRH analogue (buserelin) on fertility performance of dairy cows with anovulation type I
Autorzy:
Barański, W.
Nowicki, A.
Zduńczyk, S.
Polak, Z.
Powiązania:
https://bibliotekanauki.pl/articles/16647577.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
anovulation type I
cows
fertility
repeated doses of GnRH
Opis:
The aim of this study was to evaluate the fertility response of dairy cows with anovulation type I on repeated low doses of GnRH agonist buserelin. The study was conducted on 83 anovulatory and 60 cyclic Polish Holstein Friesian cows. Anovulation type I was defined as small ovaries with follicles of ≤ 5 mm in diameter and without corpus luteum on two examinations in a 7-10 day interval between 50–60 days after parturition. Cows from the experimental group (n=58) received 0.4 μg of buserelin i.m. once a day for 5 consecutive days. Cows from the negative control group (n = 25) received saline. Sixty cyclic cows receiving no treatment served as positive controls. Intervals from calving to estrus and from calving to conception, pregnancy rate 30-35 days and 260 days after AI, and pregnancy loss were calculated. The anovulatory cows had a substantially prolonged calving to conception interval, decreased pregnancy rate and increased pregnancy loss and culling rate compared to cyclic herd mates. The average calving to conception interval was significantly (p<0.05) shorter in treated cows compared to non-treated anovulatory cows (153.7 days vs 209.3 days). In conclusion, repeated low doses of GnRH analogue buserelin led to a significant shortening of calving to conception interval. More clinical trials are needed to determine the practical usefulness of this method for the treatment of anovulation type I in dairy cows.
Źródło:
Polish Journal of Veterinary Sciences; 2023, 26, 2; 223-229
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ małych dawek promieni X na rozkruszka mącznego (tyroglyphus farinae)
Effects of low doses X-ray radiation on tryloglyphus farinae
Autorzy:
Szyszko, E.
Jaworski, J.
Młodecki, H.
Broszkiewicz, R.
Powiązania:
https://bibliotekanauki.pl/articles/877040.pdf
Data publikacji:
1961
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Źródło:
Roczniki Państwowego Zakładu Higieny; 1961, 12, 6
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Occupational exposure to ionizing radiation and lens opacity in interventional cardiologists
Autorzy:
Domienik-Andrzejewska, Joanna
Kałużny, Paweł
Piernik, Gabriela
Jurewicz, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/2161953.pdf
Data publikacji:
2019-10-16
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
occupational exposure
ionizing radiation
cataract
low doses
cumulative eye lens doses
interventional cardiologists
Opis:
Objectives Interventional cardiologists (ICs) are occupationally exposed to low or moderate doses of ionizing radiation from repeated exposures. It is not clear whether these occupational conditions may affect their eye lens. Therefore, the risk of radiation-induced cataract in the cohort of Polish interventional cardiologists is analyzed in this paper. Material and Methods The study group consisted of 69 interventional cardiologists and 78 control individuals occupationally unexposed to ionizing radiation. The eye lens opacities were examined using a slit camera and evaluated with Lens Opacities Grading System III. Cumulative eye lens doses were estimated retrospectively using a questionnaire including data on occupational history. Results The average cumulative dose to the left and right eye lens of the ICs was 224 mSv and 85 mSv, respectively. Nuclear opalescence and nuclear color opacities in the most exposed left eye were found in 38% of the ICS for both types, and in 47% and 42% of the controls, respectively. Cortical opacities were found in 25% of the ICS and 29% of the controls. Posterior subcapsular opacities were rare: about 7% in the ICs group and 6% in the control group. Overall, there was some, but statistically insignificant, increase in the risk for opacity in the ICs group, relative to the control group, after adjusting for the subjects’ age, gender, smoking status and medical exposure (adjusted OR = 1.47, 95% CI: 0.62–3.59 for the pooled “any-eye any-type” opacity). There was also no evidence for an increased opacity risk with an increase in the dose. Conclusions The study found no statistically significant evidence against the hypothesis that the risk of cataract in the group of the ICs occupationally exposed to low doses of ionizing radiation is the same as in the control group. Nevertheless, the adverse effect of ionizing radiation still cannot be excluded due to a relatively small study sample size. Int J Occup Med Environ Health. 2019;32(5):663–75
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2019, 32, 5; 663-675
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative study on the efficiency of peracetic acid and chlorine dioxide at low doses in the disinfection of urban wastewaters
Autorzy:
De, Luca G
Sacchetti, R.
Zanetti, F.
Leoni, E.
Powiązania:
https://bibliotekanauki.pl/articles/51934.pdf
Data publikacji:
2008
Wydawca:
Instytut Medycyny Wsi
Tematy:
chlorine dioxide
disinfection
waste water treatment plant
urban waste water
irrigation
low dose
waste water treatment
paracetic acid
Źródło:
Annals of Agricultural and Environmental Medicine; 2008, 15, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Low-level exposures to ionising radiation modulate the anti-tumour activity of murine NK cells
Autorzy:
Nowosielska, E.
Wrembel-Wargocka, J.
Cheda, A.
Lisiak, E.
Janiak, M.
Powiązania:
https://bibliotekanauki.pl/articles/147802.pdf
Data publikacji:
2005
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
low doses
X-rays
NK cells
cytotoxicity
anti-asialo GM1 antibody
FasL
Opis:
Experimental evidence from the recent years indicates that low-level irradiations with X- or gamma rays may inhibit development of both primary and secondary tumours and stimulate the activity of natural anti-tumour immune mechanisms. Natural killer (NK) cells play an important role in anti-tumour defence of the host. In the present investigation cytotoxic activity, production of interferon-ă, and expression of the Fas ligand (FasL) were estimated in the NK splenocytes collected from BALB/c mice whose whole body was pre-exposed to irradiation with 0.1, 0.2, or 1.0 Gy X-rays. The results indicate that cytotoxic activity of the irradiated NK cells was significantly stimulated compared to that of the NK effectors obtained from the sham-exposed mice. This effect was totally abrogated by injection of the anti-asialo GM1 antibody. In addition, compared to the control mice, NK cells obtained from the irradiated animals exhibited reduced surface expression of FasL. Collectively, the obtained results suggest that the inhibitory effect of the low-level irradiations with X-rays on the development of pulmonary tumour nodules may be directly associated with stimulation by such exposures of anti-neoplastic functions mediated by NK cells.
Źródło:
Nukleonika; 2005, 50,suppl.2; 21-24
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of repeated low doses of GnRH on follicular development and ovulation in anovulatory dairy cows with follicle growth to emergence size
Autorzy:
Barański, W.
Nowicki, A.
Zduńczyk, S.
Tobolski, D.
Powiązania:
https://bibliotekanauki.pl/articles/16539311.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
cows
anovulation
repeated doses of GnRH
ovulation
Opis:
The aim of the study was to evaluate the effect of repeated low doses of GnRH agonist buserelin once a day for 5 days on follicle development and ovulation in anovulatory dairy cows with follicles growth only to emergence. The study was conducted on 71 anovulatory Polish Holstein Friesian cows. Anovulation with growth of follicles to emergence was defined as small ovaries with follicles of ≤ 5 mm in diameter and without corpus luteum on two examinations in a 7-10 day interval between 50-60 days after parturition. Cows were allocated to one of two group. Cows from group 1 (n = 58) received 0.4 μg of buserelin (Receptal, MSD, Poland) i.m. once a day for 5 days. Control cows from group 2 (n = 13) received saline. Ovarian structures were monitored weekly after the end of treatment by ultrasound for 4 weeks. The diameter of ovarian follicles on the ovaries was measured and recorded. Occurrence of ovulation was determined by the presence of corpus luteum. Overall, ovulation occurred in 46.6% (27/58) of cows treated with repeated doses of GnRH, while no corpus luteum was observed in the control group during the study period. There were significantly (p<0.05) more follicles 6-9 mm in diameter and 10-20 mm in diameter in cows treated with GnRH than in control cows. In conclusion, repeated low doses of GnRH analogue buserelin once a day for 5 days stimulate the development of ovarian follicles in anovulatory dairy cows with small ovarian follicles and led to ovulation in 46.6% of cows during 4 weeks after the end of the treatment.
Źródło:
Polish Journal of Veterinary Sciences; 2022, 25, 3; 391-396
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The low doses effect of experimental zearalenone (ZEN) intoxication on the presence of Ca2+ in selected ovarian cells from pre-pubertal bitches
Autorzy:
Gajecka, M.
Przybylska-Gornowicz, B.
Powiązania:
https://bibliotekanauki.pl/articles/31848.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
The objective of this study was to determine the effect of 42-day ZEN intoxication on the presence of Ca2+ in selected ovarian cells from beagle bitches, using the potassium pyroantimonate (PPA) method. Samples were collected from 30 clinically healthy, pre-pubertal, genetically homogeneous animals. The bitches were divided into three groups of 10 animals each: experimental group I - 50 μg ZEN/kg BW (100% NOAEL) administered once daily per os; experimental group II - 75 μg ZEN/kg BW (150% NOAEL) administered once daily per os; control group - placebo containing no ZEN administered per os. An electron microscopic analysis revealed that cells died due to apoptosis, depending on the ZEN dose and the type of cells exposed to intoxication. Lower ZEN doses led to apoptosis-like changes in the cells. Cell death was a consequence of excess Ca2+ accumulation in the mitochondria, followed by cell dysfunction and a decrease in or the absence of mitochondrial metabolic activity in oocytes, follicle cells and interstitial cells in experimental bitches.
Źródło:
Polish Journal of Veterinary Sciences; 2012, 15, 4
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression of cellular isoform of prion protein on the surface of peripheral blood lymphocytes among women exposed to low doses of ionizing radiation
Autorzy:
Klucinski, P
Mazur, B.
Hrycek, A.
Masluch, E.
Cieslik, P.
Kaufman, J.
Martirosian, G.
Powiązania:
https://bibliotekanauki.pl/articles/50336.pdf
Data publikacji:
2007
Wydawca:
Instytut Medycyny Wsi
Tematy:
blood lymphocyte
ionizing radiation
low dose
lymphocyte
cellular isoform
woman
radiation exposure
expression
prion protein
Opis:
Ionizing radiation affects the expression of adhesive and co-stimulatory molecules in lymphocytes. The physiological function of cellular isoform of prion protein (PrPc) is little known. Evidences indicate a link between lymphocytes activation and PrPc expression on their surface; however, no direct effect of radiation on PrPc level in these cells was investigated. The objective of this study was to determinate the effect of low doses of ionizing radiation on the expression of PrPc on the surface peripheral blood lymphocytes in the women operating X-ray equipment. In 36 female workers and 30 persons of the control group the PrPc expression on CD3 (T lymphocytes), CD4 (T helper), CD8 (T cytotoxic) and CD19 (B lymphocytes), as well as the percentage of lymphocytes with PrPc on their surface, were tested. Subgroups with respect to age and length of employment were selected. A signifi cant increase was observed in PrPc expression on CD3 and CD4 with lowered PrPc level on CD8 and percentage of CD8 cells with PrPc in workers compared to control. The PrPc level did not show signifi cant changes in subgroups in relation to age (below and over 40 years old) both in the investigated and control groups, whereas a lower percentage of PrPc expressing CD19 cells showed in employed women below 40 years of age. A signifi cant decrease was found in PrPc expression on the surface of CD3, CD4 and CD8 cells in the subgroup employed for over 10 years than in the subgroup with less than 10 years of employment.
Źródło:
Annals of Agricultural and Environmental Medicine; 2007, 14, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunohistochemical evaluation of apoptosis and proliferation in the mucous membrane of selected uterine regions in pre - pubertal bitches exposed to low doses of zearalenone
Autorzy:
Stopa, E.
Babinska, I.
Zielonka, L.
Gajecki, M.
Gajecka, M.
Powiązania:
https://bibliotekanauki.pl/articles/30158.pdf
Data publikacji:
2016
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
Mycotoxins are toxic secondary metabolites produced by fungi. Those biologically active compounds occur naturally and they include zearalenone (ZEN), a mycotoxin that contaminates plant material, including the ingredients used in the production of commercial dog food. The influence of monotonic, low-dose and long-term exposure to ZEN on pre-pubertal bitches has not been fully explored to date. This paper describes a 42-day experiment performed on clinically healthy female dogs aged approximately 70 days, with estimated body weight of 8 kg. The animals were randomly divided into two experimental groups (EI and EII) and a control group (C) of 10 animals each. Group EI received 50 μg ZEN/kg (of body weight) per os, group EII received 75 μg ZEN/kg BW per os, and the control group was administered placebo. The bitches were ovariohysterectomized at the end of the experiment (at around 112 days of age), and selected sections of the uterine wall were subjected to immunohistochemical analyses (TUNEL and PCNA). A shift towards higher apoptotic (AI) and proliferative index (PI) was observed, in particular in group EI. Higher AI and PI values were noted in the epithelium of all uterine regions analysed and in the uterine glands in the uterine horn proximal to the body of the uterus.
Źródło:
Polish Journal of Veterinary Sciences; 2016, 19, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zgony wewnątrzmaciczne u niewsobnych myszy napromienionych w rożnym wieku małymi dawkami promieniowania X
Intra-uterine death in outbred strain of mice irradiated with low-doses of x-radiation at different ages
Autorzy:
Gajewski, A.K.
Slowikowska, M.G.
Powiązania:
https://bibliotekanauki.pl/articles/871963.pdf
Data publikacji:
1977
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
promieniowanie
myszy
zgony
zgony wewnatrzmaciczne
wzrost
wiek zwierzat
poronienia
Źródło:
Roczniki Państwowego Zakładu Higieny; 1977, 28, 4
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ przewlekłego stosowania małych ilości Tritoxu-30 w wodzie do picia na wątrobę szczura
Effect of long-term administration of low doses of Tritox-30 in drinking water on rat liver
Autorzy:
Wojcik, J.
Suwala, Z.
Beskid, M.
Powiązania:
https://bibliotekanauki.pl/articles/873608.pdf
Data publikacji:
1974
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
Tritox-30
szczury
zwierzeta doswiadczalne
woda pitna
watroba
zmiany morfologiczne
miazsz
Źródło:
Roczniki Państwowego Zakładu Higieny; 1974, 25, 6
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Safety of nuclear power
Autorzy:
Strupczewski, A.
Powiązania:
https://bibliotekanauki.pl/articles/147940.pdf
Data publikacji:
2005
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
low radiation doses
LNT
hormesis
epidemiological studies
biological defense mechanism
Chernobyl effects
Opis:
The main questions related to nuclear power development concern effects of small radiation doses typical for the operation of nuclear power plants (NPPs) and hazards of NPP accidents. The last decade has brought many results of large scale epidemiological studies indicating that there are no detrimental effects of low radiation doses. On the contrary, many results indicate that among the people receiving increased radiation doses the frequency of cancer mortality is reduced. The review shows that such results are obtained in the studies of people living in high background radiation areas, of workers exposed to ionizing radiation and of patients exposed to radiation for diagnostic purposes. The latest studies in molecular biology suggest an explanation for possible beneficial effects of low radiation doses. This is reflected in the statements of several scientific bodies and international organizations, although the official regulations remain unchanged. The other important issue is the safety of NPPs in case of accidents. Reasons for the Chernobyl accident are shown not to be applicable to the reactors planned for Poland and the effects of Chernobyl are shown to be much smaller than feared in original estimates after the accident. Polish NPPs will satisfy the requirements of EU utilities and will provide safety for the population even in case of hypothetical severe accidents. Nevertheless, discussion with antinuclear organizations must be expected, although the recent examples of changing attitudes of leading ecological authorities show that nuclear power is gaining recognition as a clean and environmentally friendly source of energy.
Źródło:
Nukleonika; 2005, 50,suppl.3; 59-66
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of Low Doses of Ionizing Radiation on Young and Two Week old Invasive Larvae of Entomopathogenic Nematodes (Heterorhabditidae, Steinernematidae)
Wpływ niskich dawek promieniowania jonizującego na młode oraz dwutygodniowe larwy nicieni entomopatogennych (Heterorhabditidae, Steinernematidae)
Autorzy:
Poleszczuk, O.
Tumialis, D.
Pezowicz, E.
Powiązania:
https://bibliotekanauki.pl/articles/389389.pdf
Data publikacji:
2011
Wydawca:
Towarzystwo Chemii i Inżynierii Ekologicznej
Tematy:
nicienie entomopatogeniczne
Steinernema feltiae
promieniowanie jonizujące
ionizing radiation
entomopathogenic nematodes
Opis:
The performed experiments were aimed at checking the effect of ionising radiation as an abiotic factor on the bionomics of young and two week old larvae of Steinernema feltiae and Heterorhabditis megidis. Features associated with nematode pathogenicity (intensity of infection) and morphometry (length and width of individuals of the giant generation) were analysed. Three doses of ionising radiation (0.1, 0.05, and 0.01 kGy) were applied. The obtained results indicate the modifying effect of ionising radiation on each of the studied features of entomopathogenic nematodes.
Przeprowadzone doświadczenie miało na celu sprawdzenie wpływu promieniowania jonizującego, jako czynnika abiotycznego, na bionomię młodych oraz dwutygodniowych larw inwazyjno-przetrwalnikowych Steinernema feltiae oraz Heterorhabditis megidis. Badano cechy związane z patogenicznooecią nicieni (intensywność zarażenia) oraz morfometrią (długość oraz szerokość osobników pokolenia olbrzymiego). Zastosowano trzy dawki promieniowania jonizujacego: 0,1; 0,05; 0,01 kGy. Otrzymane wyniki wskazują na modyfikujący charakter promieniowania jonizującego u każdej z badanych cech nicieni entomopatogenicznych.
Źródło:
Ecological Chemistry and Engineering. A; 2011, 18, 3; 407-411
1898-6188
2084-4530
Pojawia się w:
Ecological Chemistry and Engineering. A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ocena wpływu małych dawek – nieterapeutycznych – na czynność bioelektryczną mózgu u pacjentów napromienianych w rejonie głowy i szyi. Doniesienie wstępne
Evaluation of the effect of small non-therapeutic doses on brain bioelectrical activity of patients irradiated in the region of head and neck
Autorzy:
Łukowiak, M.
Jezierska, K.
Podraza, H.
Podraza, W.
Lewocki, M.
Powiązania:
https://bibliotekanauki.pl/articles/261431.pdf
Data publikacji:
2015
Wydawca:
Politechnika Wrocławska. Wydział Podstawowych Problemów Techniki. Katedra Inżynierii Biomedycznej
Tematy:
radiobiologia
radioterapia
małe dawki promieniowania
elektroencefalografia
planowanie leczenia
radiobiology
radiotherapy
low radiation doses
electroencephalography
treatment planning
Opis:
W ostatnich latach radiobiolodzy we współpracy z fizykami medycznymi i radioterapeutami próbują oszacować toksyczność małych dawek promieniowania jonizującego na zdrowe tkanki znajdujące się w sąsiedztwie obszarów eksponowanych na wysokie dawki terapeutyczne. Poniższa praca jest próbą oszacowania wpływu małych dawek, w zakresie od 50 do 1000 cGy, na obszar mózgowia u pacjentów poddawanych radioterapii w obszarze głowy i szyi, na podstawie zapisu czynności bioelektrycznej mózgu zarejestrowanego przed i po leczeniu. W badaniu analizowane są dwa schematy napromieniania pacjentów techniką IMRT (ang. Intensity-Modulated Radiation Therapy), różniące się liczbą wiązek terapeutycznych oraz kątami ich wejścia.
In the last years, radiobiologists together with medical physicists and radiotherapeutists try to estimate the toxicity of low doses ionizing radiation on healthy tissue located near the regions exposed to high therapeutic doses. This work presents an attempt to examine the low doses ionizing radiation in range of 50 to 1000 cGy brain tissue in patients irradiated in head and neck region by exploiting the bioelectric brain signals registered before and after the treatment. Two modes of Intensity-Modulated Radiation Therapy (IMRT) irradiation, with various numbers of therapeutic beams and input angles, were analysed.
Źródło:
Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna; 2015, 21, 1; 16-23
1234-5563
Pojawia się w:
Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna
Dostawca treści:
Biblioteka Nauki
Artykuł

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