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Wyszukujesz frazę "lipophilic fraction" wg kryterium: Wszystkie pola


Wyświetlanie 1-2 z 2
Tytuł:
Analysis of lipophilic fraction from leaves, inflorescences and rhizomes of Silphium perfoliatum L.
Autorzy:
Kowalski, R
Powiązania:
https://bibliotekanauki.pl/articles/59206.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Botaniczne
Tematy:
Compositae
rhizome
inflorescence
qualitative analysis
quantitative analysis
sesquiterpene
lipophilic fraction
leaf
Silphium perfoliatum
chromatographic analysis
Silphium
Opis:
This paper presents a qualitative and quantitative chromatographic analysis (GC/MS) of the lipophilic fraction extracted from leaves, inflorescences and rhizomes of Silphium perfoliatum L. collected in 1998-2000. It was shown that the extracts of leaves and inflorescences are similar in composition, containing among their main constituents: α-amyrine (up to 13.9% of total components in leaves, up to 11.3% in inflorescences), heptacosane (up to 7.1% in leaves, up to 7.6% in inflorescences), stigmasterol (up to 8.1% in leaves, up to 2.2% in inflorescences), γ-sitosterol (up to 6.9% in leaves, up to 2.2% in inflorescences), β-amyrine (up to 4.1% in leaves, up to 5.8% in inflorescences), β-caryophyllene (up to 2.6% in leaves, up to 1.5% in inflorescences), caryophyllene oxide (up to 4.4% in leaves, up to 2.9% in inflorescences), germacrene D (up to 13.8% in leaves, up to 9.7% in inflorescences) and α-pinene (up to 3.3% in leaves, up to 2.4% in inflorescences). The chemical composition of lipophilic extract of rhizomes significantly differs from that of leaves and inflorescences. The following compounds can be counted among the dominant ones occurring in rhizome extracts: diterpene of labdane type - 16-acetoxycarterochaetol (up to 45%) and sesquiterpenes - 7-b-H-silphiperfol-5-ene (up to 9.1%), 7-a-H-silphiperfol-5-ene (up to 10.7%), d-elemene (up to 7.6%), isocomene (up to 5.6%), germacrene D (up to 5.2%) and modhephene (up to 5.1%).
Źródło:
Acta Societatis Botanicorum Poloniae; 2005, 74, 1
0001-6977
2083-9480
Pojawia się w:
Acta Societatis Botanicorum Poloniae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Surface-active agents from the group of polyoxyethylated glycerol esters of fatty acids. Part IV. Equilibrium micellar solubilization of selected lipophilic therapeutic agents (BCS class II and III) in aqueous solutions of products of catalytic oxyethylation of triglyceride fractions extracted from pharmacopoeial lard (Adeps suillus PP XI) of nTE≥50
Autorzy:
Marczyński, Zbigniew
Kołodziejczyk, Michał K.
Nachajski, Michał J.
Zgoda, Marian M.
Powiązania:
https://bibliotekanauki.pl/articles/895709.pdf
Data publikacji:
2019-08-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
valsartan
gemfibrozil
micellar solubilization
products of triglyceride fraction ethoxylation
loratadine
Opis:
Summary: Preformulation studies were carried out to estimate the solubilization capacity of products of catalytic oxyethylation of triglyceride fractions extracted from the pharmacopoeial lard (Adeps suillus, PP XI). There were determined basic viscosity ([ɳ], Mɳ) and hydrodynamic (Ro, Robs., Ω) values of micellar solutions of oxyethylated derivatives as well as their surface activity - . Critical micellar concentration (cmc) was used to calculate the thermopotential for the formation of micelles (∆ ). Model studies on micellar solubilization of gemfibrozil, loratadine and valsartan from the solid body surface (phase boundary) were performed under equilibrium conditions at the surfactant concentration of cexp>>cmc. The amount of dissolved lipophilic therapeutic agents with qualitative and quantitative involvement of micellar solubilization was determined by spectrophotometric (UV) method - cǀsǀ (mg/100mL) as well as by calculating the solubilization indices - n|s| (mol / mol). The research study has identified structures of oxyethylated derivatives of triglyceride fractions which selectively and effectively solubilize gemfibrozil, loratadine and valsartan from the solid surface in the equilibrium system. The obtained results are a technological inspiration to create a model form of the drug (tablet) with continuous dispersion of lipophilic therapeutic agents (gemfibrozil, loratadine and valsartan), obtained on the basis of the liquefied surfactant structure. Key words: micellar solubilization, products of triglyceride fraction ethoxylation, gemfibrozil, loratadine, valsartan
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 4; 707-714
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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