Wszystkie pola: labile iron pool - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Association between body iron stores and level of oxidatively modified DNA bases
Autorzy:: Dziaman, T.
Jurgowiak, M.
Olinski, R.
Powiązania:: https://bibliotekanauki.pl/articles/80695.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: atherosclerosis
cancer
cardiovascular disease
cellular DNA
free radical damage
heterozygosity
iron deficiency anaemia
labile iron pool
oxidative damage
oxidative stress
reactive oxygen species
vascular disease
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2011, 92, 2
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Iron-sulfur cluster proteins: electron transfer and beyond
Autorzy:: Brzóska, Kamil
Męczyńska, Sylwia
Kruszewski, Marcin
Powiązania:: https://bibliotekanauki.pl/articles/1041158.pdf
Data publikacji:: 2006
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: IRP1 protein
labile iron pool
aconitase
DNA glycosylases
Opis:: Iron-sulfur clusters-containing proteins participate in many cellular processes, including crucial biological events like DNA synthesis and processing of dioxygen. In most iron-sulfur proteins, the clusters function as electron-transfer groups in mediating one-electron redox processes and as such they are integral components of respiratory and photosynthetic electron transfer chains and numerous redox enzymes involved in carbon, oxygen, hydrogen, sulfur and nitrogen metabolism. Recently, novel regulatory and enzymatic functions of these proteins have emerged. Iron-sulfur cluster proteins participate in the control of gene expression, oxygen/nitrogen sensing, control of labile iron pool and DNA damage recognition and repair. Their role in cellular response to oxidative stress and as a source of free iron ions is also discussed.
Źródło:: Acta Biochimica Polonica; 2006, 53, 4; 685-691
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: The role of labile iron pool in cardiovascular diseases.
Autorzy:: Kruszewski, Marcin
Powiązania:: https://bibliotekanauki.pl/articles/1043284.pdf
Data publikacji:: 2004
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: ischemia
atherosclerosis
reperfusion
reactive nitrogen species
reactive oxygen species
oxidative stress
Opis:: Although multiple factors are associated with cardiovascular pathology, there is now an impressive body of evidence that free radicals and nonradical oxidants might cause a number of cardiovascular dysfunctions. Both direct damage to cellular components and/or oxidation of extracellular biomolecules, e.g. LDL, might be involved in the aetiology of cardiovascular diseases. The key molecules in this process seem to be iron and copper ions that catalyse formation of the highly reactive hydroxyl radical. Chelation of iron ions has a beneficial effect on the processes associated with the development of atherosclerosis and formation of post-ischemic lesions. These findings are indirectly supported by the increasing body of evidence that stored body iron plays a crucial role in pathogenesis of atherosclerosis and ischemia/reperfusion injury.
Źródło:: Acta Biochimica Polonica; 2004, 51, 2; 471-480
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Labile iron pool correlates with iron content in the nucleus and the formation of oxidative DNA damage in mouse lymphoma L5178Y cell lines.
Autorzy:: Kruszewski, Marcin
Iwaneńko, Teresa
Powiązania:: https://bibliotekanauki.pl/articles/1043668.pdf
Data publikacji:: 2003
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: iron homeostasis
hydrogen peroxide
comet assay
Opis:: Labile iron pool (LIP) constitutes a crossroad of metabolic pathways of iron-containing compounds and is midway between the cellular need for iron, its uptake and storage. In this study we investigated oxidative DNA damage in relation to the labile iron pool in a pair of mouse lymphoma L5178Y (LY) sublines (LY-R and LY-S) differing in sensitivity to hydrogen peroxide. The LY-R cells, which are hydrogen peroxide-sensitive, contain 3 times more labile iron than the hydrogen peroxide-resistant LY-S cells. Using the comet assay, we compared total DNA breakage in the studied cell lines treated with hydrogen peroxide (25 μM for 30 min at 4°C). More DNA damage was found in LY-R cells than in LY-S cells. We also compared the levels of DNA lesions sensitive to specific DNA repair enzymes in both cell lines treated with H2O2. The levels of endonuclease III-sensitive sites and Fapy-DNA glycosylase-sensitive sites were found to be higher in LY-R cells than in LY-S cells. Our data suggest that the sensitivity of LY-R cells to H2O2 is partially caused by the higher yield of oxidative DNA damage, as compared to that in LY-S cells. The critical factor appears to be the availability of transition metal ions that take part in the OH radical-generating Fenton reaction (very likely in the form of LIP).
Źródło:: Acta Biochimica Polonica; 2003, 50, 1; 211-215
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Lymphocyte labile iron pool, plasma iron, transferrin saturation and ferritin levels in colon cancer patients.
Autorzy:: Gackowski, Daniel
Kruszewski, Marcin
Banaszkiewicz, Zbigniew
Jawien, Arkadiusz
Olinski, Ryszard
Powiązania:: https://bibliotekanauki.pl/articles/1043840.pdf
Data publikacji:: 2002
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: labile iron pool
iron metabolism
colon cancer
Opis:: Patients with colorectal carcinoma showed statistically significant lower values of transferrin saturation, total iron binding capacity and serum iron level as compared with control group, while the level of ferritin and the size of labile iron pool in carcinoma patients were higher, although this difference was not statistically significant. Our observations are in favour of the hypothesis which suggests that changes in iron metabolism restrict iron availability for tumour cells and as consequence, slow their growth.
Źródło:: Acta Biochimica Polonica; 2002, 49, 1; 269-273
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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