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Tytuł:
Pandemic Influenza Threat
Autorzy:
Kaudhry, Harish
Fangriya, Ruchita
Powiązania:
https://bibliotekanauki.pl/articles/1194041.pdf
Data publikacji:
2015
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
H5N1
human influenza
pandemic influenza
threat
Opis:
The threat of a human influenza pandemic has greatly increased over the past several years with the emergence of highly virulent avian influenza viruses, notably H5N1 viruses, which have infected humans in several Asian and European countries. Previous influenza pandemics have arrived with little or no warning, but the current widespread circulation of H5N1 viruses among avian populations and their potential for increased transmission to humans and other mammalian species may afford us an unprecedented opportunity to prepare for the next pandemic threat. The US Department of Health and Human Services is coordinating a national strategy to respond to an influenza pandemic that involves multiple agencies, including the Centers for Disease Control and Prevention, the Food and Drug Administration, and the National Institutes of Health (NIH). Within NIH, the National Institute of Allergy and Infectious Diseases (NIAID) conducts basic and clinical research to develop new vaccine technologies and antiviral drugs against influenza viruses. We describe recent research progress in preparing for pandemic influenza.
Źródło:
World Scientific News; 2015, 11; 80-96
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antivirals - current trends in fighting influenza
Autorzy:
Król, Ewelina
Rychłowska, Małgorzata
Szewczyk, Bogusław
Powiązania:
https://bibliotekanauki.pl/articles/1039254.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
influenza virus
antivirals
novel anti-influenza drugs
antiviral therapy
inhibitors
Opis:
Influenza virus infection is a major source of morbidity and mortality worldwide. Due to the variable effectiveness of existing vaccines, especially in the early stages of an epidemic, antiviral drugs represent the first line of defense against the virus. Currently, there are two major classes of anti-influenza drugs approved by the FDA for clinical use: M2 protein inhibitors (amantadine and rimantadine) and neuraminidase inhibitors (zanamivir and oseltamivir). However, increasing resistance to these available influenza antivirals among circulating influenza viruses highlights the need to develop alternative approaches for the prevention and/or treatment of influenza. This review presents an overview of currently available drugs for influenza treatment as well as summarizes some new antiviral strategies that are now being tested covering agents targeting both the viral proteins and the host-virus interaction. We discuss their mechanisms of action, resistance and the therapeutic potential as new antiviral drug for use in future influenza pandemics. Additionally, combination therapy based on these drugs is also described.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 495-504
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Upper respiratory tract infections and influenza-like illnesses among healthcare workers: are serological tests useful in monitoring influenza and influenza-like illness?
Autorzy:
Toczek-Kubicka, Katarzyna
Szenborn, Filip
Kuchar, Ernest P.
Szenborn, Leszek
Powiązania:
https://bibliotekanauki.pl/articles/2153866.pdf
Data publikacji:
2022-12-29
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
IgM antibodies
vaccination
humoral response
influenza
healthcare workers
influenza-like illness
Opis:
Background Healthcare workers (HCWs) are at high risk for exposure to upper respiratory tract infections (URTIs) and influenza-like illnesses (ILIs). The present study aimed to surveil URTIs and ILIs and their impact among the Department of Pediatric Infectious Diseases in Wroclaw employees and evaluate their humoral response to influenza. Material and Methods Thirty-six HCWs participated in the first season and 32 HCWs in the second season during years of the study. The authors carried out a URTI/ILI surveillance, and all HCWs were asked to complete a weekly report during 2 influenza seasons: 2016/2017 (S1) and 2017/2018 (S2). In S1 both IgG and IgM antibodies against influenza A and B were assessed. The HCWs with symptoms of ILI were encouraged to undergo PCR tests for influenza. Results No significant differences in reporting URTI were found among vaccinated and non-vaccinated HCWs and HCWs and the control group. Depending on the year 5.5–17.2% of HCWs were treated with antibiotics because of URTI. In the study 58.7% of participants in S1 and 66.7% in S2 decide to work despite the URTI symptoms. There was no statistical relationship between the concentration of anti-influenza IgG and the number of URTIs and ILIs reported. Only vaccinated were willing to undergo voluntary influenza testing. Conclusions The URTI and ILI occur commonly in HCWs, and HCWs contract URTIs as often as the control group. Despite their medical education, HCWs work with the symptoms of infection and overuse antibiotics to treat the URTI. Serology testing is not able to follow the infection’s dynamics or identify the people immune to the influenza-like illness. The diagnostic value of IgM antibodies in acute influenza infection is negligible. Vaccinated HCWs are more focused on their health and are more willing to undergo influenza tests.
Źródło:
Medycyna Pracy; 2022, 73, 6; 441-447
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influenza virus hemagglutinin as a vaccine antigen produced in bacteria
Autorzy:
Sączyńska, Violetta
Powiązania:
https://bibliotekanauki.pl/articles/1039263.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
recombinant influenza hemagglutinin
recombinant influenza vaccine
subunit influenza vaccine
bacterial hemagglutinin
prokaryotic protein production
Opis:
Recombinant subunit vaccines based on hemagglutinin proteins produced in bacteria (bacterial HAs) are promising candidates for enhancing the supply of vaccines against influenza, especially for a pandemic. Over 20 years after the failure to obtain the antigen with native HA characteristics in the early 1980’s, there are increasing data on successful production of HA proteins in bacteria. The vast majority of bacterial HAs have been based on the HA1 subunit of HA expressed separately or as a component of conjugate vaccines, but those based on the ectodomain and the HA2 subunit have also been reported. The most of HAs have been efficiently expressed as insoluble aggregates called inclusion bodies. Refolded and purified proteins were extensively studied for structure, the ability to bind to sialic acid-containing receptors, antigenicity, immunogenicity and efficacy. The results from these studies contradict the view that glycosylation determines the correct structure of the hemagglutinin, as they proved that bacterial HAs can be valuable vaccine antigens when appropriate folding and purification methods are applied to rationally designed proteins. The best evidence for success in bacterial production of protective HA is that vaccines based on proprietary Toll-like Receptor (VaxInnate) and bacteriophage Qβ-VLPs (Cytos Biotechnology) technologies have been advanced to clinical studies.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 561-572
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influenza viruses resistant to neuraminidase inhibitors
Autorzy:
Nitsch-Osuch, Aneta
Brydak, Lidia
Powiązania:
https://bibliotekanauki.pl/articles/1039255.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
influenza
resistance
neuraminidase inhibitors
Opis:
Neuraminidase inhibitors (NAIs) are antiviral drugs for treatment and prophylaxis of influenza. By blocking the activity of the enzyme neuraminidase, NAIs prevent new viral particles from being released. The increasing use of NAIs brings into focus the risk of drug resistance arising to the class. There are three levels of antiviral resistance according to the way that resistance can be detected or inferred: genotypic, phenotypic and clinical resistance. For many years seasonal influenza viruses resistance to NAIs was low (0.33%). Recently, there has been described an increasing number of resistant seasonal influenza strains to oseltamivir (2% in adults, 5-18% in children). In 2007 there were published data describing 14% resistant to oseltamivir strains of influenza A/H1N1/ in Europe. Approximately 0.5-1.0% of influenza A/H1N1/pdm09 isolates are currently resistant to oseltamivir. The established markers of the resistance to oseltamivir were found in 2.4% of human and 0.8% of avian isolates of influenza A/H5N1/. It has been not observed a cross resistance among oseltamivir and zanamivir. NAIs resistance in influenza viruses is relative and despite its presence patients with resistant viruses may still benefit from receiving these antivirals. The response to treatment with antivirals remains the most important proof of antiviral effectiveness. The rational use of NAIs is essential to preserve the best choice for treatment and prophylaxis of seasonal, avian and pandemic influenza.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 505-508
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zakażenia wirusem grypy typu A u gołębi
Influenza A virus infections of pigeons
Autorzy:
Abolnik, Celia
Powiązania:
https://bibliotekanauki.pl/articles/22016002.pdf
Data publikacji:
2020
Wydawca:
Krajowa Izba Lekarsko-Weterynaryjna
Tematy:
ptaki
wirus influenzy A
epidemiologia
gołębie
choroby zwierząt
influenza ptaków
avian influenza
epidemiology
pigeons
Opis:
Influenza A viruses of all subtypes, in their low pathogenic state, form part of the natural microbiota of water bird species. Four intercontinental transmission waves of Goose/Guangdong H5 lineage viruses swept the globe since 2005, each characterized by epidemics in poultry and contact transmission to humans. A significant shift in ecology of avian influenza had occurred. The risks that columbids pose in the ecology and epidemiology of AI have been thoroughly investigated over the course of several decades. Cumulatively, the studies on free-living pigeons, market pigeons and those experimentally infected with LPAI and HPAI demonstrated, that pigeons were of no epidemiological significance in the transmission and spread of HPAI to humans.
Źródło:
Życie Weterynaryjne; 2020, 95, 06; 362-364
0137-6810
Pojawia się w:
Życie Weterynaryjne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
In vivo reassortment of influenza viruses
Autorzy:
Urbaniak, Kinga
Markowska-Daniel, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/1039242.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
influenza A viruses
Opis:
The genetic material of influenza A virus consists of eight negative-sense RNA segments. Under suitable conditions, the segmented structure of the viral genome allows an exchange of the individual gene segments between different strains, causing formation of new reassorted viruses. For reassortment to occur, co-infection with two or more influenza virus strains is necessary. The reassortment is an important evolutionary mechanism which can result in antigenic shifts that modify host range, pathology, and transmission of the influenza A viruses. In this process, the influenza virus strain with epidemic and/or pandemic potential can be created. Cases of this kind were in 1957 (Asian flu), 1968 (Hong Kong flu) and recently in 2009 (Mexico). Viruses containing genes of avian, swine, and/or human origin are widespread around the world, for example the triple reassortant H1N1 virus causing the 2009 influenza pandemic in 2009 that has become a seasonal virus. The aim of the study is to present the mechanism of reassortment and the results of experimental co-infection with different influenza viruses.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 427-431
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Vaccination against influenza in pregnant women
Autorzy:
Brydak, Lidia
Nitsch-Osuch, Aneta
Powiązania:
https://bibliotekanauki.pl/articles/1039266.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
influenza
vaccination
pregnancy
Opis:
Pregnancy places otherwise healthy women at an increased risk of complications arising from an influenza infection. It is suggested that physiological changes such as immunological changes, increased cardiac output and oxygen consumption, as well as lung tidal volume might increase the susceptibility to influenza complications if infection occurs during pregnancy. Immunization of pregnant women against influenza is currently recommended in many countries and has been proven to be safe and effective in reducing rates and severity of the disease in vaccinated mothers and their children. Influenza vaccination is also cost-effective. Nevertheless, influenza vaccine coverage remains low in pregnant women. This might stem from the lack of healthcare workers' education, a feeling among the general public that influenza is not a serious disease and a failure of prenatal care providers to offer the vaccine. In order to protect pregnant women and infants from influenza related morbidity and mortality an educational programme targeting healthcare workers in charge of pregnant women should be implemented.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 589-591
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Seasonal influenza vaccination of healthcare workers: a narrative review
Autorzy:
Jędrzejek, Michał J.
Mastalerz-Migas, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/2084883.pdf
Data publikacji:
2022-04-11
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
infection control
influenza
healthcare facilities
healthcare workers
healthcare personnel
influenza vaccination
Opis:
Influenza is an acute respiratory disease caused by the influenza virus which often occurs in outbreaks and epidemics worldwide. The World Health Organization recommends annual vaccination of healthcare workers (HCWs) against influenza, because most of them are involved in the direct care of patients with a high risk of influenza-related complications. Given the significance of the disease burden, a targeted literature review was conducted to assess issues related to influenza vaccination among HCWs. The primary aim of this review was to assess the incidence of influenza among medical personnel and healthcare-associated influenza, and to outline the benefits of influenza vaccination for patients and HCWs themselves. Vaccination of HCWs seems to be an important strategy for reducing the transmission of influenza from healthcare personnel to their patients and, therefore, for reducing patient morbidity and mortality, increasing patient safety, and reducing work absenteeism among HCWs. The benefits of influenza vaccination for their patients and for HCWs themselves are addressed in literature, but the evidence is mixed and often of low-quality.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2022, 35, 2; 127-139
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Avian influenza in Poland
Autorzy:
Śmietanka, Krzysztof
Minta, Zenon
Powiązania:
https://bibliotekanauki.pl/articles/1039245.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
avian influenza
H5N1 virus
Opis:
Poland has experienced four episodes of avian influenza (AI) outbreaks over the past two decades. The first epidemic was caused by a low pathogenicity (LPAIV) H7N7 subtype and occurred in fattening and breeder turkeys in 1995. Two waves of H5N1 high pathogenicity avian influenza (HPAI) took place in 2006 and 2007. In spring 2006, 64 cases of the H5N1 virus were detected, mostly in mute swans. In December 2007, ten outbreaks of H5N1 HPAI were detected in commercial poultry (n=9) and wild birds kept in captivity (n=1). The outbreaks in 2006 and 2007 were caused by genetically similar but clearly distinguishable viruses of the 2.2 clade. In 2013, an H9N2 avian influenza virus was detected in 4 fattening turkey holdings. The virus was low pathogenic and a phylogenetic study has shown a close relatedness to the Eurasian lineage of AIV of the wild bird origin. Neither preventive nor prophylactic vaccinations have ever been used in poultry or other birds. Emergency vaccinations using autogenous vaccine were introduced only to control the H7N7 LPAI outbreaks in 1995. The baseline surveillance for AI in live migratory birds and poultry provides a valuable insight into the ecology of AIV at the wild and domestic bird interface. Passive surveillance is in place of early detection of HPAIV infection in dead or moribund birds.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 453-457
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
DNA vaccines against influenza
Autorzy:
Stachyra, Anna
Góra-Sochacka, Anna
Sirko, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1039258.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
DNA vaccine
influenza
hemagglutinin
immunization
adjuvant
cross-protection
Opis:
Genetic vaccine technology has been considerably developed within the last two decades. This cost effective and promising strategy can be applied for therapy of cancers and for curing allergy, chronic and infectious diseases, such as a seasonal and pandemic influenza. Despite numerous advantages, several limitations of this technology reduce its performance and can retard its commercial exploitation in humans and its veterinary applications. Inefficient delivery of the DNA vaccine into cells of immunized individuals results in low intracellular supply of suitable expression cassettes encoding an antigen, in its low expression level and, in turn, in reduced immune responses against the antigen. Improvement of DNA delivery into the host cells might significantly increase effectiveness of the DNA vaccine. A vast array of innovative methods and various experimental strategies have been applied in order to enhance the effectiveness of DNA vaccines. They include various strategies improving DNA delivery as well as expression and immunogenic potential of the proteins encoded by the DNA vaccines. Researchers focusing on DNA vaccines against influenza have applied many of these strategies. Recent examples of the most successful modern approaches are discussed in this review.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 515-522
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
ReCOMmendations for the treatment of INFLUENZA in children for Primary care physiciAnS – COMPAS INFLUENZA
Autorzy:
Doniec, Zbigniew
Mastalerz-Migas, Agnieszka
Jackowska, Teresa
Kuchar, Ernest
Sybilski, Adam
Powiązania:
https://bibliotekanauki.pl/articles/552248.pdf
Data publikacji:
2019
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
influenza
children
treatment
vaccinations.
Opis:
Influenza is an acute infectious disease of the airways that occurs in every age group. The course of the disease may have a different severity and clinical picture, from asymptomatic to severe with symptoms of respiratory failure. The possibilities of pandemic infections and serious complications throughout the course of influenza distinguish it from other viral respiratory diseases, prompting us to treat it in a special way. Diagnosis of the disease is usually clinical in nature, and additional studies may be helpful in clinically relevant cases. The drug recommended for treatment and chemoprophylaxis is oseltamivir. Clinical benefits are greatest if treatment starts as early as possible, within 48 hours of the first symptoms of influenza. Clinical studies indicate that early treatment with oseltamivir may shorten the duration of the disease and reduce the risk of its complications. Annual influenza vaccination is the most effective method of preventing this disease, and the only contraindication to vaccination is the occurrence of an anaphylactic or other severe allergic reaction after a previous vaccination
Źródło:
Family Medicine & Primary Care Review; 2019, 2; 189-198
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Factors affecting decision concerning influenza vaccination among students of medical faculties
Autorzy:
Woźniak-Kosek, Agnieszka
Kempińska-Mirosławska, Bogumiła
Mendrycka, Mariola
Saracen, Agnieszka
Hoser, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/1039225.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
influenza
vaccination against influenza- knowledge
infections
students
Opis:
Influenza is one of the most common cyclic respiratory diseases in humans. Methods of prevention are multidirectional, but the most effective and most efficacious way to prevent influenza and its complications is through preventive vaccination. This work aims to determine different factors affecting the decision concerning influenza vaccine. The percentage of people vaccinated against the flu was evaluated, as well as their knowledge of post-influenza complications, etc. among full-time students and bridging studies of nursing and physiotherapy (full-time and part-time) at the University of Technology and Life Sciences in Radom, and students of medicine and pharmacy at the Medical University of Łódź. The research tool was the authors' questionnaire with 18 questions. The surveys conducted, consisting of multiple choice questions, were anonymous. In total, the survey involved 470 students. Overall, the number of people who were vaccinated against influenza in the 2012/13 epidemic season numbered 15 respondents, representing 5.84% of the total group of respondents. For the group of nursing students it was 6%, for physiotherapy students 5%, for students of medicine and pharmacy 14%. The percentage of respondents who said they would get vaccinated if the vaccinaton was free of charge was also low. Increasing the percentage of people vaccinated against influenza (immunization coverage) is a very important measure in preventing influenza epidemics. Therefore, it is necessary to identify the reasons why people are reluctant to be vaccinated against influenza, particularly among students who will work in the future in the health care services sector.
Źródło:
Acta Biochimica Polonica; 2014, 61, 4; 829-832
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influenza vaccination among healthcare workers – realization, promotion
Autorzy:
Tomaszewski, Mateusz
Łuniewski, Michał
Kulczyński, Marcin
Olender, Alina
Powiązania:
https://bibliotekanauki.pl/articles/1179527.pdf
Data publikacji:
2017
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Vaccines
healthcare workers
infectious disease prevention
influenza
Opis:
Influenza vaccination is the most important component of prevention of occurring and spreading of this disease. 80% vaccination coverage of healthcare personnel provides a substantial reduction of transmission; each and every next vaccinated person results in a decrease of morbidity, especially amongst elder or immunocompromised patients. In the analyzed studies most common reasons of insufficient vaccination coverage among healthcare workers were fear of side effects, lack of knowledge, conviction of vaccine inefficiency, lack of feeling of social responsibility, and inadequate accessibility of vaccine. Healthcare workers who were vaccinated regularly did it mostly in order to provide safety to themselves, their relatives and patients; they did it also due to the knowledge of vaccination efficiency. The most effective actions to improve vaccination coverage were: vaccination requirement by the employer, active encouragement, effective promotion, better vaccine accessibility and promotion of vaccination as prosocial behavior. Offering surgical masks as an alternative did not improve vaccination rate in most analyzed studies. In conclusion, most important reasons of declining influenza vaccination by healthcare workers are lack of knowledge and low accessibility of vaccination, so evidently education, promotion and facilitating the vaccination in workplace are the most effective ways causing the growth of vaccination rate.
Źródło:
World Scientific News; 2017, 76; 50-59
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Structural biology of the influenza virus fusion peptide
Autorzy:
Worch, Remigiusz
Powiązania:
https://bibliotekanauki.pl/articles/1039239.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
influenza virus
viral entry
membrane fusion
fusion peptide
peptide-lipid interactions
Opis:
The release of influenza RNA inside the host cell occurs through the fusion of two membranes, the viral envelope and that of the cellular endosome. The fusion is mediated by the influenza hemagglutinin protein (HA), in particular by the fusion peptide (HAfp) located in the N-terminal fragment of HA2 subunit. This protein fragment anchors in the internal endosomal membrane, whereas the C-terminal HA2 part comprises a transmembrane domain (TMD) embedded in the viral envelope. A drop of pH in the endosome acts as the main trigger for HA2 large conformational change that leads to anchoring of the fusion peptide, close contact of the membranes and the subsequent fusion. Throughout the years the major research effort was focused on a 20-aminoacid fragment (HAfp1-20), shown by NMR to adopt a 'boomerang'-like structure. However, recent studies showed that extending HAfp1-20 by three highly conserved residues W21-Y22-G23 leads to formation of a unique, tight helical hairpin structure. This review summarizes recently discovered structural aspects of influenza fusion peptides and their relations with the membrane fusion mechanism.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 421-426
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Detection of the influenza virus yesterday and now
Autorzy:
Woźniak-Kosek, Agnieszka
Kempińska-Mirosławska, Bogumiła
Hoser, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/1039248.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
influenza
virus
detection method
diagnostics
PCR
viral respiratory tract infection
Opis:
Demographic changes and the development of transportation contribute to the rapid spread of influenza. Before an idea of a 'person to person' spread appeared, divergent theories were developed to explain influenza epidemics in the past. Intensified virological and serological tests became possible after isolation of the human influenza virus in 1933. The first influenza virus detection methods were based on its isolation in egg embryos or cell lines and on demonstration of the presence of the viral antigens. Molecular biology techniques associated with amplification of RNA improved the quality of tests as well as sensitivity of influenza virus detection in clinical samples. It became possible to detect mixed infections caused by influenza types A and B and to identify the strain of the virus. Development of reliable diagnostic methods enabled fast diagnosis of influenza which is important for choosing an appropriate medical treatment.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 465-470
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Aktualna sytuacja epidemiologiczna grypy w województwie śląskim
Current epidemiological situation of influenza in Silesian voivodeship
Autorzy:
Kowalska, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/1426961.pdf
Data publikacji:
2021-05-05
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
grypa
epidemiologia
rejestr
influenza
epidemiology
registry
Opis:
Grypa jest chorobą zakaźną układu oddechowego podlegającą stałemu monitorowaniu w zakresie liczby nowych zachorowań oraz zgonów. W drugiej połowie marca 2020 r. zaobserwowano spadek liczby zachorowań na grypę w woj. śląskim i postanowiono sprawdzić, czy ma to związek z pojawieniem się nowego zagrożenia, jakim jest pandemia COVID. W modelu badania opisowego dokonano analizy trendu zachorowalności i hospitalizacji z powodu grypy, a jednocześnie przedstawiono dynamikę wzrostu nowych zakażeń wirusem SARS-CoV-2. Dokonano również chronologicznego usystematyzowania ważnych działań administracyjnych ograniczających rozwój epidemii. Nie można wykluczyć, że obserwowany spadek zachorowań i hospitalizacji z powodu grypy w woj. śląskim ma związek z restrykcyjnymi przepisami organizacji pracy i życia społecznego podjętymi dla ograniczenia epidemii COVID. Jednoznaczne wnioskowanie będzie wymagało wnikliwych badań i dłuższego okresu obserwacji.
Influenza is an infectious disease of the respiratory system subject to constant monitoring in terms of the number of new cases and deaths. It was observed that the number of new cases of influenza decreased in the Silesian voivodeship in the second half of March 2020, and it was decided to verify whether it is related to the emergence of a new threat, which is the COVID pandemic. In the descriptive model of the study, the trend of influenza morbidity and hospitalization was analyzed, and at the same time the dynamics of the increase in new SARS-CoV-2 infections was presented. Chronological systematization of important administrative activities limiting development of the epidemic was also carried out. It cannot be ruled out that the observed decrease in the incidence and hospitalization due to influenza in the province of Silesia is related to the restrictive regulations on the organization of work and social life taken to minimize the COVID epidemic. Unambiguous conclusions will require in-depth research and a longer observation period.
Źródło:
Annales Academiae Medicae Silesiensis; 2021, 75; 33-40
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influenza A viruses of avian origin circulating in pigs and other mammals
Autorzy:
Urbaniak, Kinga
Kowalczyk, Andrzej
Markowska-Daniel, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/1039243.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
influenza A viruses
hemagglutinin
neuraminidase
Opis:
Influenza A viruses (IAVs) are zoonotic agents, capable of crossing the species barriers. Nowadays, they still constitute a great challenge worldwide. The natural reservoir of all influenza A viruses are wild aquatic birds, despite the fact they have been isolated from a number of avian and mammalian species, including humans. Even when influenza A viruses are able to get into another than waterfowl population, they are often unable to efficiently adapt and transmit between individuals. Only in rare cases, these viruses are capable of establishing a new lineage. To succeed a complete adaptation and further transmission between species, influenza A virus must overcome a species barrier, including adaptation to the receptors of a new host, which would allow the virus-cell binding, virus replication and, then, animal-to-animal transmission. For many years, pigs were thought to be intermediate host for adaptation of avian influenza viruses to humans, because of their susceptibility to infection with both, avian and human influenza viruses, which supported hypothesis of pigs as a 'mixing vessel'. In this review, the molecular factors necessary for interspecies transmission are described, with special emphasis on adaptation of avian influenza viruses to the pig population. In addition, this review gives the information about swine influenza viruses circulating around the world with special emphasis on Polish strains.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 433-439
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influenza prevention and treatment by passive immunization
Autorzy:
Kalenik, Barbara
Sawicka, Róża
Góra-Sochacka, Anna
Sirko, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1039265.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
antibody
clinical trials
hemagglutinin
influenza
neutralization
passive immunity
Opis:
Passive immunity is defined as a particular antigen resistance provided by external antibodies. It can be either naturally or artificially acquired. Natural passive immunization occurs during pregnancy and breast-feeding in mammals and during hatching in birds. Maternal antibodies are passed through the placenta and milk in mammals and through the egg yolk in birds. Artificial passive immunity is acquired by injection of either serum from immunized (or infected) individuals or antibody preparations. Many independent research groups worked on selection, verification and detailed characterization of polyclonal and monoclonal antibodies against the influenza virus. Numerous antibody preparations were tested in a variety of in vitro and in vivo experiments for their efficacy to neutralize the virus. Here, we describe types of antibodies tested in such experiments and their viral targets, review approaches resulting in identification of broadly neutralizing antibodies and discuss methods used to demonstrate their protective effects. Finally, we shortly discuss the phenomenon of maternal antibody transfer as a way of effective care for young individuals and as an interfering factor in early vaccination.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 573-587
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Knowledge and compliance with recommendations for seasonal influenza vaccination among medical and dental students
Autorzy:
Kawalec, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1178226.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
dental students
influenza vaccines
medical staff
medical students
Opis:
Vaccination against seasonal influenza is recommended for everyone older than 6 months. It is underlined, that healthcare workers and students may contribute to nosocomial influenza transmission, however, flu vaccination rate among medical stuff remains low. The aim of this study was the assessment of knowledge of flu vaccination recommendations and compliance with them among medical and dental students in conjunction with analysis of potential differences according to the type of faculty. The study was conducted from 10th to 16th October 2017 with the use of anonymous survey among 203 healthcare students of Wroclaw Medical University (131 medical students, 72 dentistry students). The questionnaire was divided into 3 sections: demographic data, vaccination status, knowledge of recommendations. Obtained data showed that declared vaccination rate in season 2016/2017 was 15.82%, and 13.92% in 2015/2016. Although we observed that influenza vaccination coverage was higher among dental students, the difference was statistically insignificant. Knowledge of recommendations was good, 78% of students knew, that influenza vaccination is recommended for healthcare workers, and 73% answered, that it also concerns healthcare students. Significant differences in identification of groups, for which flu vaccination is especially recommended, were observed. Dental students more frequently chose all correct answers (p-value 0,006). Also sources of knowledge differed (p-value 0,007), medical students more often declared using professional medical journals, while dental students more frequently indicated impact of family. Although the knowledge of recommendations for influenza vaccination is rather good among students, vaccination coverage remains low. Identification of gaps in students' knowledge and differences according to faculty, may suggest directions in which activities promoting regular vaccination against influenza should concentrate.
Źródło:
World Scientific News; 2018, 93; 50-59
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influenza vaccine efficacy in patients aged 60–75 years in the 2016/2017 season
Autorzy:
Sławin, Agata
Brydak, Lidia
Doniec, Zbigniew
Mastalerz-Migas, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/552677.pdf
Data publikacji:
2018
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
influenza
human
vaccination
aged
immunization
Źródło:
Family Medicine & Primary Care Review; 2018, 3; 263-266
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Testing of human specimens for the presence of highly pathogenic zoonotic avian influenza virus A [H5N1] in Poland in 2006-2008 - justified or unnecessary steps?
Autorzy:
Romanowska, M
Nowak, I.
Brydak, L.B.
Wojtyla, A.
Powiązania:
https://bibliotekanauki.pl/articles/50626.pdf
Data publikacji:
2009
Wydawca:
Instytut Medycyny Wsi
Tematy:
avian influenza virus type A
zoonosis
influenza
H5N1 subtype
avian influenza
disease outbreak
diagnostic test
Polska
Źródło:
Annals of Agricultural and Environmental Medicine; 2009, 16, 2; 239-247
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Native nucleic acid electrophoresis as an efficient alternative for genotyping method of influenza virus
Autorzy:
Pajak, Beata
Lepek, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1039250.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
gel electrophoresis
SSCP
influenza
minor genetic variants
Opis:
Influenza viruses are the worldwide major causative agents of human and animal acute respiratory infections. Some of the influenza subtypes have caused epidemics and pandemics among humans. The varieties of methods are available for the rapid isolation and identification of influenza viruses in clinical and environmental samples. Since nucleic acids amplification techniques such as RT-PCR have been adapted, fast and sensitive influenza type and subtype determination is possible. However, in some ambiguous cases other, more detailed assay might be desired. The genetic material of influenza virus is highly unstable and constantly mutates. It is known that single nucleotide polymorphisms (SNPs) results in resistance to commercially available anti-viral drugs. The genetic drift of the virus could also result in weakening of immune response to infection. Finally, in a substantial number of patients co-infection with various virus strains or types has been confirmed. Although the detection of co-infection or presence of minor genetic variants within flu-infected patients is not a routine procedure, a rapid and wide spectrum diagnostics of influenza virus infections could reveal an accurate picture of the disease and more importantly, is crucial for choosing the appropriate therapeutics and virus monitoring. Herein we present the evidences that native gel electrophoresis and MSSCP - a method based on multitemperature single strand conformation polymorphism could furnish a useful technique for minor variants, which escape discovery by conventional diagnostic assays.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 479-483
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A clinical utility of a strip test for influenza A/B and comparison with detection by RT PCR
Autorzy:
Miarka, Maciej
Horban, Andrzej
Maliszewska, Henryka
Biliński, Przemysław
Prus-Kowalczuk, Wanda
Powiązania:
https://bibliotekanauki.pl/articles/1039251.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
A/H1N1/v influenza virus
strip test
influenza RT PCR
Opis:
Introduction and objective: In June 2009 the World Health Organization announced influenza pandemic caused by A/H1N1/v virus. It became crucial to recognize new cases of A/H1N1/v infection. An effective screening diagnostic procedure was needed for patients suffering from influenza-like symptoms for making an initial diagnosis and analyzing epidemiological pattern of infection. We used a strip test for influenza A/B as a screening diagnostic procedure for patients suffering from influenza-like symptoms for making an initial diagnosis. For comparison, RT PCR for detecting A/H1N1/v was performed. The aim of this study was to assess the efficacy and sensitivity of the strip test and its value for making initial diagnosis of influenza A/H1N1/v. Material and methods: Strip testing for the influenza A/B infection was performed on 1123 patients with influenza-like symptoms in the Admission Unit of the Regional Infectious Diseases Hospital in Warsaw. Strip test results were analyzed according to the age of patients and season of the year. For 97 patients strip test results for detecting A/H1N1 infection were compared with those obtained by RT PCR. Results: There were no statistically significant differences found between the methods and strip testing demonstrated sensitivity of 61% and specificity of 71%. Conclusions: No statistically significant differences were found between the two methods, however, strip test had low sensitivity and specificity.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 485-487
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mapping of the influenza A hemagglutinin serotypes evolution by the ISSCOR method
Autorzy:
Radomski, Jan
Słonimski, Piotr
Zagórski-Ostoja, Włodzimierz
Borowicz, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1039244.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
ISSCOR descriptors
phylogenetic analysis
influenza virus
hemagglutinin
phylogenetic maps
Opis:
Analyses and visualizations by the ISSCOR method of influenza virus hemagglutinin genes of different A-subtypes revealed some rather striking temporal relationships between groups of individual gene subsets. Based on these findings we consider application of the ISSCOR-PCA method for analyses of large sets of homologous genes to be a worthwhile addition to a toolbox of genomics - allowing for a rapid diagnostics of trends, and ultimately even aiding an early warning of newly emerging epidemiological threats.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 441-451
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
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