Skocz do pozycji: 1.

Tytuł:

Head and Neck Lymphomas - Diagnostic Difficulties

Autorzy:

Neskoromna-Jędrzejczak, Aneta
Tyndorf, Marta
Arkuszewski, Piotr
Kobos, Józef

Powiązania:

https://bibliotekanauki.pl/articles/1396619.pdf

Data publikacji:

2012-02-01

Wydawca:

Index Copernicus International

Tematy:

lymphoma
head
neck
diagnostics

Opis:

Malignant lymphomas represent approximately 5% of all malignant neoplasm of the head and neck and may involve nodal or extranodal sites. The head and neck region is the second most frequent anatomical site of extranodal lymphomas (after the gastrointestinal tract). Most are non-Hodgkin lymphomas (NHL) of B-cell lineage. Hodgkin's lymphoma (HL) rarely occurs in extranodal site.The aim of the study was to evaluate head and neck manifestation of lymphoma (both HL and NHL) and emphasize diagnostic difficulties of these pathologies.Material and methods. Retrospective review of medical records of patients diagnosed for lymphomas in our department was performed. Authors analyzed demographic data as well as clinical manifestation and diagnostic trials.Results. 9 patients were included to the study. 7 of them suffered from extranodal NHL and 2 of them from HL (one patient - extranodal and one nodal manifestation). There were diagnostic complications in all cases and final diagnosis was made after surgical material analysis.Conclusions. This data demonstrate low sensivity of fine needle aspiration for identification of lymphoma as well as clinical picture is non characteristic.

Źródło:

Polish Journal of Surgery; 2012, 84, 3; 113-118
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

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Tytuł:

Dermoidal cysts of head and neck in children

Autorzy:

Piszcz, Małgorzata
Skotnicka, Bożena
Hassmann-Poznańska, Elżbieta
Gościk, Elżbieta
Reszeć, Joanna

Powiązania:

https://bibliotekanauki.pl/articles/1401794.pdf

Data publikacji:

2015

Wydawca:

Index Copernicus International

Tematy:

dermoid cysts
head and neck
children

Opis:

Introduction: Dermoid cysts are benign epidermal tumors; in 7% of cases, they are located in the head and neck region. They are lesions of congenital origin, mostly presenting within the midline of the body. About 70% of cases are diagnosed before the age of 5 years. Methods: A retrospective analysis of medical data of children with dermoid cysts located within the head and neck region treated in the Department of Pediatric Otolaryngology in Bialystok in the period of 1994-2014 was performed. A review of relevant literature was presented. Results: A total of 17 patients were included in this study, with a mean age of 8.9 years; 76.5% of the study population was female. Dermoid cysts were mostly located in the anterior neck region and the floor of the mouth (76%). US and CT imaging scans were used in diagnostics. No recurrences were observed after surgical excision. Conclusion: Dermoid cysts should be taken into consideration when diagnosing head and neck masses in pediatric patients.

Źródło:

Polski Przegląd Otorynolaryngologiczny; 2015, 4, 2; 66-70
2084-5308
2300-7338

Pojawia się w:

Polski Przegląd Otorynolaryngologiczny

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 3.

Tytuł:

Report from the analysis of implementiation of 4th Head and Neck Cancer Awareness Week in Department of Otolaryngology in Międzyleski Hospital in Warsaw

Autorzy:

Dżaman, Karolina
Piskadło–Zborowska, Karolina
Pietniczka–Załęska, Mirosława

Powiązania:

https://bibliotekanauki.pl/articles/1398499.pdf

Data publikacji:

2017

Wydawca:

Index Copernicus International

Tematy:

European Head and Neck Cancer Awareness Week
head and neck tumors

Opis:

Introduction: The aim of the study was to analyze the profile of patients who reported for free screening examinations during the 4th European Head and Neck Cancer Awareness Week to the Department of Otolaryngology, Miedzylesie Specialist Hospital, Warsaw, Poland. Material and methods: We enrolled 225 patients, aged 26-92 years (mean, 63 years). There were 149 women (66%) and 76 men (34%). All patients filled out a survey regarding risk factors of head and neck cancer (HNC), including symptoms and lifestyle characteristics. Subsequently, all participants underwent a complete laryngological examination. Results: Among the studied patients, we found the following lifestyle-related risk factors of HNC: tobacco use (22%), alcohol use more than 1 time per week (12%), oral sex (17%), multiple sexual partners (10%), rare dental checkups (24%), and dental prostheses (45%). The most frequent symptoms that prompted the patients to report for screening exams were as follows: chronic hoarseness (64%), xerostomia (39%), dysphagia (37%), nasal congestion (6%), and neck tumor (5%). Further imaging studies were ordered in 15 patients (7%), fiberoscopy in 25 (11%), and lesion excision in 18 (8%). Among the studied patients, 17 were referred for further oncological treatment, of whom 14 had benign tumors and 4 malignant tumors. Conclusions: The Head and Neck Cancer Awareness campaign increased the awareness of HNC, and it should systematically encompass people at increased risk. By implementing this program in our department, we were able to detect and initiate early treatment in 7.5% of the screened people. However, appropriate workup and treatment require funding and therefore systemic measures should be taken to enable a wide implementation of such screening programs.

Źródło:

Polish Journal of Otolaryngology; 2017, 71, 6; 35-39
0030-6657
2300-8423

Pojawia się w:

Polish Journal of Otolaryngology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 4.

Tytuł:

Neuroendocrine Carcinoma of the Head and Neck – review of literature

Autorzy:

Berger, G
Dawidziuk, T
Chyczewski, L

Powiązania:

https://bibliotekanauki.pl/articles/1401521.pdf

Data publikacji:

2016

Wydawca:

Index Copernicus International

Tematy:

neuroendocrine carcinoma
head and neck

Opis:

Neuroendocrine carcinoma is a rare neoplasm, and its most common location in the head and neck area is the larynx, especially the epiglottis and the supraglottic region. The first case of neuroendocrine carcinoma of the larynx was reported in 1969 by Goldman et al. Expression of the two crucial markers, synaptophysin and chromogranin, along with neural cell adhesion molecule (CD56) should be mentioned among the neuroendocrine features detected on immunohistochemistry. Human papilloma virus (HPV16/18) infection in the laryngeal neuroendocrine carcinoma can be one of the causal factors, and the detection of HPV should be considered as a standard procedure for the diagnosis and treatment.

Źródło:

Polski Przegląd Otorynolaryngologiczny; 2016, 5, 4; 16-21
2084-5308
2300-7338

Pojawia się w:

Polski Przegląd Otorynolaryngologiczny

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 5.

Tytuł:

Multiple paragangliomas of the head and neck - a case report

Autorzy:

Wojciechowski, Tomasz
Drożdż, Adrian
Niemczyk, Kazimierz

Powiązania:

https://bibliotekanauki.pl/articles/1399908.pdf

Data publikacji:

2018

Wydawca:

Index Copernicus International

Tematy:

multiple paragangliomas
facial nerve
neck tumor
tinnitus

Opis:

Paragangliomas are rare, most commonly non-malignant tumors of the autonomic nervous system. Their location within the head is rather an exception than a rule, similarly as their multifocal prevalence. The authors of this paper present a case of a patient with bi-focal paraganglioma. The first symptom of illness was facial nerve palsy, diagnosed for the period of about 3 years. After making the initial diagnosis of tympanic paraganglioma, the tumor was operated. During the next 7 years, there was a recurrence within the temporal bone. What is more, periodic imaging examination showed second foci within the neck, moreover asymptomatic. The authors discuss the natural development of paragangliomas in the region of head and neck and present the current knowledge about management of patients with a suspicion, diagnosis, and treatment of this disease.

Źródło:

Polski Przegląd Otorynolaryngologiczny; 2018, 7, 2; 60-66
2084-5308
2300-7338

Pojawia się w:

Polski Przegląd Otorynolaryngologiczny

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 6.

Tytuł:

Modern radiation techniques for treatment of head and neck cancers

Autorzy:

Kiprian, Dorota

Powiązania:

https://bibliotekanauki.pl/articles/1401820.pdf

Data publikacji:

2015

Wydawca:

Index Copernicus International

Tematy:

positron emission tomography
radiotherapy
throat
apoptosis

Opis:

Alongside surgery, radiation therapy remains the mainstay of treatment for head and neck cancers.  Because the head and neck contain a number of critically important structures, it is crucial to try to curtail the adverse effects of radiation therapy by increasing its precision. Such precise radiation techniques include the three-dimensional conformal as well as highly conformal radiotherapy. The latter includes, for instance, intensity modulated radiation therapy (IMRT), stereotactic radiation, and proton-beam therapy. All of the above-mentioned techniques are available in Poland and give the opportunity of a more aggressive treatment that lead to improved outcomes, curtailment of adverse effects, and by that, a better quality of life.

Źródło:

Polski Przegląd Otorynolaryngologiczny; 2015, 4, 4; 1-10
2084-5308
2300-7338

Pojawia się w:

Polski Przegląd Otorynolaryngologiczny

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 7.

Tytuł:

Clinical manifestation of malignant lymphomas of the head and neck region

Autorzy:

Bojanowska-Poźniak, Katarzyna
Nurkowska, Monika
Danilewicz, Marian
Pietruszewska, Wioletta

Powiązania:

https://bibliotekanauki.pl/articles/1398500.pdf

Data publikacji:

2017

Wydawca:

Index Copernicus International

Tematy:

malignant lymphoma
head and neck neoplasm
extranodal lymphoma

Opis:

Introduction: Malignant lymphoma (ML) is a neoplasm caused by clonal expansion of undifferentiated B, T and NK-lymphoid cells. WHO classification divides lymphomas into two main types, i.e. Hodgkin lymphoma (HL), and non-Hodgkin lymphoma (NHL), with numerous subtypes. The majority of MLs are localized in lymph nodes, but extranodal locations are also possible. MLs represent approximately 3-5% of all malignant neoplasms in Poland, but their incidence has been increasing in recent years, especially in young patients. The objective of the study was to evaluate clinical manifestations and diagnostic process in patients with malignant lymphomas of the head and neck region as diagnosed in the Department of Otorhinolaryngology of the Medical University of Lodz in years 2013-2017. Material and method: 30 patients diagnosed with malignant lymphomas of the head and neck region at the Departbadament of Otorhinolaryngology of the Medical University of Lodz in 2013-2017. Results: The study group consisted of 8 cases of nodal lymphomas and 22 cases of extranodal lymphomas. In 29 cases B-cell lymphomas were diagnosed. The most common symptoms included lymphadenopathy or neck tumor. Other symptoms were associated with the location of tumors in particular body organs. The diagnosis was based on histopathological examination of biopsy (needle or surgical) samples. Conclusion: Malignant lymphomas should be taken into account during differential diagnosis of the tumor or lymphadenopathy of the neck. The diagnosis is difficult because of the nonspecificity of symptoms and the need for interdisciplinary cooperation of many specialists.

Źródło:

Polish Journal of Otolaryngology; 2017, 71, 6; 14-21
0030-6657
2300-8423

Pojawia się w:

Polish Journal of Otolaryngology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 8.

Tytuł:

Head and neck posture in sauropod dinosaurs inferred from extant animals

Autorzy:

Taylor, M P
Wedel, M.J.
Naish, D.

Powiązania:

https://bibliotekanauki.pl/articles/22737.pdf

Data publikacji:

2009

Wydawca:

Polska Akademia Nauk. Instytut Paleobiologii PAN

Tematy:

paleontology
dinosaur
sauropod dinosaur
extant animal
head posture
neck posture
Dinosauria
Sauropoda

Opis:

The neck posture of sauropod dinosaurs has long been controversial. Recent reconstructions position the cervical vertebrae and skull in an “osteological neutral pose” (ONP), the best fit arrived at by articulating the vertebrae with the zygapophyses in maximum contact. This approach in isolation suggests that most or all sauropods held their necks horizontally. However, a substantial literature on extant amniotes (mammals, turtles, squamates, crocodilians and birds) shows that living animals do not habitually maintain their necks in ONP. Instead, the neck is maximally extended and the head is maximally flexed, so that the mid−cervical region is near vertical. Unless sauropods behaved differently from all extant amniote groups, they must have habitually held their necks extended and their heads flexed. The life orientation of the heads of sauropods has been inferred from the inclination of the semi−circular canals. However, extant animals show wide variation in inclination of the “horizontal” semi−circular canal: the orientation of this structure is not tightly constrained and can give only a general idea of the life posture of extinct animals’ heads.

Źródło:

Acta Palaeontologica Polonica; 2009, 54, 2; 213-220
0567-7920

Pojawia się w:

Acta Palaeontologica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 9.

Tytuł:

Immunotherapy of head and neck squamous cell carcinoma (HNSCC). Immune checkpoint blockade

Autorzy:

Przybylski, Krzysztof
Majchrzak, Ewa
Weselik, Liucija
Golusiński, Wojciech

Powiązania:

https://bibliotekanauki.pl/articles/1398281.pdf

Data publikacji:

2018

Wydawca:

Index Copernicus International

Tematy:

head and neck squamouscell carcinoma
immunotherapy
CTLA - 4
PD - 1
nivolumab
pembrolizumab

Opis:

Treating patients with squamous cell carcinoma of the head and neck is a significant problem. There is an increase in the incidence of malignant neoplasms in this region. Surgery, radiotherapy and chemotherapy are often not sufficient methods of treatment. Thorough analysis of processes occurring in the tumor microenvironment has allowed to distinguish three stages that make up the reaction of the human body to hostile antigens, which are tumor antigens. Understanding these mechanisms has resulted in the introduction of a new term immune-oncology. It is an area of cancer treatment that focuses on use of the patient’s immune system to combat the disease. Immunotherapy has had positive effects in cancer patients. The use of immune checkpoint inhibitors, such as anti-CTLA-4 and PD-1 monoclonal antibodies has enabled the modulation of T cell functions, consequently eliminating immunosuppression in the tumor microenvironment. Clinical trials were conducted using nivolumab and ipilimumab, which confirmed their clinical usefulness. The approval by FDA of nivolumab in treatment of recurrent and metastatic squamous cell carcinoma of the head and neck has increased the overall survival time of patients as well as disease free survival. Statistical data indicate an advantage of immunotherapy over other treatment methods at an advanced stage of cancer. This work aims to discuss basic issues related to immunotherapy, in particular immunotherapy in patients with squamous cell carcinoma of the head and neck.

Źródło:

Polish Journal of Otolaryngology; 2018, 72, 6; 10-16
0030-6657
2300-8423

Pojawia się w:

Polish Journal of Otolaryngology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 10.

Tytuł:

Comparison of criteria for elective tracheostomy in head and neck cancer surgery

Autorzy:

Kissin, Filip
Rysz, Maciej
Budziszewska, Magdalena
Krajewski, Romuald

Powiązania:

https://bibliotekanauki.pl/articles/1397292.pdf

Data publikacji:

2021

Wydawca:

Index Copernicus International

Tematy:

elective tracheostomy
head and neck surgery
postoperative complications

Opis:

Elective tracheostomy before resection of a malignancy in head and neck region assures unobstructed ventilation during postoperative period but is associated with an increased risk of complications. We aimed to evaluate retrospectively, how the application of elective tracheostomy scales would influence the frequency of tracheostomy in comparison with preoperative clinical judgement. In 205 patients operated on from 2013 till 2017, theresection of a malignancy involved suprahyoid or pharyngeal muscles, neck dissection and flap reconstruction. The decision on elective tracheostomy was made on the clinical basis. Score for each patient in 3 published scales was calculated. In the study group 76 patients had elective tracheostomy at the outset of a resection procedure. Among 129 patients without elective tracheostomy, 9 had tracheostomy in the postoperative period. Indications for elective tracheostomy were calculated for scale I, II and III. Only in 120 patients the decision whether to perform elective tracheostomy would be identical in each scale. Our results suggest that decisions to perform elective tracheostomy based on 3 scales show low specificity. The factors used in the published scales should be evaluated in a prospective multicenter study

Źródło:

Polish Journal of Otolaryngology; 2021, 75, 4; 20-26
0030-6657
2300-8423

Pojawia się w:

Polish Journal of Otolaryngology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 11.

Tytuł:

Tumor of the pharynx – an unexpected diagnosis

Autorzy:

Ura-Sabat, Katarzyna
Domka, Wojciech
Gamrot-Wrzoł, Marta
Szuber, Krzysztof

Powiązania:

https://bibliotekanauki.pl/articles/454943.pdf

Data publikacji:

2017

Wydawca:

Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego

Tematy:

head and neck,
haemangioma
diagnosis
treatment

Opis:

Introduction. Head and neck haemangiomas occur quite rarely. These are benign lesions, often involving the pharynx and larynx. They almost always pose a diagnostic and therapeutic problem. Case description. This paper describes the case of an asymptomatic internal carotid artery aneurysm manifested by a throat tumour. A 78-year old woman with sudden deafness and vertigo was additionally diagnosed with a throat tumour. After radiological diagnosis of a haemangioma, the patient refused surgery. This article presents diagnostic methods and various types of treatments for head and neck haemangiomas. Attention was paid to the possibility of serious complications when deciding on surgical intervention of haemangiomas without a confirmed diagnosis. Conclusion. Suspicion of head and neck haemangiomas necessitates using all available diagnostic methods. The treatment plan should take into account the pace of progression, the patient’s age and co-morbid conditions. .

Źródło:

European Journal of Clinical and Experimental Medicine; 2017, 1; 78-81
2544-2406
2544-1361

Pojawia się w:

European Journal of Clinical and Experimental Medicine

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 12.

Tytuł:

Dental care for cancer patients undergoing radiotherapy of the head and neck region

Autorzy:

Pytko-Polonczyk, J.
Macura, A.B.

Powiązania:

https://bibliotekanauki.pl/articles/3048.pdf

Data publikacji:

2012

Wydawca:

Instytut Medycyny Wsi

Źródło:

Journal of Pre-Clinical and Clinical Research; 2012, 06, 2
1898-2395

Pojawia się w:

Journal of Pre-Clinical and Clinical Research

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 13.

Tytuł:

Antioxidative assessment of new trans-palladium (II) complexes in head and neck cancer

Autorzy:

Malinowska, Katarzyna
Kaczmarczyk, Dariusz
Zajdel, Radosław
Merecz-Sadowska, Anna
Olszewski, Jurek
Majczyk, Małgorzata
Nowak-Zduńczyk, Alicja
Zielińska-Bliźniewska, Hanna

Powiązania:

https://bibliotekanauki.pl/articles/1397298.pdf

Data publikacji:

2020

Wydawca:

Index Copernicus International

Tematy:

antioxidant enzymes
head and neck cancer
oxidative stress
Pd (II) complexes
reactive oxygen species

Opis:

Background: Head and neck neoplasms stand for 6% of all malignant neoplasms worldwide. Chemotherapy has limited use due to the biological properties of the tumor (in the majority of cases moderately and poorly differentiated squamous cell carcinoma). The fundamental molecule used in treatment is cisplatin and its derivates, that can be associated with fluorouracil. The new chemotherapeutic agents are not in common use during the treatment of head and neck malignancies. However, the use of low molecular weight complexes Pd (II) carries the potential of being more effective in therapy. Material and Methods: Fifty-one patients, 30 men and 21 women (aged 52.9 ± 12.1 years) with head and neck cancer were included in the study. Fifty-one healthy subjects, 31 men and 20 women, (aged 54.1 ± 14.7 years) years formed the control group. Antioxidant enzymes, superoxide dismutase, and catalase activities in erythrocytes were examined. Results: An increased level of antioxidant enzymes was seen in the blood samples from patients with head and neck cancer after incubation with Pd (II) complex. In the group we obtained a statistically significant result p = <0.001. Discussion: That project may contribute to the development of new, more efficient head and neck cancer treatment strategies. In our opinion, the results can be used in the future to develop a valuable prognostic marker of the disease. This is important because the initial phase of cancer is asymptomatic. The search for factors involved in pathogenesis translates into economic benefits and makes therapy more effectiveness through the reduction of treatment expenses.

Źródło:

Polish Journal of Otolaryngology; 2020, 74, 1; 23-28
0030-6657
2300-8423

Pojawia się w:

Polish Journal of Otolaryngology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 14.

Tytuł:

Robotic surgery (da Vinci Xi system) in head and neck cancer – own experience

Autorzy:

Golusiński, Wojciech
Pieńkowski, Piotr
Majchrzak, Ewa

Powiązania:

https://bibliotekanauki.pl/articles/1397295.pdf

Data publikacji:

2020

Wydawca:

Index Copernicus International

Tematy:

da Vinci Surgical System
oropharyngeal cancer
robotic surgery

Opis:

Introduction: Patients before 50 years of age with HPV-positive oropharyngeal cancer are characterized by significantly better survival than HPV-negative patients. The consequences of oncological treatment directly affect physiological function of the organs of the upper respiratory tract and, in consequence, the quality of life of these individuals. Therefore, the choice of therapy is of great importance. Minimally invasive surgery offers radical oncological treatment, while preserving the quality of life. The principal surgical methods are transoral access using TLM, electrosurgery and TORS. Radiochemotherapy as primary treatment is equally effective in the first and second stages of clinical advancement of cancer. However, occurrence of late complications such as swallowing, breathing, taste and smell disorders led to a recent re-emergence of minimally invasive surgery, particularly transoral robotic surgery, which has been widely used in head and neck surgery in the United States of America, Asia and Western European countries for more than 20 years. After many years, Poland joined the community of countries where the head and neck interventions are performed using the da Vinci Surgical System. Objective: The purpose of the work is to present our own experience with the TORS at the Department of the Head and Neck Surgery and Laryngological Oncology of the Poznan University of Medical Sciences and to analyze the latest literature reports on the use of TORS in the treatment of oropharyngeal squamous cell carcinoma.

Źródło:

Polish Journal of Otolaryngology; 2020, 74, 1; 1-5
0030-6657
2300-8423

Pojawia się w:

Polish Journal of Otolaryngology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 15.

Tytuł:

Effect of copper(II) the activity of glutathione peroxidase in patients with head and neck cancer

Autorzy:

Malinowska, Katarzyna
Morawiec-Sztandera, Alina
Majsterek, Ireneusz
Kaczmarczyk, Dariusz

Powiązania:

https://bibliotekanauki.pl/articles/1398625.pdf

Data publikacji:

2016

Wydawca:

Index Copernicus International

Tematy:

pyrazole complex
glutathione peroxidase
head and neck cancer

Opis:

Introduction: Head and neck squamous cell carcinoma (HNSCC) accounts for about 6% of all malignant cancers. In the epidemiology of oral cavity neoplasm, important risk factors include: tobacco smoking, alcohol abuse, bad oral hygiene, papilloma virus infection, riboflavin and iron deficiency. Objective: The objective of the investigation was a synthesis of Cu(II) complex and the evaluation of antioxidative enzymatic barrier in red blood cells of patients with head and neck tumor as well as in the control group. Materials and methods: For the investigation conduction, a consent of Bioethics Committee number RNN/142/09/KB was obtained. Blood for the examination was obtained from the patients of the Dapartment of Head and Neck Neoplasms Surgery Medical University of Łódź. The experiment was conducted on the group of 40 patients with HNSCC and 40 healthy people, using spectrophotometric method, glutathione peroxidase was marked. Results: The investigation was conducted on the hemolysate obtained from the patients that were divided into two groups – a study group (1 and 2), which consisted of patients diagnosed with head and neck cancer and a control group (1 and 2) – healthy people. A significant statistical result for GPX occurred in control-1 and study-1 group with complex compound Cu(II) (p<0,001). Conclusions: Presented research prove, that complex compound Cis-dichlorobis(N1-hydroxymethyl-3methylpyrazole-κN2)copper (II) has an impact on the activity of the antioxidative GPX enzyme.

Źródło:

Polish Journal of Otolaryngology; 2016, 70, 6; 20-25
0030-6657
2300-8423

Pojawia się w:

Polish Journal of Otolaryngology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 16.

Tytuł:

Ocena wiedzy pacjentów na temat czynników ryzyka związanych ze stylem życia, a występowanie chorób nowotworowych głowy i szyi
Risk factors related to lifestyle affecting the occurrence of head and neck cancer

Autorzy:

Karbowiak, Urszula
Serzysko, Bogusława

Powiązania:

https://bibliotekanauki.pl/articles/1029873.pdf

Data publikacji:

2018

Wydawca:

Państwowa Uczelnia Zawodowa we Włocławku

Tematy:

head and neck cancer
lifestyle
quality of life

Opis:

Introduction. Cancer is a complex pathological process that develops in the human body, destroying healthy cells progressively and leading to significant limitations in functioning and severe pain, sometimes persissitng even with the aid of painkillers. Cancerous diseases of the head and neck organs significantly reduce the quality of life compared to the population of healthy people. Aim. The aim of this study was to show whether smoking, alcohol and HPV are risk factors for head and neck cancer. Materials and methods. The study was conducted among 149 patients diagnosed with head and neck cancer in the Clinical Outpatient Center of Oncology Center in Gliwice with the consent of this heaktcare facility. The study used a questionnaire containing 38 questions. The study was carried out from November 2016 to January 2017. Results. The analysis of the results did not confirm that smoking, alcohol and HPV are the main risk factors for head and neck cancer. A large number of respodents did not answer the questions , which suggests patients' lack of knowledge or their denial of the harmfulness of the above-mentioned addictions. Conclusions. The majority of respondents were aware of the harmfulness of smoking and its effect on the development of cancer. However, they were not aware of the impact of drinking alcohol on the development of cancer. Most of the subjects knew what HPV is. However, the majority of respondents did not know that HPV belongs to oncogenic viruses. Smoking cigarettes differentiated their awareness of the impact of smoking on the development of cancer.
Wstęp. Choroba nowotworowa to złożony proces patologiczny, który rozwija się w ludzkim organizmie, który niszcząc zdrowe komórki prowadzi progresywnie do znacznych ograniczeń w funkcjonowaniu oraz znacznych dolegliwości bólowych, czasem nieustępujących po lekach przeciwbólowych. Choroba nowotworowa narządów głowy i szyi w znaczny sposób obniża jakość życia w porównaniu do populacji osób zdrowych. Cel. Celem tego badania była ocena wiedzy pacjentów na temat czynników ryzyka związanych ze stylem życia, a występowaniem chorób nowotworowych głowy i szyi. Materiał i metody. Badanie przeprowadzono wśród 149 pacjentów, u których rozpoznano chorobę nowotworową głowy i szyi w Przyklinicznej Przychodni Centrum Onkologii w Gliwicach za zgodą tejże palcówki. W badaniu posłużono się autorska ankietą zawierającą w 38 pytań. Badanie realizowano od listopada 2016 r. do stycznia 2017r. Wyniki. Analiza wyników nie potwierdziła, że palenie wyrobów tytoniowych, picie alkoholu i wirus HPV są głównymi czynnikami ryzyka chorób nowotworowych głowy i szyi. Spora ilość zaznaczanych odpowiedzi to nie udzielenie odpowiedzi, co sugeruje o braku wiedzy pacjentów lub wyparcia przez nich szkodliwości w/w nałogów. Wnioski. Badani w zdecydowanej większości byli świadomi szkodliwości palenia papierosów i jego wpływu na powstanie choroby nowotworowej. Nie mieli natomiast świadomości wpływu picia alkoholu na rozwój choroby nowotworowej. Większość badanych wiedziała, czym jest wirus HPV. Natomiast badani w większości nie mieli wiedzy, że wirus HPV należy do onkogennych. Palenie papierosów kiedykolwiek przez badanych różnicowało ich świadomość wpływu palenia papierosów na powstanie choroby nowotworowej.

Źródło:

Innowacje w Pielęgniarstwie i Naukach o Zdrowiu; 2018, 3, 2; 9-26
2451-1846

Pojawia się w:

Innowacje w Pielęgniarstwie i Naukach o Zdrowiu

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 17.

Tytuł:

The impact of radiotherapy on the quality of life in patients with early-stage clinical head and neck cancer

Autorzy:

Milecki, Jakub
Żmijewska-Tomczak, Małgorzata
Osmola, Krzysztof
Wierzbicka, Małgorzata

Powiązania:

https://bibliotekanauki.pl/articles/23203207.pdf

Data publikacji:

2021-05-07

Wydawca:

Index Copernicus International

Tematy:

head and neck cancer
Quality of life
radiotherapy

Opis:

Introduction: Radiotherapy (RT) for patients with head and neck squamous cell carcinoma (HNSCC) affects vital functions related to the irradiation volume of the head and neck region and, in addition, has a negative impact on social functioning, thereby significantly impairing patients’ quality of life (QoL). Aim: The aim of this study was to assess changes in the quality of life in patients with head and neck cancer treated with curative RT at 12 months after completion of RT. The aim of this study was to assess the differences between the baseline QoL of patients with early clinical stage HNSCC and at 12 months after curative/radical RT. Material and methods: The prospective clinical study included 92 patients in good general condition (ECOG 0–1 – Eastern Cooperative Oncology Group performance status), without regional or distant metastases, diagnosed with pathomorphologically confirmed early-stage head and neck squamous cell carcinoma treated with definitive RT. All patients participating in the study signed an informed consent form. QoL was assessed using the standard EORTC QLQ-C30 and QLQH&N35 questionnaires. In addition, information on clinical aspects and data relating to socio-demographic factors were obtained from each patient. Statistical analysis was performed using a statistical package (SPSS 17.0). T-test was used for dependent and independent samples. A general linear model was used for repeated measures. Results: Patients’ QoL deteriorated significantly after definitive RT. Worse QoL Core-30 scores in patients 12 months after the end of RT, compared with baseline QoL, before the start of RT, were observed in domains such as physical performance, fulfillment of life roles, cognitive functioning, loss of appetite, fatigue and constipation. For the QLQ-H&N35 questionnaires, patients 12 months after the end of RT reported problems in relation to aspects of life such as senses, mouth opening, dry mouth, thick saliva, pain, and weight loss. Conclusion: RT, even in early clinical stage head and neck cancer, has a negative impact on QoL, despite modern treatment techniques.

Źródło:

Polish Journal of Otolaryngology; 2021, 75, 5; 1-8
0030-6657
2300-8423

Pojawia się w:

Polish Journal of Otolaryngology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 18.

Tytuł:

The influence of age and comorbidities on the outcomes of surgical treatment with free tissue transfer: a retrospective study

Autorzy:

Czesak, Małgorzata
Sobol, Maria
Bruzgielewicz, Antoni
Niemczyk, Kazimierz
Osuch-Wójcikiewicz, Ewa

Powiązania:

https://bibliotekanauki.pl/articles/1397380.pdf

Data publikacji:

2020

Wydawca:

Index Copernicus International

Tematy:

elderly patient
head and neck cancer
reconstructive surgery

Opis:

Introduction: Microvascular free tissue transfer enables the reconstruction of complex head and neck defects. The aim of the study was to assess the results of treatment of patients undergoing reconstructive surgery and to identify factors affecting these results, with particular reference to patient’s age. Materials and Methods: All patients who underwent free-flap head and neck reconstruction in our institution between 2010 and 2017 were included in this retrospective study. A series of 66 patients met the inclusion criteria and were divided into 2 age groups: group G1 aged <65 years (n = 41) and group G2 aged ≥65 years (n = 25). Minor local complications and general complications as well as comorbidities were analyzed. Results: No correlation was found between advanced age and the risk of free flap failure as well as the incidence of local minor complications. General complications were more frequent in the G2 group (32%) than in the G1 group (19.5%), although this is not a statistically significant difference. A statistically significant difference was found between the age and the patient’s health status according to ASA (P = 0.010). In the younger low-risk group, 12 patients (29.3%) had general and local complications, while in the older low-risk group only 1 (4%). General and local complications were found in 5 (12.2%) high-risk G1 patients and in 7 (28%) high-risk G2 patients. Conclusion(s): Patients with advanced head and neck malignant tumors should undergo reconstructive microsurgery regardless of age.

Źródło:

Polish Journal of Otolaryngology; 2020, 74, 4; 8-12
0030-6657
2300-8423

Pojawia się w:

Polish Journal of Otolaryngology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 19.

Tytuł:

Application of cone beam computed tomography in ENT and reconstructive head and neck surgery – literature review and own experience

Autorzy:

Piotrowska-Seweryn, Agnieszka
Krakowczyk, Łukasz
Maciejewski, Adam
Kaniszewska-Dorsz, Żaneta
Markowski, Jarosław
Pietrauszka, Kornelia
Goroszkiewicz, Karolina

Powiązania:

https://bibliotekanauki.pl/articles/1399645.pdf

Data publikacji:

2019

Wydawca:

Index Copernicus International

Tematy:

computed tomography
ENT
free flap
head and neck
reconstruction

Opis:

CBCT is a relatively new diagnostic imaging method. It was first used in 1982 at the Mayo Clinic Biodynamics Research Laboratory [1], and has been commercially used in dentistry since 2001. It differs from multidetector computed tomography in terms of implementation technique and some parameters. A low dose of radiation is its greatest advantage, thanks to which many specialists, including ENT doctors and reconstructive surgeons, are more willing to use it. In otorhinolaryngology, CBCT is applied in pre- and perioperative diagnostics in both rhinology and otology. In reconstructive surgery, CBCT facilitates precise planning of the flap and intraoperatively allows a perfect match of the reconstructed tissue elements. In the article, the authors present current information on CBCT in ENT obtained on the basis of a review of Polish and foreign literature and share their own experience in its application in reconstructive surgery within the craniofacial region.

Źródło:

Polski Przegląd Otorynolaryngologiczny; 2019, 8, 3; 1-7
2084-5308
2300-7338

Pojawia się w:

Polski Przegląd Otorynolaryngologiczny

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 20.

Tytuł:

Ionizing radiation affects protein composition of exosomes secreted in vitro from head and neck squamous cell carcinoma

Autorzy:

Jelonek, Karol
Wojakowska, Anna
Marczak, Lukasz
Muer, Annika
Tinhofer-Keilholz, Ingeborg
Lysek-Gladysinska, Malgorzata
Widlak, Piotr
Pietrowska, Monika

Powiązania:

https://bibliotekanauki.pl/articles/1039103.pdf

Data publikacji:

2015

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

exosomes
head and neck cancer
ionizing radiation
proteome
radiobiology

Opis:

Exosomes are membrane vesicles of endocytic origin that participate in inter-cellular communication. Environmental and physiological conditions affect composition of secreted exosomes, their abundance and potential influence on recipient cells. Here, we analyzed protein component of exosomes released in vitro from cells exposed to ionizing radiation (2Gy dose) and compared their content with composition of exosomes released from control not irradiated cells. Exosomes secreted from FaDu cells originating from human squamous head and neck cell carcinoma were analyzed using LC-MS/MS approach. We have found that exposure to ionizing radiation resulted in gross changes in exosomal cargo. There were 217 proteins identified in exosomes from control cells and 384 proteins identified in exosomes from irradiated cells, including 148 "common" proteins, 236 proteins detected specifically after irradiation and 69 proteins not detected after irradiation. Among proteins specifically overrepresented in exosomes from irradiated cells were those involved in transcription, translation, protein turnover, cell division and cell signaling. This indicated that exosomal cargo reflected radiation-induced changes in cellular processes like transient suppression of transcription and translation or stress-induced signaling.

Źródło:

Acta Biochimica Polonica; 2015, 62, 2; 265-272
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 21.

Tytuł:

The role of MGMT polymorphisms rs12917 and rs11016879 in head and neck cancer risk and prognosis

Autorzy:

Kiczmer, Paweł
Prawdzic Seńkowska, Alicja
Strzelczyk, Joanna
Szydło, Błażej
Biernacki, Krzysztof
Osadnik, Tadeusz
Krakowczyk, Łukasz
Ostrowska, Zofia

Powiązania:

https://bibliotekanauki.pl/articles/1038528.pdf

Data publikacji:

2018

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

MGMT
head and neck cancer
polymorphism
rs12917
rs11016879

Opis:

Head and neck squamous cell carcinoma (HNSCC) is one of the leading cancers by incidence worldwide. The risk of these cancers is strictly associated with alkylation factors present in tobacco smoke. The crucial role in preventing DNA alkylation is played by O6-methylguanine-DNA methyltransferase (MGMT). Dysfunction or lack of MGMT is associated with an increased risk of cancer. The aim of the study was to assess the influence of MGMT polymorphisms: rs12917 and rs11016879 on HNSCC risk and course. The study consisted of 69 HNSCC patients and 242 healthy individuals. Case samples were taken from resected tumour tissue. The control group comprised samples of epithelial cells collected from mucous membranes using swabs. DNA samples were genotyped by employing the 5' nuclease assay for allelic discrimination using TaqMan SNP Genotyping Assays. The significance between distributions of genotypes and alleles was tested using Pearson's χ2 test analysis. Our results indicated that the MGMT rs12917 TT genotype increases the risk of HNSCC. The MGMT rs11016879 AG genotype and A allele were associated with increased HNSCC risk. We noted higher risk of nodal metastasis in rs11016879 AA homozygotes. Mechanisms leading to MGMT enzymatic defect are unknown and hence further studies need to be carried out. Our data suggest that the examined polymorphisms may be considered as potential prognostic factors for HNSCC risk and outcome. Further studies are necessary to verify our results.

Źródło:

Acta Biochimica Polonica; 2018, 65, 1; 87-92
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 22.

Tytuł:

Updated National Comprehensive Cancer Network guidelines for treatment of head and neck cancers 2010-2017

Autorzy:

Wierzbicka, Małgorzata
Napierała, Joanna

Powiązania:

https://bibliotekanauki.pl/articles/1398501.pdf

Data publikacji:

2017

Wydawca:

Index Copernicus International

Tematy:

head and neck cancers treatment guidelines
biological therapy
personalized treatment
recommendations

Opis:

Introduction: The diagnostic and therapeutic recommendations have been changing over the years to improve treatment outcomes and quality of life of Head and Neck Cancer (HNC) patients. Aim: The aim of this study was to present currently recommended Head and Neck Cancer treatment guidelines based on the literature review with particular emphasis on novel approaches the NCCN algorithms. Material and methods: The review of literature covering articles published in the last five years and pointing out essential changes in HNC treatment regarding evidence based medicine. The study focused on the analysis of novel approaches for the particular primaries, the implementation of biological therapies and personalized cancer therapies. Results: Updates in the oncological NCCN guidelines for all ENT primaries except major salivary glands and subglottis are based on knowledge derived from the basic sciences, clinical trials and the best evidence available currently. The latest recommendations emphasize value of biological therapies use.

Źródło:

Polish Journal of Otolaryngology; 2017, 71, 6; 1-6
0030-6657
2300-8423

Pojawia się w:

Polish Journal of Otolaryngology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 23.

Tytuł:

BERBERINE INDUCES AUTOPHAGY, APOPTOSIS AND MODULATES MIR-155 IN HEAD AND NECK SQUAMOUS CARCINOMA CELLS.

Autorzy:

Xue, Kai
Zhang, Binbin
He, Jingchuan

Powiązania:

https://bibliotekanauki.pl/articles/895286.pdf

Data publikacji:

2020-06-29

Wydawca:

Polskie Towarzystwo Farmaceutyczne

Tematy:

apoptosis
miR-155
Autophagy
berberine
Head and Neck cancer cells

Opis:

Berberine (BBR) an active natural plant alkaloid extracted from Coptidis rhizoma, displays potent anticancer activity over a variety of cancer cell lines. The cytotoxic activity of BBR in cancer cells is attributed to persuade, programmed cell death characterized by the release of cytochrome c, accompanied by activation of caspase-3 and caspase-9. In the present study, we evaluated BBR significantly reduces the cell viability and clonogenic property of head and neck squamous carcinoma (HNSC) cells. Our results revealed that BBR simultaneously induces apoptosis and autophagy in HNSC cells. Mechanistically, BBR induces autophagy in HNSC cells which were confirmed by acridine orange (AO) staining by visualization of prominent orange red color acidic autophagosomes in the cytoplasm. However, immunoblotting shows the steady conversion of MAP-LC-3I to LC-3II with concomitant degradation of autophagy substrate protein SQSTM1/p62. Annexin V FITC staining analysis by flow cytometry revealed a significant induction of apoptosis at higher doses of BBR. Furthermore, the immunoblotting analysis revealed a prominent cleavage of proapoptotic proteins procaspase-3 and PARP1 at higher doses of BBR. Additionally, we found significant upregulation and downregulation of tumor suppressor microRNA-155 (miR-155) and oncogenic miR-21 respectively, when HNSC cells were exposed to higher doses of BBR. In conclusion, these results demonstrate that BBR exhibits a significant anti-proliferative effect with the simultaneous induction of autophagy and apoptosis and modulates miRNA expression in HNSC cells.

Źródło:

Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 485-494
0001-6837
2353-5288

Pojawia się w:

Acta Poloniae Pharmaceutica - Drug Research

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 24.

Tytuł:

THE EFFECT OF NICLOSAMIDE ON THE HEAD AND NECK CARCINOMA CELLS SURVIVAL AND THE EXPRESSION OF WNT/β-CATENIN SIGNALING AND GLYCOLYSIS PATHWAY COMPONENTS

Autorzy:

Kleszcz, Robert
Paluszczak, Jarosław
Baer-Dubowska, Wanda

Powiązania:

https://bibliotekanauki.pl/articles/895272.pdf

Data publikacji:

2019-08-30

Wydawca:

Polskie Towarzystwo Farmaceutyczne

Tematy:

Wnt signaling
glycolysis
β-catenin
niclosamide
head and neck carcinoma

Opis:

The aim of this study was to evaluate the effect of niclosamide, an antihelminthic drug recently identified as potential anti-cancer agent, on head and neck squamous carcinoma cells (HNSCC) viability, cell cycle distribution and apoptosis. The expression of key components of Wnt (CTNNB1, GSK-3β, CCND1, c-MYC, MMP7, BIRC5, Axin2) and glycolysis (GLUT1, MCT1, HK2, PFKM, PKM2, PDHA1, PDK1, LDHA) pathways was also examined to assess possible involvement in niclosamide anti-carcinogenic activity. HNSCC cells (FaDu, BICR6, H314 lines) were used in the research. Niclosamide treatment affected hypopharyngeal FaDu cells to the most extent (IC50 = 0.40 µM), while H314 cells derived from the floor of mouth were the least sensitive (IC50 = 0.94 µM). In FaDu cells the increased percentage of the cells in the S phase was observed along with the induction of apoptosis. Treatment with niclosamide in FaDu cells reduced the expression of MMP7 and the majority of glycolytic genes except increased LDHA. These results indicate that niclosamide is efficient inhibitor of HNSCC cells viability, however this effect depends on the cell type. In FaDu cells, the most sensitive to its anti-proliferative effect and prone to cell cycle arrest and apoptosis, this effect might be related to slightly modulation of canonical Wnt signaling and increased expression of LDHA.

Źródło:

Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 4; 661-669
0001-6837
2353-5288

Pojawia się w:

Acta Poloniae Pharmaceutica - Drug Research

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 25.

Tytuł:

Microvascular nose reconstruction after extended tumor resection

Autorzy:

Krakowczyk, Łukasz
Szymczyk, Cezary
Wierzgoń, Janusz
Oleś, Krzysztof
Smyczek, Dominika
Ulczok, Rafał
Donocik, Karolina
Hadasik, Grzegorz
Piotrowska, Agnieszka
Maciejewski, Adam

Powiązania:

https://bibliotekanauki.pl/articles/1391900.pdf

Data publikacji:

2020

Wydawca:

Index Copernicus International

Tematy:

free flaps
head and neck
nasal cancer
nasal reconstruction

Opis:

Introduction: The nose is the central and probably the most important organ of the face. In view of the three-dimensional shape and variety of tissues, reconstructive surgery after tumor resection in this anatomical region requires the surgeon’s knowledge of anatomy. Materials and Method: In the years 2010–2019, 48 patients were treated in the Oncological and Reconstructive Surgery Clinic for extended nasal tumors, which required the use of free microvascular flaps after resection for functional and aesthetic supply of anatomical structures of the nose. Results: In 48 patients, a total of 92 free microvascular flaps were used for nasal reconstruction including: radial forearm free flap in 24 patients, radial forearm free flap with radial bone in 14 patients, auricular free flap in 16 patients, radial forearm free flap in combination with auricle free flap in 7 patients, double auricular free flap in 6 patients, radial forearm free flap in combination with double auricular free flap in 4 patients. Total necrosis of the free flap was noted in 4 cases, partial in 6 patients. Conclusions: The presented surgical techniques using microvascular free flaps constitute a recognized method of treatment and should be used in everyday surgeon practice. The results demonstrated in this article allow to obtain optimal functional and aesthetic effects.

Źródło:

Polish Journal of Surgery; 2020, 92, 5; 1-7
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 26.

Tytuł:

THE COMPARISON OF THE EFFECTS OF PANOBINOSTAT AND PKF118-310 ON β-CATENIN-DEPENDENT TRANSCRIPTION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA CELL LINES

Autorzy:

Paluszczak, Jarosław
Kleszcz, Robert
Witczak, Olga
Krajka-Kuźniak, Violetta

Powiązania:

https://bibliotekanauki.pl/articles/895659.pdf

Data publikacji:

2020-02-29

Wydawca:

Polskie Towarzystwo Farmaceutyczne

Tematy:

Wnt signaling
head and neck cancer
panobinostat
PKF118-310

Opis:

Advanced head and neck squamous cell cancers (HNSCC) have unfavorable prognosis and new therapeutic options are necessary to improve treatment outcomes. The Wnt pathway plays an important role in the pathogenesis and progression of HNSCC. The aim of this study was to assess the effects of a histone deacetylase inhibitor – panobinostat on Wnt-dependent gene expression and on cell migration. Cell viability in HNSCC cell lines (BICR6, CAL27, FaDu, H314, SCC-25) was evaluated by MTT assay. The expression of β-catenin-target genes was assessed by qPCR and TCF/LEF-dependent reporter assay. Protein content was evaluated by Western blot. Cell migration was analyzed by the wound healing assay. Panobinostat showed differential modulation of gene expression. It reduced the level of Axin2 in CAL27 and SCC-25 cells but upregulated its expression in BICR6 and H314 cell lines. Moreover, it diminished the expression of MMP7 in BICR6, H314 and CAL27 cell lines. In contrast, the inhibitor of β-catenin transcriptional activity – PKF118-310 down-regulated the expression of β-catenin-target genes in HNSCC cell lines. Interestingly, panobinostat had opposite effects on cell migration in CAL27 and FaDu where it inhibited or stimulated migration, respectively. On the other hand, PKF118-310 reduced cell migration. The anti-cancer effects of panobinostat in HNSCC cells are rather not related to the inhibition of Wnt signaling. PKF118-310 attenuates Wnt signaling, but only in a limited number of HNSCC cell lines. Importantly, the inhibition of Wnt pathway reduces the capacity of cells for migration suggesting that it may potentially therapeutically reduce cell invasion.

Źródło:

Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 1; 77-88
0001-6837
2353-5288

Pojawia się w:

Acta Poloniae Pharmaceutica - Drug Research

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 27.

Tytuł:

Fibromatosis aggressiva of parapharyngeal space – a case report and review of literature.

Autorzy:

Piotrowska, Angelika
Rzepakowska, Anna
Chęciński, Piotr
Niemczyk, Kazimierz

Powiązania:

https://bibliotekanauki.pl/articles/1400253.pdf

Data publikacji:

2017

Wydawca:

Index Copernicus International

Tematy:

desmoid-type fibromatosis
parapharyngeal space tumor
head and neck neoplasms

Opis:

Desmoid fibromatosis is defined as a rare fibroblastic proliferation. Although histologically benign, desmoids are locally invasive and associated with a high local recurrence rate. When located in the head and neck region, fibromatosis tends to be more aggressive and associated with significant morbidity, which may be attributed to the proximity of the vital structures. We report a case of 33-year-old woman with aggressive fibromatosis of parapharyngeal space. Complete surgical excision of the lesion was performed and the postoperative period was without complications. The patient remains under careful follow-up and there is no recurrence of the disease.

Źródło:

Polski Przegląd Otorynolaryngologiczny; 2017, 6, 2; 10-15
2084-5308
2300-7338

Pojawia się w:

Polski Przegląd Otorynolaryngologiczny

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 28.

Tytuł:

Review of surgical techniques for the reconstruction of the maxillofacial region used in the Department of Maxillo-Facial Surgery in Rzeszów

Autorzy:

Frańczak, Jan
Pakla, Paweł
Brodowski, Robert
Stopyra, Wojciech
Burdzy, Danuta
Lewandowski, Bogumił

Powiązania:

https://bibliotekanauki.pl/articles/454921.pdf

Data publikacji:

2017

Wydawca:

Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego

Tematy:

reconstructive surgery
microsurgery
surgical flaps
cancer of head and neck

Opis:

Postoperative reconstruction of tissue loss within the head and neck after extensive resections due to malignant neoplasms or traumas has always been a challenge for maxillo-facial surgeons or ENT physicians. Due to the complex anatomical structure of the head and neck region, every patient requires an individual approach and there is no standard method of management appropriate for all patients. The number of patients treated for malignancy is increasing year by year. The possibility of performing extensive resections in the head and neck region are conditioned by appropriate reconstruction. Aim. The aim of the paper is to present the reconstructive methods used in the Clinical Department of Maxillofacial Surgery, F. Chopin Hospital No. 1 in Rzeszow. A short review of the most commonly used flaps is presented, taking into account their advantages, disadvantages and surgical technique in terms of their usefulness in daily clinical practice.

Źródło:

European Journal of Clinical and Experimental Medicine; 2017, 3; 273-278
2544-2406
2544-1361

Pojawia się w:

European Journal of Clinical and Experimental Medicine

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 29.

Tytuł:

Serum and saliva levels of matrix metalloproteinase 3 and 9 in pharynx and larynx cancer

Autorzy:

Polz-Dacewicz, Małgorzata
Maciąg, Paweł
Kliszczewska, Ewa
Rolniak, Łukasz

Powiązania:

https://bibliotekanauki.pl/articles/972529.pdf

Data publikacji:

2017

Wydawca:

Instytut Medycyny Wsi

Tematy:

matrix metalloproteinases
larynx cancer
throat cancer
head and neck cancer

Opis:

Introduction and objective. Matrix metalloproteinases (MMPs) are proteolytic enzymes responsible for the decomposition of extracellular matrix elements. They play an important role during embryogenesis, wound healing, endometrial epithelial exfoliation, the formation of new blood vessels, and also during cancer development. Throat and larynx tumours are included in a large group of head and neck cancers. These tumours are characterized by a poor prognosis. Despite advances in medical science, cancer treatment is difficult and often ineffective. The aim of the study was to evaluate the level of MMP-3 and MMP-9 in the serum and saliva of patients with pharynx and larynx tumours. Materials and method. Samples of saliva and serum were collected from 60 patients with larynx or throat cancer. Twenty patients without cancer comprised the control group. MMPs in saliva and serum were determined by the ELISA method. Results. In the study group, concentrations of MMP-3 in saliva were from 0.2 – 77.6 ng/ml. Patients with malignant tumours had higher saliva MMP-3 levels than healthy subjects. The concentration of MMP-3 in the serum of the study group ranged from 10.9 – 200.00 ng/ml, which was also higher than in the control group. There were no statistically significant difference in the MMP-9 level between the study and control groups (both in serum and saliva). Conclusions. This study is another element that shows the phenomena taking place at the cellular level during oncological disease. In serum and saliva samples, higher values of MMP3 were found in patients with cancer. The increase in the concentration of this enzyme in the risk group may be used for early detection of tumour transformation and evaluation of treatment.

Źródło:

Journal of Pre-Clinical and Clinical Research; 2017, 11, 2; 106-110
1898-2395

Pojawia się w:

Journal of Pre-Clinical and Clinical Research

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 30.

Tytuł:

Instrumental evaluation of dysphagia after oropharyngeal cancer surgery with free flap reconstruction

Autorzy:

Jamróz, Barbra
Chmielewska, Joanna
Milewska, Magdalena
Niemczyk, Kazimierz

Powiązania:

https://bibliotekanauki.pl/articles/1401527.pdf

Data publikacji:

2016

Wydawca:

Index Copernicus International

Tematy:

FEES
VFS
dysphagia
head and neck cancer
free flap reconstruction

Opis:

Introduction: Assessment of usefulness of instrumental method of evaluation of dysphagia in creating a therapeutic plan among patients after oropharyngeal cancer surgery with free flap reconstruction. Material and Method: Seven patients after oropharyngeal cancer surgery with free flap reconstruction hospitalized from January to September 2016 in the ENT Department of Warsaw Medical University were included in this study. All patients underwent few times after surgery: clinical swallowing examination, water swallowing screening test and fiberoptic endoscopic evaluation of swallowing and/or videofluoroscopy. Results: All patients were diagnosed with dysphagia and had unitentional weight loss (average 5,9% of initial weight during 3 months). In water swallowing test only three participant achieved negative score for 5 ml, and two for 10 ml, 20 ml and 90 ml of water. Fiberoptic endoscopic evaluation of swallowing was analyzed for swallowing patterns and laryngeal pathology. FEES showed following abnormalities: aspiration (saliva, liquid), penetration (puree, liquid), premature swallowing (liquid, puree) and multiswallowing (liquid, puree, solid food), retention (saliva, puree, liquid, solid food). Videofluroscopy showed on the first place problems with oral phase of swallowing: difficulty forming and propeling bolus, tongue pumping movements, oral cavity residue, premature spillage and delayed oral onset. During the pharyngeal phase we observed: residue in valleculae and piriform sinuses, reduced laryngeal elevation, penetration and aspiration, multiple swallows. Conclusion: Instrumental assessment of swallowing helps during diagnostic and therapeutic process of patients with dysphagia after oncological treatment. a.

Źródło:

Polski Przegląd Otorynolaryngologiczny; 2016, 5, 4; 22-28
2084-5308
2300-7338

Pojawia się w:

Polski Przegląd Otorynolaryngologiczny

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 31.

Tytuł:

Enteral feedıng vıdeo traınıng for the relatıves of head and neck cancer patıents: evaluatıon of ıts ımpact on knowledge and practıce

Autorzy:

Günay Ismailoğlu, Elif
Orkun, Nilay
Zaybak, Ayten
Çepken Kanlıoğlu, Makbule

Powiązania:

https://bibliotekanauki.pl/articles/1918968.pdf

Data publikacji:

2021-06-14

Wydawca:

Uniwersytet Medyczny w Białymstoku

Tematy:

enteral feding
head and neck cancer
patient
patient relatives
video training

Opis:

Purpose: The purpose of the study was to examine the effect of using videos during enteral feeding training on the level of relevant knowledge and practice. Materials and methods: A randomized controlled quasi-experimental, post-test research design was used. We included 33 patients and relatives in the video group while 31 patients their relatives in the control group. In video group, the video recording was shown to the relatives in addition to verbal training however only verbal training was given in the control group. The relatives’ level of knowledge and practice score was evaluated. Results: Mean enteral feeding knowledge scores of patient relatives were found to be 76.7 ± 7.97 in the video group and 42.1 ± 12.57 in the control group. Mean enteral feeding practice scores were as follows: 19.64 ± 3.3 for the video group and 13 ± 3.63 for the control group. Conclusions: It was concluded that the enteral feeding training provided by using the video method increased the knowledge and practice levels of patient relatives. Implications for Practice: Video material prepared for the clinic will be a guide for clinical nurses and help them in their enteral feeding training and care planning.

Źródło:

Progress in Health Sciences; 2021, 11(1); 15-22
2083-1617

Pojawia się w:

Progress in Health Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 32.

Tytuł:

Ionizing radiation affects profile of serum metabolites: increased level of 3-hydroxybutyric acid in serum of cancer patients treated with radiotherapy

Autorzy:

Roś-Mazurczyk, Małgorzata
Wojakowska, Anna
Marczak, Łukasz
Polański, Krzysztof
Pietrowska, Monika
Jelonek, Karol
Domińczyk, Iwona
Hajduk, Agata
Rutkowski, Tomasz
Składowski, Krzysztof
Widłak, Piotr

Powiązania:

https://bibliotekanauki.pl/articles/1038706.pdf

Data publikacji:

2017

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

head and neck cancer
mass spectrometry
metabolomics
radiation response
serum metabolome

Opis:

Radiotherapy causes molecular changes observed at the level of body fluids, which are potential biomarker candidates for assessment of radiation exposure. Here we analyzed radiotherapy-induced changes in a profile of small metabolites detected in sera of head and neck cancer patients using the gas chromatography coupled with mass spectrometry approach. There were about 20 compounds, including carboxylic acids, sugars, amines and amino acids, whose levels significantly differed between pre-treatment and post-treatment samples. Among metabolites upregulated by radiotherapy there was 3-hydroxybutyric acid, whose level increased about three times in post-treatment samples. Moreover, compounds affected by irradiation were associated with several metabolic pathways, including protein biosynthesis and amino acid metabolism.

Źródło:

Acta Biochimica Polonica; 2017, 64, 1; 189-193
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 33.

Tytuł:

Retrospective evaluation of risk factors for oral cavity and oropharynx cancers in patients under the program of head and neck cancers prevention

Autorzy:

Kowalski, Andrzej
Olszewski, Jurek
Zielińska-Bliźniewska, Hanna

Powiązania:

https://bibliotekanauki.pl/articles/1397748.pdf

Data publikacji:

2019

Wydawca:

Index Copernicus International

Tematy:

Head and Neck Cancer Prophylaxis Program
oral cavity
oropharynx cancer
risk factors

Opis:

Introduction: The aim of the study was to analyze the risk factors for oral cavity and pharyngeal cancer in people examined under the Head and Neck Cancer Prophylaxis Program. Material and methods: The study was conducted in a total of 300 patients, including 186 women and 114 men, as part of the Head and Neck Cancer Prevention Program in 2014–2018. Before the laryngological examination, the patients completed a demographic and medical questionnaire regarding the risk factors of head and neck cancer, including education, reported disease symptoms, smoking addiction, number of cigarettes smoked daily, alcohol consumption, frequency of visits in a dental office, oral hygiene measures, number of sexual partners, oral sex, family medical history of head and neck cancer. Results: The subjects reported the following symptoms: hoarseness 43.33%, difficulty swallowing 21.33%, pain or mouth burning 20.33% and other symptoms were observed in 46.33%. The main dental symptoms were: bleeding from the gums during teeth brushing in 48.89%, dry mouth 45.56%. Currently 20.33% of respondents smoke, whereas 54% of patients smoked in the past. In the analyzed material, the majority (80%) consumed alcoholic beverages. 27.67% of respondents admitted having oral sex, including 24.73% of women and 32.46% of men. After performing the extended diagnostics, the tumor was found in 10% of the subjects. C onclusions: Statistical significance of differences was found: between hoarseness and alcohol consumption, both in women and in men, between hoarseness and smoking in women, between difficulty in swallowing and smoking in women, between burning/pain in the mouth and smoking in men, between hoarseness and the cultivation of oral sex in men, between the difficulty of swallowing and the practice of oral sex in the studied men and between burning/pain in the oral cavity and the occurrence of malignancy.

Źródło:

Polish Journal of Otolaryngology; 2019, 73, 6; 24-31
0030-6657
2300-8423

Pojawia się w:

Polish Journal of Otolaryngology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 34.

Tytuł:

Health-related quality of life in oropharyngeal cancer survivors – a population-based study

Autorzy:

Guenzel, Thomas
Walliczek-Dworschak, U
Teymoortash, A
Singer, S
Eichler, M
Wilhelm, T
Schimmer, M
Franzen, A

Powiązania:

https://bibliotekanauki.pl/articles/1398253.pdf

Data publikacji:

2018

Wydawca:

Index Copernicus International

Tematy:

EORTC
oropharynx
tonsil
tongue
cancer
head and neck
quality of life

Opis:

Objective: The aim of this study was to compare QoL of oropharyngeal cancer survivors who had received different treatments. Subjects and methods: We contacted 954 survivors. Each survivor received the QoL questionnaires EORTC QLQ-C30 and EORTC QLQ-H&N35. Results: A total of 263 survivors completed the questionnaires (28% responses). Forty-five of them had undergone surgery, 20 had received definitive radiotherapy or chemo-radiotherapy, 85 surgery plus adjuvant radiotherapy, and 111 surgery plus adjuvant chemo-radiotherapy. Survivors who had received adjuvant radiotherapy and surgery reported significantly more problems with swallowing (B=13.43 [95% Confidence Interval (CI) 1.83-25.03]), senses (B=24,91 [CI 11.86-37.97]), eating (B=16.91 [CI 3.46-30.36]), dry mouth (B=26.42 [CI 12.17-40.67]), sticky saliva (B=22.37 [CI 6.23-38.50]) and nutritional supplements (B=18.59 [CI 0.62-36.56]) than those who had received surgery only. Survivors who had received adjuvant chemo-radiotherapy and surgery reported significantly many more problems with dry mouth (B=34.15 [CI 18.91-49.39]) and sticky saliva (B=22.90 [CI 5.65-40.16]), and fewer problems with physical functioning (B=-12.07 [CI 0.49-23-64]). Conclusion: Survivors who participated in this survey and who had undergone surgery alone reported in some head- and neck-specific domains a better health-related quality of life than patients who had undergone multi-modal treatment or adjuvant radiotherapy.

Źródło:

Polish Journal of Otolaryngology; 2018, 72, 2; 30-35
0030-6657
2300-8423

Pojawia się w:

Polish Journal of Otolaryngology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 35.

Tytuł:

Virtual surgical planning and cone beam computed tomography in reconstruction of head and neck tumors – pilot study

Autorzy:

Krakowczyk, Łukasz
Piotrowska-Seweryn, Agnieszka
Szymczyk, Cezary
Wierzgoń, Janusz
Oleś, Krzysztof
Ulczok, Rafał
Donocik, Karolina
Dowgierd, Krzysztof
Maciejewski, Adam

Powiązania:

https://bibliotekanauki.pl/articles/1397270.pdf

Data publikacji:

2021

Wydawca:

Index Copernicus International

Tematy:

cone beam computed tomography
free flap
head and neck
reconstruction
virtual surgical planning

Opis:

Introduction: The aim of the study was to prove that a combination of visual surgical planning (VSP) and cone beam computed tomography (CBCT) is an optimal technique in fibular free flap reconstructions after complex tumor resections in the head and neck region and that it leads to better functional and aesthetic outcomes. Material and method: Six patients (3 females, 3 males) with head and neck tumors were included in the study. The region concerned midface in 2 cases and mandible in 4 patients. On the basis of computed tomography of the head, fibular free flap (FFF) reconstruction was planned with the VSP technique. The 3D-printed models were prepared. At the beginning of the operation and a few minutes after the reconstruction, an xCAT CBCT by XORAN was performed. Minor corrections of the angles of the reconstructed bony parts were made where needed. The time of the operation was assessed for each case. Functional and cosmetic results were evaluated in a 1-year follow-up. Results: The mean time of operation was 6 hours and 48 minutes, which was approximately 1hour and 40 minutes less than standard reconstructive surgery. Functional recovery was achieved in all patients. Aesthetic result was unsatisfactory for 2 patients due to insufficient soft tissue masses of FFF. Conclusions: The authors claim that intraoperative CBCT imaging, regardless of the cost, improves the accuracy of aesthetic outcome of reconstructive surgeries based on VSP, especially in the region of the midface and the mandible. Further studies on a higher number of subjects are required.

Źródło:

Polish Journal of Otolaryngology; 2021, 75, 2; 28-33
0030-6657
2300-8423

Pojawia się w:

Polish Journal of Otolaryngology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 36.

Tytuł:

Dosimetric Comparison of IMRT Simultaneous Integrated Boost With Conventional IMRT Treatment Planning for Head and Neck Cancer

Autorzy:

Yazici, A.
Dirican, B.
Kara, E.

Powiązania:

https://bibliotekanauki.pl/articles/1401992.pdf

Data publikacji:

2015-08

Wydawca:

Polska Akademia Nauk. Instytut Fizyki PAN

Tematy:

87.53.Tf
87.55.D

Opis:

Intensity Modulated Radiation Therapy (IMRT) provides the ability to not only conform the radiation dose to the shape of the target thereby reducing dose to normal tissues, it also allows to deliver different doses each day to different parts of the target. This approach is known as a simultaneous integrated boost (SIB). This study aims that dosimetric parameters of SIB with IMRT treatment planning technique are compared with conventional treatment planning technique using NTCP for 2 head and neck cancer patients.

Źródło:

Acta Physica Polonica A; 2015, 128, 2B; B-236-B-238
0587-4246
1898-794X

Pojawia się w:

Acta Physica Polonica A

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 37.

Tytuł:

Head and neck amyloidosis – a report on five cases
Amyloidoza w rejonie głowy i szyi – opis serii przypadków

Autorzy:

Orłowska, Anna
Mastalerek, Jan
Jaskólska, Magdalena
Rzepakowska, Anna
Grzybowski, Jakub
Gotlib, Tomasz
Niemczyk, Kazimierz

Powiązania:

https://bibliotekanauki.pl/articles/1399353.pdf

Data publikacji:

2020

Wydawca:

Index Copernicus International

Tematy:

amyloidosis
amyloidosis of the nasopharynx
head and neck amyloidosis
larynx amyloidosis
localized amyloidosis
salivary gland amyloidosis
tongue amyloidosis
amyloidoza
amyloidoza głowy i szyi
amyloidoza języka
amyloidoza krtani
amyloidoza miejscowa
amyloidoza nosogardła
amyloidoza ślinianek

Opis:

Background: Amyloidosis is a group of diseases caused by the extracellular accumulation of insoluble fibers called amyloid in the tissues and organs. They have a secondary beta-sheet structure, which makes them resistant to proteolysis. In histological examination amyloid deposits stain with Congo red and show an apple-green birefringence in polarized light. Amyloid deposits disturb the function of organs and cause clinical symptoms. Their formation or accumulation in the system may be acquired or inherited. Due to the location of amyloid deposits we distinguish systemic and localized amyloidosis with the formation of tumors (usually from light chains). Case reports: 5 cases of amyloidosis in the head and neck region are presented in this paper. The locations of the amyloid deposits were as follows: larynx, nasopharynx, sublingual and submandibular gland and the tongue. The initial clinical presentation correlated with location of amyloid tumour in our patients. Two patients had history of local recurrence of the disease. Surgical resection and histopathological examination were performed. Sections stained with Congo red confirmed the diagnosis of amyloidosis. Three patients had potential conditions predisposing to amyloidosis: previous radiotherapy, chronic inflammation due to hepatitis C virus infection and graft versus host disease. Conclusion: Amyloidosis should be considered as the cause of symptoms in pathologies of the head and neck region. The diagnosis requires a histopathological examination. The systemic form of the disease must be ruled out in all patients with head and neck amyloidosis. In localized amyloidosis the surgical resection of the lesions is the procedure of choice, however the organ’s functionality should be taken into account.
Podstawy naukowe: Amyloidoza, czyli skrobawica, to grupa chorób, których wspólną cechą jest pozakomórkowe gromadzenie się w tkankach i narządach nierozpuszczalnych białek o budowie włókienkowej, zwanych amyloidem. Mają one drugorzędową strukturę β-kartki, co czyni je opornymi na proteolizę. W skrawkach histologicznych złogi amyloidu wybarwiają się czerwienią Kongo i wykazują zielone świecenie w świetle spolaryzowanym. Depozyty amyloidu zaburzają funkcje narządów i powodują objawy kliniczne. Ich powstawanie lub gromadzenie się w ustroju może być stanem nabytym lub dziedzicznym. Ze względu na lokalizację złogów amyloidu rozróżniamy: (1) amyloidozę układową, czyli uogólnioną, oraz (2) miejscową z tworzeniem guzów (najczęściej z łańcuchów lekkich immunoglobulin). Opisy przypadków: W niniejszej pracy opisano 5 przypadków amyloidozy w regionie głowy i szyi. Zmiany zlokalizowane były w obrębie: krtani, nosogardła, ślinianki podjęzykowej i podżuchwowej oraz języka. Pacjenci zgłaszali objawy typowe dla procesu rozrostowego obejmującego wymienione narządy. U dwóch osób choroba miała charakter nawrotowy. Zmiany usunięto operacyjnie. Na podstawie badania histopatologicznego pobranych tkanek i charakterystycznego barwienie czerwienią Kongo i Saturna, rozpoznano obecność złogów amyloidu. U trzech pacjentów występowały stany predysponujące do wystąpienia amyloidozy: uprzednia radioterapia, przewlekły stan zapalny związany z zakażeniem wirusem zapalenia wątroby typu C i choroba przeszczep przeciwko gospodarzowi. U chorego z makroglosją rozpoznano postać uogólnioną amyloidozy. Podsumowanie: Amyloidoza może imitować objawy zmian rozrostowych w rejonie głowy i szyi. Jej rozpoznanie wymaga badania histopatologicznego. U każdego chorego z miejscową amyloidozą musi zostać wykluczona postać uogólniona. W przypadku postaci miejscowej, resekcja chirurgiczna zmian jest postępowaniem z wyboru. Należy wziąć pod uwagę zachowanie funkcjonalności narządu.

Źródło:

Polski Przegląd Otorynolaryngologiczny; 2019, 8, 2; 32-37
2084-5308
2300-7338

Pojawia się w:

Polski Przegląd Otorynolaryngologiczny

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 38.

Tytuł:

Metastasis of clear cell renal cell carcinoma to the organs of the head and neck – an ongoing problem

Autorzy:

Torchalla, Patrycja
Czesak, Małgorzata
Osuch-Wójcikiewicz, Ewa

Powiązania:

https://bibliotekanauki.pl/articles/1398949.pdf

Data publikacji:

2021

Wydawca:

Index Copernicus International

Tematy:

clear cell renal cancer
renal cell carcinoma
metastases
submandibular salivary gland

Opis:

Renal cell carcinoma accounts for about 2-3% of all malignancies. It is characterized by a high frequency of metastases, which are most often observed in the lungs, bones, liver, brain and regional lymph nodes. Literature highlights the rare occurrence of renal cancer metastases to the head and neck, even though it is the third most common cancer that metastasizes to the head and neck. Below we present a case report of metastases of clear cell carcinoma from a kidney to the organs of the head and neck. The analysis was carried out retrospectively based on medical records of a patient hospitalized at the Department of Otorhinolaryngology, Head and Neck Surgery of the Medical University of Warsaw in the years 2009-2019. We describe an 81-year-old man after left-sided nephrectomy due to clear cell carcinoma, with numerous distant metastases, who was diagnosed with metastases to the left submandibular salivary gland 8 years after primary surgery, followed by a diagnosis of metastasis to the right submandibular salivary gland 3 years later. The patient underwent 2 radical procedures to remove the submandibular salivary glands. Due to the presence of lung metastases, treatment with a tyrosine kinase inhibitor was also implemented.

Źródło:

Polski Przegląd Otorynolaryngologiczny; 2021, 10, 1; 42-48
2084-5308
2300-7338

Pojawia się w:

Polski Przegląd Otorynolaryngologiczny

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 39.

Tytuł:

Use of 3D printing in head and neck surgery
Zastosowanie druku 3D w chirurgii głowy i szyi

Autorzy:

Likus, Wirginia
Nechoritis, Konstantinos
Różycka-Nechoritis, Aleksandra
Wilk, Renata
Hudecki, Andrzej
Gaweł, Wojciech
Przytuła-Kandzia, Katarzyna
Markowski, Jarosław

Powiązania:

https://bibliotekanauki.pl/articles/1035511.pdf

Data publikacji:

2020

Wydawca:

Śląski Uniwersytet Medyczny w Katowicach

Tematy:

3d printing
otolaryngology
head and neck
surgery
education
reconstruction
druk 3d
otolaryngologia
głowa i szyja
chirurgia
edukacja
rekonstrukcje

Opis:

Currently, 3D printing in medicine does not comprise only prostheses or implants, but also medical modelling and surgical planning. The future of 3D printing is printing combined with tissue bioengineering (bioprinting). Scaffolds made in 3D technology containing living cells are a step to creating tissues and organs. Three-dimensional printing in surgery is now considered the future of reconstructive and regenerative medicine. Head and neck surgery also benefits from advances in 3D printing. In this article, we will describe some of the possibilities offered by 3D printing in the aspect of education, training, and printed prostheses for the needs of head and neck surgery.
Obecnie druk 3D w medycynie oznacza nie tylko protezy czy implanty, ale także modelowanie medyczne i planowanie chirurgiczne. Przyszłością będzie druk 3D połączony z bioinżynierią tkankową (bioprinting). Rusztowania wykonane w technologii 3D zawierające żywe komórki są krokiem do tworzenia tkanek i narządów. Druk trójwymiarowy w chirurgii uważany jest obecnie za przyszłość medycyny rekonstrukcyjnej i regeneracyjnej, a z dokonań na tym polu korzysta także chirurgia głowy i szyi. W prezentowanym artykule opiszemy niektóre możliwości, jakie daje druk 3D w aspekcie edukacji, szkoleń oraz drukowanych protez na potrzeby chirurgii głowy i szyi.

Źródło:

Annales Academiae Medicae Silesiensis; 2020, 74; 99-115
1734-025X

Pojawia się w:

Annales Academiae Medicae Silesiensis

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 40.

Tytuł:

Association of the cytochrome P450 and arylamine N-acetyltransferase gene polymorphisms with the incidence of head and neck cancer in Polish population

Autorzy:

Gogolewska, Monika
Kabziński, Jacek
Majsterek, Ireneusz

Powiązania:

https://bibliotekanauki.pl/articles/23381296.pdf

Data publikacji:

2023-12-15

Wydawca:

Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi

Tematy:

xenobiotics
head and neck cancer
CYP1A
NAT2
CYP2D
NAT1

Opis:

Objectives Head and neck cancer (HNC) is one of the most common cancers. Most exogenous HNC is head and neck squamous cell carcinomas. Scientists are striving to develop diagnostic tests that will allow the prognosis of HNC. The aim of the study was to determine the risk of HNC. The research concerned changes caused by polymorphisms in genes encoding proteins responsible for the metabolism of xenobiotics. Material and Methods In group of 280 patients with HNC, the occurrence of polymorphic variants in NAT1(rs72554606), NAT2(rs1799930), CYP1A(rs1799814), CYP2D(rs3892097) were studied with TaqMan technique. The control group consisted of 260 cancer free people. The TNM scale was analyzed. Gene interactions of genotyped polymorphisms were investigated. The effects of smoking and alcohol consumption on HNC were assessed. Results The results indicated an increased risk of HNC in NAT1 polymorphisms in the GC genotype (OR = 1.772, 95% CI: 1.184–2.651, p = 0.005) and NAT2 polymorphism in the GA genotype (OR = 1.506, 95% CI: 1.023–2.216, p = 0.037). The protective phenomenon in the CYP1A polymorphism the GT genotype (OR = 0.587, 95% CI: 0.381–0.903, p = 0.015) and the TT genotype (OR = 0.268, 95% CI: 0.159–0.452, p = 0.001). The coexistence of GA-GC polymorphisms (OR = 2.687, 95% CI: 1.387–5.205, p = 0.003) in NAT2-NAT1 genes increases the risk of HNC. Risk-reducing effect in the polymorphism GG-GT (OR = 0.340, 95% CI: 0.149–0.800, p = 0.011), GG-TT (OR = 0.077, 95% CI: 0.028–0.215, p < 0.0001), GA-TT (OR = 0.250, 95% CI: 0.100–0.622, p = 0.002), AA-GT (OR = 0.276, 95% CI: 0.112–0.676, p = 0.002) in NAT2-CYP1A genes. In the CYP2D-CYP1A genes in the polymorphisms CT-CC (OR = 0.338, 95% CI: 0.132–0.870, p = 0.020), TT-GG (OR = 0.100, 95% CI: 0.027–0.359, p = 0.001), TT-GC (OR = 0.190, 95% CI: 0.072–0.502, p = 0.0004), TT-CC (OR = 0.305, 95% CI: 0.107–0.868, p = 0.024). Correlation was noted between cigarette smoking and HNC (OR = 7.297, 95% CI: 4.989–10.674, p < 0.0001) and consuming alcohol (OR = 1.572, 95% CI: 1.003–2.464, p = 0.047). Conclusions The CYP1A polymorphism shows a protective association with HNC. On the other hand, NAT2, NAT1 polymorphism influence the susceptibility to developing HNC. The coexistence of the NAT2-NAT1 genotypes increases the risk of HNC. In contrast, NAT1-CYP1A and CYP1A-CYP2D reduce this risk. Smoking and alcohol consumption increase the incidence of HNC.

Źródło:

International Journal of Occupational Medicine and Environmental Health; 2023, 36, 6; 812-824
1232-1087
1896-494X

Pojawia się w:

International Journal of Occupational Medicine and Environmental Health

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 41.

Tytuł:

Rak gruczołowo-torbielowaty regionu głowy i szyi – opis przypadków
Adenoid cystic carcinoma of the head and neck – case report

Autorzy:

Markowski, Jarosław
Piotrowska-Seweryn, Agnieszka
Wardas, Piotr
Paluch, Jarosław
Smółka, Wojciech
Wodołażski, Anatol
Pietrauszka, Kornelia
Goroszkiewicz, Karolina

Powiązania:

https://bibliotekanauki.pl/articles/1033383.pdf

Data publikacji:

2017

Wydawca:

Oficyna Wydawnicza Mediton

Tematy:

leczenie operacyjne

Opis:

Introduction. Adenoid cystic carcinoma (ACC) is a rare, slowly growing, malignant tumor derived from adenoid tissue. It accounts for about 1% of head and neck head malignancies. ACC can infiltrate the nerves and is usually diagnosed at an advanced stage. Aim. The aim of the study was to present our own experience in the treatment of patients with head and neck ACCs. Material and methods. The authors present cases of 10 patients treated for adenocarcinoma in the Department of Laryngology of Medical University of Silesia in Katowice in 2011-2017. Results. The group of patients described consisted of 7 women and 3 men at the age of 31 to 68 years. Tumors were present in different, locations of head and neck region. All patients were surgically treated, 7 of them also received adjuvant radiotherapy. Conclusions. Treatment of ACC of head and neck region is a challenge for many specialists, including otorhinolaryngologists, most of all because of difficulties in radical surgical treatment of this location. In the case of ACC salivary gland preoperative tumor biopsy results are often false negative. Proper diagnosis is always based on rigorous pathological analysis.
Wprowadzenie. Rak gruczołowo-torbielowaty (adenoid cystic carcinoma, ACC), nazywany też oblakiem, jest rzadkim, wolno rosnącym, złośliwym guzem wywodzącym się z tkanki gruczołowej. Stanowi około 1% nowotworów złośliwych regionu głowy i szyi. ACC może naciekać nerwy i zazwyczaj jest diagnozowany w zaawansowanym stadium. Cel pracy. Zaprezentowanie własnego doświadczenia w leczeniu pacjentów z oblakami regionu głowy i szyi. Materiał i metody. Autorzy przedstawiają przypadki 10 pacjentów leczonych z powodu raka gruczołowo-torbielowatego w Klinice Laryngologii Śląskiego Uniwersytetu Medycznego w Katowicach w latach 2011-2017. Wyniki. Grupa opisywanych pacjentów składała się z 7 kobiet i 3 mężczyzn w wieku od 31 do 68 lat. Guzy umiejscowione były w różnych lokalizacjach regionu głowy i szyi. Wszyscy pacjenci byli leczeni operacyjnie, 7 z  nich otrzymało również radioterapię uzupełniającą. Wnioski. Leczenie pacjentów z oblakami regionu głowy i szyi stanowi wyzwanie dla wielu specjalistów, w tym otorynolaryngologów, przede wszystkim z uwagi na trudną do radykalnego leczenia operacyjnego lokalizację. W przypadku ACC gruczo- łów ślinowych przedoperacyjny wynik biopsji guza często jest fałszywie ujemny. Właściwe rozpoznanie opiera się zawsze na skrupulatnej analizie patomorfologicznej.

Źródło:

Otorynolaryngologia - przegląd kliniczny; 2017, 16, 4; 156-163
1643-658X

Pojawia się w:

Otorynolaryngologia - przegląd kliniczny

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 42.

Tytuł:

DNA damage and repair in lymphocytes of normal individuals and cancer patients: studies by the comet assay and micronucleus tests.

Autorzy:

Palyvoda, Olena
Polańska, Joanna
Wygoda, Andrzej
Rzeszowska-Wolny, Joanna

Powiązania:

https://bibliotekanauki.pl/articles/1043662.pdf

Data publikacji:

2003

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

ionizing radiation
DNA damage
human lymphocytes
comet assay
head and neck tumors
DNA repair

Opis:

A population study is reported in which the DNA damage induced by γ-radiation (2 Gy) and the kinetics of the subsequent repair were estimated by the comet and micronucleus assays in isolated lymphocytes of 82 healthy donors and patients with head and neck cancer before radiotherapy. The parameters of background and radiation-induced DNA damage, rate of repair, and residual non-repaired damage were measured by comet assay, and the repair kinetics for every donor were computer-fitted to an exponential curve. The level of background DNA damage before irradiation measured by comet assay as well as the level of micronuclei were significantly higher in the head and neck cancer patient group than in the healthy donors, while the parameters of repair were widely scattered in both groups. Cancer patient group contained significantly more individuals, whose irradiated lymphocytes showed high DNA damage, low repair rate and high non-repaired DNA damage level. Lymphocytes of donors belonging to this subgroup showed significantly lower inhibition of cell cycle after irradiation.

Źródło:

Acta Biochimica Polonica; 2003, 50, 1; 181-190
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 43.

Tytuł:

Signs, symptoms and the prevalence of fungi detected from the oral cavity and pharynx of radiotherapy subjects with head and neck tumors, and their susceptibility to chemotherapeutics

Autorzy:

Kurnatowski, P.
Moqbil, S.
Kaczmarczyk, D.

Powiązania:

https://bibliotekanauki.pl/articles/5644.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Parazytologiczne

Tematy:

disease symptom
prevalence
fungi
detection
oral cavity
pharynx
radiotherapy
head
neck
tumour
susceptibility
chemotherapeutic drug

Opis:

Radio- and chemotherapy for malignant neoplasms, especially in head and neck region, is associated with a greater risk of fungal infections due to secondary alterations in the mucous membranes. The study had three aims: 1. to determine the signs and symptoms which occur among patients undergoing radiotherapy; 2. to determine the fungi prevalence in the mouth and throat of patients before, during and after radiotherapy; 3. to examine the sensitivity of strains to antimycotic drugs. The study comprised 44 patients (11 female, 33 male) with head and neck cancers, examined at the following stages: before radiotherapy (44 patients – batch 1), 3rd week of therapy (30 of the 44 patients – batch 2), last day of therapy (28 of batch 2 – batch 3) and the 6th week after completion of radiotherapy (10 of batch 3 – batch 4). Clinical examination was performed and mycological status was estimated from an oral rinse on a selected medium. The fungal strains were isolated and sensitivity to antifungal drugs was determined. The most common symptoms were pain, dysphagia, and dysgeusia. Physical examination revealed signs of mucositis mainly among patients from batches 2 and 3. The presence of fungi in the mouth and throat was noted in over 2/3 (66.2%) of the patients from batch 1, and in 4/5 (80%) of batch 2. The fungi were detected in over half (57.1%) of patients from batch 3 and also in patients from batch 4. In all cases, fungi of various Candida species were identified: 6 species in batch 1, 8 in batch 2, 6 in batch 3 and 5 in batch 4. The most frequently detected species was C. albicans, constituting 40–60%; the other species detected are known to be resistant to antimycotic drugs. The isolated strains were the most sensitive to nystatin and miconazole, and the least to ketoconazole and fluconazole. Conclusions: 1. Patients undergoing radiotherapy complain of pain, dysphagia, and dysgeusia; in most cases mucositis is diagnosed. 2. The high prevalence of fungi in the mouth and throat of patients treated by radiotherapy reinforces the need to perform mycological examinations in this group of patients to detect fungi, identify their species and determine of their sensitivity to drugs in order to prevent complications. 3. The species most frequently isolated from the patients are C. albicans and C. glabrata. The latter is characterized by resistance to the majority of antimycotic medications. 4. Most of the isolated strains are sensitive to nystatin and miconazole (applied locally) and to itraconazole (absorbed from the gastrointestinal tract).

Źródło:

Annals of Parasitology; 2014, 60, 3
0043-5163

Pojawia się w:

Annals of Parasitology

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 44.

Tytuł:

Secretion of hydrolytic enzymes by fungal strains, isolated from patients with malignant tumors of head and neck, before, during and after radiotherapy

Autorzy:

Moqbil, S.
Kurnatowski, P.

Powiązania:

https://bibliotekanauki.pl/articles/6133.pdf

Data publikacji:

2012

Wydawca:

Polskie Towarzystwo Parazytologiczne

Tematy:

secretion
hydrolytic enzyme
fungal strain
isolation
patient
malignant tumour
head
neck
radiotherapy

Źródło:

Annals of Parasitology; 2012, 58, 1
0043-5163

Pojawia się w:

Annals of Parasitology

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 45.

Tytuł:

Teraźniejszość i przyszłość leków biologicznych w terapii nowotworów głowy i szyi
Biological agents in head and neck cancer: current and future considerations

Autorzy:

Pawłowska, Ewa
Dziadziuszko, Rafał
Narożny, Waldemar

Powiązania:

https://bibliotekanauki.pl/articles/1033411.pdf

Data publikacji:

2018

Wydawca:

Oficyna Wydawnicza Mediton

Tematy:

inhibitory kinaz
leki biologiczne
nowotwory głowy i szyi
przeciwciała monoklonalne

Opis:

According to European Medicines Agency’s definition, biological agents are pharmaceuticals whose active substance is made by a living organism. Biologics modulate immunological response by mimicking endogenous proteins or interacting with signaling pathways. The vast majority of biologics used in oncology are monoclonal antibodies. Use of four biologics in treatment of head and neck cancers - cetuximab, afatinib, pembrolizumab, nivolumab, is supported by National Comprehensive Cancer Network (NCCN) and National Institute for Health and Care Excellence (NICE) guidelines. In Poland only cetuximab can be applied in everyday practice, with some limitations. Cetuximab should be administered concurrently with radical radiotherapy to patients with contraindications for cisplatin. Due to rapid development of immunotherapy and biologics in the last decades there are currently hundreds of clinical trials conducted, seeking for most optimal regimens of biological drugs in head and neck cancer treatment, both in radical treatment (neoadjuvant and adjuvant therapy or in combination with radiotherapy) and in paliative treatment (in monotherapy, in combination with chemotherapeutic agents or other biological agents).
Zgodnie z definicją Europejskiej Agencji Leków leki biologiczne są farmaceutykami, których substancja aktywna wytwarzana jest przez żyjący organizm. Mechanizm ich działania polega na modulacji reakcji immunologicznych poprzez naśladowanie naturalnie występujących cząsteczek lub interakcji z ich szlakiem molekularnym. Największą grupę leków biologicznych stanowią przeciwciała monoklonalne. Cztery leki biologiczne zostały zaaprobowane przez zagraniczne towarzystwa onkologiczne (amerykańską Narodową Sieć Ośrodków Onkologicznych NCCN oraz Narodowy Instytut Zdrowia i Doskonałości Klinicznej Wielkiej Brytanii NICE) do terapii nowotworów płaskonabłonkowych głowy i szyi – cetuksymab, afatynib, pembrolizumab i niwolumab. W Polsce tylko pierwszy z nich jest dostępny w codziennej praktyce klinicznej, we wskazaniach ograniczonych ministerialnym programem lekowym. Kwalifikują się do niego chorzy poddawani radykalnej radioterapii, z przeciwwskazaniami do cisplatyny. Gwałtowny rozwój immunoterapii i leczenia celowanego w ostatnich dekadach sprawił, że obecnie toczą się setki badań klinicznych oceniających skuteczność leków biologicznych w terapii nowotworów rejonu głowy i szyi zarówno w leczeniu radykalnym (neoadjuwantowo, adjuwantowo lub w skojarzeniu z radioterapią) jak i paliatywnym (w monoterapii, skojarzeniu z chemioterapeutykami lub innymi lekami biologicznymi).

Źródło:

Otorynolaryngologia - przegląd kliniczny; 2018, 17, 1; 1-14
1643-658X

Pojawia się w:

Otorynolaryngologia - przegląd kliniczny

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 46.

Tytuł:

40th anniversary (1980–2020) of the establishment of the Oncological Section of the Polish Society of Otorhinolaryngologists of Head and Neck Surgeons

Autorzy:

Bruzgielewicz, Antoni
Osuch-Wójcikiewicz, Ewa
Kaczmarczyk, Dariusz
Niemczyk, Kazimierz

Powiązania:

https://bibliotekanauki.pl/articles/1399275.pdf

Data publikacji:

2020

Wydawca:

Index Copernicus International

Tematy:

history of medicine
oncological section
otorhinolaryngology

Opis:

The Oncology Section of the Polish Society of Otorhinolaryngologists of Head and Neck Surgeons is one of the oldest sections of the PSOHNS. It was established by a resolution of the General Meeting of the PSOHNS in Poznań on September 22, 1980 upon request of prof. Stanisław Iwankiewicz, who became its Chairman. On December 12, 1981, the 1st Conference of the Section was held in Wrocław. The overarching theme of the conference was laryngeal cancer. During its 40 years of existence, the Oncology Section organized 3 conferences and 17 symposia, bringing pride to the entire Society, and promoted the latest scientific trends in the approach to head and neck cancer. With the development of basic sciences, genetic and molecular tests as well as new diagnostic and therapeutic methods, the topics of meetings gradually expanded to include new sections and issues in ENT oncology.

Źródło:

Polski Przegląd Otorynolaryngologiczny; 2020, 9, 4; 17-22
2084-5308
2300-7338

Pojawia się w:

Polski Przegląd Otorynolaryngologiczny

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 47.

Tytuł:

Ultrasound diagnostics of a spontaneous arteriovenous fistula of the head and neck
Diagnostyka ultrasonograficzna spontanicznych przetok tętniczo-żylnych w rejonie głowy i szyi

Autorzy:

Vadimovna Zakharkina, Maria
Olegovich Chechetkin, Andrey
Victorovna Krotenkova, Marina
Nikolaevich Konovalov, Rodion

Powiązania:

https://bibliotekanauki.pl/articles/1033413.pdf

Data publikacji:

2017

Wydawca:

Medical Communications

Tematy:

arteriovenous fistula
malformation
ultrasound

Opis:

An arteriovenous fistula is an abnormal connection between the arterial and venous systems. In the literature, there are well-described ultrasound findings of iatrogenic arteriovenous fistula as a potential complication from percutaneous transarterial or transvenous procedures. The most important sign is direct visualization of the fistula in the place of the access site. It is necessary to look for secondary signs of arterialization of the veins, which can suggest a diagnosis of an arteriovenous fistula. However, the accuracy and diagnostic quality of duplex scanning in the diagnostics of a congenital or spontaneous arteriovenous fistula of the head and neck area in adults have been poorly described in the literature. In this study, we discuss the opportunities of duplex scanning, based on two different cases of an arteriovenous fistula revealed by ultrasound and then confirmed by computer tomographic angiography.
Przetoka tętniczo-żylna jest niefizjologicznym połączeniem wytworzonym pomiędzy układem tętniczym a żylnym. W piśmiennictwie znaleźć można dobrze opisane przypadki jatrogennych przetok tętniczo-żylnych będących powikłaniem przezskórnych zabiegów wewnątrznaczyniowych. Najważniejszym objawem jest bezpośrednie uwidocznienie przetoki w miejscu dostępu. Należy szukać wtórnych objawów arterializacji żył, mogących sugerować istnienie przetoki tętniczo-żylnej. Dokładność i jakość obrazowania przetoki w badaniu ultrasonograficznym metodą duplex-scan w diagnostyce wrodzonych i spontanicznych przetok tętniczo-żylnych głowy i szyi u dorosłych nie zostały dostatecznie opisane w literaturze. W niniejszej pracy omawiamy możliwości badania duplex-scan w tejże diagnostyce na podstawie dwóch różnych przypadków przetoki tętniczo-żylnej, ujawnionej w badaniu ultrasonograficznym, a następnie potwierdzonej w angiografii tomografii komputerowej. Artykuł w wersji polskojęzycznej jest dostępny na stronie http://jultrason.pl/index.php/wydawnictwa/volume-17-no-70

Źródło:

Journal of Ultrasonography; 2017, 17, 70; 217-221
2451-070X

Pojawia się w:

Journal of Ultrasonography

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 48.

Tytuł:

New lexical materials for the Proto-Afro-Asiatic anatomical and physiological terminology I: Body part names with initial labials: General terms, head and neck

Autorzy:

Takács, Gábor

Powiązania:

https://bibliotekanauki.pl/articles/2183711.pdf

Data publikacji:

2022-12-31

Wydawca:

Poznańskie Towarzystwo Przyjaciół Nauk

Tematy:

Afro-Asiatic (Semito-Hamitic)
Semitic
Egyptian
Berber
Cushitic
Omotic
Chadic
comparative linguistic
etymology
anatomical-physiological vocabulary

Opis:

The paper constitutes the first part of a long-range series of studies gradually elaborating the enormous new materials of the anestral anatomical-physiological vocabulary of Proto-Afro-Asiatic, supposed to be the earliest known parental language spoken by the earliest known neolithic community on earth. This series is parallel to the author’s ongoing projects for a comprehensive analysis of the diverse segments of the immense new cultural lexicon that has emerged in course of the author’s root research over the past some three decades.

Źródło:

Lingua Posnanensis; 2022, 64, 2; 107-144
0079-4740
2083-6090

Pojawia się w:

Lingua Posnanensis

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 49.

Tytuł:

Clinical manifestations of granulomatosis with polyangiitis (GPA) in dermatology and otolaryngology

Autorzy:

Ziuzia, Laura
Dobrzyński, Paweł
Sobolewski, Piotr
Walecka-Herniczek, Irena

Powiązania:

https://bibliotekanauki.pl/articles/1400276.pdf

Data publikacji:

2017

Wydawca:

Index Copernicus International

Tematy:

granulomatosis with polyangitis
head and neck
rhinosinusitis
otitis media
sensineurinal leasing loss
subglottic stenosis
cutaneous changes
ocular changes
oral changes

Opis:

The diseases caused by vasculitis are rare. The difficulties in diagnosis may be due to this low frequency, as well as to rather slow development and various symptoms and locations of the symptoms. In the diagnosis of the vasculitis one should consider all of the clinical features, for they may include diagnostic criteria for various clinical entities.

Źródło:

Polski Przegląd Otorynolaryngologiczny; 2017, 6, 2; 8-14
2084-5308
2300-7338

Pojawia się w:

Polski Przegląd Otorynolaryngologiczny

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 50.

Tytuł:

Determination of the Risk of Head and Neck Injuries of the User of Bulletproof Helmets
Określenie ryzyka wystąpienia urazów głowy i szyi użytkowników hełmów kuloodpornych

Autorzy:

Landwijt, M.
Romek, R.

Powiązania:

https://bibliotekanauki.pl/articles/233422.pdf

Data publikacji:

2015

Wydawca:

Sieć Badawcza Łukasiewicz - Instytut Biopolimerów i Włókien Chemicznych

Tematy:

behind armour blunt trauma (BABT)
ballistic helmet
head injury criterion (HIC)
odporność balistyczna hełmów
BABT
hełm kuloodporny
kryteria urazu (HIC)

Opis:

Introduction of more and more effective body ballistic shields, especially for head, allowed decreasing of the extent of injuries caused by projectiles and fragments. Application of modern materials (aramides, high molecular weight polyethylene) reduced the risk of projectile penetration through the shield, resulting in reduction of contact injuries, head trauma, breaking of skull bones and brain damage caused by penetrating bullet. Standard tests for determination of ballistic resistance of helmets define penetration of a projectile into ballistic shield and deflexion of shell. The energy of shot is partially absorbed by helmet, but it is mostly transmitted to a head, giving it a linear and/or angular acceleration. This phenomenon is a direct cause of inertial trauma. Performed tests, proved that optimisation of ballistic helmet’s construction is a very complex process and it depends on many parameters starting from the shape of a shell ending with fixing-absorbing solutions.
Wprowadzanie coraz doskonalszych osłon balistycznych ciała, przede wszystkim głowy, pozwoliło na zmniejszenie rozległości urazów związanych z działaniem pocisków i odłamków. Zastosowanie nowoczesnych materiałów (aramidy, polietylen o ultra wysokiej masie cząsteczkowej) zminimalizowało ryzyko penetracji pocisków przez osłony, co spowodowało istotne ograniczenie ilości urazów o charakterze kontaktowym urazów głowy, złamań kości czaszki, uszkodzeń mózgu przez penetrujący pocisk. Standardowe badania wyznaczające odporność balistyczną hełmów określają penetrację pocisku w ochronę balistyczną i ugięcie czerepu. Energia postrzału jest częściowo absorbowana przez hełm, ale w znacznej części zostaje przekazana na głowę nadając jej pewne przyspieszenie liniowe i/lub kątowe. Jest to bezpośrednia przyczyna urazu bezwładnościowego. Wykonane badania pokazały, że optymalizacja konstrukcji hełmów balistycznych jest bardzo złożonym procesem, zależnym począwszy od kształtu czerepu po rozwiązania mocująco-amortyzujące.

Źródło:

Fibres & Textiles in Eastern Europe; 2015, 4 (112); 103-108
1230-3666
2300-7354

Pojawia się w:

Fibres & Textiles in Eastern Europe

Dostawca treści:

Biblioteka Nauki

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