Wszystkie pola: glutathione reductase activity - Katalog OPAC zbiorów

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Tytuł:: Glutathione level and glutathione reductase activity in serum of coronary heart disease patients
Autorzy:: Zuzak, Ewa
Horecka, Anna
Kiełczykowska, Małgorzata
Dudek, Aneta
Musik, Irena
Kurzepa, Joanna
Kurzepa, Jacek
Powiązania:: https://bibliotekanauki.pl/articles/972495.pdf
Data publikacji:: 2017
Wydawca:: Instytut Medycyny Wsi
Tematy:: glutathione reductase
glutathione
coronary heart disease
oxidative stress
Opis:: Introduction. Oxidative stress induced by the generation of excess reactive oxygen species is one of the cause of atherosclerosis finally leading to coronary heart disease (CHD). Glutathione reductase (GR), a flavoprotein antioxidant enzyme, regenerates glutathione (GSH) from its oxidized form, which is essential for scavenging of hydrogen peroxide by glutathione peroxidase. The aim of this study was to analyze the activity of GR and GSH level in serum of patients with various stages of CHD. Materials and method. Sixty consecutive patients with diagnosis of stable angina (SA, n=20), unstable angina (UA, n=20) and non-fatal myocardial infarction (MI, n=20) together with 20 healthy control subjects were enrolled. Venous blood samples were collected just before the coronary catheterization procedure (in study patients). GR activities and GSH concentration was determined using commercially available colorimetric kits. Results. The highest GR activity and GSH serum level was noticed in UA patients. However, statistical evaluation showed that only glutathione reductase activity was significantly higher in serum obtained from myocardial infarction patients, compared to stable angina pectoris patients (19.52 ± 13.88 vs 11.63 ± 5.45 nmol/min/ml for MI and SA, respectively; p<0.048). There were no significant differences in GSH between the CHD patients and controls. Conclusion. The elevated activity of glutathione reductase in serum of patients with unstable angina pectoris and myocardial infarction suggests the role of antioxidant system acute coronary syndromes.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2017, 11, 2; 103-105
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Glutathione reductase activity correlates with concentration of extracellular matrix degradation products in synovial fluid from patients with joint diseases
Autorzy:: Średzińska, Krystyna
Galicka, Anna
Porowska, Halina
Średziński, Łukasz
Porowski, Tadeusz
Popko, Janusz
Powiązania:: https://bibliotekanauki.pl/articles/1040477.pdf
Data publikacji:: 2009
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: glutathione reductase
collagen
glycosaminoglycans
synovial fluid
Opis:: The mechanisms underlying cartilage matrix degradation in joint diseases is not fully understood but reactive oxygen species are implicated as main causative factors. Comparative studies of glutathione reductase (GR) activity in synovial fluid from patients with rheumatoid arthritis (RA), reactive arthritis (ReA) and osteoarthritis (OA) as well as correlations between GR activity and concentration of the major cartilage components in synovial fluid are presented in this study. We found significantly higher activity of GR in RA (about three-fold) and ReA (about two-fold) than in OA. In RA and ReA patients, GR activity in synovial fluid correlates negatively with the concentrations of collagen and degradation products of sulfated glycosaminoglycans. In OA patients the activity of GR was significantly lower than in RA and ReA, which positively correlated with the concentration of collagen and showed a tendency for positive correlation with the degradation products of sulfated glycosaminoglycans. Our results suggest that in RA and ReA patients increased activity of GR does not prevent the increased degradation of collagen and proteoglycans by ROS.
Źródło:: Acta Biochimica Polonica; 2009, 56, 4; 635-640
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Intrygujący wpływ albendazolu na aktywność reduktazy glutationu w mięśniach myszy zarażonych Trichinella spiralis
The intriguing influence of albendazole on glutathione reductase activity in the muscles from Trichinella spiralis infected mice.
Autorzy:: Przydanek, A.
Boczoń, K.
Wandurska-Nowak, E.
Wojt, W.
Wojtkowiak, A.
Powiązania:: https://bibliotekanauki.pl/articles/2146462.pdf
Data publikacji:: 2004
Wydawca:: Polskie Towarzystwo Parazytologiczne
Tematy:: aktywnosc enzymatyczna
Trichinella spiralis
miesnie
parazytologia
albendazol
myszy
reduktaza glutationowa
infekcja pasozytnicza
Opis:: A clear stimulation of the activity of glutathione reductase (RG, EC 1.6.4.2), one of the major enzymes participating in glutathione metabolism, was observed in the skeletal muscles from Trichinella spiralis infected mice. The maximal, almost twofold increase in RG activity was observed in week 5 post-infection. Administration of albendazole, an anthelmintic widely used in trichinellosis treatment, resulted in an additional, about 40% stimulation of RG activity (small, but statistically significant) on week 2 post-infection. In weeks 6 and 7 postinfection, when no stimulation of RG activity in infected mice caused by drug was observed, the drug modified the structure of that allosteric enzyme, affecting the kinetics of its substrate saturation in this way that the shape of the substrate saturation curve changed from „double sigmoidal”, typical of this enzyme kinetics in the muscles from infected mice, to hyperbolic, typical of this enzyme kinetics in the control, uninfected animals.
Źródło:: Wiadomości Parazytologiczne; 2004, 50, 2; 273-277
0043-5163
Pojawia się w:: Wiadomości Parazytologiczne
Dostawca treści:: Biblioteka Nauki