Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "genetic risk factors" wg kryterium: Wszystkie pola

  Lista filtrów
Wyrównaj
    Wyświetlanie 1-5 z 5
    Tytuł:
    Genetic risk factors of Alzheimer’s disease
    Autorzy:
    Skrzypa, Marzena
    Potocka, Natalia
    Bartosik-Psujek, Halina
    Zawlik, Izabela
    Powiązania:
    https://bibliotekanauki.pl/articles/1597329.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    autosomal genetic mutations early-onset Alzheimer Disease genetic polymorphisms
    late-onset Alzheimer Disease
    Opis:
    Introduction. Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases, which is a serious health problem for societies that live longer. Spontaneous dominant mutations and polymorphisms of selected genes play an important role in development of AD. Aim. Several polymorphisms in selected genes strongly associated with development of Alzheimer’s disease were highlighted in this review: APOE, CYP46, APP, PSEN1, PSEN2, UBQLN1, BACE1, PRND, APBB2, TOMM 40. These gene polymorphisms have a significant role in the development of Alzheimer’s disease and they have potential to be biomarkers. Researchers combine efforts to find significant polymorphisms that would ensure that a person is predisposed to the occurrence of disease symptoms. This topic is often taken up by scientists seeking to develop effective genetic tests for diagnosing AD. Material and methods. Analysis of literature from web of knowledge: Web of Science (all database), NCBI and PubMed. Results. We reviewed the selected important genes and polymorphisms which are most often associated with development of AD. Conclusion. It should be noted that nowadays scientists strive not to focus on only one polymorphism in the gene but on several polymorphisms in different genes concomitantly and above all on interactions between them to the diagnosis of this disease. Only this approach to AD will contribute to the creation of appropriate identification methods. Moreover, we should use the new generation tools - the platform for collecting data and personalized medicine.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 1; 57-66
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Clinical, biochemical and genetic risk factors for 30-day and 5-year mortality in 518 adult patients subjected to cardiopulmonary bypass during cardiac surgery - the INFLACOR study
    Autorzy:
    Kowalik, Maciej
    Lango, Romuald
    Siondalski, Piotr
    Chmara, Magdalena
    Brzeziński, Maciej
    Lewandowski, Krzysztof
    Jagielak, Dariusz
    Klapkowski, Andrzej
    Rogowski, Jan
    Powiązania:
    https://bibliotekanauki.pl/articles/1038396.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    cardiac surgery
    cardiopulmonary bypass
    30-day mortality
    5-year mortality
    ICAM1 rs5498
    ICAM-1
    renal replacement therapy.
    Opis:
    There is increasing evidence that genetic variability influences patients' early morbidity after cardiac surgery performed using cardiopulmonary bypass (CPB). The use of mortality as an outcome measure in cardiac surgical genetic association studies is rare. We publish the 30-day and 5-year survival analyses with focus on pre-, intra-, postoperative variables, biochemical parameters, and genetic variants in the INFLACOR (INFLAmmation in Cardiac OpeRations) cohort. In a prospectively recruited cohort of 518 adult Polish Caucasians, who underwent cardiac surgery in which CPB was used, the clinical data, biochemical parameters, IL-6, soluble ICAM-1, TNFα, soluble E-selectin, and 10 single nucleotide polymorphisms were evaluated for their association with 30-day and 5-year mortality. The 30-day mortality was associated with: pre-operative prothrombin international normalized ratio, intra-operative blood lactate, postoperative serum creatine phosphokinase, and acute kidney injury requiring renal replacement therapy (AKI-RRT) in logistic regression. Factors that determined the 5-year survival included: pre-operative NYHA class, history of peripheral artery disease and severe chronic obstructive pulmonary disease, intra-operative blood transfusion; and postoperative peripheral hypothermia, myocardial infarction, infection, and AKI-RRT in Cox regression. Serum levels of IL-6 and ICAM-1 measured three hours after the operation were associated with 30-day and 5-year mortality, respectively. The ICAM1 rs5498 was associated with 30-day and 5-year survival with borderline significance. Different risk factors determined the early (30-day) and late (5-year) survival after adult cardiac surgery in which cardiopulmonary bypass was used. Future genetic association studies in cardiac surgical patients should account for the identified chronic and perioperative risk factors.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 2; 241-250
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Aktualne poglądy na etiopatogenezę reumatoidalnego zapalenia stawów
    Current opinions on etiopathogenesis of rheumatoid arthritis
    Autorzy:
    Jura-Półtorak, Agnieszka
    Olczyk, Krystyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1038437.pdf
    Data publikacji:
    2011
    Wydawca:
    Śląski Uniwersytet Medyczny w Katowicach
    Tematy:
    reumatoidalne zapalenie stawów
    genetyczne czynniki ryzyka
    środowiskowe czynniki ryzyka
    zaburzenia immunologiczne
    cytokiny prozapalne
    rheumatoid arthritis
    genetic risk factors
    environmental risk factors
    immune disorders
    proinflammatory cytokines
    Opis:
    Rheumatoid arthritis is a chronic, systemic autoimmune connective tissue disease characterized by the non-specifi c, arthritis of symmetric joint. Rheumatoid arthritis presents an extremely complex disease manifested by a number of autoimmune phenomena. Susceptibility genes, environmental and immunological factors play of an important role as initiating agents. The paper reviews current opinions on the etiopathogenesis of rheumatoid arthritis.
    Reumatoidalne zapalenie stawów jest przewlekłą, autoimmunologiczną chorobą tkanki łącznej, charakteryzującą się nieswoistym, symetrycznymzapaleniem stawów. Choroba ta należy do najbardziej złożonych pod względem patogenezy chorób autoimmunologicznych. O ryzyku jej rozwoju oraz ciężkości przebiegu stanowią czynniki genetyczne, środowiskowe i zaburzenia immunologiczne. W niniejszej pracy przedstawiono aktualne poglądy na temat etiopatogenezy reumatoidalnego zapalenia stawów.
    Źródło:
    Annales Academiae Medicae Silesiensis; 2011, 65, 4; 51 -57
    1734-025X
    Pojawia się w:
    Annales Academiae Medicae Silesiensis
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The value of pedigrees and clinical assessment in identification of a high risk cancer group – our experience
    Autorzy:
    Jaworowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1400526.pdf
    Data publikacji:
    2016
    Wydawca:
    Index Copernicus International
    Tematy:
    laryngeal cancer
    genetic susceptibility
    risk factors
    pedegrees
    Opis:
    Pedigree and clinical data are still very important diagnostic tool useful in estimation of a high risk of a cancer devel-opment, molecular basis research and also determining optimal screening for a single family. In this study the own experience was presented in identification of the risk of cancer prevalence with different organ location among the first degree relatives of 760 patients with laryngeal cancer.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2016, 5, 2; 51-56
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Znaczenie uwarunkowań genetycznych w dysfunkcjach układu hemostazy w cukrzycy - potencjalne czynniki ryzyka powikłań naczyniowych
    Significance of genetic po lymorphisms in haemostatic dysfunctions in diabetes mellitus - potential risk factors of vascular complications
    Autorzy:
    Watała, Cezary
    Boncler, Magdalena
    Różalski, Marcin
    Powiązania:
    https://bibliotekanauki.pl/articles/945055.pdf
    Data publikacji:
    1999
    Wydawca:
    Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
    Opis:
    The unambiguous determination of etiopathogenetic factors underlying the increased risk of vascular disease in diabetic patients remains to be established. Evidence accumulated hitherto points that such an increased risk might be a constellation of metabolic disorders and genetic background. Thus, the impairments in coagulation and fibrinolysis, which are believed to partly result from metabolic disorders encountered in diabetes, and genetic factors might be compounding in predisposing a diabetic individual to develop the late diabetic sequelae sooner. The role of the latter seems superior with respect to some dysfunctions in haemostasis. Hence, the monitoring of the frequency and distribution of genetic polymorphisms of selected haemostatic proteins might be promising in an attempt to define the reasons of altered haemostatic imbalance in patients with diabetes mellitus. Based on such a knowledge one could discriminate the groups of patients with high risk for the development of vascular disease, in whom pharmacological strategy to attenuate haemostatic impairments would be desirable.
    Źródło:
    Acta Universitatis Lodziensis. Folia Biochimica et Biophysica; 1999, 14
    0208-614X
    Pojawia się w:
    Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

      Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies