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Tytuł:
The effect of hydrazine derivatives of 3-formylchromones on angiogenic basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanoma cell line WM-115
Autorzy:
Łazarenkow, Andrzej
Michalska, Marta
Mirowski, Marek
Słomiak, Krzysztof
Nawrot-Modranka, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/1038629.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
angiogenesis
basic fibroblast growth factor
fibroblast growth factor receptor 1
human melanoma
hydrazone derivatives of benzo-γ-pyrones
Opis:
The hydrazine derivatives of benzopyrones remain an unexplored group of chemical compounds. This preliminary study investigates the influence of A-5, CH-3 and K-2 derivatives at concentrations of 1, 10, 100 nM and 1 μM on selected biochemical factors of a melanoma cell line WM-115, with regard to their potential angiogenic properties. The studied compounds were found to influence cell proliferation, as well as total protein, bFGF and FGFR1 concentration.
Źródło:
Acta Biochimica Polonica; 2017, 64, 3; 585-590
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Binding of the basic fibroblast growth factor (bFGF) by soluble components of human umbilical cord.
Autorzy:
Sobolewski, Krzysztof
Bańkowski, Edward
Pałka, Jerzy
Jaworski, Stefan
Powiązania:
https://bibliotekanauki.pl/articles/1043707.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
umbilical cord artery
fibroblast growth factor
Wharton's jelly
pre-eclampsia
EPH-gestosis
Opis:
Pre-eclampsia, the most common pregnancy associated syndrome, is connected with remodelling of extracellular matrix of the umbilical cord tissues. Since the fibroblast growth factor (FGF) is known to be a stimulator of collagen and glycosaminoglycan biosynthesis, one may expect that it plays an important role in such a remodelling. Studies performed on the umbilical cords of 10 control and 10 pre-eclamptic newborns demonstrated that both the umbilical cord arterial wall and Wharton's jelly contain FGF mainly in complexes with the components of different molecular mass. Pre-eclampsia is associated with a decrease of endogenous FGF-binding by soluble high molecular mass components of the umbilical cord. It is suggested that FGF released from these complexes may be actively bound by fibroblasts of the umbilical cord, stimulating them to produce collagen and sulphated glycosaminoglycans.
Źródło:
Acta Biochimica Polonica; 2002, 49, 4; 999-1004
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Obtainment of transgenic porcine fibroblast cell lines for the purpose of xenotransplantation
Autorzy:
Hryhorowicz, M.
Nowak, A.
Grzeskowiak, B.
Zeyland, J.
Slomski, R.
Lipinski, D.
Powiązania:
https://bibliotekanauki.pl/articles/951232.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
pig
xenotransplantation
porcine fibroblast
cell line
interspecies somatic cell nuclear transfer
genetic modification
transgene expression
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2015, 96, 1
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The potential impact of the hypovitaminosis D on metabolic complications in obese adolescents - preliminary results
Autorzy:
Wójcik, Małgorzata
Janus, Dominika
Kalicka-Kasperczyk, Anna
Sztefko, Krystyna
Starzyk, Jerzy B.
Powiązania:
https://bibliotekanauki.pl/articles/986678.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
obesity
hypovitaminosis d
uric acid
arterial hypertension
fibroblast growth factor 23
fibroblast growth factor 19
adolescents
Opis:
Introduction and objective. Vitamin D deficiency is common in obesity; however, its contribution in the development of metabolic complications remains uncertain. The aim of the study was to examine the relationships between vitamin D status and metabolic complications. Materials and method. The results of blood pressure measurements, biochemical tests and ultrasound of the liver were compared in both groups. The study was conducted at the Children’s University Hospital in Krakow, Poland. 30 obese adolescents (mean 13.23y.o.); 18 with 25OHD levels <20ng/mL, 12 with 25OHD>20 ng/mL. Results. The vitamin D deficient group presented with significantly higher values of the diastolic blood pressure (125.9vs.115mmHg), uric acid level (384.7vs.301.5umol/L) and lower phosphorus level (1.4vs.1.65mmol/L), higher prevalence of arterial hypertension (44vs.8.3%), and liver steatosis (25vs.8.3%); lower, but not significantly, levels of fibroblast growth factor 23 and fibroblast growth factor 19. Conclusions. Hypovitaminosis D in obese adolescents is associated with higher prevalence of arterial hypertension, liver steatosis, elevated serum uric acid and low phosphorus levels. The potential contribution of the fibroblast growth factor 23 and fibroblast growth factor 19 in these complications development needs further investigation.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 4
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pentoxifylline and its active metabolite lisofylline attenuate transforming growth factor β1-induced asthmatic bronchial fibroblast-to-myofibroblast transition
Autorzy:
Wójcik-Pszczoła, Katarzyna
Hińcza, Kinga
Wnuk, Dawid
Kądziołka, Dominika
Koczurkiewicz, Paulina
Sanak, Marek
Madeja, Zbigniew
Pękala, Elżbieta
Michalik, Marta
Powiązania:
https://bibliotekanauki.pl/articles/1038759.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
theophylline
pentoxifylline
lisofylline
transforming growth factor type β
fibroblast-to-myofibroblast transition
asthma
Opis:
Bronchial asthma is characterized by persistent airway inflammation and airway wall remodeling. Among many different cells and growth factors triggering changes in bronchi structure, transforming growth factor β1-induced fibroblast to myofibroblast transition is believed to be very important. The aim of this study was to evaluate whether theophylline (used in asthma therapy) and two other methylxanthines (pentoxifylline and its active metabolite lisofylline), may affect transforming growth factor β1-induced fibroblast to myofibroblast transition in bronchial fibroblasts derived from asthmatic patients. We show here for the first time that selected methylxanthines effectively reduce transforming growth factor β1-induced myofibroblast formation in asthmatic bronchial fibroblast populations. PTX was found to be the most effective methylxanthine. The number of differentiated myofibroblasts after PTX, LSF and THEO administration was reduced at least twofold. Studies on the use of methylxanthines opens a new perspective in the development of novel strategies in asthma therapy through their two-pronged, anti-inflammatory and anti-fibrotic action. In the future they can be considered as promising anti-fibrotic drugs.
Źródło:
Acta Biochimica Polonica; 2016, 63, 3; 437-442
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pojedyncze pęknięcia DNA fibroblastów od osób z zespołem Downa
DNA single strand breaks in fibroblast from Down syndrome patients
Autorzy:
Rózga, Błażej
Powiązania:
https://bibliotekanauki.pl/articles/944960.pdf
Data publikacji:
1992
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Źródło:
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica; 1992, 9
0208-614X
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
FGF binding by extracellular matrix components of Whartons jelly
Autorzy:
Malkowski, Andrzej
Sobolewski, Krzysztof
Jaworski, Stefan
Bankowski, Edward
Powiązania:
https://bibliotekanauki.pl/articles/1041086.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
umbilical cord
fibroblast growth factor
metalloproteinases
Opis:
Our earlier paper has reported that Wharton's jelly is a reservoir of several peptide growth factors, including acidic and basic fibroblast growth factors (aFGF and bFGF, respectively). Both can be extracted by buffered salts solutions in the form of high molecular mass complexes, probably with a component(s) of the extracellular matrix. Both aFGF and bFGF from such extracts hardly penetrate 10% polyacrylamide gels during electrophoresis. Pre-treatment of Wharton's jelly with hyaluronidase slightly increased the extractability of aFGF, but did not affect the extractability of bFGF. In contrast, the pre-treatment of tissue homogenate with bacterial collagenase (2000 U/ml, 37°C, 18 h) increased the extractability of bFGF. The presence of β-mercaptoethanol in the extracting solutions increased the extractability of both FGFs, but did not release FGFs in their free form, despite reducing the molecular mass of the FGF-containing complexes. We conclude that both aFGF and bFGF are bound through disulphide bonds to a protein component of Wharton's jelly. We propose that ground substance composed mainly of collagen fibrils and hyaluronate molecules, which surrounds the cells of Wharton's jelly, prevents the access of the extracting solution to aFGF and bFGF. Although hyaluronate and collagen do not bind aFGF or bFGF directly, they may constitute a barrier which prevents the dispersion of FGFs in Wharton's jelly. Thus, the high concentration of FGFs around the cells of Wharton's jelly may facilitate the interaction of these factors with membrane receptors, thereby resulting in stimulation of cell division and differentiation, as well as of the synthesis of extracellular matrix components.
Źródło:
Acta Biochimica Polonica; 2007, 54, 2; 357-363
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of X-ray on fibroblast mechanical properties
Autorzy:
Heydarian, Ashkan
Khorramymehr, Siamak
Vasaghi-Gharamaleki, Behnoosh
Powiązania:
https://bibliotekanauki.pl/articles/280421.pdf
Data publikacji:
2019
Wydawca:
Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
Tematy:
viscoelastic
biomechanics
cellular mechanics
X-ray effects
Opis:
Concerning the widespread use of X-rays to detect various diseases, such as oral and dental ones, it is essential to study the effects of this radiation on living cells. From the past, genetic effects and cell death because of X-rays have been studied. In addition, the effect of this ionizing radiation on the mechanical properties of the cell and cytoskeleton has been studied, but different results have been obtained based on different models. In this study, post-culture gingival fibroblast cells were classified into two groups of control and radiation with Nano Magnetic Particles functionalized by folic acid. The cells of the radiation group were exposed to X-rays of 3 mGy·cm2 . The specimens were undergone static creep test by a magnetic tweezer. Spring and damper coefficients were obtained based on the viscoelastic solid modeling. The static and dynamic stiffness of the groups was also calculated. The maximum deformation was decreased after radiation from 0.049 ± 0.01 µm to 0.029 ± 0.01 µm and the static stiffness of the model was 1.6 times decreased. Also, the gel point frequency for the control group was 27 Hz and for the radiation group was 7.5 Hz. The results show that the static and dynamic stiffness of the cells decreases after radiation, and less deformation appears in the cells after irradiation. These changes can be due to the breakdown of membrane chemical bonds and activation of actin fibers after radiation.
Źródło:
Journal of Theoretical and Applied Mechanics; 2019, 57, 4; 999-1008
1429-2955
Pojawia się w:
Journal of Theoretical and Applied Mechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Carbon nanoscaffolds for fibroblast and hepatocellular carcinoma cells adhesion, migration and regeneration
Autorzy:
Sosnowska, M.
Sawosz, E.
Kutwin, M.
Chwalibog, A.
Powiązania:
https://bibliotekanauki.pl/articles/283817.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
nanoscaffolds
carbon allotropes
regeneration
Źródło:
Engineering of Biomaterials; 2017, 20, no. 143 spec. iss.; 58
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fibroblast biological activity on poly(l-lactide) and poly(l-lactide-co-trimethylene carbonate)
Autorzy:
Ścisłowska-Czarnecka, A.
Pamuła, E.
Kołaczkowska, E.
Powiązania:
https://bibliotekanauki.pl/articles/284073.pdf
Data publikacji:
2011
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
fibroblasts
biomaterials
PLLA
Opis:
Poly-L-lactide (PLLA) is acknowledged biocompatible polyester. However, it possesses high crystallinity/brittleness/stiffness and requires long time for complete degradation. In the current study we present data on PLTMC, a copolymer of L-lactide and trimethylene carbonate (TMC). Poly(trimethylene carbonate) (PTMC) is characterised by good mechanical properties and rapid degradation rate and for this it might possess new desired features for medical applications. During the experiments, adhesion and activity of fibroblasts cultured on PLLA and PLTMC were studied and compared during two time points of 3 and 5 days. On day 3, the number of adherent fibroblasts was compromised when fibroblasts were cultured in the presence of PLTMC but the proper adherence was recovered by day 5. The same pat-tern was observed when we evaluated some activity parameters of fibroblasts. In particular, the release of proteins and nitric oxide was studied as the increased levels of the mediators might indicate unwanted inflammatory-like condition. Overall, the results suggest that the synthesized PLTMC initially shows unwanted effects on fibroblasts but with the time these effects are abolished. Therefore PLTMC seems to represent a new material that is non-cytotoxic and compatible with the living cells.
Źródło:
Engineering of Biomaterials; 2011, 14, 102; 7-10
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
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