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Tytuł:
Z badań nad populacją szczurów na terenie miasta Torunia
Issledovanija nad demografiejj krys na territorii goroda Torunja
Studies on rat population in the town area of Torun
Autorzy:
Brodniewicz, A.
Lewicki, C.
Szuber, T.
Powiązania:
https://bibliotekanauki.pl/articles/874041.pdf
Data publikacji:
1963
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
gryzonie
szczury
obiekty przemyslowe
magazyny zywnosciowe
tuczarnie
zagrozenia epidemiologiczne
zagrozenia epizootiologiczne
deratyzacja
Torun
rodent
rat
industrial building
food storage
epidemiological hazard
disinfestation
Torun area
Źródło:
Roczniki Państwowego Zakładu Higieny; 1963, 14, 1
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Występowanie Giardia intestinalis w środowiskach rodzinnych w świetle badań epidemiologicznych
The occurrence of Giardia intestinalis in family environments in the light of epidemiological studies
Autorzy:
Głowniak, C.
Powiązania:
https://bibliotekanauki.pl/articles/2152556.pdf
Data publikacji:
1989
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parazytologia lekarska
choroby pasozytnicze
giardioza
pasozyty czlowieka
pasozyty przewodu pokarmowego
Giardia intestinalis
wystepowanie
srodowisko rodzinne
rodziny miejskie
rodziny wiejskie
wiek czlowieka
inwazja pasozytnicza
ekstensywnosc inwazji
badania epidemiologiczne
Polska Poludniowo-Wschodnia
Opis:
Coproscopy parasitological studlies were carried out in family environments. Samples of feces were taken three times from 1728 persons (400 familes) from urban and rural environments in south-eastern regions of Poland. The general extensity of giardiasis amounted to 39.6% and was higher in urban families (average 41.3%) than in those inhabiting rural areas (average 36.6%). The giardiasis dominated in children from 1 to 4 years (average more than 78% infected), especially in urban areas (extensity of infection 80.1%). It was also frequent in persons of male sex.
Źródło:
Wiadomości Parazytologiczne; 1989, 35, 1; 25-34
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ infradźwięków i hałasu niskoczęstotliwościowego na zdrowie i samopoczucie człowieka. Część II: przegląd badań epidemiologicznych
Impact of infrasound and low frequency noise on human health and well-being. Part II: Review of epidemiological studies
Autorzy:
Pawlaczyk-Łuszczyńska, Małgorzata
Dudarewicz, Adam
Myshchenko, Iryna
Bortkiewicz, Alicja
Powiązania:
https://bibliotekanauki.pl/articles/22646698.pdf
Data publikacji:
2023-12-15
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
ekspozycja zawodowa
ekspozycja środowiskowa
infradźwięki
hałas niskoczęstotliwościowy
skutki ekspozycji
badania epidemiologiczne
occupational exposure
environmental exposure
infrasound
low frequency noise
effects of exposure
epidemiological studies
Opis:
Niniejsza praca podsumowuje dostępną wiedzę na temat wpływu infradźwięków i hałasu niskoczęstotliwościowego (HNcz) na zdrowie i samopoczucie ludzi. Podstawą tego narracyjnego przeglądu piśmiennictwa były wybrane, głównie recenzowane prace badawcze, artykuły poglądowe i metaanalizy opublikowane w latach 1971–2022. Uwagę skoncentrowano na wynikach badań epidemiologicznych dotyczących dokuczliwości przypisywanej infradźwiękom i HNcz, a także ich wpływowi na układ sercowo-naczyniowy i zaburzenia snu. Szczególną uwagę poświęcono także ostatnim wynikom badań i swoistym źródłom infradźwięków i HNcz, tj. turbinom wiatrowym.
This paper summarizes the currently available knowledge on the impact of infrasound (IS) and low frequency noise (LFN) on human health and well-being. This narrative review of the literature data was based on the selected, mostly, peer-reviewed research papers, review articles, and meta-analyses that were published in 1971–2022. It has been focused on the results of epidemiological studies concerning the annoyance related to infrasound and low frequency noise, as well as their impact on the cardiovascular system and sleep disorders. Particular attention was also paid to the latest research results and specific sources of IS and LFN, i.e., wind turbines.
Źródło:
Medycyna Pracy. Workers’ Health and Safety; 2023, 74, 5; 409-423
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy. Workers’ Health and Safety
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Validity test of the IPD-Work consortium approach for creating comparable job strain groups between Job Content Questionnaire and Demand-Control Questionnaire
Autorzy:
Choi, Bongkyoo
Ko, Sangbaek
Ostergren, Per-Olof
Powiązania:
https://bibliotekanauki.pl/articles/2177398.pdf
Data publikacji:
2015-03-26
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
epidemiological studies
Malmö
sensitivity
specificity
scoring methods
misclassification
Opis:
Objectives This study aims to test the validity of the IPD-Work Consortium approach for creating comparable job strain groups between the Job Content Questionnaire (JCQ) and the Demand-Control Questionnaire (DCQ). Material and Methods A random population sample (N = 682) of all middle-aged Malmö males and females was given a questionnaire with the 14-item JCQ and 11-item DCQ for the job control and job demands. The JCQ job control and job demands scores were calculated in 3 different ways: using the 14-item JCQ standard scale formulas (method 1); dropping 3 job control items and using the 11-item JCQ standard scale formulas with additional scale weights (method 2); and the approach of the IPD Group (method 3), dropping 3 job control items, but using the simple 11-item summation-based scale formulas. The high job strain was defined as a combination of high demands and low control. Results Between the 2 questionnaires, false negatives for the high job strain were much greater than false positives (37–49% vs. 7–13%). When the method 3 was applied, the sensitivity of the JCQ for the high job strain against the DCQ was lowest (0.51 vs. 0.60–0.63 when the methods 1 and 2 were applied), although the specificity was highest (0.93 vs. 0.87–0.89 when the methods 1 and 2 were applied). The prevalence of the high job strain with the JCQ (the method 3 was applied) was considerably lower (4–7%) than with the JCQ (the methods 1 and 2 were applied) and the DCQ. The number of congruent cases for the high job strain between the 2 questionnaires was smallest when the method 3 was applied. Conclusions The IPD-Work Consortium approach showed 2 major weaknesses to be used for epidemiological studies on the high job strain and health outcomes as compared to the standard JCQ methods: the greater misclassification of the high job strain and lower prevalence of the high job strain.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2015, 28, 2; 321-333
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Studies of the radon progeny particle size distributions in the domestic environment. Epidemiological and dosimetric dose estimates
Autorzy:
Mamont-Cieśla, K.
Stawarz, O.
Powiązania:
https://bibliotekanauki.pl/articles/146844.pdf
Data publikacji:
2012
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
radon progeny particle size distribution (RPPSD)
weighted dose conversion factors
dosimetric/epidemiological effective dose estimate
conversion convention
unattached fraction
radon dose evaluation program (RADEP)
Opis:
Measurements of the short-lived radon progeny particle size distributions were performed under realistic natural conditions in 54 dwellings in 6 regions of Poland by means of the Radon Progeny Particle Size Spectrometer (RPPSS). The RPPSS comprises a one open face stage, a 4-stage diffusion battery and a 3-stage multi-hole inertial impactor. It was manufactured at the ARPaNSA (Melbourne, Australia), under supervision of Dr S. B. Solomon and supplied with his software. While using the continuous mode, the programme provides analysis of the potential alpha energy concentration on each stage, particle size distributions and weighted dose conversion factors based on the ICRP human respiratory tract model (HRTM) as implemented in the computer code RADEP (radon dose evaluation program). The unattached fraction indoors ranges from ca. 0 to 53% with an arithmetic mean and median of 17%. The equilibrium factor F was observed in the range from 7 to 64% with an arithmetic mean of 32% and median of 29%. The annual effective doses from radon progeny for the general population were estimated according to two models: epidemiological and dosimetric. The mean values of the ratios of the dosimetric to epidemiological dose estimates for the general population (breathing rate 0.78 m3/h) and workers (breathing rate 1.2 m3/h) are 1.0 and 1.4, respectively. The epidemiological dose estimates for the general population are smaller in comparison with the dosimetric estimates for the unattached fraction fp greater than 17%. It was shown that the dependence of the ratio of the doses estimated on the basis of two models on the unattached fraction fp is well described by a linear equation.
Źródło:
Nukleonika; 2012, 57, 3; 411-420
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Some Practical Problems of Multivariate Survival Analysis of Epidemiological Studies
Niektore praktyczne problemy wielozmiennej analizy przeżyć w badaniach epidemiologicznych
Autorzy:
Jasiński, Bogdan
Kawalec, Ewa
Kupść, Witold
Powiązania:
https://bibliotekanauki.pl/articles/906538.pdf
Data publikacji:
2002
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
epidemiological study
risk factors
proportional hazards regression
logistic regression
Opis:
In the epidemiological analysis of chronic diseases (most often cardiovascular or cancer) the main problem of interest is the estimation of the risk of death (or getting ill) related to set of characteristics called risk factors. For epidemiological studies typical features are: - large sample size (at least 1000 persons), - long follow up period for survival analysis (5 or more years), - large percentage of censored observations (patients who survive the whole time of study, more than 90%), - large number of registered risk factors. Some practical problems that concern the statistical analysis of the epidemiological data are following: - selection of the survival function model, - selection of the variables included into the model, - inclusion of interaction and/or higher order effect into the model. Some solutions of presented problems were applied to the Polish Part of Cardiovascular Diseases Prevention Program (Euro 8202). The program was conducted in 1976-1982 years with long follow up period concerning mortality till 1994 year. The program covered 8603 working men aged 40-59 years in two regions - Warsaw and South-Eastern Poland. Most of statistical analyses were performed on the basis of standard Statistical Analysis System (SAS) package.
Jednym z głównych celów epidemiologicznych badań nad chorobami przewlekłymi (najczęściej układu krążenia lub nowotworowymi) jest oszacowanie ryzyka zachorowania lub zgonu w zależności od zespołu cech - czynników ryzyka. Badania epidemiologiczne charakteryzują się najczęściej następującymi własnościami: - duża liczebność próby, powyżej 1000 badanych; długi okres obserwacji badanych osób, ponad kilka lat; - wysoka frakcja (ok. 90%) osób, które przeżyły cały okres badania bez incydentu chorobowego, tzw. cenzorowanie administracyjne; - duża liczba czynników ryzyka rejestrowanych w badaniu. Analiza statystyczna badania epidemiologicznego wymaga, między innymi, rozwiązania następujących problemów: - wybór modelu funkcji oceniającej ryzyko, - selekcja badanych w modelu czynników ryzyka, - ocena wzajemnego oddziaływania (interakcji) badanych czynników i ocena nieliniowych efektów ich oddziaływania. Rozwiązanie przedstawionych zadań przeprowadzono na przykładzie analizy wyników Polskiego Programu Prewencji Chorób Układu Krążenia przeprowadzonego w latach 1976-1982, obejmującego 8603 mężczyzn zatrudnionych w zakładach pracy w dwóch regionach Polski -Warszawy i Polski Południowo-Wschodniej i rozszerzonego o obserwację postępującą w zakresie zgonu do roku 1994.
Źródło:
Acta Universitatis Lodziensis. Folia Oeconomica; 2002, 162
0208-6018
2353-7663
Pojawia się w:
Acta Universitatis Lodziensis. Folia Oeconomica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Smoking and alcohol drinking during pregnancy as the risk factors for poor child neurodevelopment – A review of epidemiological studies
Autorzy:
Polańska, Kinga
Jurewicz, Joanna
Hanke, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2177372.pdf
Data publikacji:
2015-05-18
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
children
behavior
prenatal smoking
prenatal alcohol
neurodevelopment
Opis:
Maternal active and passive smoking and low or moderate alcohol drinking during pregnancy, taking into account the level of exposure and developmental or behavioral outcomes, are recognized as a significant issue from both a clinical and a public health perspective. The article aims at evaluating the impact of prenatal exposure to tobacco smoke constituents and low or moderate alcohol drinking during pregnancy on children neurodevelopment by reviewing the most recently published literature. Relevant studies were identified by searching the Pubmed, Medline and Ebsco literature databases. This review is restricted to 29 human studies published in English in peer reviewed journals since 2006. The studies published recently continued to show some relationship between tobacco smoke exposure, from active and passive maternal smoking during pregnancy, and children’s psychomotor development independent of other variables, but this relationship is not straightforward. The association is mostly consistent for measures of academic achievements and behavioral problems which require further attention. The results of the studies on low or moderate exposure to alcohol are not fully conclusive, but some of them suggest that consumption of alcohol during pregnancy may adversely affect children’s intelligence quotient (IQ), mental health, memory and verbal or visual performance. As the reviewed studies indicate, maternal lifestyle during pregnancy like alcohol drinking or smoking may affect children neurodevelopment. All effort should be taken to eliminate such exposure to ensure appropriate children’s development.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2015, 28, 3; 419-443
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Safety of nuclear power
Autorzy:
Strupczewski, A.
Powiązania:
https://bibliotekanauki.pl/articles/147940.pdf
Data publikacji:
2005
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
low radiation doses
LNT
hormesis
epidemiological studies
biological defense mechanism
Chernobyl effects
Opis:
The main questions related to nuclear power development concern effects of small radiation doses typical for the operation of nuclear power plants (NPPs) and hazards of NPP accidents. The last decade has brought many results of large scale epidemiological studies indicating that there are no detrimental effects of low radiation doses. On the contrary, many results indicate that among the people receiving increased radiation doses the frequency of cancer mortality is reduced. The review shows that such results are obtained in the studies of people living in high background radiation areas, of workers exposed to ionizing radiation and of patients exposed to radiation for diagnostic purposes. The latest studies in molecular biology suggest an explanation for possible beneficial effects of low radiation doses. This is reflected in the statements of several scientific bodies and international organizations, although the official regulations remain unchanged. The other important issue is the safety of NPPs in case of accidents. Reasons for the Chernobyl accident are shown not to be applicable to the reactors planned for Poland and the effects of Chernobyl are shown to be much smaller than feared in original estimates after the accident. Polish NPPs will satisfy the requirements of EU utilities and will provide safety for the population even in case of hypothetical severe accidents. Nevertheless, discussion with antinuclear organizations must be expected, although the recent examples of changing attitudes of leading ecological authorities show that nuclear power is gaining recognition as a clean and environmentally friendly source of energy.
Źródło:
Nukleonika; 2005, 50,suppl.3; 59-66
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Residual aluminium in water intended for human consumption
Autorzy:
Krupińska, Izabela
Płuciennik-Koropczuk, Ewelina
Gągała, Sylwia
Powiązania:
https://bibliotekanauki.pl/articles/396047.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Zielonogórski. Oficyna Wydawnicza
Tematy:
potable water
residual aluminium
coagulation
non-prehydrolysed coagulant
environmental factors
epidemiological studies
woda pitna
resztki aluminium
koagulacja
koagulanty niehydrolizowane
czynniki środowiskowe
badania epidemiologiczne
Opis:
Aluminium is one of the environmental factors that may have an impact on Alzheimer's and Parkinson's disease. Some epidemiological studies show a relationship between the concentration of aluminium in drinking water and the incidence of Alzheimer's disease. The article presents and discusses the results of research on the effect of the type and dose of non-prehydrolyzed aluminium coagulants on the concentration of residual aluminium in water intended for human consumption. Aluminium sulphate (VI) and sodium aluminate were tested as coagulants. Analysis of the obtained test results showed that lower concentrations of residual aluminium were found after coagulation with aluminium sulphate (VI), which is hydrolyzed acidally, lowering the pH of the water in the range of 7.47 to 7.12 providing good conditions for the formation of Al(OH)3. A less useful coagulant due to the concentration of residual aluminium was sodium aluminate, which undergoes basic hydrolysis creating conditions for the transition of Al(OH)3 into soluble Al(OH).
Źródło:
Civil and Environmental Engineering Reports; 2019, 29, 4; 248-256
2080-5187
2450-8594
Pojawia się w:
Civil and Environmental Engineering Reports
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physical activity among women at reproductive age and during pregnancy (Youth Behavioural Polish Survey - YBPS and Pregnancy-related Assessment Monitoring Survay - PrAMS) - epidemiological population studies in Poland during the period 2010-2011
Autorzy:
Wojtyla, A.
Kapka-Skrzypczak, L.
Bilinski, P.
Paprzycki, P.
Powiązania:
https://bibliotekanauki.pl/articles/50037.pdf
Data publikacji:
2011
Wydawca:
Instytut Medycyny Wsi
Tematy:
physical activity
woman
reproductive age
pregnancy
risk
public health
epidemiological study
Polish population
Polska
2010-2011 period
Źródło:
Annals of Agricultural and Environmental Medicine; 2011, 18, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physical activity among women at reproductive age and during pregnancy (Youth Behavioural Polish Survey – YBPS and Pregnancy-related Assessment Monitoring Survay – PrAMS) – epidemiological population studies in Poland during the period 2010-2011
Autorzy:
Wojtyla, A.
Kapka-Skrzypczak, L.
Bilinski, P.
Paprzycki, P.
Powiązania:
https://bibliotekanauki.pl/articles/51114.pdf
Data publikacji:
2011
Wydawca:
Instytut Medycyny Wsi
Tematy:
physical activity
woman
reproductive age
pregnancy
human behaviour
pregnancy risk
monitoring
epidemiological study
Polish population
Polska
2010-2011 period
Źródło:
Annals of Agricultural and Environmental Medicine; 2011, 18, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Outdoor work and solar radiation exposure: Evaluation method for epidemiological studies
Praca na wolnym powietrzu a narażenie na promieniowanie słoneczne – metoda oceny do stosowania w badaniach epidemiologicznych
Autorzy:
Modenese, Alberto
Bisegna, Fabio
Borra, Massimo
Grandi, Carlo
Gugliermetti, Franco
Militello, Andrea
Gobba, Fabriziomaria
Powiązania:
https://bibliotekanauki.pl/articles/2164265.pdf
Data publikacji:
2016-10-17
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
narażenie zawodowe
promieniowanie optyczne
praca na wolnym powietrzu
ocena narażenia
promieniowanie słoneczne
promieniowanie ultrafioletowe
occupational exposure
optical radiation
outdoor work
exposure assessment
solar radiation
ultraviolet radiation
Opis:
Background The health risk related to an excessive exposure to solar radiation (SR) is well known. The Sun represents the main exposure source for all the frequency bands of optical radiation, that is the part of the electromagnetic spectrum ranging between 100 nm and 1 mm, including infrared (IR), ultraviolet (UV) and visible radiation. According to recent studies, outdoor workers have a relevant exposure to SR but few studies available in scientific literature have attempted to retrace a detailed history of individual exposure. Material and Methods We propose a new method for the evaluation of SR cumulative exposure both during work and leisure time, integrating subjective and objective data. The former is collected by means of an interviewer administrated questionnaire. The latter is available through the Internet databases for many geographical regions and through individual exposure measurements. The data is integrated into a mathematical algorithm, in order to obtain an esteem of the individual total amount of SR the subjects have been exposed to during their lives. Results The questionnaire has been tested for 58 voluntary subjects. Environmental exposure data through online databases has been collected for 3 different places in Italy in 2012. Individual exposure by electronic UV dosimeter has been measured in 6 fishermen. A mathematical algorithm integrating subjective and objective data has been elaborated. Conclusions The method proposed may be used in epidemiological studies to evaluate specific correlations with biological effects of SR and to weigh the role of the personal and environmental factors that may increase or reduce SR exposure. Med Pr 2016;67(5):577–587
Wstęp Ryzyko zdrowotne związane z nadmiernym narażeniem na promieniowanie słoneczne (solar radiation – SR) jest dobrze znane. Słońce stanowi główne źródło promieniowania optycznego wszystkich zakresów częstotliwości, które obejmuje część widma elektromagnetycznego w zakresie od 100 nm do 1 mm, w tym podczerwień (infrared – IR), ultrafiolet (ultraviolet – UV) i promieniowanie widzialne. Według najnowszych badań osoby pracujące na wolnym powietrzu mogą być znacznie narażone na promieniowanie słoneczne, ale w niewielu badaniach odtworzono szczegółową historię indywidualnej ekspozycji. Materiał i metody W artykule zaproponowano nową metodę oceny skumulowanego narażenia na SR podczas pracy i w czasie wolnym, uwzględniającą dane subiektywne i obiektywne. Pierwsze z nich są zbierane w wywiadzie, drugie można uzyskać z baz internetowych dla regionów geograficznych i poprzez indywidualne pomiary narażenia. Dane są łączone za pomocą algorytmu matematycznego w celu uzyskania wartości indywidualnego całkowitego narażenia na SR badanych osób w trakcie ich całego życia. Wyniki Kwestionariusz przetestowano wśród 58 ochotników. Dane dotyczące narażenia na SR w 3 różnych miejscach we Włoszech w 2012 r. uzyskano z internetowych baz danych. Pomiar indywidualnego narażenia na SR u 6 rybaków wykonano elektronicznym dozymetrem UV. Opracowano również matematyczny algorytm scalania danych subiektywnych i obiektywnych. Wnioski Proponowana metoda może być stosowana w badaniach epidemiologicznych do określenia zależności między efektami biologicznymi a narażeniem na promieniowanie słoneczne oraz do oceny roli czynników osobniczych i środowiskowych, które mogą zwiększać lub zmniejszać narażenie na promieniowanie słoneczne. Med. Pr. 2016;67(5):577–587
Źródło:
Medycyna Pracy; 2016, 67, 5; 577-587
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mycobacterium tuberculosis - the 10 years of epidemiological and diagnostics studies
Autorzy:
Boruń-Popławska, Marta
Sajduda, Anna
Brzostek, Anna
Dziadek, Jarosław
Powiązania:
https://bibliotekanauki.pl/articles/764949.pdf
Data publikacji:
2005
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
Mycobacterium tuberculosis
insertion sequences
PCR
epidemiology
diagnosis
Opis:
Tuberculosis (ТВ) is the main bacterial pathogen that causes more deaths than AIDS, malaria and all infectious diseases. The unusual long doubling time (about 24h), highly hydrophobic cell envelope resistant to chemical lysis was the reason to delay the molecular study of this bacteria. Fifteen years ago, we did not have any molecular tools and methods for genetic manipulation or isolation and analysis of intracellular protein and nucleic acids. Today we have many useful shuttle or integration vectors for basic study of mycobacteria. The full sequence of M. tuberculosis genome is already known. At the present time the diagnosis of tuberculosis is supported with fast-culture system BACTEC and molecular techniques based on PCR and DNA hybridization. The mechanisms of resistance to antituberculosis drugs were described, and first identification of resistance profile is available by using PCR and sequencing or real time PCR methods. In our group in the Center for Microbiology and Virology Polish Academy of Sciences and in the Dept, of Genetics of Microorganisms, University Łódź we have characterized new insertion sequences from M. tuberculosis complex- 18990 and IS1607. In diagnostic studies we have proposed the DIG-PCR ELISA assay as a reliable, specific and sensitive test to identify M. tuberculosis directly in clinical samples. We have performed wide epidemiological studies of M. tuberculosis strains isolated from Polish ТВ patients including drug - and multidrug - resistant strains. Finally we identified the most frequently present mutations responsible for drug resistance of polish clinical isolates of M. tuberculosis.
Źródło:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2005, 2
1730-2366
2083-8484
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exposure to phthalates: Reproductive outcome and children health. A review of epidemiological studies
Autorzy:
Jurewicz, Joanna
Hanke, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2185370.pdf
Data publikacji:
2011-06-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
exposure to phthalates
children health
reproductive outcome
Opis:
Phthalates are a family of industrial chemicals that have been used for a variety of purposes. As the potential consequences of human exposure to phthalates have raised concerns in the general population, they have been studied in susceptible subjects such as pregnant women, infants and children. This article aims at evaluating the impact of exposure to phthalates on reproductive outcomes and children health by reviewing most recent published literature. Epidemiological studies focusing on exposure to phthalates and pregnancy outcome, genital development, semen quality, precocious puberty, thyroid function, respiratory symptoms and neurodevelopment in children for the last ten years were identified by a search of the PubMed, Medline, Ebsco, Agricola and Toxnet literature bases. The results from the presented studies suggest that there are strong and rather consistent indications that phthalates increase the risk of allergy and asthma and have an adverse impact on children's neurodevelopment reflected by quality of alertness among girls, decreased (less masculine) composite score in boys and attention deficit hyperactivity disorder. Results of few studies demonstrate negative associations between phthalate levels commonly experienced by the public and impaired sperm quality (concentration, morphology, motility). Phthalates negatively impact also on gestational age and head circumference; however, the results of the studies were not consistent. In all the reviewed studies, exposure to phthalates adversely affected the level of reproductive hormones (luteinizing hormone, free testosterone, sex hormone-binding globulin), anogenital distance and thyroid function. The urinary levels of phthalates were significantly higher in the pubertal gynecomastia group, in serum in girls with premature thelarche and in girls with precocious puberty. Epidemiological studies, in spite of their limitations, suggest that phthalates may affect reproductive outcome and children health. Considering the suggested health effects, more epidemiologic data is urgently needed and, in the meantime, precautionary policies must be implemented.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2011, 24, 2; 115-141
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exposure to environmental and lifestyle factors and attention-deficit / hyperactivity disorder in children — A review of epidemiological studies
Autorzy:
Polańska, Kinga
Jurewicz, Joanna
Hanke, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2180010.pdf
Data publikacji:
2012-09-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
children
environmental toxicants
attention–defi cit/hyperactivity disorder
inattention
impulsivity
Opis:
Attention-defi cit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders in children. Although the mechanisms that lead to the development of ADHD remain unclear, genetic and environmental factors have been implicated. These include heavy metals and chemical exposures, nutritional and lifestyle/psychosocial factors. The aim of this review was to investigate the association between ADHD or ADHD-related symptoms and widespread environmental factors such as phthalates, bisphenol A (BPA), tobacco smoke, polycyclic aromatic hydrocarbons (PAHs), polyfl uoroalkyl chemicals (PFCs) and alcohol. Medline, PubMed and Ebsco search was performed to identify the studies which analyze the association of prenatal and postnatal child exposure to environmental toxicants and lifestyle factors and ADHD or ADHD-related symptoms. The review is restricted to human studies published since 2000 in English in peer reviewed journals. Despite much research has been done on the association between environmental risk factors and ADHD or ADHD symptoms, results are not consistent. Most studies in this fi eld, focused on exposure to tobacco smoke, found an association between that exposure and ADHD and ADHD symptoms. On the other hand, the impact of phthalates, BPA, PFCs, PAHs and alcohol is less frequently investigated and does not allow a fi rm conclusion regarding the association with the outcomes of interest.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2012, 25, 4; 330-355
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
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