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Tytuł:
Imaging of hypoxia in small animals with 18F fluoromisonidasole
Autorzy:
Kilian, K.
Rogulski, Z.
Cheda, Ł.
Drzał, A.
Gerszewska, M.
Cudny, M.
Elas, M.
Powiązania:
https://bibliotekanauki.pl/articles/148618.pdf
Data publikacji:
2016
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
18F-fluoromisonidazole
radiopharmaceuticals
hypoxia imaging
Opis:
A method of automated synthesis of [18F]fluoromisonidazole ([18F]FMISO) for application in preclinical studies on small animals was presented. A remote-controlled synthesizer Synthra RNplus was used for nucleophilic substitution of NITTP (1-(2'-nitro-1'-imidazolyl)-2-O-tetrahydropyranyl-3-O-toluenesulfonyl-propanediol) with 18F anion. Labeling of 5 mg of precursor was performed in anhydrous acetonitrile at 100°C for 10 min, and the hydrolysis with HCl was performed at 100°C for 5 min. Final purifi cation was done with high-performance liquid chromatography (HPLC) and the radiochemical purity of radiotracer was higher than 99%. Proposed [18F]FMISO synthesis was used as a reliable tool in studies on hypoxia in Lewis lung carcinoma (LLC) in mouse models.
Źródło:
Nukleonika; 2016, 61, 2; 119-223
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
X-band and S-band EPR detection of nitric oxide in murine endotoxaemia using spin trapping by ferro-di(N-(dithiocarboxy)sarcosine).
Autorzy:
Plonka, Przemyslaw
Wisniewsk, Magdalena
Chlopicki, Stefan
Elas, Martyna
Rosen, Gerald
Powiązania:
https://bibliotekanauki.pl/articles/1043457.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
NO-metry
DTCS
NOS
septic shock
lung injury
oxidative stress
Opis:
Ammonium salt of N-(dithiocarboxy)sarcosine (DTCS) chelated to ferrous salt was tested as an NO-metric spin trap at room temperature for ex vivo measurement of g·NO production in murine endotoxaemia. In a chemically defined in vitro model system EPR triplet signals of NO-Fe(DTCS)g2 were observed for as long as 3 hours, only if samples were reduced with sodium dithionite. This procedure was not necessary for the ex vivo detection of ·NO in endotoxaemic liver homogenates at X-band or in the whole intact organs at S-band, whereas only a weak signal was observed in endotoxaemic lung. These results suggest that in endotoxaemia not only high level of ·NO, but also the redox properties of liver and lung might determine the formation of complexes of ·NO with a spin trap. Nevertheless, both S- and X-band EPR spectroscopy is suitable for ·NO-metry at room temperature using Fe(DTCS)2 as the spin trapping agent. In particular, S-band EPR spectroscopy enables the detection of ·NO production in a whole organ, such as murine liver.
Źródło:
Acta Biochimica Polonica; 2003, 50, 3; 799-806
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Metastasis inhibition after proton beam, β- and γ-irradiation of melanoma growing in the hamster eye
Autorzy:
Romanowska-Dixon, Bożena
Elas, Martyna
Swakoń, Jan
Sowa, Urszula
Ptaszkiewicz, Marta
Szczygieł, Małgorzata
Krzykawska, Martyna
Olko, Paweł
Urbańska, Krystyna
Powiązania:
https://bibliotekanauki.pl/articles/1039523.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
metastases
melanoma
ocular
proton beam
iodine-125
ruthenium-106
Opis:
Standard ocular tumor treatment includes brachytherapy, as well as proton therapy, particularly for large melanoma tumors. However, the effects of different radiation types on the metastatic spread is not clear. We aimed at comparing ruthenium (106Ru, emitting β electrons) and iodine (125I, γ-radiation) brachytherapy and proton beam therapy of melanoma implanted into the hamster eye on development of spontaneous lung metastases. Tumors of Bomirski Hamster Melanoma (BHM) implanted into the anterior chamber of the hamster eye grew aggressively and completely filled the anterior chamber within 8-10 days. Metastases, mainly in the lung, were found in 100% of untreated animals 30 days after enucleation. Tumors were irradiated at a dose of 3-10 Gy with a 106Ru plaque and at a dose of 6-14 Gy using a 125I plaque. The protons were accelerated using the AIC-144 isochronous cyclotron operating at 60 MeV. BHM tumors located in the anterior chamber of the eye were irradiated with 10 Gy, for the depth of 3.88 mm. All radiation types caused inhibition of tumor growth by about 10 days. An increase in the number of metastases was observed for 3 Gy of β-irradiation, whereas at 10 Gy an inhibition of metastasis was found. γ-radiation reduced the metastatic mass at all applied doses, and proton beam therapy at 10 Gy also inhibited the metastastic spread. These results are discussed in the context of recent clinical and molecular data on radiation effects on metastasis.
Źródło:
Acta Biochimica Polonica; 2013, 60, 3; 307-311
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gniazdowanie gawrona Corvus frugilegus w Warszawie w latach 2013-2014
Nesting of the Rook Corvus frugilegus in Warsaw in 2013-2014
Autorzy:
Redlisiak, M.
Kajzer, K.
Wardecki, L.
Elas, M.
Powiązania:
https://bibliotekanauki.pl/articles/32938.pdf
Data publikacji:
2014
Wydawca:
Mazowiecko-Świętokrzyskie Towarzystwo Ornitologiczne
Tematy:
ptaki
gawron
Corvus frugilegus
kolonie legowe
inwentaryzacja zwierzat
spadek liczebnosci
gniazdowanie
Warszawa
lata 2013-2014
Źródło:
Kulon; 2014, 19
1427-3098
Pojawia się w:
Kulon
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Acute hepatologic and nephrologic effects of calcitriol in Syrian golden hamster (Mesocricetus auratus)
Autorzy:
Podgorska, Ewa
Sniegocka, Martyna
Mycinska, Marianna
Trybus, Wojciech
Trybus, Ewa
Kopacz-Bednarska, Anna
Wiechec, Olga
Krzykawska-Serda, Martyna
Elas, Martyna
Krol, Teodora
Urbanska, Krystyna
Slominski, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1038358.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
calcitriol
Syrian golden hamster
hepatologic toxicity
nephrologic toxicity
Opis:
Although vitamin D is included in the group of fat-soluble vitamins, it must be considered as a prohormone. Its active forms, including calcitriol, have pleiotropic effects and play an important role in the regulation of cell proliferation, differentiation and apoptosis, as well as in hormone secretion, and they demonstrate anti-cancer properties. Since calcitriol delivery can be beneficial for the organism, and Syrian golden hamsters represent a unique experimental model, we decided to investigate its toxicity in this species. In this study, we injected calcitriol intraperitoneally at doses 0 (control), 0.180±0.009 µg/kg and 0.717±0.032 µg/kg. Animal behavior was observed for 72 hrs after injection, and afterwards blood, liver and kidneys were collected for post-mortem examination, electron microscopy, and hematology analyses. The highest dose of calcitriol induced a change in animal behavior from calm to aggressive, and the liver surface showed morphological signs of damage. Following injection of calcitriol, ultrastructural changes were also observed in the liver and kidneys, e.g. vacuolization and increased number of mitochondria. There was also a trend for increased serum levels of aspartate aminotransferase (AST), but not of alanine aminotransferase (ALT) or GGTP (gamma-glutamyl transpeptidase). There was no change in Ca, Mg and P levels, as well as in blood morphology between experimental and control groups. These results indicate that calcitriol at 0.717, but not at 0.180 µg/kg, may induce acute damage to the liver and kidneys, without inducing calcemia. We propose that the hepatotoxic effect of calcitriol in hamster constitutes the primary cause of behavioral changes.
Źródło:
Acta Biochimica Polonica; 2018, 65, 3; 351-358
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Awifauna lęgowa koryt wybranych rzek centralnej Polski
Breeding avifauna of river beds of selected small rivers in Central Poland
Autorzy:
Węgrzynowicz, A.
Elas, M.
Sikora, D.
Grzębkowski, M.
Jejno, J.
Rapczyński, J.
Powiązania:
https://bibliotekanauki.pl/articles/2090085.pdf
Data publikacji:
2021
Wydawca:
Mazowiecko-Świętokrzyskie Towarzystwo Ornitologiczne
Tematy:
Polska Centralna
rzeki
awifauna legowa
koryta rzeczne
river
wetland avifauna
Mazovian avifauna
birds of river beds
Opis:
In 2015-2016 the survey of breeding bird assemblage associated with river beds (wetland Non-Passeriformes and Sand Martin Riparia riparia) was carried out. The study was conducted at the sections of small rivers, each several dozen kilometres long, running through the Mazovian Lowland:Wkra,Liwiec,Pilica,andWieprz.Twocanoesurveyswerecarriedoutoneachriver–in the first half of May and first half of June. 5 to 6-7 species representing the studied group were recorded on these rivers. The Mallard Anas platyrhynchos, Little Ringed Plover Charadrius dubius, Common Sandpiper Actitis hypoleucos, Kingfisher Alcedo atthis, and Sand Martin were recorded on all rivers. Moreover, breeding Goosander Mergus merganser was recorded on three of the surveyed rivers, while a pair of the Mandarin Duck Aix galericulata, probably breeding, was recorded on the Wkra river. On a national scale, the studied rivers were the most important for the Common Sandpiper (Liwiec and Pilica), Sand Martin (Wieprz), and Goosander (Wkra and Pilica).
W latach 2015-2016 przeprowadzono inwentaryzację zespołu ptaków lęgowych związa- nych z korytami rzecznymi (wodno-błotne Non-Passeriformes oraz brzegówka Riparia riparia). Ba- daniami objęto ujściowe odcinki czterech rzek przepływających przez obszar Niziny Mazowieckiej: Wkry, Liwca, Pilicy i Wieprza. Na każdej z rzek wykonano po dwa spływy kajakowe – w pierw- szej połowie maja i pierwszej połowie czerwca. Na poszczególnych rzekach wykazano od 5 do 6-7 gatunków ptaków lęgowych z badanej grupy. Gatunkami stwierdzonymi na wszystkich rzekach były: krzyżówka Anas platyrhynchos, sieweczka rzeczna Charadrius dubius, brodziec piskliwy Actitis hypoleucos, zimorodek Alcedo atthis i brzegówka. Ponadto na trzech rzekach stwierdzono lęgową nurogęś Mergus merganser, a na Wkrze – mandarynkę Aix galericulata (gniazdowanie prawdopo- dobne). W skali kraju, badane odcinki rzek miały największe znaczenie dla brodźca piskliwego (Liwiec i Pilica), brzegówki (Wieprz) i nurogęsi (Wkra i Pilica).
Źródło:
Kulon; 2021, 26; 19-28
1427-3098
Pojawia się w:
Kulon
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wysoka liczebność derkacza Crex crex we fragmencie OSO Dolina Dolnego Bugu w latach 2011-2013
High number of the Corncrake Crex crex in the Lower Bug Valley in 2011-2013
Autorzy:
Elas, M.
Powiązania:
https://bibliotekanauki.pl/articles/79648.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Zoologiczne
Tematy:
ptaki
derkacz
Crex crex
liczebnosc populacji
lata 2011-2013
dolina Dolnego Bugu
obszary specjalnej ochrony ptakow
Europejska Siec Ekologiczna Natura 2000
Źródło:
Ornis Polonica; 2014, 55, 2
2081-9706
Pojawia się w:
Ornis Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Quando a morte encontra as línguas, elas estão vivas
When death meets languages, they remain alive
Autorzy:
Barzotto, Valdir Heitor
Perina de Souza, Sheila
Powiązania:
https://bibliotekanauki.pl/articles/45691269.pdf
Data publikacji:
2022
Wydawca:
Uniwersytet Warszawski. Ośrodek Studiów Amerykańskich
Tematy:
línguas africanas
kimbundu
necropolítica
atitudes linguísticas
African languages
Kimbundu
necropolitics
language attitudes
Opis:
Este artigo objetiva refletir sobre os atentados à vida das línguas africanas, que vivenciaram a colonização, por meio das atitudes linguísticas frente a elas no período colonial e na atualidade. Discutimos a metáfora de morte direcionada às línguas, utilizamo-nos do conceito de necropolítica aplicado à língua, discorremos sobre o direito de matar estendido às línguas africanas na sociedade colonial e, especificamente, refletimos sobre os atentados à vida das línguas, lançando um olhar para as atitudes linguísticas frente ao kimbundu, língua de Angola. Diante das análises, observamos duas atitudes linguísticas: a) Ausência de nomeação e especificação da língua a que pertence o vocabulário em kimbundu; e b) Tratamento diferenciado entre as línguas europeias e africanas. Consideramos que essas atitudes linguísticas são oriundas de discursos pertencentes à mesma formação discursiva colonial, e atentam contra a vida das línguas africanas ainda hoje. Observamos uma certa limitação do uso dessas línguas em relação às línguas de origem europeias. Consideramos que no âmbito da linguagem, a necropolítica na colônia era pautada pelo desejo de morte social das línguas africanas expresso por meio de leis que proibiam o seu uso. Hoje as ações necropolíticas também podem ser expressas pelas atitudes que buscam circunscrever as línguas africanas a espaços específicos, atribuindo menor valor social quando comparadas às línguas europeias. Apesar das diferentes ações necropolíticas vivenciadas desde o período colonial, as línguas africanas seguem vivas.
Este artículo pretende reflexionar sobre los ataques a la vida de las lenguas que vivieron la colonización, a través de las actitudes lingüísticas hacia ellas en el período colonial y en la actualidad. Desde Heller-Roazen (2010) y Campbell y Muntzel (1989) reflexionan sobre la metáfora de la muerte dirigida a los lenguajes. Inspirándose en el libro de Fanon “Os damned da Terra” (1968) y el concepto de necropolítica de Mbembe (2016), reflexionan sobre el deseo de muerte social de las lenguas africanas en la sociedad colonial. Consideramos que no se trata de una muerte natural, por el contrario, es un proyecto de muerte propuesto por el Estado colonial aún presente. Utilizamos el concepto de necropolítica aplicado al lenguaje, en cuanto se refiere al control del derecho a vivir o morir. Reflexionar sobre el libro de actitudes lingüísticas de Angola, lanzado con una mirada al libro “A Rainha Ginga como os Africanos inventa o mundo” Agualusa, y al manual/libro de texto de lengua portuguesa de 6º curso utilizado en las escuelas angoleñas. Frente a las propuestas, observamos dos actitudes lingüísticas presentadas en los dos textos analizados: a) Ausencia de denominación y especificación de la lengua a la que pertenece lo permitido en Kimbundu; yb) Trato diferenciado entre lenguas europeas y africanas. Tanto en el libro literario como en el libro de texto, existe cierta regularidad en el modo de tratar el kimbundu, en la ausencia de nomenclatura y en el trato diferenciado en cuanto al respeto de los orígenes de sus principios de información. Consideramos que estas actitudes lingüísticas africanas provienen de discursos pertenecientes a la misma formación discursiva colonial, y atacan la vida de las lenguas. Observamos cierta limitación en el uso de estos idiomas, ya que en la época colonial, que los idiomas locales ocupan espacio, no están en igual espacio en el texto. En cuanto a la lengua, la necropolítica en la colonia estuvo guiada por el deseo de muerte social de las lenguas africanas en la sociedad expresada a través de leyes que prohibían su uso. Hoy en día, como necropolíticas en el campo del lenguaje, también pueden expresarse mediante actitudes que se describen como espacios específicos en el texto y en la sociedad africana que atribuyen valor a las acciones sociales cuando son alternativas a los lenguajes europeos.
This paper aims to reflect on the attempts on the lives of African languages, which experienced colonization, through the linguistic attitudes towards them in the colonial period and today. We discuss the metaphor of death directed at languages, we use the concept of necropolitics applied to language, as it concerns the control of the right to live or die, we discuss the right to kill extended to African languages in colonial society, and, specifically, we reflect on the attempts on the life of languages that suffered colonization even today, and we look at the linguistic attitudes towards Kimbundu, the language of Angola. In view of the analyses, we observed two linguistic attitudes: a) absence of naming and specifying the language to which the vocabulary in Kimbundu belongs; and b) differentiated treatment between European and African languages. We believe that these linguistic attitudes stem from discourses belonging to the same colonial discursive formation and threaten the life of African languages even today. We observe a certain limitation of the use of these languages, just as in the colonial period, there is a circumscription of the space that African languages should occupy, they are not in equal space in the text in relation to the languages of European origin. We consider that in the realm of language, necropolitics in the colony was guided by the desire for the social death of African languages in society expressed through laws that prohibited their use. Today necropolitical actions can also be expressed by attitudes that seek to circumscribe African languages to specific spaces, assigning less social value when compared to European languages. Despite the different necropolitical actions experienced since the colonial period, African languages are still alive.
Źródło:
Revista del CESLA. International Latin American Studies Review; 2022, 30; 177-188
1641-4713
Pojawia się w:
Revista del CESLA. International Latin American Studies Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ocena liczby par lęgowych brodźca piskliwego Actitis hypoleucos w zależności od przyjętej metody liczeń
Assessment of the number of breeding pairs of the Common Sandpiper Actitis hypoleucos depending of the survey method
Autorzy:
Elas, M.
Kajzer, K.
Grzebkowski, M.
Kolinski, A.
Rozycki, A.
Sikora, D.
Wardecki, L.
Wegrzynowicz, A.
Powiązania:
https://bibliotekanauki.pl/articles/79551.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Zoologiczne
Tematy:
ptaki
brodziec piskliwy
Actitis hypoleucos
populacje legowe
gniazdowanie
terytoria legowe
pary legowe
stan ilosciowy
metody liczenia
Dolina Srodkowej Wisly
Źródło:
Ornis Polonica; 2015, 56, 3
2081-9706
Pojawia się w:
Ornis Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-10 z 10

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