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Tytuł:
Klinicznie nieczynne hormonalnie guzy przysadki
NFPAs-non-functioning pituitary adenomas
Autorzy:
Zawada, Natalia Bożena
Kunert-Radek, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/1032601.pdf
Data publikacji:
2012
Wydawca:
Łódzkie Towarzystwo Naukowe
Tematy:
klinicznie nieczynne gruczolaki przysadki
guzy przysadki
immunohistochemia guzów przysadki
scyntygrafia receptorowa
receptory
dopaminergiczne
receptory somatostatynowe
leczenie operacyjne
radioterapia
nóż gamma
analogi somatostatyny
agoniści dopaminy
clinically non-functioning pituitary adenomas
pituitary tumours
immunohistochemistry of pituitary tumours
receptor scintigraphy
dopamine
receptors
somatostatin receptors
surgery
radiotherapy
gamma knife
somatostatin analogues
dopamine agonists
Opis:
The significant progress made in recent years, especially in the field of imaging techniques and immunohistochemistry, enables an earlier diagnosis and the treatment of clinically non-functioning pituitary adenomas (NFPAs). In spite of this, these tumours still remain an important medical issue for a large number of specialities. The aim of this article is to provide an overview of the etiopathogenesis, diagnosis and treatment of clinically non-functioning pituitary adenomas with special reference to the development of highly advanced methods in surgery as well as radiotherapy and, especially, in pharmacotherapy.
Istotny postęp, jaki dokonał się w ostatnich latach, zwłaszcza w zakresie rozwoju diagnostyki obrazowej i badań immunohistochemicznych, umożliwia wcześniejsze rozpoznawanie, a następnie leczenie nieczynnych hormonalnie gruczolaków przysadki (NFPAs). Mimo to guzy te dalej pozostają istotnym problemem klinicznym dla lekarzy wielu specjalności. Celem pracy jest szczegółowe przedstawienie poglądów na temat etiopatogenezy, obrazu klinicznego, diagnostyki i metod leczenia klinicznie nieczynnych hormonalnie gruczolaków przysadki ze szczególnym uwzględnieniem postępów w technikach chirurgicznych oraz rozszerzających się możliwości radioterapii, a szczególnie farmakoterapii.
Źródło:
Folia Medica Lodziensia; 2012, 39, 1; 85-136
0071-6731
Pojawia się w:
Folia Medica Lodziensia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cortical localization of dopamine D4 receptors in the rat brain - immunocytochemical study
Autorzy:
Wedzony, K.
Chocyk, A.
Mackowiak, M.
Fijal, K.
Czyrak, A.
Powiązania:
https://bibliotekanauki.pl/articles/69855.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
prefrontal cortex
neuroleptic drug
brain
cortical localization
immunocytochemistry
polyclonal antibody
dopamine D4 receptor
rat
neurofilament H
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 2
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fluorymetryczna metoda oznaczania wolnej adrenaliny, noradrenaliny i dopaminy w moczu
Fluorimetricheskijj metod opredelenija svobodnogo adrenalina, noradrenalina i dopamina v moche
The fluorimetric method for the adrenalin, noradrenalin and dopamine estimation in urine
Autorzy:
Tyburczyk, W.
Zawiślak, H.
Powiązania:
https://bibliotekanauki.pl/articles/2189736.pdf
Data publikacji:
1971
Wydawca:
Polskie Towarzystwo Diagnostyki Laboratoryjnej
Źródło:
Diagnostyka Laboratoryjna; 1971, 07, 3; 307-311
0867-4043
Pojawia się w:
Diagnostyka Laboratoryjna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Affording Our Culture: “Smart” Technology and the Prospects for Creative Democracy
Autorzy:
Solymosi, Tibor
Powiązania:
https://bibliotekanauki.pl/articles/451283.pdf
Data publikacji:
2018-12-28
Wydawca:
Uniwersytet Warszawski. Wydział Filozofii
Tematy:
digital devices
social media
democracy
neuropragmatism
dopamine
affordances
neuroscience
Opis:
John Dewey, as Sidney Hook characterized him, was the philosopher of science and freedom. Dewey, as Larry Hickman has demonstrated, was also a philosopher of technology. And, as most people familiar with Dewey know, he was a philosopher of education and democracy. The complex of technology, science, freedom, education and democracy requires re-examination, not only because of our contemporary cultural political situation but also because of our growing insights into the human condition thanks to the technosciences of life, especially human life. Dewey’s philosophical method of reconstruction, equipped with insights from evolutionary neuroscience and ecological psychology, offers means of reconceiving and thus reevaluating our conception of tools and technology within our cultural context. I begin to take up Mark Tschaepe’s challenge to neuropragmatism to counter what he calls “dopamine democracy” – Plato’s critique of democracy resurrected in neural garb coupled with a critical examination of how social media and other so-called “smart” technologies undermine healthy democratic life. Central to this neuropragmatist approach are cultural affordances – opportunities for action humans have created initially for specific purposes and later retrofitted for other ends-in-view. Dewey’s reconstruction – as method as well as the reconstruction of technology, science, freedom, education and democracy as an entangled complex – is thus imagined as our best strategy for achieving the culture of creative democracy.
Źródło:
Eidos. A Journal for Philosophy of Culture; 2018, 2, 4(6); 46-69
2544-302X
Pojawia się w:
Eidos. A Journal for Philosophy of Culture
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
How to Handle Humility? Audaciously: A Response to Mark Tschaepe
Autorzy:
Solymosi, Tibor
Bywater, Bill
Powiązania:
https://bibliotekanauki.pl/articles/451557.pdf
Data publikacji:
2019-10-31
Wydawca:
Uniwersytet Warszawski. Wydział Filozofii
Tematy:
neuropragmatism
dopamine democracy
digital devices
social media
information and news
education
Opis:
We address Mark Tschaepe’s response to Tibor Solymosi, in which Tschaepe argues that neuropragmatism needs to be coupled with humility in order to redress “dopamine democracy,” Tschaepe’s term for our contemporary situation of smartphone addiction that undermines democracy. We reject Tschaepe’s distinction between humility and fallibility, arguing that audacious fallibility is all we need. We take the opportunity presented by Tschaepe’s constructive criticism of neuropragmatism to reassert some central themes of neuropragmatism. We close with discussion of Bywater’s method of apprenticeship, as an imaginative education for creative democracy, thereby rejecting Tschaepe’s claim that neuropragmatism lacks a pedagogical method.
Źródło:
Eidos. A Journal for Philosophy of Culture; 2019, 3, 3(9); 145-159
2544-302X
Pojawia się w:
Eidos. A Journal for Philosophy of Culture
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Era dopaminy – jak znaleźć równowagę w czasach obfitości. Anna Lembke. Dopamine Nation: Finding Balance in the Age of Indulgence. New York: Dutton, 2021. 304 ss. ISBN: 9781-52-474672-8.
The Age of Dopamine — How to Find a Balance in Times of Abundance. Anna Lembke. Dopamine Nation: Finding Balance in the Age of Indulgence. New York: Dutton, 2021. 304 ss. ISBN: 9781-52-474672-8.
Autorzy:
Sikora, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/31232008.pdf
Data publikacji:
2022
Wydawca:
Katolicki Uniwersytet Lubelski Jana Pawła II. Towarzystwo Naukowe KUL
Źródło:
Roczniki Filozoficzne; 2022, 70, 3; 505-511
0035-7685
Pojawia się w:
Roczniki Filozoficzne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Enhancing the Safety of Medical Personel Through the Use of Modern Technology
Autorzy:
Ratusiński, Tadeusz
Szczeblowska, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/1832572.pdf
Data publikacji:
2017
Wydawca:
Wyższa Szkoła Bezpieczeństwa Publicznego i Indywidualnego Apeiron w Krakowie
Tematy:
security
health
modern technologies
teaching process
education
dopamine
GeoGebra
infusion pump
Opis:
Security of a society is related to the level of its health which largely depends on the level of professional education of medical staff whose task is to help a person in life-threatening situations. Life-threatening situations include among others acute cardiac failure or renal failure. One of the methods to improve health condition of patients with these medical problems is intravenous treatment with dopamine administered by an infusion pump. Medical staff is responsible for proper programming of a pump so that it gives a patient the appropriate dose. Introduction of modern technology to training programme can facilitate the process of learning how to programme an automatic infusion pump. The article describes an example of a simple computer programme created on the basis of free software which is GeoGebra and shared as HTML pages. The prepared learning resource does not require from its receivers any programming skills or special software.
Źródło:
Security Dimensions; 2017, 24(24); 150-162
2353-7000
Pojawia się w:
Security Dimensions
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Administration of Greek Royal Jelly produces fast response in neurotransmission of aged Wistar male rats
Autorzy:
Pyrzanowska, J.
Piechal, A.
Blecharz-Klin, K.
Joniec-Maciejak, I.
Graikou, K.
Chinou, J.
Widy-Tyszkiewicz, E.
Powiązania:
https://bibliotekanauki.pl/articles/3504.pdf
Data publikacji:
2015
Wydawca:
Instytut Medycyny Wsi
Tematy:
administration
Greek product
natural product
Royal Jelly
fast response
neurotransmission
Wistar rat
male
rat
hippocampus
dopamine
serotonin
Opis:
Introduction. Royal Jelly (RJ) is a popular bee-derived product used widely in European and Asian traditional medicine. RJ has some pharmacological activities to support health and longevity as well as prevent ageing. Objectives. To evaluate whether a short-term 6-day Royal Jelly administration is able to induce behavioural and neurochemical effects in aged rats. Materials and method. RJ (previously chemically characterized by GC-FID and GC–MS) was given to 18-month-old male Wistar rats (100 and 500mg of powder/kg b.w./day) in subcutaneous injection for 6 days. Spatial memory was assessed in a water maze. Afterwards, the level of neurotransmitters, their metabolites and turnover in the selected brain regions were estimated by HPLC. Results. Short-term RJ administration did not change spatial memory in aged rats in the water maze, although it was sufficiently active to modify most of all the serotonergic and dopaminergic transmission in the prefrontal cortex and hippocampus. Conclusion. The obtained results indicate that Royal Jelly is able to affect very quickly the neurotransmission in the brain structures responsible for cognitive performance; however, short-term administration is not sufficient to exert behavioural consequences.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2015, 09, 2
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of Fragment Molecular Orbital Method to investigate dopamine receptors
Autorzy:
Preikša, Jokūbas
Śliwa, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/93092.pdf
Data publikacji:
2019
Wydawca:
Państwowa Wyższa Szkoła Zawodowa w Tarnowie
Tematy:
Fragment Molecular Orbital
molecular dynamic
dopamine receptor
Fragment Molecular Orbital (FMO)
dynamika molekularna
receptor dopaminowy
Opis:
GPCRs are a vast family of seven-domain transmembrane proteins. This family includes dopamine receptors (D1, D2, D3, D4, and D5), which mediate the variety of dopamine-controlled physiological functions in the brain and periphery. Ligands of dopamine receptors are used for managing several neuropsychiatric disorders, including bipolar disorder, schizophrenia, anxiety, and Parkinson’s disease. Recent studies have revealed that dopamine receptors could be part of multiple signaling cascades, rather than of a single signaling pathway. For these targets, a variety of experimental and computational drug design techniques are utilized. In this work, dopamine receptors D2, D3, and D4 were investigated using molecular dynamic method as well as computational ab initio Fragment Molecular Orbital method (FMO), which can reveal atomistic details about ligand binding. The results provided useful insights into the significances of amino acid residues in ligand binding sites. Moreover, similarities and differences between active-sites of three studied types of receptors were examined.
Źródło:
Science, Technology and Innovation; 2019, 6, 3; 24-32
2544-9125
Pojawia się w:
Science, Technology and Innovation
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polypharmacology – a challenge for current drug design approaches
Autorzy:
Podlewska, Sabina
Kurczab, Rafał
Powiązania:
https://bibliotekanauki.pl/articles/93192.pdf
Data publikacji:
2019
Wydawca:
Państwowa Wyższa Szkoła Zawodowa w Tarnowie
Tematy:
G protein-coupled receptor
polypharmacology
serotonin receptor
dopamine receptor
antipsychotic profile
ligand
receptor sprzężony z białkiem G
polifarmakologia
receptor serotoninowy
receptor dopaminowy
profil przeciwpsychotyczny
Opis:
Drug design process faces many challenges, and the most important ones are connected with side effects. Finding compounds that possess affinity towards target of interest is relatively simple; however, an approach one disease-one target is now making space for the search of polypharmacological ligands, where activity towards several proteins is considered at one time. Such proteins are not always the target ones, but very often such panels include also anti-targets, interaction with which is not desired, due to the side effects that may occur upon such contact. In the study, we examined ligands of four G protein-coupled receptors, forming antipsychotic profile: dopamine receptor D2, serotonin receptors 5-HT2A, 5-HT2C (anti-target), and 5-HT6. Number of ligands belonging to particular activity groups, as well as the selected compound structures are examined in detail. Also compound similarity between sets of different activity groups is analysed, giving a picture of difficulty of constructing molecular modeling methodologies that can help in the search of compounds with desired activity profile.
Źródło:
Science, Technology and Innovation; 2019, 6, 3; 19-23
2544-9125
Pojawia się w:
Science, Technology and Innovation
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Kinetics and specificity of guinea pig liver aldehyde oxidase and bovine milk xanthine oxidase towards substituted benzaldehydes.
Autorzy:
Panoutsopoulos, Georgios
Beedham, Christine
Powiązania:
https://bibliotekanauki.pl/articles/1041542.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
xanthine oxidase
dopamine
benzaldehydes
aldehyde oxidase
protocatechuic aldehyde
isovanillin
Opis:
Molybdenum-containing enzymes, aldehyde oxidase and xanthine oxidase, are important in the oxidation of N-heterocyclic xenobiotics. However, the role of these enzymes in the oxidation of drug-derived aldehydes has not been established. The present investigation describes the interaction of eleven structurally related benzaldehydes with guinea pig liver aldehyde oxidase and bovine milk xanthine oxidase, since they have similar substrate specificity to human molybdenum hydroxylases. The compounds under test included mono-hydroxy and mono-methoxy benzaldehydes as well as 3,4-dihydroxy-, 3-hydroxy-4-methoxy-, 4-hydroxy-3-methoxy-, and 3,4-dimethoxy-benzaldehydes. In addition, various amines and catechols were tested with the molybdenum hydroxylases as inhibitors of benzaldehyde oxidation. The kinetic constants have shown that hydroxy-, and methoxy-benzaldehydes are excellent substrates for aldehyde oxidase (Km values 5×10-6 M to 1×10-5 M) with lower affinities for xanthine oxidase (Km values around 10-4 M). Therefore, aldehyde oxidase activity may be a significant factor in the oxidation of the aromatic aldehydes generated from amines and alkyl benzenes during drug metabolism. Compounds with a 3-methoxy group showed relatively high Vmax values with aldehyde oxidase, whereas the presence of a 3-hydroxy group resulted in minimal Vmax values or no reaction. In addition, amines acted as weak inhibitors, whereas catechols had a more pronounced inhibitory effect on the aldehyde oxidase activity. It is therefore possible that aldehyde oxidase may be critical in the oxidation of the analogous phenylacetaldehydes derived from dopamine and noradrenaline.
Źródło:
Acta Biochimica Polonica; 2004, 51, 3; 649-663
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Deuterium isotope effects in oxidation of dopamine by tyramine oxidase
Autorzy:
Pająk, M.
Byszewska, W.
Kańska, M.
Powiązania:
https://bibliotekanauki.pl/articles/147724.pdf
Data publikacji:
2013
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
deuterium
dopamine (DA)
isotope effects
oxidation
tyramine oxidase
Opis:
We report the studies on the mechanism of oxidation of dopamine (DA) to 3’,4’-dihydroxyphenylacetaldehyde (DOPAL) by enzyme tyramine oxidase (EC 1.4.3.6) using kinetic isotope effects (KIE) and solvent isotope effects (SIE) methods. For kinetic studies, the selectively deuterium labelled isotopologues of dopamine, i.e., [(1R)-2H]-, and [(1S)- -2H]-DA were used. The numerical values of KIE’s for the (1R)- and (1S)-isotopologues of dopamine in the enzymatic oxidation of DA to DOPAL were determined using the non competitive spectrophotometric method. Also, the SIE’s for this reaction carried out in heavy water were obtained spectrophotometrically. Some mechanistic details of enzymatic oxidation of DA to DOPAL were discussed.
Źródło:
Nukleonika; 2013, 58, 2; 255-259
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
INFLAMMATORY MARKERS AND NEUROPEPTIDES CHARACTERISTIC OF PARKINSON’S DISEASE AND THEIR RESPONSE TO VISUALIZATION AND SUGGESTION BASED MIND-BODY THERAPY
Autorzy:
Ostapiuk-Karolczuk, Joanna
Kasperska, Anna
Botwina, Ryszard
Powiązania:
https://bibliotekanauki.pl/articles/2137791.pdf
Data publikacji:
2017-12-23
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
mind-body therapy
visualization
inflammation
dopamine
BDNF Parkinson`s disease
Opis:
Progress in elucidating neuroimmune connections has created new opportunities for improving the treatment of Parkinson’s disease (PD). In recent years, mind-body therapies have been shown to have positive effects on the immune and nervous systems, but interactions at the molecular level have not been tested. Thus, the main aim of the present study was to investigate the effects of therapy based on visualization and suggestion on the concentrations of IL-6, CRP, DA, BDNF, CoQ10, and TAC in patients with advanced PD. Eight patients with PD and 8 elderly healthy men (control group) were enrolled in the study. The therapy lasted 19 days and consisted of three parts: individual sessions with the therapist, mixed (therapist and audio-file), and self-training (audio-file). Blood samples were taken before training and at the end of each part. The expected changes in the investigated markers was observed during therapy: the serum concentration of IL-6 and CRP decreased, whereas DA and BDNF increased, however, this change was observed only after the first part of intervention when the therapy was conducted by the therapist. In the subsequent stages, the levels returned to the baseline. Noteworthy, after the therapy, we observed a significant increase in the motor and intellectual skills of the PD patients. No such changes were observed in the control group. Mind-body therapy based on visualization and suggestions aimed at changing the concentrations of signaling molecules, which are crucial in the development or treatment of PD, may be an effective element in supporting pharmacological therapy.
Źródło:
Acta Neuropsychologica; 2017, 15(4); 443-456
1730-7503
2084-4298
Pojawia się w:
Acta Neuropsychologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Znaczenie dopaminy w regulacji stanów snu i czuwania
The role of dopamine in the control of sleep-wake states
Autorzy:
Orzeł-Gryglewska, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/1192573.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Przyrodników im. Kopernika
Opis:
Sen i czuwanie regulowane są przez szereg neurotransmiterów i neuromodulatorów ośrodkowego układu nerwowego. W pracy przedstawiono fakty przemawiające za udziałem dopaminergicznego układu mezostriatalnego i mezokortykolimbicznego w regulacji snu i czuwania. Omówiono wpływ dopaminy, jej agonistów i transportera dopaminowego na stan czuwania i snu, zaburzenia snu towarzyszące dysfunkcjom układu dopaminergicznego oraz rolę dopaminy w śnie REM i indukcji marzeń sennych. Przedstawiono także propozycję modelu uwzględniającego udział dróg mezolimbicznych w systemie generacji hipokampalnego rytmu theta, który jest jedną z kryterialnych cech snu REM.
Sleep and wakefulness are regulated by a number of neurotransmitters and neuromodulators of the central nervous system. This paper presents the facts supporting the role of the dopaminergic mesocorticolimbic and mesostriatal systems in the regulation of sleep and wakefulness. The effects of dopamine, its agonists and dopamine transporter on wakefulness, sleep, sleep disorders and the role of dopamine in the induction of REM sleep and dreams are discussed. Mesolimbic pathways are included in a suggested model of generation of hippocampal theta rhythm, which is one of the criterial features of REM sleep.
Źródło:
Kosmos; 2014, 63, 2; 189-200
0023-4249
Pojawia się w:
Kosmos
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pattern classification by spiking neural networks combining self-organized and reward-related spike-timing-dependent plasticity
Autorzy:
Nobukawa, Sou
Nishimura, Haruhiko
Yamanishi, Teruya
Powiązania:
https://bibliotekanauki.pl/articles/91886.pdf
Data publikacji:
2019
Wydawca:
Społeczna Akademia Nauk w Łodzi. Polskie Towarzystwo Sieci Neuronowych
Tematy:
spiking neural network
spike timing-dependent plasticity
dopamine-modulated spike timing-dependent plasticity
pattern classification
Opis:
Many recent studies have applied to spike neural networks with spike-timing-dependent plasticity (STDP) to machine learning problems. The learning abilities of dopaminemodulated STDP (DA-STDP) for reward-related synaptic plasticity have also been gathering attention. Following these studies, we hypothesize that a network structure combining self-organized STDP and reward-related DA-STDP can solve the machine learning problem of pattern classification. Therefore, we studied the ability of a network in which recurrent spiking neural networks are combined with STDP for non-supervised learning, with an output layer joined by DA-STDP for supervised learning, to perform pattern classification. We confirmed that this network could perform pattern classification using the STDP effect for emphasizing features of the input spike pattern and DA-STDP supervised learning. Therefore, our proposed spiking neural network may prove to be a useful approach for machine learning problems.
Źródło:
Journal of Artificial Intelligence and Soft Computing Research; 2019, 9, 4; 283-291
2083-2567
2449-6499
Pojawia się w:
Journal of Artificial Intelligence and Soft Computing Research
Dostawca treści:
Biblioteka Nauki
Artykuł
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