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    Wyświetlanie 1-8 z 8
    Tytuł:
    D-dimery w chemioterapii pierwszego rzutu w raku jajnika
    Significance of D-dimers in first-line chemotherapy of ovarian cancer
    Autorzy:
    Stanisławiak, Joanna
    Markowska, Janina
    Mądry, Radosław
    Powiązania:
    https://bibliotekanauki.pl/articles/908506.pdf
    Data publikacji:
    2009
    Wydawca:
    Medical Communications
    Tematy:
    D-dimers
    neoplasm
    ovarian cancer
    rirst-line chemotherapy
    thromboembolic complications
    Opis:
    Background: Ovarian cancer is usually diagnosed late and is one of leading causes of genital malignan-cies-related mortality in women. Thromboembolic events are a frequent complication of neoplastic disease, occurring four-fold more often in patients with this disease and six-fold more often in persons undergoing chemotherapy. The aim of paper was to answer the following questions: What is the impact of first-line chemotherapy on D-dimer level during treatment? Is there any correlation between D-dimer level and FIGO stage of ovarian cancer? Is there a correlation between D-dimer level during chemotherapy and completeness of tumour resection? Is there a correlation between D-dimer level and incidence of thromboembolic complications during chemotherapy of ovarian cancer? Material and method: Study population initially consisted of 20 women with ovarian cancer treated at the Department of Oncologic Gynaecology of the K. Marcinkowski Medical University in Poznan. Each patient underwent cytoreductive surgery with subsequent paclitaxel-plati-num chemotherapy. Peripheral blood has been obtained four times from each patient in order to assess D-dimer level, CA 125 tumour marker and blood count. Results: In persons with ovarian cancer, preoperative D-dimer level several-fold exceeded normal range. Application of chemotherapy significantly (p<0.05) reduced D-dimer level in women with ovarian cancer. Conclusions: Assessment of risk of thromboembolic complications in women with ovarian cancer during chemotherapy based on D-dimer level is not possible.
    Rak jajnika jest nowotworem późno diagnozowanym i jedną z głównych przyczyn zgonów z powodu nowotworów złośliwych narządu rodnego kobiet. Incydenty zakrzepowo-zatorowe są częstym powikłaniem choroby nowotworowej, występują cztery razy częściej u pacjentów z tą chorobą i sześć razy częściej u osób leczonych chemioterapią. Cel badania: Celem badania była próba odpowiedzi na pytania: Jak chemioterapia pierwszego rzutu wpływa na stężenie D-dimerów podczas leczenia? Czy istnieje związek pomiędzy: stężeniem D-dimerów a stopniem zaawansowania raka jajnika według FIGO; stężeniem D-dimerów podczas chemioterapii a radykalnością zabiegu operacyjnego; stężeniem D-dimerów a występowaniem zaburzeń zakrzepowo-zatorowych podczas chemioterapii w raku jajnika? Materiały i metody: Grupę badaną początkowo stanowiło 20 kobiet z rozpoznanym rakiem jajnika hospitalizowanych na Oddziale Ginekologii Onkologicznej Uniwersytetu Medycznego im. K. Marcinkowskiego w Poznaniu. Każda pacjentka została poddana operacji cytoredukcyjnej z następową chemioterapią według schematu paklitaksel i pochodna platyny. Każdej pacjentce czterokrotnie pobrano krew obwodową na oznaczenie stężenia D-dimerów, markera CA 125 oraz morfologii. Wyniki: Stężenie D-dimerów u osób z rakiem jajnika przed zabiegiem operacyjnym kilkakrotnie przewyższało wartości prawidłowe. Stosowanie chemioterapii znamiennie statystycznie (p<0,05) wpływa na obniżenie stężenia D-dimerów u kobiet z rakiem jajnika. Wnioski: Ocena ryzyka wystąpienia zaburzeń zakrzepowo-zatorowych u kobiet z rakiem jajnika podczas chemioterapii na podstawie stężenia D-dimerów nie jest możliwa.
    Źródło:
    Ginekologia Onkologiczna; 2009, 7, 2; 114-122
    1731-5379
    Pojawia się w:
    Ginekologia Onkologiczna
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Very High Concentration of D-Dimers in Portal Blood in Patients with Pancreatic Cancer
    Autorzy:
    Durczyński, Adam
    Szymański, Dariusz
    Nowicki, Michał
    Hogendorf, Piotr
    Poznańska, Grażyna
    Strzelczyk, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1396873.pdf
    Data publikacji:
    2012-12-01
    Wydawca:
    Index Copernicus International
    Tematy:
    D-dimers
    pancreatic cancer
    portal blood
    peripheral blood
    Opis:
    Nowadays, increasing attention has been focused on relation between increased D-dimer levels and cancer among patients without detectable thrombosis. The aim of the study was to measure plasma D-dimer levels in portal and peripheral blood in pancreatic cancer patients with absence of venous thromboembolism. Material and methods. Fifteen consecutive patients hospitalized in the Department of General and Transplant Surgery of Medical University in Łódź, from January to March 2012 who underwent surgery due to a pancreatic cancer were enrolled. At laparotomy, portal and peripheral blood were sampled concurrently. D-dimer and fibrinogen levels were measured. Moreover, to investigate overall coagulation function prothrombin time (PT), prothrombin index (PI), international normalized ratio (INR), thrombin time (TT), activated partial thromboplastin time (APTT), TT and APTT index were evaluated. Results. Peripheral plasma D-dimmer levels above normal range were found in 10/15 patients (66,67%), whereas D-dimer above normal values were confirmed in all portal blood samples. Mean D-dimer values were higher in portal than in peripheral blood (3279.37 vs 824.64, by 297%, p=0,025). These discrepancies were accompanied by normal limits of portal and peripheral levels of fibrinogen and comparable coagulation function indexes. Conclusion. Our preliminary study showed the close relation between activation of hemostasis, reflected by elevated D-dimers in portal blood and presence of pancreatic cancer. These data suggest that measurement of portal blood D-dimer levels may be a potentially useful technique for screening the pancreatic cancer.
    Źródło:
    Polish Journal of Surgery; 2012, 84, 10; 521-525
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Charakterystyka oddziaływań międzycząsteczkowych : od dimerów do modeli mikrosolwatacyjnych
    Characterization of intermolecular interactions : from dimers to microsolvation models
    Autorzy:
    Panek, Jarosław J.
    Jezierska, Aneta
    Powiązania:
    https://bibliotekanauki.pl/articles/172152.pdf
    Data publikacji:
    2020
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    SAPT
    międzycząsteczkowe wiązania wodorowe
    mikrosolwatacja
    dimery
    trimery
    asocjaty molekularne
    intermolecular hydrogen bond
    microsolvation
    dimers
    trimers
    molecular associates
    Opis:
    Intermodular interactions play an important role in many processes at the molecular level. In the contemporary science, there is a growing interest concerning the characteristics of such interactions. Therefore, the computational chemistry can provide answers to many questions, which could not be answered using experimental methods. The Symmetry-Adapted Perturbation Theory (SAPT) method was applied to characterize the energy partitioning in dimers, trimers and microsolvation models. The investigated complexes belong to various classes of compounds, e.g. • dimers of: NH3 ˑˑˑHX, HF-pyridine, cycloalkanes, hypohalous acids; • trimers of: NH3 ˑˑˑNH3ˑˑˑHF or NH3ˑˑˑHFˑˑˑHF; • microsolvation models (biotin - water molecules). The current study summarizes recent years of our research devoted to the intermolecular interactions.
    Źródło:
    Wiadomości Chemiczne; 2020, 74, 9-10; 645-662
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Overproduction and purification of the CcpA protein from Lactococcus lactis.
    Autorzy:
    Kowalczyk, Magdalena
    Bardowski, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/1043621.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    His-tag
    cross links
    dimers
    CcpA
    Opis:
    In this work we present cloning and overexpression of lactococcal CcpA protein in Escherichia coli Xl1blue strain as a fusion with 6×His tag. A high yield of the CcpA protein was obtained when the cells were cultured in liquid medium LB with 100 Μg/ml ampicillin at 37°C and subsequently for 4 h after induction by IPTG. The procedure let us obtain 5 mg of homogenous CcpA protein. Glutaraldehyde crosslinking analysis indicated the formation of dimer or tetramer forms of the CcpA protein.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 2; 455-459
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ultrafast Energy Relaxation and Excitation Delocalization in Excited States of Zinc Porphyrin Dimers and Trimer
    Autorzy:
    Yamazaki, I.
    Akimoto, S.
    Yamazaki, T.
    Shiratori, H.
    Osuka, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1994082.pdf
    Data publikacji:
    1999-01
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    31.50.+w
    78.47.+p
    Opis:
    Ultrafast excited-state relaxation process has been studied with zinc porphyrin dimers and circular trimer. Following 80 fs excitation at Soret band (420 nm) or Q band (580 nm) of zinc porphyrin, the fluorescence decay curves exhibit ultrafast decays with lifetimes of 80 fs in o-dimer, 450 fs in trimer and 540 fs in m-dimer. The timeresolved fluorescence spectra show that the fast decay process correspond to disappearance of monomer-like emission followed by red-shifted and broaden spectra. These ultrafast processes are assigned as due to excitation transfer among monomers and delocalization of excitation yielding excitonic states.
    Źródło:
    Acta Physica Polonica A; 1999, 95, 1; 105-120
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Heat and SDS insensitive NDK dimers are largely stabilised by hydrophobic interaction to form functional hexamer in Mycobacterium smegmatis
    Autorzy:
    Arumugam, Muthu
    Ajitkumar, Parthasarathi
    Powiązania:
    https://bibliotekanauki.pl/articles/1039575.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    dimer
    ANS fluorescence assay
    nucleoside diphosphate kinase
    hexamer
    hydrophobic interaction
    oligomerisation
    homology modeling
    Mycobacterium smegmatis
    Opis:
    The primary structure and function of nucleoside diphosphate kinase (NDK), a substrate non-specific enzyme involved in the maintenance of nucleotide pools is also implicated to play pivotal roles in many other cellular processes. NDK is conserved from bacteria to human and forms a homotetramer or hexamer to exhibit its biological activity. However, the nature of the functional oligomeric form of the enzyme differs among different organisms. The functional form of NDKs from many bacterial systems, including that of the human pathogen, Mycobacterium tuberculosis (MtuNDK), is a hexamer, although some bacterial NDKs are tetrameric in nature. The present study addresses the oligomeric property of MsmNDK and how a dimer, the basic subunit of a functional hexamer, is stabilized by hydrogen bonds and hydrophobic interactions. Homology modeling was generated using the three-dimensional structure of MtuNDK as a template; the residues interacting at the monomer-monomer interface of MsmNDK were mapped. Using recombinant enzymes of wild type, catalytically inactive mutant, and monomer-monomer interactive mutants of MsmNDK, the stability of the dimer was verified under heat, SDS, low pH, and methanol. The predicted residues (Gln17, Ser24 and Glu27) were engaged in dimer formation, however the mutated proteins retained the ATPase and GTPase activity even after introducing single (MsmNDK- Q17A, MsmNDK-E27A, and MsmNDK-E27Q) and double (MsmNDK-E27A/Q17A) mutation. However, the monomer-monomer interaction could be abolished using methanol, indicating the stabilization of the monomer-monomer interaction by hydrophobic interaction.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 2; 199-207
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Calcium-binding calmyrin forms stable covalent dimers in vitro, but in vivo is found in monomeric form.
    Autorzy:
    Sobczak, Adam
    Blazejczyk, Magdalena
    Piszczek, Grzegorz
    Zhao, Gang
    Kuznicki, Jacek
    Wojda, Urszula
    Powiązania:
    https://bibliotekanauki.pl/articles/1041431.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    covalent dimer
    calmyrin monomer
    human lymphocytes
    EF-hand calcium-binding proteins
    Opis:
    The EF-hand Ca^(2+)-binding protein calmyrin is expressed in many tissues and can interact with multiple effector proteins, probably as a sensor transferring Ca^(2+) signals. As oligomerization may represent one of Ca^(2+)-signal transduction mechanisms, we characterised recombinant calmyrin forms using non-reducing SDS/PAGE, analytical ultracentrifugation and gel filtration. We also aimed at identification of biologically active calmyrin forms. Non-reducing SDS/PAGE showed that in vitro apo- and Ca^(2+)-bound calmyrin oligomerizes forming stable intermolecular disulfide bridges. Ultracentrifugation indicated that at a 220 µM initial protein concentration apo-calmyrin existed in an equilibrium of a 21.9 kDa monomer and a 43.8 kDa dimer (trimeric or tetrameric species were not detected). The dimerization constant was calculated as Ka = 1.78 × 103 M^(-1) at 6oC. Gel filtration of apo- and Ca^(2+)-bound calmyrin at a 100 µM protein concentration confirmed an equilibrium of a monomer and a covalent dimer state. Importantly, both monomer and dimer underwent significant conformational changes in response to binding of Ca^(2+). However, when calmyrin forms were analyzed under non-reducing conditions in cell extracts by Western blotting, only monomeric calmyrin was detected in human platelets and lymphocytes, and in rat brain. Moreover, in contrast to recombinant calmyrin, crosslinking did not preserve any dimeric species of calmyrin regardless of Ca^(2+) concentrations. In summary, our data indicate that although calmyrin forms stable covalent dimers in vitro, it most probably functions as a monomer in vivo.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 2; 469-476
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Selective Resonance Raman Scattering of Peierls-Hubbard (TTF$\text{}^{+}$)$\text{}_{2}$ Dimers in (TTF)$\text{}_{2}$Mo$\text{}_{6}$O$\text{}_{19}$ and (TTF)$\text{}_{2}$W$\text{}_{6}$O$\text{}_{19}$ Salts
    Autorzy:
    Kruszewski, S.
    Feltre, L.
    Bozio, R.
    Bellitto, C.
    Powiązania:
    https://bibliotekanauki.pl/articles/1929169.pdf
    Data publikacji:
    1993-04
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    34.70.+e
    78.30.-j
    Opis:
    Raman investigation of Peierls-Hubbard (TTF$\text{}^{+}$)$\text{}_{2}$ dimers in (TTF)$\text{}_{2}$Mo$\text{}_{6}$O$\text{}_{19}$ and (TTF)$\text{}_{2}$W$\text{}_{6}$O$\text{}_{19}$ salts have been performed. It was found that the resonance enhancement of Raman intensity of intramolecular vibration modes exists only when the frequency of excitation light fits to the localised electron transition, however, the resonance enhancement of intermolecular modes occurs when the frequency of excitation light corresponds to the charge transfer transition.
    Źródło:
    Acta Physica Polonica A; 1993, 83, 4; 431-440
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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