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Tytuł:
Hemocompatibility of ultrafine systems on the basis of chitosan and its derivatives polymer-colloid complexes
Autorzy:
Bazunova, M. V.
Kulish, E. I.
Tukhvatullin, R. F.
Sharafutdinova, L. A.
Shamratova, V. G
Klimecka-Tatar, D.
Zaikov, G. E.
Powiązania:
https://bibliotekanauki.pl/articles/111928.pdf
Data publikacji:
2015
Wydawca:
Stowarzyszenie Menedżerów Jakości i Produkcji
Tematy:
colloidal complexes
сhitosan
micelles of silver iodide
hemocompatibility
acid resistance of erythrocytes
koloidalne kompleksy
micele jodku srebra
hemokompatybilność
odporność na kwas erytrocytów
Opis:
This article presents the results of the development process for the preparation of micro and nano-sized polymer-colloid complexes (РСС) on the basis of water-soluble natural polymer chitosan (СTZ) and the sodium salt of chitosan succinylamid (SСTZ) with silver halide sols in aqueous media. Results of research of СTZ, sodium salt of SСTZ solutions and PСС of CTZ and SСTZ with colloidal particles of silver iodide influence on structurally-functional properties of erythrocytes’ membranes on model of acidic hemolisis are presented in the article. Their influence on the nature of erythrocytes distribution by degree of their stability and on kinetic parameters (the beginning, intensity and completion of process of their destruction) under the influence of the damaging agent (HCl) is shown. The comparative analysis of results convinces that СTZ, SСTZ solutions and disperse systems on the basis of PСС of СTZ and SСTZ with colloidal particles of the silver iodide are capable of modulating variously matrix properties of erythrocytes of blood.
Źródło:
Production Engineering Archives; 2015, 6, 1; 30-34
2353-5156
2353-7779
Pojawia się w:
Production Engineering Archives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and characterization of amphiphilic chitosan derivatives as nano/microstructures
Autorzy:
Goszczyńska, A.
Niemczyk, A.
Piegat, A.
Powiązania:
https://bibliotekanauki.pl/articles/284331.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
microstructures
chitosan
drug delivery systems
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 38
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The formation of hydrogels based on chitosan and its water-soluble derivatives
Autorzy:
Il’ina, Alla V.
Shagdarova, Balzhima Ts.
Lunkov, Alexey P.
Varlamov, Valery P.
Powiązania:
https://bibliotekanauki.pl/articles/1034059.pdf
Data publikacji:
2020
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan
crosslinking agent
gelation
hydrogels
quaternized chitosan
succinyl chitosan
Opis:
This review considers articles on the formation of hydrogels based on chitosan as well as succinylated and quaternized chitosan derivatives. They are synthesized using low toxicity reagents, under ordinary conditions (low production costs). Chitosan derivatives are soluble in an extended range of pH values and characterized by mucoadhesiveness, bioavailability and biodegradability, which extends the potential of their medical applications. One of the most important properties of chitosan and its derivatives is the ability to form hydrogels. Depending on the nature of the bonds that occur during formation, hydrogels are divided into chemically or physically crosslinked, or a mixture of the two. Chemically crosslinked gels have covalent bonds, while physically crosslinked gels are formed by noncovalent interactions, for example, ionic. Mixed hydrogels have both types of crosslinking.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2020, 25; 5-15
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biomaterials based on chitosan and its derivatives to prevent adhesion formation
Autorzy:
Konovalova, Mariya
Tsaregorodtseva, Daria
Svirshchevskaya, Elena
Powiązania:
https://bibliotekanauki.pl/articles/2129557.pdf
Data publikacji:
2021
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
biomaterials
chitosan
derivatives of chitosan
polymers
prevention of adhesions
Opis:
An increase in the number and volume of surgical interventions leads to an increase in the frequency of postoperative adhesions. The development of the adhesion process in the abdominal cavity causes pain, a decrease in the quality of life of patients, a violation of the reproductive function of women as well as acute adhesion intestinal obstruction. Recently, polymer biomaterials, including those based on chitosan, have been widely used for the prevention of adhesions. Due to their biocompatibility and biodegradation ability, they do not require repeated operations to extract the material. It is believed that these materials act as barriers, physically separating the damaged surfaces. The molecular mechanism of their action is still poorly understood. In this review, the main mechanisms of adhesion formation, as well as ways to prevent them with the help of materials based on chitosan and its derivatives, are discussed
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2021, 26; 11-22
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Express analysis of chitosan and its derivatives by gel electrophoresis
Autorzy:
Konovalova, Mariya
Shagdarova, Balzhima Ts.
Zubov, Vitaliy
Svirshchevskaya, Elena
Powiązania:
https://bibliotekanauki.pl/articles/1034210.pdf
Data publikacji:
2019
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
agarose gel electrophoresis
chitosan
chitosan derivatives
degree of deacetylation
molecular weight
Opis:
Chitosan is one of the most promising polymers for biomedical applications due to its unique properties, such as its biocompatibility, low toxicity, biodegradation, and the presence of reactive amino and hydroxyl groups. Analysis of physicochemical properties of chitosan and its derivatives is a time-consuming process and requires expensive equipment and large amounts of the sample. This paper proposes a method for express analysis of the molecular weight (MW), the degree of deacetylation (DD), the substitution degree (SD), and the charge of chitosan and its derivatives using agarose gel electrophoresis under acidic and neutral conditions with Coomassie staining. Positively charged chitosan samples required acidic Tris Acetate-EDTA (TAE) buffer to move in the gel. The electrophoretic mobility of chitosan depended on MW, DD, SD, and the chitosan charge. Based on the dependences obtained by the proposed method, the MW and DD of commercial chitosan samples were determined. Express analysis of chitosan and its derivatives in agarose gel can be used to monitor the reactions of chitosan modification and to analyse samples with unknown characteristics.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2019, 24; 84-95
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biological properties of new chitosan-fatty acids derivatives
Autorzy:
Niemczyk, A.
El Fray, M.
Powiązania:
https://bibliotekanauki.pl/articles/284574.pdf
Data publikacji:
2014
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
chitosan
biomaterials
biodegradation
Źródło:
Engineering of Biomaterials; 2014, 17, no. 128-129; 107-108
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Novel chitosan derivatives as films with an antimicrobial effect
Autorzy:
Niemczyk, Agata
El Fray, Mirosława
Powiązania:
https://bibliotekanauki.pl/articles/1035315.pdf
Data publikacji:
2013
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
antimicrobial films
chitosan
dilinoleic acid
fatty acids
Opis:
This paper presents the results of chitosan acylation with linoleic (LA) and dilinoleic acid (DLA). The chemical structures of the new derivatives with different degrees of substitution of LA and DLA were assessed by Fourier transform infrared spectroscopy. Polymer films were prepared by solution casting and drying. The resistance of films to bacterial degradation was tested according ISO 846 standard: “Plastic-Evaluation of the Action of Microorganisms” and the antimicrobial properties were assessed using Gram-negative bacterium Escherichia coli and the fungi Candida albicans in an agar diffusion test. Bioassays showed an antimicrobial effect in direct contact with the material.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 59-66
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of c18-fatty acids on chemical structure of chitosan derivatives and their thermal properties
Autorzy:
Niemczyk, Agata
Kmieciak, Alan
El Fray, Mirosława
Piegat, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1034661.pdf
Data publikacji:
2016
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
N
O-acylation
chemical structure
chitosan
fatty acids
thermal properties
Opis:
Chitosan derivatives with a series of fatty acids (FA) have been developed using simultaneous N- and O-acylation reaction by the combination of two ways of conducting the reaction, i.e. a carbodiimide catalysis and ionic amino group protection. The chemical structure of chitosan derivatives as well as the characterization of the FA substitution degree were done by the IR spectra analysis. The correlation between the substitution of the chitosan functional groups as well as the saturation of FA and the changes of structural and thermal properties of the derivatives has been presented.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 165-175
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modyfikacja chitozanu : krótki przegląd
Modification of chitosan : a concise overview
Autorzy:
Ostrowska-Czubenko, J.
Pieróg, M.
Gierszewska, M.
Powiązania:
https://bibliotekanauki.pl/articles/172373.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
chitozan
modyfikacja chitozanu
pochodne chitozanu
sieciowanie
chitosan
chitosan modification
chitosan derivatives
crosslinking
Opis:
Chitosan is the most important derivative of chitin, a polysaccharide found in the exoskeleton of shellfish like shrimp and crab. It is a product of deacetylation of chitin under alkaline conditions or enzymatic hydrolysis in the presence of chitin deacetylase. Both chitin and chitosan are linear polysaccharides and are chemically defined as copolymers consisting of varying amounts of β-(1→4)- linked 2-acetamido-2-deoxy β-D-glucopyranose (GlcNAc) and 2-amino-2-deoxy- β-D-glucopyranose (GlcN). The difference between chitin and chitosan lies in the content of GlcNAc and GlcN units. Chitin samples contain a high content of Glc- NAc units. Due to excellent properties of chitosan, such as biocompatibility, biodegradability, hydrophilicity, non-toxicity, cationicity, ease of modification, film forming ability, affinity to metals, protein and dyes, etc., this polymer has found applications in medicine and pharmacy, as food additive, antimicrobial agent, in paper and textile industry, in environmental remediation and other industrial areas. The presence of functional groups, reactive amino and hydroxyl groups, in chitosan backbone makes it suitable candidate for chemical modification. Chemical modification of chitosan to generate new polymers with useful physicochemical properties and distinctive biological functions is of key interest because it would not change the fundamental skeleton of the polymer. In this article the main three methods of chitosan modification: substitution reactions, reactions leading to the chain elongation and/or molecular weight increasing and methods of depolymerization are shortly characterized. Moreover, the selected methods of chitosan modification, i.e. quaternization, alkylation, acylation, carboxyalkylation, phosphorylation, sulfation, graft copolymerisation, crosslinking and depolymerization are discussed in more detail. A special attention is drawn to chitosan crosslinking with low and high molecular compounds. Chitosan modification by covalent and ionic crosslinking allows to obtain polymer materials with improved mechanical and chemical resistance and suitable for example for chitosan hydrogel membranes formation. Keywords: chitosan, chitosan modification, chitosan derivatives, crosslinking
Źródło:
Wiadomości Chemiczne; 2016, 70, 9-10; 657-679
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wykorzystanie pochodnych chitozanu w celu stymulacji wzrostu roślin ozdobnych
Use of chitosan derivatives to improve the growth of ornamentals
Autorzy:
Salachna, P.
Powiązania:
https://bibliotekanauki.pl/articles/400936.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Inżynierii Ekologicznej
Tematy:
biopolimery
biostymulator
oligochitozan
polisacharydy
śniedek Saundersa
biopolymers
Giant Chincherinchee
biostimulants
oligochitosan
polysaccharides
Opis:
Obecnie w rolnictwie wzrasta stosowanie bezpiecznych dla środowiska biopolimerów w celu poprawy plonowania roślin. Szczególnie obiecującym biopolimerem jest chitozan i jego pochodne mogące mieć wiele zastosowań w uprawie roślin jako potencjalne biostymulatory. Na temat wpływu ciężaru cząsteczkowego pochodnych chitozanu na wzrost roślin ozdobnych jest niewiele danych. Śniedek Saundersa jest cennym gatunkiem uprawianym w ogrodach, doniczkach i na kwiat cięty, a także ma znaczenie w farmakologii. W eksperymencie zastosowano 0,5% roztwory oligochitozanu o dwóch ciężarach cząsteczkowych (MW 5000 i MW 100 000 g mol-1) do otoczkowania cebul. Biopolimery zostały oznaczone metodą HPLC. Stwierdzono, że otoczkowanie cebul w roztworze oligochitozanu miało stymulujący wpływ na większość analizowanych cech biometrycznych, wskaźniki fizjologiczne i plon cebul. Najkorzystniejszy wpływ na jakość kwiatostanów, przewodność szparkową liści i masę cebul potomnych miało traktowanie roślin oligochitozanem o ciężarze cząsteczkowym MW 100 000 g·mol-1.
Nowadays, the use of natural biopolymers in the field of agriculture has increased in order to achieve sufficient yields and quality. Chitosan and its derivatives have a great potential with various applications in agriculture. Minimal research on effect of chitosan oligomers with different molecular weight on growth ornamental plants has been published. Ornithogalum saundersiae is a valuable species, recommended for cultivation in gardens and green areas, as well as for cut and pot plant. This species can also be potentially used in pharmacology. In the experiment, 0.5% solutions of oligochitosan with molecular weights MW 5000 and 100,000 g·mol-1 were used for coating Ornithogalum saundersiae bulbs. The biopolymers have been characterized using HPLC method. The results indicated that oligochitosan significantly enhanced the growth attributes, physiological parameters, as well as the weight and numerical coefficient of bulbs. Oligochitosan with MW 100,000 g·mol-1 proved best and gave maximum width of inflorescence, number of flowers per inflorescence, stomatal conductance and weight of bulbs over the control.
Źródło:
Inżynieria Ekologiczna; 2017, 18, 6; 63-68
2081-139X
2392-0629
Pojawia się w:
Inżynieria Ekologiczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Large size dna in vitro and in vivo delivery using chitosan transfection
Autorzy:
Sankov, Vladislav
Shagdarova, Balzhima
Varlamov, Valerii
Esipov, Roman
Svirshchevskaya, Elena
Powiązania:
https://bibliotekanauki.pl/articles/1034546.pdf
Data publikacji:
2017
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
DNA delivery
chitosan derivatives
hydrophobic groups
рRFP pmKate2 reporter plasmid
Opis:
In modern medicine, many diseases can be treated using gene therapy, which requires a DNA delivery system to prevent DNA from degradation and to transport it to the cells. Liposomal reagents are expensive for such a therapy and new inexpensive biodegradable DNA carriers are required. Chitosan (Ch) is a cationic polymer with promising potency for gene delivery. Some Ch derivatives have been shown to efficiently transfect mammalian cells in vitro. However, there are many inconsistencies in the literature concerning the effectiveness of Ch systems for in vivo gene transfer. The aim of this work was to develop a Ch-based vector for in vivo delivery of a large-size DNA fragment coding for the far-red fluorescent protein (RFP). Among several Ch derivatives, hexanoyl-Ch (HCh) with a molecular weight of 20 kDa effectively transfected cells in vitro. Intratumoural injection of polyplexes in colon and lung tumours resulted in local expression of RFP in tumours.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 190-200
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Functional-technological properties of meat-and-vegetable emulsions with the addition of chitosan derivatives
Autorzy:
Shestopalova, Irina Anatolyevna
Kolodyaznaya, Valentina Stepanovna
Kiprushkina, Elena Ivanovna
Kuprina, Elena Eduardovna
Petrova, Valentina Aleksandrovna
Rogozina, Elena Andreevna
Danko, Veronika Olegovna
Powiązania:
https://bibliotekanauki.pl/articles/1034377.pdf
Data publikacji:
2018
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan derivative
functional-technological properties
meat-and-vegetable emulsion
micronising
rheological properties
Opis:
This article provides data on the analysis of the properties of chitosan derivatives as a functional ingredient used in food technologies as a structure-forming agent, immunomodulator, enterosorbent of xantobiotics, anti-sclerotic and anti-arthritic factor, and as a regulator of the acidity of gastric juice. The expediency of the use of N-methylallyl-chitosan (chitosan derivative) as a substance that improves the functional-technological (moisture and fat-retaining power) and rheological properties of meat-and-vegetable emulsions is shown. The modes of micronising the emulsion depending on the chitosan derivative mass concentration, the speed of rotation of the knives of the microniser and the processing time were studied. Dependences on the change of moisture and fat-retaining power (MRP, FRP) and effective viscosity (η) on the above-mentioned parameters were investigated. The parameters of micronising were validated: the speed of rotation of the knives (υ) was 2500 rpm, the processing time (τ) was 60 s, υ was 3000 rpm, and τ was 50 s; also, the mass fraction of chitosan derivatives was 0.06%, which ensures the production of meat-and-vegetable emulsions of high quality.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2018, 23; 170-178
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adsorption of iron by polyphosphate derivatives of chitin and chitosan
Adsorpcja jonow zelaza przez polifosforanowe pochodne chityny i chitozanu
Autorzy:
Sieliwanowicz, B.
Komorowska, A.
Jedrzejczak, R.
Powiązania:
https://bibliotekanauki.pl/articles/1372758.pdf
Data publikacji:
1995
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
chityna
polifosforan sodu
adsorpcja
jony zelaza
chitozan krylowy
biotechnologia
kwas polifosforowy
filtracja
Opis:
Polyphosphate derivatives of krili chitin and krili chitosan obtained with the use of a mixture of sodium polyphosphates and polyphosphoric acid are virtually m solution of pH ca. 4.0. At pH 3.7 iron ions are adsorbed in the highest adsorption yields, amounting for the polyphosphate of chitin and chitosan to 95% and 65%, respectively. Other bivalent ions (Cu+2, Pb+2, Cd+2) are distinctly adsorbed only by chitosan polyphosphate in an adsorption yield of 45-50%. The presence of up to 15% of ethanol in the medium does not reduce adsorption of all these cations. Zn+2 ions fail to be adsorbed on both carriers. Washing of carriers with 0.1 mol/L HCl results in complete release of the adsorbed ions. Industrial filter-paper sheets impregnated with chitosan polyphosphate were applied in laboratory tests for filtration of beer as well as of apple juice and apple wine, and "fortified" with Zn+2, Cu+2, Fe+2, Pb+2and Cd+2 ions.
Polifosforanowe pochodne chityny i chitozanu krylowego, otrzymywane przy użyciu mieszaniny polifosforanu sodu i kwasu polifosforowego, są praktycznie nierozpuszczalne w roztworach o pH około 4 (Tabela 2). Z największą wydajnością wynoszącą odpowiednio 95% i 65% adsorbowane są w pH 3,7 jony żelaza (Rysunek 1 i 2). Inne jony dwu wartościowe (Cu+2, Pb+2,Cd+2) adsorbowane są przez polifosforan chitozanu z wydajnością wynoszącą 45-50% (Tabela 1). Obecność w środowisku do 15% etanolu nie zmniejsza adsorpcji tych jonów. Jony Zn+2 nie ulegają adsorpcji na żadnym z badanych nośników. Przemycie nośników 0.1 mol/L HCl powoduje całkowite uwolnienie zaadsorbowanych jonów. Impregnowane polifosforanem chitozanu sączki wykonane z przemysłowych kartonów filtracyjnych zastosowano do laboratoryjnych prób filtracji piwa oraz soku i wina jabłkowego, fortyfikowanych jonami: Zn+2, Cu+2,Fe+2, Pb+2, Cd+2 (Tabela 3).
Źródło:
Polish Journal of Food and Nutrition Sciences; 1995, 04, 1; 55-61
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Praktyczne aspekty zastosowania chityny i jej pochodnych w leczeniu ran
Practical aspects related to application of chitin and its derivatives in wound management
Autorzy:
Skołucka-Szary, K.
Rieske, P.
Piaskowski, S.
Powiązania:
https://bibliotekanauki.pl/articles/1208698.pdf
Data publikacji:
2016
Wydawca:
Stowarzyszenie Inżynierów i Techników Przemysłu Chemicznego. Zakład Wydawniczy CHEMPRESS-SITPChem
Tematy:
chityna
chitozan
dibutyrylochityna
leczenie ran
chitin
chitosan
dibutyryl chitin
wound healing
Opis:
Chityna jest polisacharydem o unikatowych właściwościach. W pracy zostały omówione właściwości biologiczne chityny, ograniczenia jej stosowania w przemyśle oraz kierunki modyfikacji chemicznej. Ze względu na rosnące zapotrzebowanie na nowoczesne materiały opatrunkowe, przedstawiono możliwości wykorzystania chityny i jej dwóch najbardziej popularnych pochodnych: chitozanu i dibutyrylochityny, w praktyce klinicznej oraz scharakteryzowano komercyjnie dostępne opatrunki na bazie chityny i chitozanu.
Chitin is a polysaccharide with unique properties. In this paper, we reviewed biological properties of chitin, limitations of its industrial applications and directions of its further chemical modifications. In view of growing demand for the modern wound dressing materials, we discussed potential clinical applications of chitin and its two most popular derivatives: chitosan and dibutyryl chitin. In addition, we characterized commercially available chitin- and chitosan- based wound dressings.
Źródło:
Chemik; 2016, 70, 2; 89-98
0009-2886
Pojawia się w:
Chemik
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chitosan-derivatives in combinations with selected porphyrinoids as novel hybrid materials for medicine and pharmacy
Autorzy:
Szczepański, Radosław
Gadomska, Laura
Michalak, Marek
Bakun, Paweł
Pawlak, Kacper
Gośliński, Tomasz
Ziegler-Borowska, Marta
Czarczyńska-Goślińska, Beata
Powiązania:
https://bibliotekanauki.pl/articles/1034035.pdf
Data publikacji:
2020
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitin
chitosan
hybrid materials
imaging
photodynamic therapy
porphyrinoids
Opis:
Chitosan and its derivatives are renewable biopolymers characterized by high biocompatibility; therefore, they are harmless to humans and allow immune tolerance and improved hydrophilicity. Moreover, chitosan has been the most studied of all polysaccharides used in biomedical applications during the last decade. Combinations of chitosan and porphyrinoid compounds in hybrid materials have revealed many potential applications for biomedical sciences. The main advantage of such materials is an increase in the solubility of porphyrinoids in body fluids and therefore greater release of singlet oxygen to the treated tissue. Chitosan-based drug delivery systems can improve the targeting of porphyrinoids and their release at predetermined locations and finally achieve desired therapeutic effects with minimal side effects. Hence, porphyrinoid-chitosan materials can be applied in drug delivery systems, cancer theranostics and magnetic resonance imaging. The combination of chitosan and porphyrinoids also appears useful in the healing and repairing of damaged organs, tissue engineering, regenerative medicine, as well as dressing materials. Huge benefits are related to the treatment of wounds, which has been presented for self-healing hydrogels based on chitosan and porphyrinoids. Furthermore, the chitosan/porphyrinoid combinations have revealed enormous benefits for antimicrobial photodynamic therapy.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2020, 25; 63-78
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 21

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