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Tytuł:
Upregulation of GRP78 and caspase-12 in diastolic failing heart
Autorzy:
Sun, Yingying
Liu, Guanghui
Song, Tao
Liu, Fang
Kang, Weiqiang
Zhang, Yun
Ge, Zhiming
Powiązania:
https://bibliotekanauki.pl/articles/1040708.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
caspase-12
diastolic heart failure
GRP78; hypertension
apoptosis
Opis:
Background: The endoplasmic reticulum (ER) fulfills multiple cellular functions. Various stimuli can potentially cause ER stress (ERS). ERS is one of the intrinsic apoptosis pathways and apoptosis plays a critical role in hypertension. Glucose regulated protein 78 (GRP78) has been widely used as a marker for ERS and caspase-12 mediated apoptosis was a specific apoptotic pathway of ER. The expression of GRP78 and caspase-12 remains poorly understood in the diastolic heart failure resulting from hypertension. Methods: We used spontaneously hypertensive rats (SHRs) to establish a model of diastolic heart failure, and performed immunohistochemistry, western blot, and real-time PCR to analyze GRP78 and caspase-12. Results: We found that GRP78 and caspase-12 had enhanced expression at protein and mRNA levels. Conclusions: These results suggest that GRP78 and caspase-12 were upregulated in cardiomyocytes and ERS can contribute to cardiac myocyte apoptosis in the diastolic heart failure resulting from hypertension.
Źródło:
Acta Biochimica Polonica; 2008, 55, 3; 511-516
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bayesowski model wzrostu niezawodności oparty na dynamicznych parametrach rozkładu
Bayesian reliability growth model based on dynamic distribution parameters
Autorzy:
Tao, Y.
Zhang, Y. A.
Chen, X.
Ming, M.
Powiązania:
https://bibliotekanauki.pl/articles/301037.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
Tematy:
statystyka populacji niejednorodnej
model monotoniczny
Bayes
model przyrostu niezawodności
rozkład wykładniczy
non-homo geneous population statistics
monotone model
reliability growth model
exponential distribution
Opis:
W artykule przestudiowano metody analizy statystycznej na różnych etapach wzrostu niezawodności w oparciu o model monotoniczny. Zamodelowano zmiany jakim dynamiczne parametry rozkładu podlegają podczas badań. Podano bayesowskie modele wzrostu niezawodności dla licznych etapów wzrostu niezawodności. Na koniec metodę zweryfikowano w oparciu o przykład praktyczny.
In this paper we study the statistical analysis methods at different stages of reliability growth based on the monotone model. The changes of dynamic distribution parameters during test are modeled. Bayesian reliability growth models for multiple stages of reliability growth are given. Finally the method is validated by a practical example.
Źródło:
Eksploatacja i Niezawodność; 2010, 2; 13-16
1507-2711
Pojawia się w:
Eksploatacja i Niezawodność
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Speech Enhancement Based on the Multi-Scales and Multi-Thresholds of the Auditory Perception Wavelet Transform
Autorzy:
Tao, Z.
Zhao, H. M.
Zhang, X-J.
Wu, D.
Powiązania:
https://bibliotekanauki.pl/articles/177021.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
speech enhancement
low SNR
auditory perception wavelet transform
unvoiced enhancement
masking effect
Opis:
This paper proposes a speech enhancement method using the multi-scales and multi-thresholds of the auditory perception wavelet transform, which is suitable for a low SNR (signal to noise ratio) environment. This method achieves the goal of noise reduction according to the threshold processing of the human ear’s auditory masking effect on the auditory perception wavelet transform parameters of a speech signal. At the same time, in order to prevent high frequency loss during the process of noise suppression, we first make a voicing decision based on the speech signals. Afterwards, we process the unvoiced sound segment and the voiced sound segment according to the different thresholds and different judgments. Lastly, we perform objective and subjective tests on the enhanced speech. The results show that, compared to other spectral subtractions, our method keeps the components of unvoiced sound intact, while it suppresses the residual noise and the background noise. Thus, the enhanced speech has better clarity and intelligibility.
Źródło:
Archives of Acoustics; 2011, 36, 3; 519-532
0137-5075
Pojawia się w:
Archives of Acoustics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pinellia ternata agglutinin produced in Bombyx mori cells exhibits bioactivity
Autorzy:
Xu, Tao
Wang, Bo
Wang, Liya
Zhang, Yaozhou
Lv, Zhengbing
Powiązania:
https://bibliotekanauki.pl/articles/1039738.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Pinellia ternata agglutinin
silkworm bioreactor
plant lectin
Bombyx mori cells
Opis:
Pinellia ternata agglutinin (PTA) is highly homologous to many other monocot mannose-binding lectins which reportedly possess antitumor activities. Its production in silkworm cells has great application potential because the baculovirus expression system can produce post-translationally modified proteins at low cost. In the current study, the pta gene was cloned and expressed in silkworm cells, and the expressed protein was analyzed using a hemagglutination assay. A preliminary in vitro study on its anti-proliferative activity was performed. The results show that the recombinant PTA with an apparent molecular mass of 29 kDa can hemagglutinate rabbit erythrocytes and this activity can be inhibited by D-mannan at a low concentration. In addition, the recombinant hemagglutinin exhibited a dose-dependent anti-proliferative activity on hepatoma cells. The results of the current study suggest that PTA and other important bioactive proteins could be produced by silkworm bioreactor for biomedicine research and application.
Źródło:
Acta Biochimica Polonica; 2012, 59, 2; 231-236
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Coelacanths from the Middle Triassic Luoping Biota, Yunnan, South China, with the earliest evidence of ovoviviparity
Autorzy:
Wen, W.
Zhang, Q.-Y.
Hu, S.-X.
Benton, M.J.
Zhou, C.-Y.
Tao, X.
Huang, J.-Y.
Chen, Z.-Q.
Powiązania:
https://bibliotekanauki.pl/articles/23008.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Instytut Paleobiologii PAN
Tematy:
coelacanth
Middle Triassic
Triassic
Yunnan province
South China
China
evidence
ovoviviparity
Anisian
Actinistia
Coelacanthoidei
Latimerioidei
Opis:
The fossil record of coelacanths is patchy, with very few taxa known from the Triassic of Asia. We report here two new genera and species of coelacanths from the Luoping Biota, a recently found site of exceptional fossil preservation from Yunnan, South China. The first new taxon, Luopingcoelacanthus eurylacrimalis, is based on four specimens, which to− gether show most aspects of the anatomy. One specimen shows two small coelacanths inside the ventral portion of the ab− dominal cavity, and these are interpreted as intrauterine embryos, close to birth size, based on comparisons with previ− ously reported embryos of the fossil coelacanths Rhabdoderma and Undina, and the extant genus Latimeria. Our new find extends the evidence for ovoviviparity in coelacanths back from the Late Jurassic to the Middle Triassic. The second new taxon, Yunnancoelacanthus acrotuberculatus, is based on one specimen, and differs from Luopingcoelacanthus in the dentary, lachrymojugal, number of rays of the first dorsal fin, and especially in the ornament on dermal bones and scales. Acladistic analysis shows that the new taxa are closest relatives to the derived clade Latimerioidei. The relatively high di− versity of coelacanths in the Early Triassic, and adaptations of living Latimeria to low−oxygen conditions, suggests that the group may have included ‘disaster taxa’ that benefited from anoxic and dysoxic ocean conditions in the aftermath of the end−Permian mass extinction.
Źródło:
Acta Palaeontologica Polonica; 2013, 58, 1
0567-7920
Pojawia się w:
Acta Palaeontologica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Four stage hybrid constructed wetlands treating low-strength aquaculture wastewater with and without artificial aeration
Autorzy:
Zhang, S.-Y.
Li, G.
Li, X.
Tao, L.
Powiązania:
https://bibliotekanauki.pl/articles/207748.pdf
Data publikacji:
2015
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
wastewater treatment
aquaculture
water pollution
wetlands
aquaculture wastewater
artificial aeration
oczyszczanie ścieków
akwakultura
zanieczyszczenie wody
mokradła
sztuczne napowietrzanie
tereny podmokłe
Opis:
Driven by the booming demands for healthy food, aquaculture industry has to deal with the problem of water pollution appropriately so as to achieve sustainable development. In this study, a combination of four stage CWs (three horizontal subsurface flows followed by one free water surface flow) was configured to treat low-strength aquaculture wastewater. For performance assessment, the wetlands were monitored over three years, during which artificial aeration was added to them. By the results, the organic matters and nutrients were mainly sequestered in the anterior subsurface flows, while the surface flow mainly contributed to DO improvement. These results probably implied no necessity of excessive subsurface flows connected in a staged manner. In addition, the artificial aeration improved the treatment performance on ammonium-N, TN and TP in the first-stage CW.
Źródło:
Environment Protection Engineering; 2015, 41, 3; 31-42
0324-8828
Pojawia się w:
Environment Protection Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Experimental study on triboelectrostatic beneficiation of wet fly ash using Microwave Heating
Autorzy:
Li, H.
Chen, Y.
Zhang, X.
Zhao, Y.
Tao, Y.
Li, C.
He, X.
Powiązania:
https://bibliotekanauki.pl/articles/110399.pdf
Data publikacji:
2016
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
wet fly ash
triboelectrostatic beneficiation
microwave heating
efficiency
Opis:
Triboelectrostatic beneficiation, as a physical method, of fly ash cannot only meet the technical requirements of fly ash application but also recycle of an unburned carbon as a useful energy source. The aim of this study was to investigate the feasibility of improving efficiency of triboelectrostatic beneficiation of wet fly ash using microwave heating. The wet fly ash with different moisture contents had an average loss-on-ignition of 12.56%. The fly ash samples were heated in a microwave oven before the experiments. The experimental conditions were electric field voltage of 40 kV and air flux ranging from 12 to 30 m3/h. The influence of the microwave heating on the wet fly ash triboelectrostatic beneficiation was discussed under the conditions of different microwave intensity and irradiation time. The results indicated that the removal rate and recycle rate of the unburned carbon showed a significant increase performance as the wet fly ash was processed by the microwave heating which was attributed to changes of moisture contents and dielectric constants caused by the microwave heating. The feasibility had been verified according to the experimental study on fly ash with different moisture contents. It can be concluded that the microwave heating process was efficiently applied for the wet fly ash triboelectrostatic beneficiation.
Źródło:
Physicochemical Problems of Mineral Processing; 2016, 52, 1; 328-341
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Combined effects of NQO1 Pro187Ser or SULT1A1 Arg213His polymorphism and smoking on bladder cancer risk: Two meta-analyses
Autorzy:
Wang, Xiao-Chun
Wang, Jian
Tao, Hui-Hui
Zhang, Chao
Xu, Li-Fa
Powiązania:
https://bibliotekanauki.pl/articles/2161894.pdf
Data publikacji:
2017-07-14
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
polymorphisms
meta-analysis
NQO1
urinary bladder neoplasms
smoking
SULT1A1
Opis:
Objectives Objectives: Cigarette smoking is the major risk factor of bladder cancer via exposure to chemical carcinogens. Nicotinamide adenine dinucleotide phosphate (NADP+): quinine oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) have been reported to involve in the metabolism of polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. Therefore, the risk of bladder cancer (BC) may be influenced by polymorphisms in the genes that modulate metabolic detoxification in particular by interacting with cigarette smoking. Considering the limited power by the individual studies with a relatively small sample size, especially when analyzing the combined effect of polymorphisms in NQO1 and SULT1A1 genes and smoking, these 2 meta-analyses have aimed to clarify the combined effects of them on BC risk by integrating related studies. Material and Methods Two meta-analyses included 1341 cases and 1346 controls concerning NQO1 Pro187Ser and smoking, and 1921 cases and 1882 controls on SULT1A1 Arg213His and smoking were performed. Odds ratios (OR) and 95% confidence intervals (CI) were used for assessing the strength of the association. Results The result has demonstrated that smokers with NQO1 Pro/Ser or Ser/Ser genotypes have a prominent association with the risk of BC as compared with non-smokers with NQO1 Pro/Pro genotype, with OR equal to 3.71 (95% CI: 2.87–4.78, $ \text{p}_\text{heterogeneity} $ = 0.376). Besides, smokers carrying SULT1A1 Arg/Arg genotypes were observed to confer 2.38 fold increased risk of BC (95% CI: 1.44–3.93, $ \text{p}_\text{heterogeneity} $ = 0.001) when compared with non-smokers with SULT1A1 Arg/Arg or His/His genotypes. Conclusions These findings have suggested that the NQO1 Pro187Ser or SULT1A1 Arg213His polymorphism combination with smoking significantly confer susceptibility to BC. Int J Occup Med Environ Health 2017;30(5):791–802
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2017, 30, 5; 791-802
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Summary of the port shoreline resource evaluation based on triangular fuzzy analytic hierarchy process
Autorzy:
Jiang, L.
Tao, T.
Zhang, C.
Jiang, H.
Wang, J.
Powiązania:
https://bibliotekanauki.pl/articles/259464.pdf
Data publikacji:
2017
Wydawca:
Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
Tematy:
port shoreline evaluation
triangular fuzzy AHP
fuzzy comprehensive evaluation
shoreline of Nanjing port
Opis:
Port shoreline resources are the basis of port and shipping development, and its assessment method has become one of the hot issues in port research. On the basis of constructing a reasonable index evaluation system, this paper constructs the fuzzy evaluation matrix based on the triangular fuzzy analytic hierarchy process and constructs the fuzzy evaluation matrix by using the fuzzy comprehensive evaluation method, and obtains the maximum membership degree of the port shoreline resources. Compared with the traditional port shoreline Resource evaluation methods, the new one got more advantages in objective and quantitative. Finally, Combined with the Nanjing section of the Yangtze River as a case for verification, the results show that the model can accurately solve the problem of resource evaluation of port shoreline.
Źródło:
Polish Maritime Research; 2017, S 3; 16-22
1233-2585
Pojawia się w:
Polish Maritime Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Existence Of P≥3-Factor Covered Graphs
Autorzy:
Zhou, Sizhong
Wu, Jiancheng
Zhang, Tao
Powiązania:
https://bibliotekanauki.pl/articles/31341575.pdf
Data publikacji:
2017-11-27
Wydawca:
Uniwersytet Zielonogórski. Wydział Matematyki, Informatyki i Ekonometrii
Tematy:
P≥3-factor
P≥3-factor covered graph
toughness
isolated toughness
regular graph
Opis:
A spanning subgraph F of a graph G is called a P≥3-factor of G if every component of F is a path of order at least 3. A graph G is called a P≥3-factor covered graph if G has a P≥3-factor including e for any e ∈ E(G). In this paper, we obtain three sufficient conditions for graphs to be P≥3-factor covered graphs. Furthermore, it is shown that the results are sharp.
Źródło:
Discussiones Mathematicae Graph Theory; 2017, 37, 4; 1055-1065
2083-5892
Pojawia się w:
Discussiones Mathematicae Graph Theory
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Experimental study and numerical simulation on fly ash separation with different plate voltages in rotary triboelectrostatic separator
Autorzy:
Zhang, L.
Tao, Y.
Tao, D.
Zhang, W.
Yang, L.
Powiązania:
https://bibliotekanauki.pl/articles/110712.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
fly ash
rotary triboelectrostatic separator
plate voltage
numerical simulation
Opis:
As the main solid wastes of coal-fired power plants, fly ash particles with different electrical properties are usually recycled using triboelectrostatic separator. The purpose of this study was to investigate the effect of different plate voltages on the separation of fly ash in a rotary triboelectrostatic separator with experiments and numerical simulation. The maximum values of yield of ash products (48.30%), and decarbonisation rate (50.89%) and the minimum loss-on-ignition (6.61%) were obtained when the plate voltage was 24 kV in the separation experiments, while 55.98%, 59.46%, 5.80% were reached respectively when the plate voltage was 26 kV in the simulation. In general, experimental data were similar with numerical simulation. The turning points appeared around 25 kV due to the increasing mismatch in products, which resulted from the reinforced rebound phenomena, namely the charged particle rebound from the electrode plate with a larger reflection velocity, when the plate voltage increased from 18 to 28 kV. It was validated by the numerical simulation results.
Źródło:
Physicochemical Problems of Mineral Processing; 2018, 54, 3; 722-731
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
NEW BETULIN NITRATES: SYNTHESIS, CYTOTOXIC ACTIVITY AND MOLECULAR DOCKING EVALUATION
Autorzy:
Feng, GaiLi
Wang, Tao
Zhang, Rong
Luo, Jin
Xiao, MinJie
He, BaoEn
Liu, YongQian
Wu, JunXiao
Powiązania:
https://bibliotekanauki.pl/articles/895411.pdf
Data publikacji:
2018-10-31
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
Molecular docking
anti-tumor
Betulin nitrates
NO donors
Opis:
Betulin and its derivatives have been reported to affect several key genes of cell-cycle regulators. However, their specific targets haven’t yet been discovered. As an important cell cycle regulator, Cyclin-dependent kinase-2 (CDK2) has become a potential target for cancer therapy. Here we describe the design, synthesis and antitumor activities in vitro of eleven new betulin nitrates. The results revealed that compound (20) possesses potent antitumor activity against MCF-7 cell lines (IC50 < 10 μM). In order to investigate potential protein target, betulin nitrates were subjected to docking studies with CDK2. Compound (20) showed very good binding affinity for CDK2 via hydrogen bonding interactions. Thus, the CDK2 inhibitory potential could make compound (20) possible candidate as antitumor agent.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 5; 1135-1145
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Numerical simulation of flow field in enhanced gravity concentrator
Autorzy:
Zhu, X.
Tao, Y.
Zhang, L..
Powiązania:
https://bibliotekanauki.pl/articles/110160.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
numerical simulation
enhanced gravity concentrator
three-dimensional velocity
turbulence characteristics
Opis:
Enhanced gravity concentrator have excellent separation accuracy for the fine mineral particles. However, its internal flow characteristics are still in unclear. Therefore, numerical simulation was conducted to study the flow characteristics of concentrator. Effect of centrifugal force and fluidization water pressure on the velocity component of fluid was studied. The simulation accuracy was verified by the theoretical calculation. The turbulence intensity in the radial direction was analyzed to reveal the gradient characteristics. Results show that the three-dimensional velocity has different order of magnitude. The increase of centrifugal force significantly improves the three-dimensional velocity of fluid. However, the fluidization water pressure has little influence on the tangential velocity and axial velocity, but it can effectively improve the radial velocity. High turbulent flow energy and high turbulence dissipation rate are presented in the near wall region, which allows the light particles reentering the separation region. Meanwhile, the fluid presents stable flow pattern in the fall wall region that is conducive to the stratification process. In addition, the increase of centrifugal force increases the turbulence in the near wall region; however, fluidization pressure has no effect.
Źródło:
Physicochemical Problems of Mineral Processing; 2018, 54, 3; 975-980
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pre-concentration of graphite and LiCoO2 in spent lithium-ion batteries using enhanced gravity concentrator
Autorzy:
Zhu, X,-N.
Tao, Y.-J.
He, Y.-Q.
Zhang, Y.
Sun, Q.-X.
Powiązania:
https://bibliotekanauki.pl/articles/109609.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
spent lithium-ion batteries
electrode material
resource utilization
pre-concentration
enhanced gravity concentrator
Opis:
The pre-concentration of electrode material of spent lithium-ion battery has great significance on the resource utilization and environmental protection. The feasibility of separation of graphite and LiCoO2 based on density difference using the enhanced gravity concentrator was verified in this paper. Combustion characteristics of LiCoO2 and graphite were used to propose a simple evaluation index of separation efficiency. Separation tests were carried out to specify the influence of operating parameters on the separation efficiency. Moreover, the effect of particle size on the separation performance was studied. Combustion characteristics results showed that mass loss of graphite was much greater than that of LiCoO2. Thus, mass loss were used to evaluate the purity of product. Effective separation of graphite and LiCoO2 was achieved by the enhanced centrifugal separator. Separation results showed that increasing centrifugal force decreased the overflow yield and increased the graphite content of the overflow stream. In addition, yield of overflow grew an increase in fluidization water pressure, while the purity of graphite in overflow decreased. The effect of particle size on the separation efficiency was also significant, the separation efficiency decreased with the decreasing of particle size.
Źródło:
Physicochemical Problems of Mineral Processing; 2018, 54, 2; 293-299
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
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