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Wyświetlanie 1-2 z 2
Tytuł:
Pektyny – występowanie, budowa chemiczna i właściwości
Pectins – occurrence, chemical constitution and physicochemical properties
Autorzy:
Pińkowska, H.
Złocińska, A.
Powiązania:
https://bibliotekanauki.pl/articles/172265.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
pektyny wysokoestryfikowane
pektyny niskoestryfikowane
homogalakturonan
ramnogalakturonan
ksylogalakturonan
żelowanie
high ester pectins
low ester pectins
homogalacturonan
rhamnogalacturonan
xylogalacturonan
gelation
Opis:
Pectins are important polysaccharide structure constituents of plant middle lamellae and primary cell walls ensuring their water retention performance and the pH stability [1, 11]. Due to the high gelling, stabilising and thickening properties they are widely used in the food and pharmaceutical industry [3, 9]. Commercial pectin substances are extracted from the waste material, especially citrus peels (from orange, grapefruit, lemon and lime fruit), apple pomace and sugar beet pulp. The high concentration of pectins is found also in other fruits and vegetables, mainly soy hull, mango peels and sunflower heads [3, 11, 12, 14]. The properties of pectins result mainly from their chemical structure. The pectin backbone is primarily composed of homogalacturonan (Fig. 1), which is a linear polymer consisting of α-1→4-linked d-galacturonic acid units, partially methylesterified or O-acetylated [3, 9]. Other structural elements of pectins are rhamnogalacturonan type I (Fig. 2) and type II (Fig. 3), xylogalacturonan (Fig. 5), arabinan (Fig. 6), arabinogalactan type I (Fig. 7) and type II (Fig. 8) [3, 5, 8]. The gelling property of pectins depends on the degree of methyl esterification of their carboxyl groups (DE). According to this parameter there are high ester pectins (DE > 50) and low ester pectins (DE < 50). The high ester pectins form gels in the presence of high sugar concentrations exceeding 55% and pH lower than 3.5, while in the case of low ester pectins the gelation process occurs even at low concentrations of sugar but the presence of divalent ions is required (e.g. calcium) [18, 21]. The aim of this study was a review of the available literature regarding the sources of pectins, their types, chemical structure and physicochemical properties.
Źródło:
Wiadomości Chemiczne; 2014, 68, 7-8; 683-700
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of a dental formulation prepared with chitosan on the pharmaceutical availability of clotrimazole
Autorzy:
Grimling, Bożena
Meler, Jan
Szcześniak, Maria
Kocoń, Martyna
Karolewicz, Bożena
Złocińska, Adrianna
Górniak, Agata
Powiązania:
https://bibliotekanauki.pl/articles/1034568.pdf
Data publikacji:
2017
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
FTIR
carrier XRPD
chitosan
clotrimazole
hydrogel
solid dispersion
Opis:
The present work involves the development of a dental gel composition obtained on the basis of clotrimazole incorporated into chitosan in order to improve drug solubility. Solid dispersions were prepared by using two methods: grinding and kneading. The solid dispersion varied the ratio of chitosan to drug to increase the volume of the drug; the ratios were 5:5, 3:7, 2:8, 1:9. The mixtures were subjected to the dissolution rate of clotrimazole. The presence of chitosan improved the drug solubility; a better solubility from the solid dispersion prepared by the grinding method was obtained from the ratio of drug to polymer of 1+9. The rate of dissolution of clotrimazole was improved 17 times compared to the pure drug. Fourier transform infrared spectroscopy (both infrared and X-ray diffraction) revealed no new chemical structure of the tested connections and concluded that there was no interaction between the drug and the polymer in the test diffractions. Solid dispersions with the best parameters were used to prepare hydrogels, and the pharmaceutical availability of clotrimazole was analysed. The best properties were characterized by a hydrogel that was composed of the ratio of the amount of drug to polymer 5:5. The study demonstrated the availability of a pharmaceutical drug release at a therapeutic concentration in the first hour of the study. The use of the appropriate balance between clotrimazole and chitosan and the development of the hydrogel composition may affect the improvement of the drug solubility and may create the possibility of obtaining sustained or controlled release of the drug substance.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 42-53
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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