Wszystkie pola: Yao, Hua - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Dendrimer-paclitaxel complexes for efficient treatment in ovarian cancer: study on OVCAR-3 and HEK293T cells
Autorzy:: Yao, Hua
Ma, Jinqi
Powiązania:: https://bibliotekanauki.pl/articles/1038392.pdf
Data publikacji:: 2018
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: Paclitaxel
Biotinylated PAMAM NH2 complex
ovarian cancer
cellular uptake
cytotoxicity
Opis:: The present paper investigates the enhancement of the therapeutic effect of Paclitaxel (a potent anticancer drug) by increasing its cellular uptake in the cancerous cells with subsequent reduction in its cytotoxic effects. To fulfill these goals the Paclitaxel (PTX)-Biotinylated PAMAM dendrimer complexes were prepared using biotinylation method. The primary parameter of Biotinylated PAMAM with a terminal HN2 group - the degree of biotinylation - was evaluated using HABA assay. The basic integrity of the complex was studied using DSC. The Drug Loading (DL) and Drug Release (DR) parameters of Biotinylated PAMAM dendrimer-PTX complexes were also examined. Cellular uptake study was performed in OVCAR-3 and HEK293T cells using fluorescence technique. The statistical analysis was also performed to support the experimental data. The results obtained from HABA assay showed the complete biotinylation of PAMAM dendrimer. DSC study confirmed the integrity of the complex as compared with pure drug, biotinylated complex and their physical mixture. Batch 9 showed the highest DL (12.09%) and DR (70%) for 72 h as compared to different concentrations of drug and biotinylated complex. The OVCAR-3 (cancerous) cells were characterized by more intensive cellular uptake of the complexes than HEK293T (normal) cells. The obtained experimental results were supported by the statistical data. The results obtained from both experimental and statistical evaluation confirmed that the biotinylated PAMAM NH2 dendrimer-PTX complex not only displays increased cellular uptake but has also enhanced release up to 72 h with the reduction in cytotoxicity.
Źródło:: Acta Biochimica Polonica; 2018, 65, 2; 219-225
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Sequence analysis of human cytomegalovirus US28 gene in low-passage clinical isolates from children and AIDS patients
Autorzy:: He, Rong
Xia, Chang
Ruan, Qiang
Qi, Ying
Ma, Yan-Ping
Ji, Yao-Hua
Guo, Jin-Jin
Powiązania:: https://bibliotekanauki.pl/articles/1039923.pdf
Data publikacji:: 2011
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: chemokine receptors
cytomegalovirus
genetic polymorphism
US28
Opis:: Human cytomegalovirus (HCMV) is often a dangerous opportunistic pathogen that causes significant morbidity and mortality in newborn children and immunocompromised patients. The different symptoms and tissue tropisms of HCMV infection may result from genetic polymorphism. This study investigated the sequence variability of the HCMV US28 ORF, which shows sequence homology to the G protein-coupled receptor. HCMV isolated from suspected pediatric cases and isolates from AIDS patients were compared in order to examine the possible associations between polymorphisms and pathogenesis. Seventy children with suspected congenital HCMV infection, who suffered from jaundice (47), megacolon (10), and microcephaly (13), and 17 AIDS patients, were studied. Mutation was prevalent among the sequences of US28, with a focus on the two ends of US28. The important functional groups of US28 are highly conserved. An unrooted tree showed that all sequences from suspected congenitally infected infants and AIDS patients were divided into three groups. Comparison showed that most of the sequences (12/17) from pediatric patients were included in the first group (G1), whereas most of the sequences (11/17) from AIDS patients were included in the third group (G3). The specific high mutation sites in US28 from children were located at the C terminus of the protein, whereas those from AIDS patients were located at the N terminus. We demonstrated the existence of polymorphisms among the US28 genes of clinical isolates of HCMV from infants with suspected congenital infection. Comparison of US28 sequences from AIDS patients with those from children showed that both sequences have their own specific high mutation points.
Źródło:: Acta Biochimica Polonica; 2011, 58, 2; 231-236
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Damage mechanism of conventional joints and proposal of a novel joint for hollow-core slab bridges
Autorzy:: Cui, Yujun
Xue, Xingwei
Yao, Hao
Hua, Xudong
Huang, Yuanming
Powiązania:: https://bibliotekanauki.pl/articles/2174082.pdf
Data publikacji:: 2022
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: The prefabricated hollow-core slab bridge is a common bridge. In prefabricated hollow-core slab bridges, joints play an important role in connecting prefabricated slabs and ensuring the integrity of the bridge. However, as the service time of the bridge increases, conventional joints have a large number of typical diseases that affect the safety and durability of bridges. In this study, a three-dimensional finite element model of the entire construction phase is established to investigate the development difference of shrinkage and creep between joints and hollow-core slabs. The effects of vehicle load and temperature gradient on joints were analysed, the failure mechanism of joints was explored, and a novel joint was proposed. The results of a nonlinear analysis showed that the novel joint can effectively improve the mechanical performance of joints and cracks can be effectively controlled. Moreover, the novel joint solves the problem in that the conventional novel joint cannot be vibrated effectively.
Źródło:: Archives of Civil Engineering; 2022, 68, 4; 571--590
1230-2945
Pojawia się w:: Archives of Civil Engineering
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: The Influence of Cycle Sputtering Deposition on the Properties of Cu₂ZnSnS₄ Thin Films
Autorzy:: Sun, Y.
Yao, B.
Long, D.
Meng, X.
Liu, L.
Hua, Z.
Powiązania:: https://bibliotekanauki.pl/articles/1398930.pdf
Data publikacji:: 2016-06
Wydawca:: Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:: 78.40.Fy
Opis:: Three kinds of precursor thin films with stacking orders of Cu/Sn/ZnS, Cu/Sn/ZnS/Cu/Sn/ZnS and Cu/Sn/ZnS/Cu/Sn/ZnS/Cu/Sn/ZnS were prepared by magnetron sputtering and annealed with sulfur powder. The microstructure, morphology and optical properties of thin films were investigated by X-ray diffraction, the Raman scattering, scanning electron microscopy and UV-visible spectrophotometer. The increase of cycle number decreases the sulfurizing temperature of the formation of Cu₂ZnSnS₄ phase. Chemical composition can be controlled by cycle sputtering deposition. After sulfurizing at 500°C, the particle size and the band gap increase with increasing cycle number.
Źródło:: Acta Physica Polonica A; 2016, 129, 6; 1169-1172
0587-4246
1898-794X
Pojawia się w:: Acta Physica Polonica A
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Effect of Annealing Temperature and Ambient on Formation, Composition and Bandgap of $Cu_2ZnSnS_4$ Thin Films
Autorzy:: Sun, Y.
Yao, B.
Meng, X.
Wang, D.
Long, D.
Hua, Z.
Powiązania:: https://bibliotekanauki.pl/articles/1205220.pdf
Data publikacji:: 2014-08
Wydawca:: Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:: 68.55.-a
Opis:: Amorphous Cu-Zn-Sn-S precursor films were prepared by sol-gel and spin-coating with copper chloride, zinc chloride, tin chloride and thiourea solutions as starting materials. A $Cu_2ZnSnS_4$ film with kesterite structure and a small amount of chlorine formed when the precursor was annealed under Ar ambient at temperature above 200°C, but its atomic ratios of Cu:Zn:Sn:S far deviated from stoichiometric ratios of the $Cu_2ZnSnS_4$. However, when the precursor films were annealed with sulfur powder together at temperatures between 360 and 480°C, the CZTS film containing a very small amount of Cl formed, and its atomic ratio change little for Cu, Zn, and Sn, increases for S and decreases for Cl with increasing temperature. When the temperature is 480°C, a CZTS only has Cu, Zn, Sn, and S element is fabricated, and the atomic ratio of Cu:Zn:Sn:S is near the stoichiometric ratio. The bandgap of the CZTS decreases with increasing annealing temperature. The mechanisms of the formation and the properties of the CZTS are suggested in the present work.
Źródło:: Acta Physica Polonica A; 2014, 126, 3; 751-756
0587-4246
1898-794X
Pojawia się w:: Acta Physica Polonica A
Dostawca treści:: Biblioteka Nauki

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