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Wyświetlanie 1-15 z 78
Tytuł:
The effect of lipegfilgrastim on hematopoietic reconstitution and supportive treatment after megachemotherapy with autologous peripheral blood stem cell transplantation in patients with lymphoproliferative malignancies
Autorzy:
Frączak, Ewa
Dybko, Jarosław
Rybka, Justyna
Biedroń, Monika
Dereń-Wagemann, Izabela
Urbaniak-Kujda, Donata
Kuliczkowski, Kazimierz
Wróbel, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/1064904.pdf
Data publikacji:
2016
Wydawca:
Medical Education
Tematy:
G-CSF
auto-PBSCT
lymphoproliferative malignancies
Opis:
Megachemotherapy with autologous peripheral blood stem cell transplantation (auto-PBSCT) is a standard treatment option in patients below 70 years of age with multiple myeloma (MM) as well as with relapsed and refractory lymphomas. Recombinant granulocyte colony-stimulating factors (G-CSF) are commonly used to accelerate bone marrow recovery after chemotherapy and reduce the duration of severe neutropenia. Lipegfilgrastim is a glicopegylated G-CSF with prolonged action registered for adult patients with malignant neoplasms in order to reduce the duration of neutropenia and the incidence of febrile neutropenia (FN). So far, there is not enough data to confirm the effectiveness and safety of this drug in patients with hematological malignancies including those undergoing auto-PBSCT. The aim of this study was to determine the effect of lipegfilgrastim on hematopoietic regeneration and supportive care after auto-PBSCT in patients with lymphoproliferative malignancies. The study population consisted of 30 patients (12 female and 18 male; median age: 50 years ± 13), including 13 patients with MM, 5 with Hodgkin’s lymphoma (HL) and 12 with non-Hodgkin’s lymphoma (nHL). The median number of transplanted CD34+ cells was 3.96 ± 1.56 × 10^6/kg of body mass. On day +1 after auto-PBSCT, the patients received lipegfilgrastim in a single 6 mg subcutaneous injection. The control group consisted of 32 patients (13 female and 19 male; median age: 50 years ± 6.4), including 13 with MM, 8 with HL and 11 with nHL, who received subcutaneous filgrastim in a dose of 5 μg/kg/day from day +1 after transplantation and continued to an absolute neutrophil count (ANC) > 1.5 × 10^9/L. There was no significant difference in the time of regeneration ANC > 0.5 × 10^9/L which was 10.65 ± 1.00 vs. 11.51 ± 2.29 days respectively in the study and control group. Similar observations were noted regarding the duration of febrile neutropenia (2.16 ± 2.22 vs. 1.70 ± 4.17 days; p = 0.998), regeneration of platelets (PLT) > 20 × 10^9/L (12.41 ± 2.41 vs. 13.82 ± 4.48 days; p = 0.233) and demand for transfusion of red blood cells (0.76 ± 1.07 vs. 1.33 ± 2.33 units; p = 0.414) and platelets (11.5 ± 6.9 vs. 19.2 ± 17.7 units; p = 0.08). Different results were observed for the length of hospitalization, which was significantly shorter in the lipegfilgrastim group (16.14 ± 14 vs. 24.46 ± 6.79 days; p = 0.000). Lipegfilgrastim is as effective as filgrastim with regards to the regeneration of the hematopoietic system, duration of febrile neutropenia, demand for transfusion of blood products and significantly reduces hospitalization in patients with lymphoproliferative malignancies after auto-PBSCT.
Źródło:
OncoReview; 2016, 6, 2; A66-71
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Baden Culture finds from Goszcza site 1 (Kielnik): new archaeological, anthropological, archaeozoological and archaeobotanical data
Autorzy:
Nowak, Maciej
Wilczyński, Jarosław
Wróbel, Jarosław
Kapcia, Magda
Moskal-del Hoyo, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/52579363.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
Tematy:
Neolithic
Baden culture
funerary rites
anthropology
archaeozoology
archaeobotany
Opis:
In spring 2019, rescue excavations were conducted at Goszcza 1 (Kielnik) site in connection with construction of a dwelling house. As a result, eleven archaeological features of various chronology were identified. The most abundant materials, dating to the Late Classic period of the Baden culture in Lesser Poland (the end of the 4th millennium and the beginning of the 3th millennium BC), were found in four pits. At the bottom of two features (nos 4 and 6) human skeletons were discovered. In the present study, only materials discovered in features attributed to the Baden culture are discussed, including pottery finds, flint artefacts, and fragments of human and animal bones. Macroscopic plant remains coming from three archaeological features have also been investigated.
Źródło:
Folia Quaternaria; 2019, 87; 27-58
0015-573X
2199-5915
Pojawia się w:
Folia Quaternaria
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Semiconductor contact layer characterization in a context of hall effect measurements
Autorzy:
Kowalewski, Andrzej
Wróbel, Jarosław
Boguski, Jacek
Gorczyca, Kinga
Martyniuk, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/220890.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
metal contact
contact layer
contact resistance
Hall effect
resistivity
van der Pauw method
MSM structure
semiconductors’ characterization
Opis:
A revision of the standard approach to characterization of thin-semiconductor-layer Hall samples has been proposed. Our results show that simple checking of I(V) curve linearity at room temperature might be insufficient for correct determination of bias conditions of a sample before measurements of Hall effect. It is caused by the nonlinear behaviour of electrical contact layers, which should be treated together with the tested layer a priori as a metal-semiconductor-metal (MSM) structure. Our approach was examined with a Be-doped p-type InAs epitaxial layer, with four gold contacts. Despite using full high-quality photolithography a significant asymmetry in maximum differential resistance (Rd) values and positions relative to zero voltage (or current) value was observed for different contacts. This suggests that such characterization should be performed before each high-precision magneto-transport measurement in order to optimize the bias conditions.
Źródło:
Metrology and Measurement Systems; 2019, 26, 1; 109-114
0860-8229
Pojawia się w:
Metrology and Measurement Systems
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 78

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