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Wyświetlanie 1-13 z 13
Tytuł:
Tumor budding as a new histological parameter in the metastasis of colorectal cancer
Autorzy:
Ustymowicz, W.
Powiązania:
https://bibliotekanauki.pl/articles/1918641.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
colon cancer
5-year survival
Opis:
Introduction:The presence of tumor budding, i.e.,single cancer cells or a nest of poorly differentiated cells at the front of tumor invasion appears to be a new histopathological indicator of increased aggressiveness of colorectal carcinoma. Purpose: The aim of this work was a retrospective evaluation of the invasion front (tumorbudding, vascular invasion,and lymphocytic infiltration) in postoperative biopsies of patients with colorectal carcinoma and analysis of the 5-year survival. Materialsand methods:The study was based on the material received after surgical treatment of 164 patients with colon cancer. Tissue was obtained directly following tumor resection, fixed in 10% formaldehyde and embedded in paraffin blocks using a routine method by melting with paraffin at a temperature of 56º C. These samples were then routinely stained with haematoxylin and eosin and underwent a histopathological evaluation, with particular attention being paid to the invasion front of the tumor. The immunohistochemical expression of cytokeratin 20 was also evaluated using anti-human CK20 monoclonal antibody (clone Ks.20.8, Dako, Poland). Results: Tumor budding was found in 124 out of 164 patients. Statistical analysis showed a correlation between the presence of tumor budding TB and depth of invasion (pT), lymph node metastasis, distant metastasis, lymphocytic infiltration,and vascular invasion. The cumulative five-year survival correlated with the lack of tumor budding and vascular invasion, as well as a decrease in lymphocyticinfiltration.
Źródło:
Progress in Health Sciences; 2018, 8(2); 118-123
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Vaginal biocoenosis examining comparing to exfoliative cervical cytology
Autorzy:
Hawryluk, M.
Ustymowicz, W.
Hawryluk, L.
Maciorkowska, M.
Prycznicz, A.
Powiązania:
https://bibliotekanauki.pl/articles/1918532.pdf
Data publikacji:
2017-11-12
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Bacterial infections
Candida sp
cervical cytology
Trichomonas vaginalis
vaginal biocoenosis
Opis:
Introduction: At present, the gynaecologists have been increasingly frequently switching from vaginal biocoenosis assessment towards cervical cytology results to obtain information on the type of infection. Exfoliative cervical cytology is a screening test for dysplastic intraepithelial lesions and ectocervical cancers. One should emphasize however that one of the four parts of the new Bethesda classification specifies such inflammatory lesions as: Trichomonas vaginalis, Candida, Actinomyces, Chlamydia, cellular changes consistent with HSV infection and changes of bacterial flora. The gynaecologists however may perform vaginal biocoenosis assessment individually and diagnose its abnormalities in a relatively short timeframe.Conclusions: Lack of 100% correlation between the vaginal biocoenosis test and cytological result according to the Bethesda system means that assessment of vaginal microflora in phase-contrast microscopy should not be abandoned. Purpose: To analyse the association between lesions revealed during vaginal biocoenosis assessment in correlation to lesions described in the studies dedicated to cytological assessment of ectocervical smear. Material and methods: The study group included 1991 female patients scheduled for the follow-up cytological screening in a gynaecological office. Patients underwent gynaecological examination covering external areas, colposcopy, vaginal pH measurement, sampling for vaginal biocoenosis assessment purposes and cytological sampling. Results: It was demonstrated that diagnostic conformity for Candida sp accounted for only 17.2%, changes of bacterial flora for only 4% and – in the case of Trichomonas vaginalis - for only 3.9%. According to observations, bacterial infections and candidiases have been more frequently diagnosed during vaginal biocoenosis examining comparing to cytological screening, whereas infections with Trichomonas vaginalis have been more frequently diagnosed in cytological screening. Conclusions: Lack of 100% correlation between the vaginal biocoenosis test and cytological result according to the Bethesda system means that assessment of vaginal microflora in phase-contrast microscopy should not be abandoned.
Źródło:
Progress in Health Sciences; 2017, 7(2); 36-42
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physiotherapy in women after breast cancer treatment – review
Autorzy:
Skutnik, K.
Ustymowicz, W.
Zubrewicz, K.
Zińczuk, J.
Kamińska, D.
Pryczynicz, A.
Powiązania:
https://bibliotekanauki.pl/articles/1918836.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
breast cancer
rehabilitation
mastectomy
physiotherapy
Opis:
Introduction: Breast cancer is the most common malignant tumor in women in the Polish region. Surgery is a basic method of breast cancer treatment. Surgery often carries a lot of unwanted changes as follows: limitation of mobility in the shoulder joint on the operated side, secondary lymphoedema, post mastectomy pain syndrome (PMPS), reduction of muscle strength or disorders in body posture. Therefore, the implementation of physiotherapeutic activities that are designed to prevent and eliminate postoperative complications seems very important. The main aim of this work was to present physiotherapeutic management in women after mastectomy based on the analysis of available literature. The physiotherapeutic process can be divided into three periods: early hospital, early ambulatory and the late ambulatory period. In the first period, active slow exercises, self-support of the upper limb on the operated side and breathing exercises on the thoracic track are used to prevent circulatory disorders, pulmonary complications, and edema. The early ambulatory period includes corrective exercises, general improvement exercises, stretching and learning of automatic massage of the upper limb of the operated side. The last period should be enriched by recreational methods of physical activity such as swimming, cycling or Nordic walking to maintain physical fitness, proper mobility of the shoulder girdle and improve the patient's psychophysical state. It is very important the patient regular continues the rehabilitation program after curing of breast cancer as well. In the case of secondary lymphoedema of the upper limb, comprehensive rehabilitation physiotherapy is used, consisting of manual lymphatic drainage, healing exercises, compression therapy, and skin care. Conclusions: Physiotherapy in women after breast cancer surgery is a complex and long-term process. Physiotherapeutic methods are effective in treating complications after surgery of breast cancer surgery. It is necessary to constantly update the physio-therapy knowledge in women after breast cancer surgery.
Źródło:
Progress in Health Sciences; 2019, 1; 162-168
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Spigelian hernia: a case report
Autorzy:
Martyniuk, M.
Ustymowicz, W.
Zińczuk, J.
Pryczynicz, A.
Guzińska-Ustymowicz, K.
Kędra, B.
Zaręba, K.
Powiązania:
https://bibliotekanauki.pl/articles/1918888.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Hernia
Spigelian hernia
incarcerated
Opis:
Spigelian hernias constitute a minute fraction of all abdominal hernias. In this monography, we present a case report of this relatively seldom seen phenomenon which some general surgeons never get to see during their medical career.
Źródło:
Progress in Health Sciences; 2019, 2; 53-56
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Whipple’s disease as a systemic infectious disease – a case presentation
Autorzy:
Maciorkowska, M.
Ustymowicz, W.
Zakrzewski, M.
Pryczynicz, A.
Markowski, A.
Romatowski, J.
Guzińska-Ustymowicz, K.
Powiązania:
https://bibliotekanauki.pl/articles/1918601.pdf
Data publikacji:
2018-06-21
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
infectious disease
systemic disease
Tropheryma whipplei
Whipple’s disease
Opis:
Introduction: Whipple’s disease is a chronic systemic infectious disorder with Tropheryma whipplei as an etiologic agent, occurring rarely and affecting numerous organs and systems. The variety of symptoms and a non-typical course make it difficult to establish a proper diagnosis. Purpose: In this study, etiopathogenesis, diagnostics and treatment of Whipple’s disease were presented based on the case report of 60-year-old man diagnosed with Whipple’s disease. Case presentation: Persistent diarrhoea with weight loss, lymphadenopathy in the abdominal cavity and moderate microcytic anemia predominated in the clinical picture. Diagnosis was put based on the clinical picture and macroscopic assessment of the small intestine and the presence of macrophages filled with a PAS-positive substance in the lamina propria. To deepen diagnostics, samples collected were assessed showing macrophages with the damaged mucosa, containing numerous elongated micro-organisms whose ultrastructure corresponded to Tropheryma whipplei. The patient’s clinical conditions improved after antibiotic therapy. Conclusions: It is vital to remember about Whipple’s disease in patients with chronic diseases due to a non-specific clinical picture and difficulties in establishing a proper diagnosis. When the disease is diagnosed unequivocally, proper and effective antibiotic therapy should be instituted immediately.
Źródło:
Progress in Health Sciences; 2018, 8(1); 212-218
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression of EpCAM protein in gastric cancer cells may contribute to its histogenesis
Autorzy:
Nizioł, M.
Kuczyńska, P.
Misiura, M.
Zińczuk, J.
Zaręba, K.
Ustymowicz, W.
Ćwiklińska-Dworakowska, M.
Baszun, M.
Jelski, S.
Guzińska-Ustymowicz, K.
Pryczynicz, A.
Powiązania:
https://bibliotekanauki.pl/articles/1918619.pdf
Data publikacji:
2018-06-18
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Adhesion
EpCAM
gastric cancer
Opis:
Introduction: EpCAM protein belongs to adhesion molecules of epithelial cells. It mediates in the homophile adhesion cell-cell reactions. EpCAM protein expression can be observed in the majority of healthy normal cells. However, mutations in EpCAM gene may lead to an increased risk of cancer development. The aim of the study was to assess EpCAM protein expression in the correlation with chosen clinical and histological parameters in gastric cancer. Materials and Methods: EpCAM protein expression was evaluated immunohistochemically in 88 patients diagnosed with gastric cancer. Results: An increase in EpCAM protein expression was demonstrated in cancer cells compared to normal gastric mucosa (59.3% cancers with the positive expression of EpCAM protein). The increased EpCAM protein expression was observed in patients with a histological type of adenocarcinoma without a mucinous component than in those with adenocarcinoma with a mucinous component (p=0.028). The higher expression of this protein was observed also in the intestinal type according to the Lauren classification (p=0.037). The expression of the protein was lower in the diffuse type of cancer. Additionally, an increase in EpCAM protein expression was revealed in cancers infiltrating to the blood vessels (p=0.013). Conclusions: A correlation between EpCAM expression and adenocarcinoma without a mucinous component as well as the intestinal type according to the Lauren classification may prove a role of this protein in the histogenesis of gastric cancer. Moreover, its positive expression is related to cancerous cells infiltrating to the blood vessels, which may suggest a role of EpCAM protein in the early stages of gastric cancer metastases.
Źródło:
Progress in Health Sciences; 2018, 8(1); 74-79
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Significance of mucin expression in pancreatic intraepithelial neoplasia (PanIN) – precursor lesions of pancreatic ductal adenocarcinoma (PDAC)
Autorzy:
Zińczuk, J.
Zaręba, K.
Pryczynicz, A.
Kuczyńska, P.
Boroń, Z.
Ustymowicz, W.
Maciorkowska, M.
Ćwiklińska-Dworakowska, M.
Baszun, M.
Jelski, S.
Guzińska-Ustymowicz, K.
Powiązania:
https://bibliotekanauki.pl/articles/1918638.pdf
Data publikacji:
2018-06-18
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Mucin
immunohistochemistry
pancreatic intraepithelial neoplasia
PanIN
Opis:
Purpose: To evaluate chosen mucins (mucin 1, 4, 5AC) expression in pancreatic intraepithelial neoplasia, which is a precursor lesion of pancreatic ductal adenocarcinoma. Materials and methods: The study group included 70 patients operated on due to inflammation, cysts and pancreatic ductal adenocarcinoma with pancreatic intraepithelial neoplasia revealed additionally. Mucin 1, 4 and 5AC expression was assessed by immunohistochemical method using polyclonal antibodies. Results: Statistical analysis proved a positive correlation between the expression of mucin 1, 4 and 5AC proteins and the presence and staging of pancreatic intraepithelial neoplasia (p<0.001). Statistically significant correlations were determined between mucin 1, 4 and 5AC and the location of PanIN lesion in the pancreas. Positive correlations were found between mucin 5AC expression and the type of a basic disease (p=0.014). Differences in the expression of MUC 1, 4 and 5AC proteins between healthy pancreatic ducts and various stages of pancreatic intraepithelial neoplasia were statistically significant (p<0.001). Conclusions: Overexpression of mucin 1, 4 and 5AC is related to the presence of pancreatic intraepithelial neoplasia. This suggests that overproduction of mucus is a phenomenon occurring early in the process of carcinogenesis in the pancreas and has its beginning in precancerous lesions of an early stage.
Źródło:
Progress in Health Sciences; 2018, 8(1); 63-73
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The expression of apoptosis-related proteins in patients with ulcerative colitis
Autorzy:
Niewiarowska, K.
Lebelt, A.
Gryko, M.
Pryczynicz, A.
Famulski, W.
Czyżewska, J.
Kemona, A.
Piekarska-Dymicka, V.
Jagodzińska, D.
Guzińska-Ustymowicz, K.
Powiązania:
https://bibliotekanauki.pl/articles/1916338.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Ulcerative colitis
Bcl-xl
Bax
Bid
Bcl-2
Opis:
Purpose: Recent literature data indicate a key role of apoptosis in the pathogenesis of inflammatory bowel disease. The aim of the study was to evaluate the expression of Bax, Bid, Bcl-2 and Bcl-xl in non-dysplastic and dysplastic epithelium in inflamated mucosa of patients with ulcerative colitis. Methods: The study consists of 18 patients with diagnosed ulcerative colitis. The expression of proteins was determined immunohistochemically. Results: Lack of Bax expression in normal epithelium of the inflamed intestinal mucosa (94.4%) and a weak expression of this protein were found in dysplastic glandular cells (67%). The Bax expression of dysplastic epithelium correlates with reduced severity of chronic inflammation (p<0.005). Bid expression in non-dysplastic glands was found in 67% of cases vs. 16% in dysplastic epithelium that was associated with the occurrence of epithelial erosions or ulcers (p<0.05). Moderate cytoplasmic expression of Bcl-xl was noted in 27.7% of patients in normal epithelium and in 66.1% within dysplastic lesions. Bcl-xl expression in dysplastic glandular cells correlated with the presence of neutrophils in the lamina propria (p <0.05). Conclusions: The immunohistochemical expressions of Bax, Bcl-2 and Bcl-xl increase and Bid protein expression decreases in dysplastic glandular tubes as compared to non-dysplastic intestinal epithelium in inflamed mucosa, which may suggest an imbalance of controlled cell death in ulcerative colitis.
Źródło:
Progress in Health Sciences; 2014, 4, 1; 75-82
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lead content in cereal products as a population health threat marker: a case study in the province of Podlasie
Zawartość ołowiu w produktach zbożowych jako marker narażenia zdrowotnego populacji na przykładzie województwa podlaskiego
Autorzy:
Filon, J.
Ustymowicz-Farbiszewska, J.
Karczewski, J.
Powiązania:
https://bibliotekanauki.pl/articles/15461.pdf
Data publikacji:
2013
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Opis:
Heavy metals, which are considered basic industrial and environmental pollutants, pose a threat to the human health if found in food products even in trace amounts. Lead may cause such conditions as functional disorders of the kidneys, liver or the circulatory system. It can also impede the biosynthesis of heme and cause disturbances in the metabo- lism of vitamin D and the following microelements: Fe, Cu, Zn Se and Ca. The aim of the study was to assess the health threat and estimate risks from the presence of Pb in cereal products available in retail shops in the Province of Podlasie. The material consisted of samples of cereal products (flour, groats, bakery products, pasta and rice) taken at random from retail shops in Podlasie in 2004-2005 and 2010-2011. The lead concentration was estimated by using the atomic absorption spectrometry method (AAS). The content of Pb was analyzed depending on a product type and sampling period; the health threat was assessed with reference to the current Polish requirements. The results were statistically analyzed using Statistica 7.1 software, Duncan?s test and Wilcoxon test. The results revealed that the average content of Pb in the examined cereal products did not exceed the norms. During the analyzed period, a decrease in the Pb concentration in cereals was found. This may indicate an improvement in the quality of the environ- ment, which can be measured by the content of Pb in cereal products. At the same time, owing to the significant role of cereal products in human nutrition, the lead content may also serve as a marker of health exposure.
Źródło:
Journal of Elementology; 2013, 18, 3
1644-2296
Pojawia się w:
Journal of Elementology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zjadliwość szczepów Trichomonas vaginalis w zależności od postaci klinicznej rzęsistkowicy
Virulence of Trichomonas vaginalis strains according to clinical form of trichomonosis
Autorzy:
Malyszko, E.
Januszko, T.
Smorczewska-Czuprynska, B.
Ustymowicz-Farbiszewska, J.
Powiązania:
https://bibliotekanauki.pl/articles/839181.pdf
Data publikacji:
1991
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parazytologia
choroby pasozytnicze
pasozyty
rzesistek pochwowy
Trichomonas vaginalis
szczepy chorobotworcze
zjadliwosc
rzesistkowica
postac kliniczna
Opis:
Estimation of virulence of T. vaginalis strains injected subcutaneously to mice was done. T. vaginalis strains were obtained from the urinogenital tracts of patients with different clinical forms of trichomonosis. The virulence of T. vaginalis strains measured by infiltration size was found to depend upon a clinical form of trichomonosis. It was moreover shown that the cutaneous infiltration size is proportional to a dose of Trichomonas administered subcutaneously. Histopathological analysis of cutaneous infiltration itself is not decisive as to the strains virulence, yet in addition to macroscopic examination it may be a criterium in the studies on strain pathogenicity.
Źródło:
Annals of Parasitology; 1991, 37, 2
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zjadliwość szczepów Trichomonas vaginalis w zależności od postaci klinicznej rzęsistkowicy
Virulence of Trichomonas vaginalis strains according to clinical form of trichomonosis
Autorzy:
Małyszko, E.
Januszko, T.
Smorczewska-Czupryńska, B.
Ustymowicz-Farbiszewska, J.
Powiązania:
https://bibliotekanauki.pl/articles/2152362.pdf
Data publikacji:
1991
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parazytologia
choroby pasozytnicze
pasozyty
rzesistek pochwowy
Trichomonas vaginalis
szczepy chorobotworcze
zjadliwosc
rzesistkowica
postac kliniczna
Opis:
Estimation of virulence of T. vaginalis strains injected subcutaneously to mice was done. T. vaginalis strains were obtained from the urinogenital tracts of patients with different clinical forms of trichomonosis. The virulence of T. vaginalis strains measured by infiltration size was found to depend upon a clinical form of trichomonosis. It was moreover shown that the cutaneous infiltration size is proportional to a dose of Trichomonas administered subcutaneously. Histopathological analysis of cutaneous infiltration itself is not decisive as to the strains virulence, yet in addition to macroscopic examination it may be a criterium in the studies on strain pathogenicity.
Źródło:
Wiadomości Parazytologiczne; 1991, 37, 2; 219-223
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Przydatność frakcji polisacharydowej i glikoproteidowej Trichomonas vaginalis w serodiagnostyce rzęsistkowicy
Usefulness of polysaccharide and glycoprotein fraction of Trichomonas vaginalis in serodiagnosis of trichomonosis
Autorzy:
Malyszko, E.
Januszko, T.
Ustymowicz-Farbiszewska, J.
Czapska, D.
Powiązania:
https://bibliotekanauki.pl/articles/838015.pdf
Data publikacji:
1991
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parazytologia lekarska
rzesistek pochwowy
Trichomonas vaginalis
frakcje biologicznie aktywne
polisacharydy
glikoproteidy
przydatnosc
diagnostyka serologiczna
rzesistkowica pochwy
Opis:
It has been shown that glycoprotein and polysaccharide fractions obtained from T. vaginalis cells can be employed as antigens in serodiagnosis of trichomonosis. This refers especially to the polysaccharide fraction because of its easy availability, solubility in aqueous solutions, high diagnostic specificity and sensitivity. It has been stated that the diagnostic value of polysaccharide antigen of T. vaginalis, in occult trichomonosis in men particularly, is higher than the effect of the secretion examination by means of culture, even after the prostatic gland massage.
Źródło:
Annals of Parasitology; 1991, 37, 2
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Przydatność frakcji polisacharydowej i glikoproteidowej Trichomonas vaginalis w serodiagnostyce rzęsistkowicy
Usefulness of polysaccharide and glycoprotein fraction of Trichomonas vaginalis in serodiagnosis of trichomonosis
Autorzy:
Małyszko, E.
Januszko, T.
Ustymowicz-Farbiszewska, J.
Czapska, D.
Powiązania:
https://bibliotekanauki.pl/articles/2152354.pdf
Data publikacji:
1991
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parazytologia lekarska
rzesistek pochwowy
Trichomonas vaginalis
frakcje biologicznie aktywne
polisacharydy
glikoproteidy
przydatnosc
diagnostyka serologiczna
rzesistkowica pochwy
Opis:
It has been shown that glycoprotein and polysaccharide fractions obtained from T. vaginalis cells can be employed as antigens in serodiagnosis of trichomonosis. This refers especially to the polysaccharide fraction because of its easy availability, solubility in aqueous solutions, high diagnostic specificity and sensitivity. It has been stated that the diagnostic value of polysaccharide antigen of T. vaginalis, in occult trichomonosis in men particularly, is higher than the effect of the secretion examination by means of culture, even after the prostatic gland massage.
Źródło:
Wiadomości Parazytologiczne; 1991, 37, 2; 225-233
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-13 z 13

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