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    Wyświetlanie 1-11 z 11
    Tytuł:
    Selected factors of fibrinolysis in the Buerger’s disease
    Autorzy:
    Terlecki, Piotr
    Feldo, Marcin
    Przywara, Stanisław
    Iłżecki, Marek
    Kęsik, Jan J.
    Borowski, Grzegorz
    Wroński, Jacek
    Zubilewicz, Tomasz
    Powiązania:
    https://bibliotekanauki.pl/articles/1396478.pdf
    Data publikacji:
    2013-11-01
    Wydawca:
    Index Copernicus International
    Tematy:
    Buerger’s disease
    fibrinolysis
    Opis:
    Thrombangiitis obliterans (TAO marked by coexistence of thrombotic and inflammatory changes of neurovascular tract has evoked a considerable dispute concerning pathogenesis of this disease. The aim of the study was to define the level of activation of fibirinolitic system in course of TAO disease by means of determination its basic constituents as well as to examine the essence of level of fibrinolysis disorders in pathogenesis and development of this disease. Material and methods. Fifty patients with thrombangiitis obliterans (TAO), 30 patients with peripheral occlusive disease - PAOD (ASO) and 20 healthy volunteers (K) have been subjected to the examination. We determined the activity some factors of fibrinolysis: t-PA, PAI-1, PAP, plasminogen, α2-antiplasminogen, D-dimmer as well as euglobulin lysis time. The analysis comprised 7 features and 8 factors of variability: a membership to a group of patients, sex, age, smoking, aggravation of the disease within last 3 months, occurrence of Raynaud’s symptom, a degree of ischemia according to Fontaine, time the disease lasted. Results. The significant differences between the average were checked by means of t-Student test or variance analysis (ANOVA) and co-relation rate r (Pearson). We concluded that the average value of PAI-1 in the group TAO was significantly higher than in comparison with ASO group. The increased values were revealed in case of 76 % of patients. The euglobulin lysis time was vitally extended in case of 60% of patients in ASO group. In all three groups higher levels of α2-antiplasmin were detected in case of elderly patients compared to the younger ones. Conclusions. The obtained results allow us to ascertain the state of potentially weakened fibrinolysis in case of patients with Buerger’s disease as well as with PAOD.
    Źródło:
    Polish Journal of Surgery; 2013, 85, 11; 630-637
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    New Method of Forced Implantation of Permanent Catheters for Hemodialysis into Critically Stenosed or Occluded Central Veins
    Autorzy:
    Przywara, Stanisław
    Iłżecki, Marek
    Terlecki, Piotr
    Zubilewicz, Tomasz
    Powiązania:
    https://bibliotekanauki.pl/articles/1395845.pdf
    Data publikacji:
    2014-12-18
    Wydawca:
    Index Copernicus International
    Tematy:
    vascular access for hemodialysis
    permanent catheters for hemodialysis
    central venous occlusive disease
    Opis:
    The aim of the study was to report a novel technique of forced implantation of catheters for hemodialysis into critically stenosed or occluded central veins, without preceding angioplasty or stenting. Material and methods. Sixteen patients with central venous occlusive disease, requiring urgent hemodialysis underwent this procedure. Catheterization of stenosis - occlusion was initially performed with soft guidewire, subsequently exchanged to stiff guidewire. Forced insertion of dilators, peel-off sheath throughout the stenosis or occlusion and finally implantation of the catheter completed the procedure. Our technique does not require pre-procedural angioplasty or stent deployment. Results. In all patients postoperative hemodialysis was managed with satisfactory adequacy. No early or late complications related to the procedure occurred. We did not observe any clinically significant aggravation of symptoms of central vein stenosis or occlusion. Complications, not-related to the procedure included one, late skin entry site infection and one, late catheter thrombosis. These were managed without the necessity of catheter exchange. Conclusions. Our technique of forced implantation of catheters for hemodialysis into critically stenosed or occluded central veins without previous balloon predilatation or stenting is simple and diminishes the total cost of the procedure. Provides quick vascular access for hemodialysis in life threatening situations.
    Źródło:
    Polish Journal of Surgery; 2014, 86, 9; 405-409
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparison of effectiveness of electrocautery and phenol application in partial matricectomy after partial nail extraction in the treatment of ingrown nails
    Autorzy:
    Misiak, Piotr
    Terlecki, Artur
    Rzepkowska -Misiak, Beata
    Wcisło, Szymon
    Brocki, Marian
    Powiązania:
    https://bibliotekanauki.pl/articles/1395707.pdf
    Data publikacji:
    2014-02-01
    Wydawca:
    Index Copernicus International
    Tematy:
    ingrowing toenail
    phenolapplication
    electrocoagulation
    Opis:
    Ingrowing nail also known as onychocryptosis is a common health problem. This disease mostly affects young people, often carrying a considerable amount of socio-economic implications. It’s foot problem that usually manifests as inflammation of tissue along the side of a toenail. The aim of the study was to asses and to compare effectiveness of electrocautery and phenol application in partial matrixectomy after partial nail extraction in the treatment of ingrown toenails. Material and methods. The group of 60 patients with ingrowing toenail which was randomized into two groups underwent partial matrixectomy in surgical outpatient clinic between 2009-2013. This group of patients was under surgical observation for 100 days in outpatient clinic. Results. In all operated patients we obtained surgical success however we had 13 recurrences during the follow up period, 5 in the phenolization group and 8 in the electrocoagulation group. Conclusions. There was statistically significant difference between these two techniques, which indicated that matrix phenolization is connected with shortened healing time vs the matrix electrocoagulation.
    Źródło:
    Polish Journal of Surgery; 2014, 86, 2; 89-93
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of patient feedback following laparoscopic cholecystectomy based on information described in the informed consent form developed by the Association of Polish Sur
    Autorzy:
    Misiak, Piotr
    Jabłoński, Sławomir
    Lazarek, Jerry
    Malinowska, Katarzyna
    Santorek-Strumiłło, Edyta
    Terlecki, Artur
    Powiązania:
    https://bibliotekanauki.pl/articles/1394302.pdf
    Data publikacji:
    2015
    Wydawca:
    Index Copernicus International
    Tematy:
    laparoscopic cholecystectomy
    informed consent
    Opis:
    The cholecystectomy procedure is the most routinely performed intervention in general surgery. The current international gold standard is via the laparoscopic approach. It is a safe, minimally-invasive procedure; however, it is associated with complications in 1% of cases. The aim of the study was to analyze patient feedback, by means of a survey, to determine how much knowledge patients possessed about their disease state and proposed surgical intervention, based primarily on information contained within the informed consent form developed by the Association of Polish Surgeons. Material and methods. This study involved the participation of 51 patients who underwent laparoscopic cholecystectomy, indicated by a diagnosis of gallstones, in the years 2014 and 2015. Results. Despite having signed the informed consent form, there was considerable variation among the responses given to the survey by the 51 patients in this study. Some patients’ responses were tangential to the questions asked; many patients did not respond to any of the sub points. Conclusions. Given that this study is based on a small sample size of patients, it must be presumed that the process by which the patient declares his or her informed consent requires further consideration with respect to the means by which it is obtained. The authors of this study thus recommend that multimedia resources be harnessed as part of the process of obtaining the informed consent of patients prior to surgical intervention.
    Źródło:
    Polish Journal of Surgery; 2015, 87, 11; 558-564
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Oesophageal perforation – therapeutic and diagnostics challenge. Retrospective, single-center case report analysis (2009–2015)
    Autorzy:
    Misiak, Piotr
    Jabłoński, Sławomir
    Piskorz, Łukasz
    Dorożała, Lechosław
    Terlecki, Artur
    Wcisło, Szymon
    Powiązania:
    https://bibliotekanauki.pl/articles/1393027.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    esophageal perforation
    diagnosis
    treatment
    Opis:
    Background: Esophageal perforation is a life-threatening condition of a complex etiology. No clear guidelines are available regarding the management of this condition. In this study, we review publications related to esophageal perforation, and analyze patients treated for this condition at our Department of Thoracic, General and Oncological Surgery. Objective: The objective of the study was to retrospectively assess and analyze management methods for esophageal perforations of different etiologies. All patients were treated in the Department of Thoracic, General and Oncological Surgery in years 2009-2015. Patients with perforations resulting from post-operational leaks within surgical anastomoses were excluded from the study. Material, methods, results: The analysis involved a total of 16 cases of esophageal ruptures. All cases were treated in years 2009-2015. Patients with perforations resulting from postoperative leaks within surgical anastomoses following elective surgeries for either oncological or non-oncological causes were excluded. The most common reason for esophageal rupture was iatrogenic injury (7 cases, 44%). Other causes included Boerhaave syndrome (5 cases, 31.2%), blunt trauma (2 cases, 12.5%), abscess perforation (1 case, 6.2%), and ulcer perforation (1 case, 6.2%). Ten patients underwent surgery, and the rest underwent esophageal prosthesis placement, of whom 2 cases required drainage of the mediastinum and pleural cavity. The mortality rate in the study group was 9/16 cases (56.2%). Conclusions: Esophageal perforation poses a significant interdisciplinary challenge regarding diagnostic workup, selection of treatment methods, and management of potential postoperative complications. This retrospective study was conducted in a single center. Although the analyzed period was long, we found only 16 cases. In spite of a variety of etiologies present, we found several statistically significant results of potential clinical value. 1. Most perforations that are not diagnosed within 48 hours affected the lower part of the esophagus and presented with unclear symptoms and imaging findings 2. Delaying diagnosis and treatment beyond 24 hours was associated with a higher mortality rate.
    Źródło:
    Polish Journal of Surgery; 2017, 89, 4; 1-4
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Perforacja przełyku – wyzwanie diagnostyczne i terapeutyczne. Jednoośrodkowa retrospektywna analiza przypadków z lat 2009–2015
    Autorzy:
    Misiak, Piotr
    Jabłoński, Sławomir
    Piskorz, Łukasz
    Dorożała, Lechosław
    Terlecki, Artur
    Wcisło, Szymon
    Powiązania:
    https://bibliotekanauki.pl/articles/1393059.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    perforacja przełyku
    diagnostyka
    leczenie
    Opis:
    Wstęp: Perforacja przełyku jest stanem bezpośrednio zagrażającym życiu pacjenta. Ten stan chorobowy charakteryzuje się złożoną etiologią oraz brakiem wytycznych co do standardów postępowania. Poniższa praca stanowi analizę przypadków leczonych w Klinice Chirurgii Klatki Piersiowej, Chirurgii Ogólnej i Onkologicznej oraz przegląd piśmiennictwa międzynarodowego dotyczącego tego zagadnienia. Cel badania: Celem badania była retrospektywna ocena i analiza postępowania u pacjentów z perforacją przełyku o zróżnicowanej etiologii, leczonych w Klinice Chirurgii Klatki Piersiowej, Chirurgii Ogólnej i Onkologicznej w latach 2009–2015. Z badania wyłączono grupę pacjentów, u których przyczyną perforacji była pooperacyjna nieszczelność w obrębie wykonanego zespolenia chirurgicznego. Materiał: Analizie poddano 16 przypadków perforacji przełyku, które były leczone w klinice w latach 2009–2016. Z analizy wykluczono przypadki nieszczelności chirurgicznych zespoleń u pacjentów poddanych planowym procedurom chirurgicznym zarówno z przyczyn nowotworowych, jak i nienowotworowych. Najczęstszą przyczyną perforacji były powikłania o charakterze jatrogennym (7 pacjentów; 44%), kolejną przyczyną był zespół Boerhaavego (5 pacjentów; 31,2%), perforacja w wyniku urazu tępego (2 pacjentów; 12,5%), perforacja w owrzodzeniu oraz perforacja w obrębie guza (po 1 pacjencie). Dziesięciu chorych leczono operacyjnie, 6 pacjentów poddano pierwotnemu protezowaniu przełyku – w tym w 2 przypadkach zastosowano drenaż śródpiersia i jamy opłucnej. W powyższej grupie chorych doszło do 9 zgonów (56,2%). Wnioski: Leczenie perforacji przełyku stanowi wyzwanie dla całego zespołu terapeutycznego. Począwszy od etapu diagnostyki, poprzez wybór metody leczenia pierwotnego, a następnie leczenie ewentualnych komplikacji. Badanie dotyczyło jednego ośrodka i pomimo szerokich ram czasowych retrospektywnie oceniono jedynie 16 przypadków. Pomimo niejednorodnej pod względem etiologii grupy, udało się uzyskać kilka istotności statystycznych niosących za sobą implikacje kliniczne. Większość rozpoznanych perforacji w czasie powyżej 48 godzin dotyczyła dolnego odcinka przełyku (częstsze ryzyko przeoczenia choroby w tym odcinku ze względu na niejasny obraz chorobowy i wyniki badań obrazowych). Rozpoznanie choroby i wdrożenie leczenia po 24 godzinach w naszym materiale wiązało się z wyższym odsetkiem zgonów.
    Źródło:
    Polish Journal of Surgery; 2017, 89, 4; 1-4
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The changes of plasma thrombin-antithrombin complex in the patients with peripheral arterial disease undergoing surgical revascularization
    Autorzy:
    Kęsik, Jan Jakub
    Wroński, Jacek
    Feldo, Marcin
    Terlecki, Piotr
    Zubilewicz, Tomasz
    Powiązania:
    https://bibliotekanauki.pl/articles/1396484.pdf
    Data publikacji:
    2013-11-01
    Wydawca:
    Index Copernicus International
    Tematy:
    thrombin-antithrombin complex (TAT)
    revascularization
    coagulation
    limb ischemia
    Opis:
    In patients with severe lower limb ischemia the coagulation and fibrinolytic systems have been found to be activated preoperatively. The aim of the study was to evaluate the changes of TAT level as a selected coagulation factor, before, during and after surgical revascularization and the analysis of the impact of coexisting diseases on the coagulation during the procedure. Material and methods. 50 patients with PAOD, in Fontaine stages IIb to IV (29 men and 21 women; median age 65.8 years, ASA II/III) undergoing elective surgical revascularization were studied. Two groups of patients were compared: 20 undergoing reconstruction on aorto-femoral and 30 on femoropopliteal level. Blood samples were collected 5 times: 24 hours before the operation; intraoperatively after artery exposure; after heparin administration and clamping; after reperfusion and -24 hours postoperatively. Results. Elevated values of TAT (10.5 g/l ±7.1) were found before the operation. The elevated value of TAT increased intraoperatively (25.1 g/l ±44.58; p<0.001) (norm 1-4.1 g/l) and maintaining higher levels after the surgery. The significant correlations between plasma level of TAT and ischemia degree were found. Also the correlation between intraoperative increase of TAT and the duration of surgery was noticed. No significant differences between two analysed groups were observed. Conclusions. The results indicate the activation of coagulation and prothrombotic state in the patients with advanced arteriosclerosis. During the surgical revascularisation permanent increase of activation of blood coagulation was observed. This activation depends on duration of the procedure and maintains increased one-day after the operation. Our findings may explain the unexpected occurrence of early thrombotic complications after technically successful vascular reconstructions.
    Źródło:
    Polish Journal of Surgery; 2013, 85, 11; 638-643
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Efficacy Evaluation Of Bio Trombina ® 400 In Mini Mall Y Invasive Treatment of Complications (Pseudoaneurysms), After Venipuncture for Diagnostic Purposes. Authors’ Own Experience – Case Study of 38 Patients
    Autorzy:
    Iłżecki, Marek
    Zubilewicz, Tomasz
    Przywara, Stanisław
    Wojtak, Andrzej
    Kęsik, Jan Jakub
    Olejniczak-Nowakowska, Małgorzata
    Terlecki, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1395774.pdf
    Data publikacji:
    2014-08-01
    Wydawca:
    Index Copernicus International
    Tematy:
    embolization
    pseudoaneurysm
    trombin
    Opis:
    Common use of venipuncture on upper and lower limbs for diagnostic purposes (such as coronarography or arteriography), and also during the course of treatment (angioplasty), very often bares a complication in the form of pseudoaneurysms. According to various reports, the incidence of pseudoaneurysms ranges from 0.005% to 0.5% of all vascular procedures requiring arterial cannulation (Common Femoral Artery, Brachial Artery, Radial Artery). The use of Bio Trombina® 400 in the embolization of pseudoaneurysms allows minimally invasive and effective treatment. The aim of the study was to evaluate the efficacy of pseudoaneurysm embolization with the use of Trombina 400, authors’ own experience. Material and methods. In the years 2011 - 2013, the authors of this study performed 38 vascular interventional procedures involving pseudoaneurysms as complications of venipuncture in upper and lower limbs for diagnostic and treatment purposes. All procedures involved the direct injection of thrombin into the chamber of the pseudoaneurysm under the guidance of USG Doppler (6.2 MHz linear head). 34 cases presented single chamber pseudoaneurysms while 4 cases involved multi- chamber pseudoaneurysms, which required several thrombin reinjections (Bio Trombina® 400) into each of the chambers. Pseudoaneurysm maximum size of 4 cm was set as an inclusion criterion for the embolization procedure. Furthermore, all pseudoaneurysms with a significantly wide tract in transverse dimensions were treated as an exclusion criterion because of high risk of the peripheral arteries embolization. Results. Initial success was observed in 36 patients (94.73%) in the first day after the procedure, 1 patient (2.63%) underwent thrombin reinjection procedure in the second day after the first embolization. Another patient (2.63%) underwent an open procedure in which the Common Femoral Artery was accessed, the clot evacuated, and CFA was sutured with continuous suture Prolene 6-0. Conclusions. 1. Embolization of pseudoaneurysms with USG Doppler-guided thrombin injection is an effective course of treatment for complications of cannulation. 2. The safety of pseudoaneurysm embolization depends on a surgeon’s experience. It is also crucial to keep in mind the inclusion and exclusion criteria for this type of procedure (the size of a pseudoaneurysm, the width of its base). 3. Furthermore, its cost effectiveness and short hospitalization period make pseudoaneurysm embolization an effective and valuable alternative to the classic approach.
    Źródło:
    Polish Journal of Surgery; 2014, 86, 8; 359-363
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Percutaneous Endovascular Abdominal Aortic Aneurysm Repair Within the Infrarenal Region. Preliminary Report
    Autorzy:
    Iłżecki, Marek
    Zubilewicz, Tomasz
    Terlecki, Piotr
    Przywara, Stanisław
    Powiązania:
    https://bibliotekanauki.pl/articles/1396436.pdf
    Data publikacji:
    2013-10-01
    Wydawca:
    Index Copernicus International
    Tematy:
    ProStar XL
    aneurysm
    PEVAR
    infrarenal
    Opis:
    The aim of the study was to thoroughly evaluate the closure device ProStar XL in terms of its efficiency and safety in the percutaneous endovascular treatment of abdominal aortic aneurysms in the infrarenal section of the body. Additionally, it was crucial to assess if there were any occurrences of regional complications at any step of the procedure. It was also important to stipulate the estimated hospitalization period as well as the overall cost of the PEVAR treatment with the use of ProStar XL. Material and methods. The analysis included 21 cases with PEVAR performed in the infrarenal region. The final success was achieved in 98.2% of the cases. One PEVAR case (that constituted 0.2% of this group) was unsuccessful because of the bleeding while the placement of the sutures with the use of ProStar XL was being performed. Results. This resulted in the emergency treatment of the CFA with the continuous stitch (Prolene 5-0). During the postoperative period the above described patient was given 2 units of the Packed Red Blood Cells (PRBC). However, this complication (unexpected bleeding) did not influence the length of the hospitalization period in any significant way. Conclusions. Percutaneous vascular closure device ProStar XL used in the treatment of the common femoral artery (CFA) constitutes a necessary and safe supplement for Endovascular Aortic Aneurysm Repair (EVAR). The implementation of ProStar XL closure device proves to significantly shorten the hospitalization period after the EVAR treatment. Additionally, the safety of the entire procedure is exponentially linked to the experience of the operating surgeon.
    Źródło:
    Polish Journal of Surgery; 2013, 85, 10; 563-568
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The evaluation of the effectiveness of Tachosil in the treatment of lymphorrhea of the postoperative wound in the selected group of patients, after vascular reconstructive surgeries – preliminary report
    Autorzy:
    Iłżecki, Marek
    Zubilewicz, Tomasz
    Przywara, Stanisław
    Terlecki, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1396515.pdf
    Data publikacji:
    2013-12-01
    Wydawca:
    Index Copernicus International
    Tematy:
    lymphorrehea
    Tachosil
    drainage
    Opis:
    Lymphorrhea of a postoperative wound after vascular reconstructive surgeries does not occur frequently but it accounts for a major complication. It should be brought to attention that during the intraoperative period it is impossible to diagnose any damages within the lymphatic system of the operated area. Additionally, the treatment of lymphorrheawith thermal abrasion does not usually bring the desired outcome. Therefore, the extended time of the postoperative wound treatment with the lymphatic drainage constitutes a standard method in such cases. The aim of the study was to evaluate the effectiveness of Tachosil surgical patch in the treatment of lymphorrhea of the postoperative wound in a selected group of patients who have undergone vascular reconstructive surgeries. Additionally, the aim of the study was to analyze the results and draw conclusions pertaining to the validity and effectiveness of the treatment with the use of Tachosil surgical patch. Material and methods. The observed group included 10 patients with lymphorrhea developed during the postoperative period. 6 of the observed patients have undergone the vascular reconstructive surgery with the implantation of the vascular prosthesis (distal femoropopliteal reconstruction bridge - 3 patients; iliofemoral reconstruction bridge - 1 patient; angioplasty of the common femoral artery (CFA) with the use of the prosthetic patch - 1 patient; the implantation of the bifurcated (type Y) aortofemoral prosthesis - 1 patient). The remaining patients in the observed group have undergone the restoration of patency of the CFA. Additionally, 1 patient has undergone the resection of the pseudo aneurysm in the distal part of the iliofemoral prosthesis. The vascular reconstructive surgery required the denudation and isolation of the common femoral artery from the surrounding tissue as a step 1. The persisting lymphorrhea of the postoperative wound, in the volume of more than 200 ml per day during the first 3 postoperative days, indicated the necessity for the inguinal wound revision. In addition, Tachosil surgical patch was applied at that time. The drain was placed over Tachosil patch. Results. Complete stop of lymphorrhea was shorter by 4.87 days in patients treated with the use of Tachosil in comparison to control group. These patients also had an average hospitalization time shorter by 3.88 days than patients in the control group. Conclusions. Early intervention in the cases of lymphorrhea of the postoperative wound allows planning and conducting successful treatment. The use of Tachosil surgical patch in the treatment of lymphorrhea of the postoperative wound shortens the treatment and hospitalization periods. The use of Tachosil in the treatment of postoperative lymphorrhea appeared to be significantly more effective than the standard drainage method of treatment. Results obtained through this study pave the way for the research on other possible applications of Tachosil in the cases of lymphorrhea after vascular reconstructive surgeries.
    Źródło:
    Polish Journal of Surgery; 2013, 85, 12; 687-692
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    CIDE-A gene expression in patients with abdominal obesity and LDL hyperlipoproteinemia qualified for surgical revascularization in chronic limb ischemia
    Autorzy:
    Feldo, Marcin
    Kocki, Janusz
    Łukasik, Sylwia
    Bogucki, Jacek
    Feldo, Jan
    Terlecki, Piotr
    Kęsik, Jan
    Wroński, Jacek
    Zubilewicz, Tomasz
    Powiązania:
    https://bibliotekanauki.pl/articles/1396483.pdf
    Data publikacji:
    2013-11-01
    Wydawca:
    Index Copernicus International
    Tematy:
    CIDE-A gene
    obesity
    femoro-popliteal revascularisation
    dyslipidemia
    Opis:
    According to the latest data, CIDE -A gene plays a key role in the regulation of body weight in both humans and mice, and therefore it is regarded a potential candidate gene for human obesity. The aim of the study was to define the role of CIDEA gene in patients with dyslipidemia and symptomatic limb ischemia. Material and methods. The study group contained 28 patients, including 17 men and 11 women. Patients were enrolled in the study group, depending on the value of body mass index (BMI); there was BMI>30 for obese patients. The group included untreated patients (n=14) and patients (n=14) receiving atorvastatin 20 mg/day for at least three months prior to the initiation of the study. The control group (n=16) contained patients with no lipid disorders. A one-step isolation of RNA from lymphocytes and adipose tissue cells was carried out using the TRI method modified by Chomczyński and Sacchi. Next, gene expression was tested using real-time PCR. Results. The highest mean relative expression of CIDE -A gene occurred in patients with normal body weight. The lowest mean relative expression of CIDE-A gene was observed in obese patients with lipid disorders. A high negative correlation (r=-0.7919) of CIDE -A gene expression, depending on BMI, was reported in the group of obese patients with lipid disorders. Conclusions. Due to an important role of Cide-A protein demonstrated in the development of metabolic diseases such as obesity, metabolic syndrome, type 2 diabetes and their vascular complications, CIDE -A gene and protein are potential therapeutic targets in the case of these diseases.
    Źródło:
    Polish Journal of Surgery; 2013, 85, 11; 644-648
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-11 z 11

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