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Tytuł:
Stem cells: applications, perspectives, misunderstandings
Autorzy:
Dulak, Józef
Powiązania:
https://bibliotekanauki.pl/articles/704245.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
stem cells
cellular therapies
gene therapy
embryonic stem cells
induced pluripotent stem cells
Opis:
Stem cells exist and can do a lot. For several decades, bone marrow and umbilical cord blood transplants containing haematopoietic stem cells have been used in the treatment of blood diseases. Genetic modifications (gene therapy) of such cells help to cure complex immunodeficiencies and severe anaemias. The limbal stem cells taken from the eye and properly multiplied can regenerate the damaged cornea, and the epidermal stem cells help in the treatment of severe burns and some hereditary, severe skin diseases. Promising experimental research is under way on other uses of stem cells. However, these cells are appropriately selected, having real ability to differentiate into specialized cells whose malfunction is the cause of the disease. Therapeutic applications of stem cells are apparently limited to date. Meanwhile, the Internet is full of advertisements for supposedly miraculous treatments for almost any disease. Stem cells have become a modern synonym of the Holy Grail. A wonderful dish, transforming every drink into elixir of health, youth and long life. Stem cells from a single source, e.g., umbilical cord blood, or so-called cells, although without proven properties of stem cells, are offered in commercial private clinics as a panacea for autism, cerebral palsy, spina bifida, eye diseases, amyotrophic lateral sclerosis and dozens other disorders. Without justification for their action in these diseases, without convincing evidence of safety, but for a high fee. This article discusses stem cells and misunderstandings about including any cells among them. It draws attention to the real possibilities and confirmed uses of stem cells and presents the problems, doubts and dangers for patients associated with commercial offers of treatments using “stem” cells. The author cites the positions of scientific institutions and societies warning against premature commercialization of unjustified and potentially dangerous therapies
Źródło:
Nauka; 2020, 1
1231-8515
Pojawia się w:
Nauka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stem cells - a new rescue in cardiology?
Autorzy:
Leśniewska, Julia
Gawryś, Jakub
Gawryś, Karolina
Pawelak, Agnieszka
Mikołajczyk, Mikołaj
Powiązania:
https://bibliotekanauki.pl/articles/1178231.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
heart failure
myocardial infarction
stable angina
stem cells
Opis:
In recent years stem cells have become the object of curiosity for many researchers and clinicians. Interest in the use of these cells is an effect of their specific properties. Their great potential for self-renewal as well as the ability to differentiate into specific cell types is particularly interesting. These unique features allow us to think about stem cells as a possible therapeutic solution in the treatment of damaged tissues. The tissue that is particularly vulnerable to damage is heart muscle, which consists of cardiomyocytes. These cells are extremely vulnerable to lack of the oxygen, what can be observed in the case of temporary cardiac ischemia, e.g. during physical exertion or in stressful situations, which initially manifests as stable angina. Prolonged ischemia and consequent hypoxia of cardiomyocytes lead to their death what is manifested as myocardial infarction. An extensive area of post-infarction necrosis impairs heart functioning as a blood pumping organ what leads to its failure. Researchers are still searching for a therapy that would replace large areas of dead cardiomyocytes with new cells, and thus potentially minimize the negative effects of myocardial necrosis and postpone the impairment of its function. Due to their properties, it seems a good idea to introduce stem cells as a method of treatment, hence many studies are conducted to demonstrate the effectiveness of these cells in the treatment of cardiac patients. This paper presents a literature review of stem cell applications in the aforementioned cardiac diseases, taking into account the obtained results.
Źródło:
World Scientific News; 2018, 93; 92-99
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stem cells in dentistry - review of literature
Autorzy:
Dziubinska, P.
Jaskolska, M.
Przyborowska, P.
Adamiak, Z.
Powiązania:
https://bibliotekanauki.pl/articles/30886.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
Stem cells have been successfully isolated from a variety of human and animal tissues, including dental pulp. This achievement marks progress in regenerative dentistry. This article reviews the latest improvements made in regenerative dental medicine with the involvement of stem cells. Although, various types of multipotent somatic cells can be applied in dentistry, two types of cells have been investigated in this review. Dental pulp cells are classified as: DPSCs, SCAPs and SHEDs.The third group includes two types of cell associated with the periodontium: PDL and DFPC. This review aims to systematize basic knowledge about cellular engineering in dentistry.
Źródło:
Polish Journal of Veterinary Sciences; 2013, 16, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stem cells are the hope of modern stomatology
Autorzy:
Gabiec, K.
Wyrzykowska, K.
Dąbrowska, Z.
Antoniak, M.
Dąbrowska, E.
Powiązania:
https://bibliotekanauki.pl/articles/1918468.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Stem cells
stomatology
Opis:
Introduction: Stem cells are often hailed as the medicine of the 21st century. They provide us with potential tools to effectively counteract not only diseases, but even aging. For stomatology, stem cells are the technology of the future in the regeneration of the periodontium and pulp, and dental replantation and transplantation. Materials and methods: On the basis of a literature review, the previous achievements and potential capabilities of stem cell therapy were discussed, focusing on dental applications. Conclusions: The paper discusses the modulation of stem cells and their therapeutic potential and capabilities. The presence and properties of stem cells in the pulp of human deciduous and permanent teeth, the periodontal membrane and the dental sac are also discussed. The results of the studies conducted by the cited researchers are promising and give hope for the development of regenerative and restorative processes of the dental and periodontal tissues. Summary: In the future, stem cells obtained from primary and permanent teeth deposited in special dental banks will be able to prevent the degradation of periodontal tissue, or even heal the teeth.
Źródło:
Progress in Health Sciences; 2017, 7(1); 175-181
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Komórki macierzyste w neurologii
Stem cells in neurology
Autorzy:
Gójska, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1058918.pdf
Data publikacji:
2008
Wydawca:
Medical Communications
Tematy:
cell therapy
nervous system
neurogenesis
progenitor cells
stem cells
komórki macierzyste
komórki progenitorowe
neurogeneza
terapia komórkowa
układ nerwowy
Opis:
Human brain is a very complex biological system considering its cytoarchitecture, neuronal network, localisation of functional regions and integration. Until second half of the XX century it was believed that CNS is deprived of regenerative processes. At present there are many studies that confirm constant formation of new neurones in the human brain. However, this process of cell exchange is far less effective in comparison with the regeneration and functional renewal of other tissues of our organism. In the following article we present current data on local neurogenesis in the adult brain. There are at least 3 regions of CNS where cell proliferembrioation takes place: subventricular zone – SVZ, subgranular zone – SGZ and posterior periventricular area – PPv. It has been estimated that single radial glial cell, which is the progenitor of cells residing in the aforementioned regions of the brain, would be enough to form 4×107 of new brains. Other tissues of our organism could become another source of stem cells for brain regeneration. This solution is tempting when we consider a theory of peripheral blood stem cells that reside in different organ niches. Injured tissue produces higher amounts of chemokines such as SDF-1 or LIF that causes increased migration of stem cells towards the “calling- for-help” organ. The last part of the article presents the progress that has been made in regeneration therapies of certain neurological disorders: cerebral stroke, Parkinson’s disease, multiple sclerosis, spinal cord injuries, amyotrophic lateral sclerosis, Huntigton’s disease and Alzheimer’s disease.
Mózg człowieka jest bardzo skomplikowanym biologicznym systemem pod względem cytoarchitektury, sieci neuronalnej, lokalizacji ośrodków funkcjonalnych oraz integracji. Do drugiej połowy XX wieku panował pogląd, że po okresie rozwoju OUN jest pozbawiony jakiejkolwiek zdolności regeneracyjnej. Istnieje obecnie wiele badań potwierdzających fakt, iż w dorosłym mózgu ludzi ma miejsce ciągły proces tworzenia się nowych neuronów, chociaż oczywiście proces wymiany komórek ośrodkowego układu nerwowego prezentuje się nie najlepiej w porównaniu z regeneracją i funkcjonalną odnową, które mają miejsce w innych organach naszego organizmu. W poniższym artykule przedstawione zostały aktualne dane dotyczące miejscowej neurogenezy w dojrzałym mózgu. W mózgu człowieka znajdują się przynajmniej 3 obszary, gdzie mają miejsce procesy proliferacji komórkowej: strefa przykomorowa (subventricularzone, SVZ), strefa przyziarnista (subgranularzone, SGZ), oraz tylna strefa okołokomorowa (posterior periventricular area, PPv). Wyliczono, że pojedyncza komórka gleju radialnego, której mitotyczni potomkowie rezydują w wymienionych strefach rozrodczych, wystarczyłaby do utworzenia 4x107 mózgów. Innym źródłem odnowy dla mózgu mogłyby stać się komórki macierzyste pozyskiwane z innych tkanek naszego organizmu. Takie rozwiązanie znajduje swoje uzasadnienie w ramach teorii o krążących w krwi obwodowej komórkach macierzystych zasiedlających poszczególne nisze narządowe. Znacznie upraszczając, uszkodzony narząd wydziela zwiększoną ilość chemoatraktantów, takich jak SDF-1 czy LIF, i tym przyciąga do siebie zwiększoną ilość komórek macierzystych. W dalszej części artykułu przedstawiono postęp, jaki dokonał się w terapiach regeneracyjnych w przypadku niektórych schorzeń neurologicznych: udaru mózgu, choroby Parkinsona, stwardnienia rozsianego, urazów rdzenia, stwardnienia zanikowego bocznego, choroby Huntingtona oraz choroby Alzheimera.
Źródło:
Aktualności Neurologiczne; 2008, 8, 1; 39-48
1641-9227
2451-0696
Pojawia się w:
Aktualności Neurologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adult stem cells: hopes and hypes of regenerative medicine
Autorzy:
Dulak, Józef
Szade, Krzysztof
Szade, Agata
Nowak, Witold
Józkowicz, Alicja
Powiązania:
https://bibliotekanauki.pl/articles/1038957.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
embryonic stem cells
induced pluripotent stem cells
myocardial infarction
very small embryonic-like stem cells
heme oxygenase-1
Opis:
Stem cells are self-renewing cells that can differentiate into specialized cell type(s). Pluripotent stem cells, i.e. embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC) differentiate into cells of all three embryonic lineages. Multipotent stem cells, like hematopoietic stem cells (HSC), can develop into multiple specialized cells in a specific tissue. Unipotent cells differentiate only into one cell type, like e.g. satellite cells of skeletal muscle. There are many examples of successful clinical applications of stem cells. Over million patients worldwide have benefited from bone marrow transplantations performed for treatment of leukemias, anemias or immunodeficiencies. Skin stem cells are used to heal severe burns, while limbal stem cells can regenerate the damaged cornea. Pluripotent stem cells, especially the patient-specific iPSC, have a tremendous therapeutic potential, but their clinical application will require overcoming numerous drawbacks. Therefore, the use of adult stem cells, which are multipotent or unipotent, can be at present a more achievable strategy. Noteworthy, some studies ascribed particular adult stem cells as pluripotent. However, despite efforts, the postulated pluripotency of such events like "spore-like cells", "very small embryonic-like stem cells" or "multipotent adult progenitor cells" have not been confirmed in stringent independent studies. Also plasticity of the bone marrow-derived cells which were suggested to differentiate e.g. into cardiomyocytes, has not been positively verified, and their therapeutic effect, if observed, results rather from the paracrine activity. Here we discuss the examples of recent studies on adult stem cells in the light of current understanding of stem cell biology.
Źródło:
Acta Biochimica Polonica; 2015, 62, 3; 329-337
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adipose-derived stem cells: a review of osteogenesis differentiation
Autorzy:
Skubis, Aleksandra
Sikora, Bartosz
Zmarzły, Nikola
Wojdas, Emilia
Mazurek, Urszula
Powiązania:
https://bibliotekanauki.pl/articles/764811.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
mesenchymal stem cells
regenerative medicine
adipose tissue
Opis:
Komórki macierzyste to komórki posiadające zdolność nieograniczonych podziałów oraz umiejętność do wielokierunkowego różnicowania. Mezenchymalne komórki macierzyste (MSC) to somatyczne komórki występujące w tkankach i narządach dorosłego organizmu takich jak: szpik kostny, tkanka tłuszczowa oraz mięśnie. Ulegają one różnicowaniu w kierunku komórek pochodzących z jednego listka zarodkowego jakim jest mezoderma. To pozwala na wykorzystanie ich w regeneracji chrząstki, kości lub wypełnienia ubytków tkanką tłuszczowa między innymi w chirurgi plastycznej. Obecnie głównym źródłem z którego pozyskiwano MSC był szpik kostny, jednak coraz szersze zastosowanie wykazuje tkanka tłuszczowa. Komórki z niej pochodzące wykazują takie same właściwości jak te pochodzące z szpiku kostnego, a procedura izolacji jest dużo mniej inwazyjna dla pacjenta. Bardzo często natomiast ich ilość jest nieporównywanie większa. Stąd też niniejsza praca porusza  temat wykorzystania MSC z tkanki tłuszczowej w regeneracji tkanki kostnej.
This review article provides an overview on adipose-derived stem cells (ADSCs) for implications in bone tissue regeneration. Firstly this article focuses on mesenchymal stem cells (MSCs) which are object of interest in regenerative medicine. Stem cells have unlimited potential for self-renewal and develop into various cell types. They are used for many therapies such as bone tissue regeneration. Adipose tissue is one of the main sources of mesenchymal stem cells (MSCs). Regenerative medicine intends to differentiate ADSC along specific lineage pathways to effect repair of damaged or failing organs. For further clinical applications it is necessary to understand mechanisms involved in ADSCs proliferation and differentiation. Second part of manuscript based on osteogenesis differentiation of stem cells. Bones are highly regenerative organs but there are still many problems with therapy of large bone defects. Sometimes there is necessary to make a replacement or expansion new bone tissue. Stem cells might be a good solution for this especially ADSCs which manage differentiate into osteoblast in in vitro and in vivo conditions.
Źródło:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2016, 12; 38-47
1730-2366
2083-8484
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of substrate stiffness on differentiation of umbilical cord stem cells
Autorzy:
Witkowska-Zimny, Małgorzata
Walenko, Katarzyna
Wałkiewicz, Anna
Pojda, Zygmunt
Przybylski, Jacek
Lewandowska-Szumieł, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/1039745.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
substrate stiffness
osteogenic differentiation
umbilical cord mesenchymal stromal/stem cells
Opis:
Tissue formation and maintenance is regulated by various factors, including biological, physiological and physical signals transmitted between cells as well as originating from cell-substrate interactions. In our study, the osteogenic potential of mesenchymal stromal/stem cells isolated from umbilical cord Wharton's jelly (UC-MSCs) was investigated in relation to the substrate rigidity on polyacrylamide hydrogel (PAAM). Osteogenic differentiation of UC-MSCs was enhanced on stiff substrate compared to soft substrates, illustrating that the mechanical environment can play a role in differentiation of this type of cells. These results show that substrate stiffness can regulate UC-MSCs differentiation, and hence may have significant implications for design of biomaterials with appropriate mechanical properties for regenerative medicine.
Źródło:
Acta Biochimica Polonica; 2012, 59, 2; 261-264
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Potential therapeutic application of mesenchymal stem cells in COVID-19 complications
Autorzy:
Kolanko, Emanuel
Mazurski, Adam
Czekaj, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/2108204.pdf
Data publikacji:
2021-12-22
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
occupational diseases
mesenchymal stem cells
cell therapy
complementary therapy
COVID-19
SARS-CoV-2 mutations
Opis:
Mesenchymal stem cells (MSCs) have remarkable immunomodulatory properties, low immunogenicity, and paracrine properties as well as the ability to differentiate into multiple cell lines. These properties make them potential candidates for clinical applications in the treatment of neurodegenerative, cardiovascular, and lung diseases, which may be occupational diseases. Preclinical studies using experimental animal models have demonstrated regenerative properties of MSCs in diseases such as silicosis and occupational asthma. Currently, treatment of the novel disease COVID-19 could be enhanced by using MSC therapies. This disease affects many professional groups with great intensity and its consequences might be considered as an occupational disease. It is a significant public health problem and a therapeutic challenge. Despite the development of vaccines against COVID-19, there is growing concern about the emergence of new mutations of the SARS-CoV-2 virus in addition to the known alpha, beta, gamma, and delta variants. There is still no effective COVID-19 treatment and the existing ones only play a supporting role. MSCs offer treatment possibilities as an alternative or complementary therapy. The clinical trials to date using MSCs in patients with COVID-19 give hope for the safe and effective use of this stem cell population.
Źródło:
Medycyna Pracy; 2021, 72, 6; 693-700
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characterization of mesenchymal stem cells and their application in experimental embryology
Autorzy:
Opiela, J.
Samiec, M.
Powiązania:
https://bibliotekanauki.pl/articles/31919.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
The efficiency of somatic cell cloning (somatic cell nuclear transfer; SCNT) as well as in vitro fertilization/in vitro embryo production (IVF/IVP) in mammals stay at relatively same level for over a decade. Despite plenty of different approaches none satisfactory break-through took place. In this article, we briefly summarize the implementation of mesenchymal stem cells (MSCs) for experimental embryology. The advantages of using MSCs as nuclear donors in somatic cell cloning and in vitro embryo culture are described. The description of results obtained with these cells in mammalian embryo genomic engineering is presented.
Źródło:
Polish Journal of Veterinary Sciences; 2013, 16, 3
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stem cells and their derivatives – hopes and challenges in regenerative medicine
Autorzy:
Zuba-Surma, E. K.
Powiązania:
https://bibliotekanauki.pl/articles/284472.pdf
Data publikacji:
2014
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
regenerative medicine
tissue engineering
biomaterials
Opis:
Major goals of contemporary regenerative medicine focus on improvement of irreversible damage of multiple organs and tissues by employing several approaches including recent achievements of cellbased therapies and tissue engineering. Several types of stem cells (SCs) such as bone marrow (BM)- derived mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs) as well as SCs with multi- and pluripotent characteristics (PSCs) have been postulated as potential source of cells for therapy. Recently, embryonic stem cells (ESCs) and so called induced pluripotent stem cells (iPS cells) representing “genetically induced” SCs with high differentiation potential, have brought great hope to the field of regenerative medicine and clinical applications. When combined with modern accomplishments of tissue engineering including biocompatible carriers and scaffolds, SCs become leading targets for cell -based regenerative applications. Although the variety of stem/ progenitor cells have been applied in experimental therapies of several organs injuries, there is still no agreement in scientific and clinical world which subpopulation/s of cells would be the most efficient in such treatment. Moreover, multiple obstacles needs to be overcome prior to optimal application of SCs in regeneration including optimization of ex vivo isolation and expansion conditions or limiting vast adverse features of some SC fractions such as teratogenic potential of ESCs and iPS cells. Recently, stem cell- derived bioactive components such as cellular microvesicles (MVs) are postulated to play important role in mediating SC activity following transplantation. MVs representing bioactive components carrying SC- derived transcripts (mRNA, miRNA), proteins, enzymes and receptors may participate in tissue regeneration via stimulation of endogenous repair mechanism by activating endogenous target cells in damaged organs. Thus, the newest trends in regenerative medicine would focus not only on combined applications of biocompatible materials with SC subpopulations, but also with their bioactive acellular components including microvesicles. Unquestionably, successful applications of stem/ progenitor cells and their derivatives in regenerative medicine would need to be safe, ethically acceptable and therapeutically efficient. Sources and application protocols for such optimal stem cell therapy are still being optimized and need scientific discussion.
Źródło:
Engineering of Biomaterials; 2014, 17, no. 128-129; 102
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Krótki przegląd na temat komórek macierzystych
A short overview of stem cells
Autorzy:
Kmiecik, B.
Skotny-Krakowian, A.
Rybak, Z.
Powiązania:
https://bibliotekanauki.pl/articles/261099.pdf
Data publikacji:
2015
Wydawca:
Politechnika Wrocławska. Wydział Podstawowych Problemów Techniki. Katedra Inżynierii Biomedycznej
Tematy:
embrionalne komórki macierzyste
indukowane pluripotencjalne komórki macierzyste
mezenchymalne komórki macierzyste
embryonic stem cells
induced pluripotent stem cells
mesenchymal stem cells
Opis:
Wykorzystanie komórek macierzystych może mieć duży potencjał w medycynie. Stale jednak toczą się debaty, jakie rodzaje komórek macierzystych powinny być w przyszłości wykorzystywane w celach regeneracyjnych. W poniższej pracy dokonano porównania embrionalnych, indukowanych pluripotencjalnych i somatycznych komórek macierzystych. Jednak, by bezpiecznie wykorzystywać komórki macierzyste do regeneracji ciała ludzkiego, należy jeszcze dokładniej poznać mechanizmy ich działania. Z tego powodu Amerykańska Agencja ds. Żywności i Leków (FDA) już w 2006 roku zdecydowała się na opracowanie procedur, które mają zapewnić bezpieczeństwo pacjentom korzystającym z terapii opartych na komórkach macierzystych.
Applications of stem cells has a huge medical potential. However, among scientists there is an ongoing debate, concerning which stem cells should be used in the future for regeneration purposes. This paper presents a comparison of embryonic, induced pluripotent, and somatic stem cells. Gaining a better understanding of the molecular functioning of stem cells will probably lead to more efficient treatment methods for many incurable diseases. For this reason, American agency for Food and Drug Administration (FDA) established some general procedures, which, to some degree, should ensure the safety of experimental stem cell therapies.
Źródło:
Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna; 2015, 21, 1; 40-45
1234-5563
Pojawia się w:
Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Utilization of graphenebased materials and mesenchymal stem cells in regenerative medicine
Autorzy:
Sekuła-Stryjewska, Małgorzata
Noga, Sylwia
Byrska, Aleksandra
Pabis, Marta
Lelek, Joanna
Jagiełło, Joanna
Madeja, Zbigniew
Lipińska, Ludwika
Zuba-Surma, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/284357.pdf
Data publikacji:
2019
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Źródło:
Engineering of Biomaterials; 2019, 22, no.153; 55
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stem cells and their derivatives – current perspectives in tissue engineering and regeneration
Autorzy:
Zuba-Surma, E.
Powiązania:
https://bibliotekanauki.pl/articles/283888.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
cells
tissue engineering
regeneration
Opis:
Several current approaches in tissue and organ regeneration focus on applications of recent achievements of cell-based therapies and biomaterial sciences. Such combined approaches relying on both components such as stem cells (SCs) with high regenerative potential and new biocompatible scaffolds opens new opportunities in tissue engineering and injured organ treatment. Several types of SCs with multi- and pluripotent characteristics such as mesenchymal stem cells (MSCs) of various origin and induced pluripotent SCs (iPSCs) have been indicated as potential source of cells for therapy. When combined with optimized biocompatible carriers and scaffolds, such SC fractions become leading targets for cell-based regenerative applications in several tissue injuries. Although such SC populations have been employed in experimental therapies of several organs injuries as well as in clinical studies, there is still discussion which subpopulation/s would be the most efficient and safe for therapies in humans. The selection of the optimal cell population for tissue regeneration would include predominantly safety aspects as well as major mechanisms of action critical for a specific tissue repair that are provided by specific SC population. Such mechanisms of SC activity includes extracellular vesicles (EVs) release. Such stem cell derivatives may modulate endogenous cell functions in place of transplantation by transferring several bioactive SC- derived molecules including proteins and transcripts. Thus, the newest trends in tissue regeneration would focus not only on combined applications of biocompatible materials with selected and optimized SC fractions, but also with their bioactive derivatives such as EVs. However, successful applications of SCs and their derivatives in regenerative medicine requires safety, ethical acceptance and therapeutic efficacy, which still need further investigations and optimization.
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 39
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Titania nanotubes as scaffolds with optimal nanotopography for adipose-derived stem cells
Autorzy:
Radtke, Aleksandra
Ehlert, Michalina
Piszczek, Piotr
Roszek, Katarzyna
Jędrzejewski, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/285262.pdf
Data publikacji:
2019
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Źródło:
Engineering of Biomaterials; 2019, 22, no.153; 49
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Factors governing the differentiation of stem cells in tissue engineering - a review
Autorzy:
Bacakova, Lucie
Powiązania:
https://bibliotekanauki.pl/articles/1844841.pdf
Data publikacji:
2021
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Źródło:
Engineering of Biomaterials; 2021, 24, 163; 8
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stem cells and their outstanding concerns
Komórki macierzyste i ich możliwości zastosowania terapeutycznego
Autorzy:
Lukomska, B.
Powiązania:
https://bibliotekanauki.pl/articles/9895.pdf
Data publikacji:
2012
Wydawca:
Okulistyka Weterynaryjna
Tematy:
stem cell
embryonic stem cell
fetal stem cell
adult stem cell
induced pluripotent stem cell
hematopoietic stem cell
mesenchymal stromal cell
veterinary medicine
Opis:
Stem cells have captured considerable scientific and clinic interest because of their potential to renew themselves and to differentiate into one or more adult cell types. Thus stem cells have been recognized as a potential tool for the development of innovative therapeutic strategies in different disease disorders. Stem cells can be discriminating based on their differentiated potential as totipotent, pluripotent, multipotent or unipotent cells. There are in general three types of stem cells: embryonic, fetal and adult stem cells. While embryonic stem cell therapy has a lot of ethical concerns due to their obtaining but also unlimited proliferation and uncontrolled differentiation, fetal and adult stem cells have been used in the treatment of different diseases. The bone marrow, peripheral blood and umbilical cord blood are ideal sources of adult stem cells because there are easily accessible and contain two types of stem cells: hematopoietic stem cells giving rise to all blood cell types and mesenchymal stem cells differentiating into cells of mesodermal lineage. This review describes the general characteristics of these stem cell populations and their current applications in regenerative medicine. Additionally induced pluripotent stem cells generated through the reprogramming of differentiated adult cells are described.
Możliwość wspomagania regeneracji nieodwracalnie uszkodzonych tkanek i narządów za pomocą transplantacji komórek macierzystych skupia uwagę środowisk medycznych i opinii publicznej. Komórki macierzyste mają zdolność do samo-odnowy oraz do różnicowania się w dojrzałe komórki struktur całego organizmu. Na określonych etapach rozwoju osobniczego wykazują różny stopień ograniczenia potencjału do dalszego różnicowania, od komórek totipotencjalnych (zygota), poprzez pluripotencjalne (komórki zarodkowe) do multipotencjalnych lub unipotencjalnych (komórki somatyczne). Zarodkowe komórki macierzyste, z uwagi na nieograniczone zdolności namnażania i pluripotencjalność wydają się najbardziej optymalne do zastosowania w terapiach regeneracyjnych, lecz zastrzeżenia natury etyczno-moralnej pozyskiwania tych komórek, a także możliwość ich niekontrolowanej proliferacji po przeszczepieniu w organizmie biorcy skłoniły badaczy do poszukiwania alternatywnych źródeł komórek macierzystych, jakimi są tkanki dojrzałego organizmu. Badania ostatnich lat wykazały, iż w dojrzałych tkankach somatycznych znajdują się pluripotencjalne komórki macierzyste, co więcej odkrycia Takahashi i Yamanaka w roku 2006 r udokumentowały możliwość przekształcenia zróżnicowanych komórek izolowanych od osobników dorosłych w komórki pluripotencjalne. Zainicjowanie nowatorskich metod badawczych, których celem będzie opracowanie skutecznych sposobów przeszczepiania somatycznych komórek macierzystych w celach regeneracyjnych jest nadzieją w terapii wielu nieuleczalnych schorzeń.
Źródło:
Okulistyka Weterynaryjna. e-kwartalnik dla lekarzy i studentów weterynarii; 2012, 1
2082-9256
Pojawia się w:
Okulistyka Weterynaryjna. e-kwartalnik dla lekarzy i studentów weterynarii
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Komórki macierzyste – możliwość ich wykorzystania do regeneracji tkanek
Stem cells and tissue regeneration
Autorzy:
Nowicka, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/1817715.pdf
Data publikacji:
2005-12-31
Wydawca:
Uniwersytet Kardynała Stefana Wyszyńskiego w Warszawie
Tematy:
komórki macierzyste
zarodkowe komórki macierzyste
regeneracja
stem cells
embryo stem cells
regeneration
Opis:
Rozwój nauk biologicznych przyczynia się do lepszego poznania procesów związanych z rozwojem i działaniem różnych organizmów, w tym organizmu człowieka, a jednym z efektów postępu naukowego w tym zakresie jest opracowywanie coraz doskonalszych metod diagnozowania i leczenia chorób. Ostatnio szczególne zainteresowanie wśród naukowców i lekarzy wzbudzają komórki macierzyste. Celem badań komórek macierzystych jest poznanie mechanizmów kierujących procesami tworzenia i rozwoju komórek, tkanek i narządów, a także opracowanie metod ich wykorzystania do regeneracji uszkodzonych tkanek i narządów np. do regeneracji mięśnia sercowego uszkodzonego w czasie zawału lub komórek trzustki, które utraciły zdolność produkcji insuliny (co leży u podstaw rozwoju cukrzycy typu I), komórek nerwowych, które utraciły zdolność syntezy dopaminy (co wiąże się z rozwojem choroby Parkinsona)
Stem cells there are undifferentiated, primitive cells with ability to differentiate into specific kinds of cells. Stem cell research has a history of more than 20 years and has made an outstanding contribution to our understanding of haematopoiesis and embryology. Stem cells hold the promise of allowing researchers to grow specialized cells or tissue, which could be used for treatment of injured tissues. Development of this area depends on the results of ethical debate over stem cel research, which is controversial, because the most powerful human stem cells there are embryonic stem cells. Adult bone marrow has been found as an important source of adult stem cells. Adult stem cells have been used in animal and human studies for tissue regeneration. The utility of stem cell transplantation for the treatment of acute myocardial infarction to repair of injured myocardium has been shown.
Źródło:
Studia Ecologiae et Bioethicae; 2005, 3, 1; 109-115
1733-1218
Pojawia się w:
Studia Ecologiae et Bioethicae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prospects for the use of the achievements of regenerative medicine in otorhinolaryngology
Autorzy:
Ciechanowicz, Andrzej K
Powiązania:
https://bibliotekanauki.pl/articles/1400044.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
regenerative medicine
pluripotent stem cells
embryonic stem cells
very small embryonic-like stem cells
tissue engineering
Opis:
Regenerative medicine is focusing on searching for stem cells, which can be efficiently and safely used for regeneration of damaged tissues and organs. Pluripotent stem cells would be ideal for this purpose. It is because they have the ability to differentiate into cells of all three germ layers (ecto-, meso- and endoderm). One of the sources of their isolation are embryos. For many years, they are made unsuccessful attempts to use of very controversial embryonic stem cells that are isolated from embryos. So strong ethical controversy forced scientists to look for other, undoubted ethically, sources of pluripotent stem cells. Induced pluripotent stem cells are proposed, as a more promising alternative to cells isolated from embryos. Unfortunately, both embryonic stem cells and induced pluripotent stem cells tend to genetic instability leading to the formation of teratomas. In parallel studies scientists try to use of stem cells isolated from adult tissues (e.g. bone marrow cells or adipose tissue) in the regeneration of parenchymal organs. Unfortunately, there is no convincing evidence for most of these cells that can regenerate damaged parenchymal organs. Regenerative medicine more frequently is employed in the otorhinolaryngological therapies. More and more researchers’ efforts are put into the development of an effective method of stimulation (in vitro) of pluripotent stem cells isolated from adult tissue for differentiation of the renewable progenitor stem cells which can keep their potential after transplantation into the recipient (e.g. in the treatment of imbalances or hearing loss). Moreover, there are promising methods for employing of the stem cells potential in tissue engineering as they are more effectively introduced as a clinical therapies.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2017, 6, 1; 1-7
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Phenotypic characteristics of feline adipose-derived stem cells affected by cell passage number
Autorzy:
Panasophonkul, S.
Samart, P.
Kongon, K.
Sathanawongs, A.
Powiązania:
https://bibliotekanauki.pl/articles/2087880.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
adipose-derived stem cell
feline
phenotypic characteristic
cell passage number
Źródło:
Polish Journal of Veterinary Sciences; 2017, 4; 651-660
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stem cells in diabetes – will implementing interdisciplinary online collaboration help to dispel ethical resistance?
Autorzy:
Kozłowska, Ewa
Grabowska, Anna
Deutsch, Nellie
Powiązania:
https://bibliotekanauki.pl/articles/1844784.pdf
Data publikacji:
2021
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Źródło:
Engineering of Biomaterials; 2021, 24, 163; 68
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stem cell biology - a never ending quest for understanding.
Autorzy:
Majka, Marcin
Kucia, Magdalena
Ratajczak, Mariusz
Powiązania:
https://bibliotekanauki.pl/articles/1041413.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
stem cells
TCSC
plasticity
Opis:
Stem cells (SC) research is an important part of biotechnology that could lead to the development of new therapeutic strategies. A lot of effort has been put to understand biology of the stem cells and to find genes and subsequently proteins that are responsible for their proliferation, self-renewal and differentiation. Different cytokines and growth factors has been used to expand stem cells, but no combination of these factors was identified that could effectively expand the most primitive stem cells. Recently, however, genes and receptors responsible for SC proliferation and differentiation have been described. Ligands for these receptors or these genes themselves are being already used for ex vivo expansion of stem cells and the first data are very promising. New markers, such as CXCR4 and CD133, have been discovered and shown to be present on surface of hematopoietic stem cells. The same markers were recently also found to be expressed on neuronal-, hepatic- or skeletal muscle-stem cells. By employing these markers several laboratories are trying to isolate stem cells for potential clinical use. New characteristics of stem cells such as transdifferentiation and cell fusion have been described. Our team has identified a population of tissue committed stem cells (TCSC). These cells are present in a bone marrow and in other tissues and they can differentiate into several cell types including cardiac, neural and liver cells.
Źródło:
Acta Biochimica Polonica; 2005, 52, 2; 353-358
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of short moderate exercise on hematological parameters and stem cells in healthy humans
Autorzy:
Sochoń, K.
Sienkiewicz, D.
Okurowska-Zawada, B.
Paszko-Patej, G.
Wojtkowski, J.
Dmitruk, E.
Żak, J
Kułak, W.
Powiązania:
https://bibliotekanauki.pl/articles/1918279.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Exercise
healthy subjects
stem cells
Opis:
Introduction: Exercise at various durations and intensities impact on blood and stem cells. This pilot study examined the effects of 30 minutes of treadmill walking on hematological indices and progenitor stem cells CD34+ in healthy subjects. Materials and methods: A total of 17 non-smoking, healthy students, aged 20 to 22 years participated. Hemoglobin, hematocrit, white blood cells, platelets, and stem cell CD34+ numbers were assessed before and after moderate exercise. Statistical analyses examined the relationships between CD34+ cells versus hematological indices, age, and body mass index. Results: Following exercise, significant increases were observed in leukocytes, neutrophils, eosinophils, and CD34+ cells numbers. For CD34+ cells, a fourfold increase was seen. Significant correlations between CD34+ cells, white blood cells, and neutrophils were found. Conclusion: Our results suggest that moderate exercise has a physiological impact on hematologic parameters and stem cells CD34+ in healthy subjects. Furthermore, our findings suggest that brief treadmill exercise may enhance tissue repair mechanisms so important in physiotherapy.
Źródło:
Progress in Health Sciences; 2016, 6(2); 184-187
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
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